Cd8+ T cell effector mechanisms in resistance to infection

Annual Review of Immunology

Volumn 18, Issue , 2000, Pages 275-308

  Harty, John T ^a   Tvinnereim, Amy R ^a   White, Douglas W ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

CD8+ T cells; Cytokines; Cytolysis; Infection; Pathogens

Indexed keywords

CD8 ANTIGEN; CYTOKINE; FAS ANTIGEN; NEUTRALIZING ANTIBODY; PERFORIN;

BACTERIAL INFECTION; CELL KILLING; CYTOKINE PRODUCTION; CYTOLYSIS; EFFECTOR CELL; HUMAN; INFECTION RESISTANCE; KNOCKOUT MOUSE; LYMPHOCYTE DEPLETION; NONHUMAN; PRIORITY JOURNAL; PROTOZOAL INFECTION; REVIEW; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION;

ANIMALS; ANTIGEN PRESENTATION; BACTERIAL INFECTIONS; CD8-POSITIVE T-LYMPHOCYTES; COMMUNICABLE DISEASES; HUMANS; IMMUNITY, NATURAL; MEMBRANE GLYCOPROTEINS; MICE; PORE FORMING CYTOTOXIC PROTEINS; PROTOZOAN INFECTIONS; VIRUS DISEASES;

EID: 0034097041     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.18.1.275     Document Type: Review

References (186)

