Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 7, 1998, Pages 2411-2416

  Liddle, Christopher ^a,b,c   Goodwin, Bryan J ^a   George, Jacob ^a   Tapner, Michael ^a   Farrell, Geoffrey C ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

^c Gastroenterological Soc Australia ^*

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; GROWTH HORMONE; LIOTHYRONINE; MESSENGER RNA; OXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENDOCRINE DISEASE; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HUMAN; HUMAN CELL; LIVER CELL; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEROID METABOLISM;

CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; GLUCOCORTICOIDS; GROWTH HORMONE; HUMANS; LIVER; MIXED FUNCTION OXYGENASES; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; TRIIODOTHYRONINE;

EID: 0031785886     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.7.2411     Document Type: Article

References (46)

1. Fishman J, Hellman L, Zumoff B, Gallagher TF. 1965 Effect of thyroid on hydroxylation of estrogen in man. J Clin Endocrinol Metab. 25:365-368.
2. Ruder H, Corval P, Mahoudeah JA, Ross GT, Lipsett MB. 1971 Effects of induced hyperthyroidism on steroid metabolism in man. J Clin Endocrinol Metab. 33:382-387.
3. Yamagi T, Motohashi K, Murakawa S, Ibayashi H. 1969 Urinary excretion of 6β-hydroxycortisol in states of altered thyroid function. J Clin Endocrinol Metab. 29:801-806.
4. Watkins PB, Wrighton SA, Maurel P, el al. 1985 Identification of an inducible form of cytochrome P-450 in human liver. Proc Natl Acad Sci USA. 82:6310-6314.
5. Watkins PB, Murray SA, Winkelman LG, Heuman DM, Wrighton SA, Guzelian PS. 1989 Erythromycin breath test as an assay of glucocorticoid-inducible liver P-450. J Clin Invest. 83:688-697.
6. Redmond GP, Bell JJ, Nichola PS, Perel JM. 1980 Effect of growth hormone on human drug metabolism. Pediatr Pharmacol. 1:63-70.
7. Levitsky LL, Scholler DA, Lambert GH, Edidin DV. 1989 Effect of growth hormone therapy in growth hormone deficient children on P450 demethylation of caffeine. Dev Pharmacol Ther. 12:90-95.
8. Cheung NW, Liddle C, Coverdale S, Lou JC, Boyages SC. 1995 Growrh hormone treatment increases cytochrome P450-mediated antipyrine clearance in man. J Clin Endocrinol Metab. 81:1999-2001.
9. Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. 1994 Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther. 270:414-423.
10. Kronbach T, Fisher V, Meyer UA. 1988 Cyclosporin metabolism in human liver: identification of a P450 3 gene as the major cyclosporin metabolizing enzyme. Clin Pharmacol Ther. 43:630-635.
11. Kronbach T, Mathys D, Umeno M, Gonzalez FJ, Meyer UA. 1989 Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Mol Pharmacol. 36:89-96.
12. Brian WR, Sari M-A, Iwasaki M, Shimada T, Kaminsky LS, Guengerich FP. 1990 Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in saccharomyces cerevisiae. Biochemistry. 29:11280-11292.
13. Bargetzi MJ, Aoyama T, Gonzalez FJ, Meyer UA. 1989 Lignocaine metabolism in human liver microsomes by cytochrome P4501IIA4. Pharmacol Ther. 46:521-527.
14. Guengerich FP, Brian WR, Iwasaki M, Sari M-A, Bäämhielm C, Berntsson P. 1991 Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4. J Med Chem. 34:1838-1844.
15. Waxman DJ, Lapenson DP, Aoyama T, Gelboin HV, Gonzalez FJ, Korzekwa K. 1991 Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochromes P450s. Arch Biochem Biophys. 290:160-166.
16. Aoyama T, Korzekwa K, Nagata K, Gillette J, Gelboin HV, Gonzalez FJ. 1990 Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s. Endocrinology. 126:3101-3106.
17. Waxman DJ, Ram PA, Notani G, et al. 1990 Pituitary regulation of the male-specific steroid 6β-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Mol Endocrinol. 4:447-454.
18. Gonzalez FJ, Song B-J, Hardwick JP. 1986 Pregnenolone 16α-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation. Mol Cell Biol. 6:2969-2976.
19. Strom SC, Jirtle RL, Jones RS, et al. 1982 Isolation, culture, and transplantation of human hepatocytes. J Natl Cancer Inst. 68:771-778.
20. George J, Good win B, Liddle C, Tapner M, Farrell GC. 1997 Time-dependant expression of cytochrome P450 genes in primary cultures of well-differentiated human hepatocytes. J Lab Clin Med. 129:638-648.
