Pharmacokinetic/pharmacodynamic models for corticosteroid receptor down- regulation and glutamine synthetase induction in rat skeletal muscle by a receptor/gene-mediated mechanism

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 720-728

  Sun, Yu Nien ^a   McKay, Lorraine I ^a,b   Dubois, Debra C ^a   Jusko, William J ^a   Almon, Richard R ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CORTICOSTEROID RECEPTOR; GLUCOCORTICOID RECEPTOR; GLUTAMATE AMMONIA LIGASE; MESSENGER RNA; METHYLPREDNISOLONE SODIUM SUCCINATE; RECEPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; GASTROCNEMIUS MUSCLE; INTRAVENOUS DRUG ADMINISTRATION; LIPID STORAGE; MALE; MESSENGER RNA SYNTHESIS; MUSCLE ATROPHY; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; SKELETAL MUSCLE; TISSUE SPECIFICITY;

ANIMALS; COMPUTER SIMULATION; DOWN-REGULATION; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOCORTICOIDS; GLUTAMATE-AMMONIA LIGASE; MALE; METHYLPREDNISOLONE; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER;

EID: 0032988932     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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