21. Kleinman HK, McGarvey ML, Hassell JR, Star VL, Canon FB, Laurie GW, Martin GR. 1986 Basement membrane complexes with biological activity. Biochemistry. 25:312-318.
22. Liddle C, Mode A, Legraverend C, Gustafsson J-A. 1992 Constitutive expression and hormonal regulation of male sexually differentiated cytochromes P450 in primary cultured rat hepatocytes. Arch Biochem Biophys. 298:159-166.
23. Melton DA, Krieg PA, Rebagliati MR, Maniatis T, Zinn K, Green MR. 1984 Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12:7035-7056.
24. Le Bouc Y, Dreyer D, Jaeger F, Binoux M, Sondermeyer P. 1986 Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library. FEBS Lett. 196:108-112.
25. George J, Liddle C, Murray M, Byth K, Farrell GC. 1995 Pretranslational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis. Biochem Pharmacol. 49:873-881.
26. Goodwin B, Liddle C, Murray M, Tapner M, Rooney T, Farrell GC. 1996 Effects of metyrapone on expression of CYPs 2C11, 3A2, and other 3A genes in rat hepatocytes cultured on matrigel. Biochem Pharmacol. 52:219-227.
27. Cantrill E, Murray M, Mehta I, Farrell GC. 1989 Down regulation of the male-specific hepatic microsomal steroid 16α-hydroxylase, cytochrome P-450UT-A, in rats with portal bypass.) Clin Invest. 83:1211-1216.
28. Waxman DJ, Ko A, Walsh C. 1983 Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver. J Biol Chem. 258:11937-11947.
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951 Protein measurement with the Folin reagent. J Biol Chem. 193:265-275.
30. Labarca C, Paigen K. 1980 A simple rapid, and sensitive DNA assay procedure. Anal Biochem. 102:344-352.
31. George J, Byth K, Farrell GC. 1995 Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver. Biochem Pharmacol. 50:727-730.
32. Hunt CM, Westerkam WR, Stave GM. 1992 Effect of age and gender on the activity of human hepatic CYP3A. Biochem Pharmacol. 44:275-283.
33. Craig PI, Tapner M, Farrell GC. 1993 Interferon suppresses interferon metabolism in rats and humans. Hepatology. 17:230-235.
34. Bentley JB, Vaughan RW, Gandolfi AJ, Cork RC. 1982 Halothane biotransformation in obese and nonobese patients. Anesthesiology. 57:94-97.
35. Nerland DE, Mannering GJ. 1986 Species, sex and developmental differences in the O- and N-dealkylation of ethylmorphine by hepatic microsomes. Drug Met Dispos. 25:312-318.
36. Mode A, Wierema-Larsson E, Strom A, Zaphiropoulos PG, Gustafsson J-A. 1989 A dual role of growth hormone as a feminizing and masculinizing factor in the control of sex-specific cytochrome P-450 isozymes in rat liver. J Endocrinol. 120:311-317.
37. Yamazoe Y, Murayama N, Shimada M, Kato R. 1989 Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b and P-450e and other neonatal P-450S in hypophysectomized rats. Biochem Biophys Res Commun. 160:609-614.
38. Ram PA, Waxman DJ. 1990 Pretranslational control by thyroid hormone of rat liver steroid 5α-reductase and comparison to the thyroid dependance of two growth hormone-regulated CYP2C mRNAs. J Biol Chem. 265:19223-19229.
39. Waxman DJ, Morrissey JJ, Naik S, Jauregui HO. 1990 Phenobarbital induction of cytochromes P-450. Biochem J. 271:113-119.
40. Murayama N, Shimada M, Yamazoe Y, Kato R. 1991 Differences in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital-inducible P4501IB2 suppression by thyroid hormone acting directly, but not through the pituitary system. Mol Pharmacol. 39:811-817.
41. Wright K, Morgan ET. 1991 Regulation of cytochrome P450IIC12 expession by interleukin-1α, interleukin-6, and dexamethasone. Mol Pharmacol. 39:468-474.
42. Kocarek TA, Schuetz EG, Strom SC, Fisher RA, Guzelian PS. 1995 Comparitive analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. J Drug Met Dispos. 23:415-421.
43. Gu L, Gonzalez FJ, Kalow W, Tang BK. 1992 Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1. Pharmacogenetics. 2:73-77.
44. Tassaneeyakul W, Birkett DJ, McManus ME, et al. 1994 Caffeine metabolism by human hepatic cytochromes P450:contributions of 1A2, 2E1 and 3A isoforms. Biochem Pharmacol. 47:1767-1776.
45. Zhang ZY, Kaminsky LS. 1995 Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation. Biochem Pharmacol. 50:205-211.
46. Schuetz EG, Schuetz JD, Strom SC, et al. 1993 Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology. 18:1254-1262.