1. Germain RN. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287-99
2. Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity Nature 392:245-52
3. Pamer E, Cresswell P. 1998. Mechanisms of MHC class I-restricted antigen processing. Annu. Rev. Immunol. 16:323-58
4. Jondal M, Schirmbeck R, Reimann J. 1996. MHC class I-restricted CTL responses to exogenous antigens. Immunity 5:295-302
5. Albert ML, Sauter B, Bhardwaj N. 1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86-89
6. + T cells. Science 280:227
7. Busch DH, Pilip IM, Vijh S, Pamer EG. 1998. Coordinate regulation of complex T cell populations responding to bacterial infection. Immunity 8:353-62
8. Murali-Krishna K, Altman JD, Suresh M, Sourdive DJ, Zajac AJ, Miller JD, Slansky J, Ahmed R. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177-87
9. + T cells during an acute virus infection. Immunity 8:167-75
10. Ahmed R, Gray D. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54-60
11. Oehen S, Waldner H, Kundig TM, Hengartner H, Zinkernagel RM. 1992. Anti-virally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen. J. Exp. Med. 176:1273-1
12. Lau LL, Jamieson BD, Somasundaram T, Ahmed R. 1994. Cytotoxic T-cell memory without antigen. Nature 369:648-2
13. Tough DF, Sprent J. 1996. Viruses and T cell turnover: evidence for bystander proliferation. Immunol. Rev. 150:129-2
14. Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057-62
15. Selin LK, Welsh RM. 1997. Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection. J. lmmunol. 158:5366-73
16. + memory T cells. J. Exp. Med. 186:859-65
17. Iezzi G, Karjalainen K, Lanzavecchia A. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8:89-95
18. Berke G. 1995. The CTL's kiss of death. Cell 81:9-12
19. Shresta S, Pham CT, Thomas DA, Graubert TA, Ley TJ. 1998. How do cytotoxic lymphocytes kill their targets? Curr. Opin. Immunol. 10:581-87
20. Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ. 1994. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76:977-87
21. Ebnet K, Hausmann M, Lehmann-Grube F, Mullbacher A, Kopf M, Lamers M, Simon M.M. 1995. Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J. 14:4230-39
22. + T cells to intracellular bacteria. Curr. Opin. Immunol. 11:89-93
23. Ashkenazi A, Dixit VM. 1998. Death receptors: signalling and modulation. Science 281:1305-8
24. Ploegh HL. 1998. Viral strategies of immune evasion. Science 280:248-53
25. Tewari M, Telford WG, Miller RA, Dixit VM. 1995. CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis. J. Biol. Chem. 270:22705-8
26. Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkemagel RM, Hengartner H. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37
27. Walsh CM, Matloubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL, Huang MT, Young JD, Ahmed R, Clark WR. 1994. Immune function in mice lacking the perform gene. Proc. Natl. Acad. Sci. USA 91:10854-58
28. Lowin B, Beermann F, Schmidt A, Tschopp J. 1994. A null mutation in the perform gene impairs cytolytic T lymphocyte-and natural killer cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA 91:11571-75
29. Kagi D, Ledermann B, Burki K, Zinkernagel RM, Hengartner H. 1996. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in imunological protection and pathogenesis. Annu. Rev. Immunol. 14:207-32
30. Kagi D, Seiler P, Pavlovic J, Ledermann B, Burki K, Zinkernagel RM, Hengartner H. 1995. The roles of perform-and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur. J. Immunol. 25:3256-62
31. Doherty PC. 1996. Cytotoxic T cell effector and memory function in viral Immunity Curr. Top. Microbiol. Immunol. 206:1-14
32. + T cells clear influenza virus by perform or Fas-dependent processes. J. Immunol. 159:5197-5200
33. Mullbacher A, Hla RT, Museteanu C, Simon MM. 1999. Perform is essential for control of ectromelia virus but not related poxviruses in mice. J. Virol. 73:1665-67
34. Froelich CJ, Orth K, Turbov J, Seth P, Gottlieb R, Babior B, Shah GM, Bleackley RC, Dixit VM, Hanna W. 1996. New paradigm for lymphocyte granule-mediated cytotoxicity - target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J. Biol Chem. 271:29073-79
35. Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ. 1999. Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity 10:595-605
36. Beresford PJ, Xia ZN, Greenberg AH, Lieberman J. 1999. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation. Immunity 10:585-94
37. Mullbacher A, Ebnet K, Blanden RV, Hla RT, Stehle T, Museteanu C, Simon MM. 1996. Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proc. Natl. Acad. Sci. USA 93:5783-87
38. Guidotti LG, Borrow P, Brown A, McClary H, Koch R, Chisari FV. 1999. Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte. J. Exp. Med. 189:1555-64
39. Ahmed R, Salmi A, Butler LD, Chiller JM, Oldstone MB. 1984. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160:521-40
40. Buchmeier MJ, Welsh RM, Dutko FJ, Oldstone MB. 1980. The virology and immunobiology of lymphocytic choriomeningitis virus infection. Adv. Immunol 30:275-331
41. Dethlefs S, Brahic M, Larsson-Sciard E-L. 1997. An early, abundant cytotoxic T-lymphocyte response against Theiler's virus is critical for preventing viral persistence. J. Virol. 71:8875-78
42. Cash E, Chamorro M, Brahic M. 1985. Theiler's virus RNA and protein synthesis in the central nervous sytem of demyelinating mice. Virology 144:290-94
43. Rossi CP, McAllister A, Tanguy M, Kagi D, Brahic M. 1998. Theiler's virus infection of perforin-deficient mice. J. Virol. 72:4515-19
44. Murray PD, McGavern DB, Lin X, Njenga MK, Leibowitz J, Pease LR, Rodriguez M. 1998. Perforin-dependent neurologie injury in a viral model of multiple sclerosis. J. Neurosci. 18:7306-14
45. Rodriguez M, Dunkel AJ, Thiermann RL, Leibowitz J, Zijlstra M, Jaenisch R. 1993. Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in β2-microglobulin. J. Immunol. 151:255-66
46. Gallimore A, Glithero A, Godkin A, Tissot AC, Pluckthun A, Elliott T, Hengartner H, Zinkernagel R. 1998. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I peptide complexes. J. Exp. Med. 187:1383-93
47. Marker O, Thomsen AR, Volkert M, Hansen BL, Clemmensen IH. 1985. High-dose survival in the lymphocytic choriomeningitis virus infection is accompanied by suppressed DTH but unaffeced T cell cytotoxicity. Scand. J. Immunol. 21:81-91
48. + T cells. J. Virol 64:4589-92
49. Lin MT, Stohlman SA, Hinton DR. 1997. Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis. J. Virol. 71:383-91
50. + T lymphocytes in coxsackie virus B3-induced myocarditis. J. Virol. 69:6720-28
51. Gebhard JR, Perry CM, Harkins S, Lane T, Mena I, Asensio VC, Campbell I, Whitton JL. 1998. Coxsackievirus B3-induced myocarditis: perform exacerbates disease, but plays no detectable role in virus clearance. Am. J. Pathol. 153:417-28
52. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68:8056-63
53. Matloubian M, Suresh M, Glass A, Galvan M, Chow K, Whitmire JK, Walsh CM, Clark W.R., Ahmed, R. 1999. A role for perform in downregulating T-cell responses during chronic viral infection. J. Virol. 73:2527-36
54. Ehtisham S, Sunil CN, Nash AA. 1993. Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells. J. Virol. 67:5247-52
55. Usherwood EJ, Brooks JW, Sarawar SR, Cardin RD, Young WD, Allen DJ, Doherty PC, Nash AA, 1997. Immunological control of murine gammaherpesvirus infection is independent of perforin. J. Gen. Virol. 78:2025-30
56. Sarawar SR, Cardin RD, Brooks JW, Mehrpooya M, Hamilton EA, Mo XY, Doherty PC. 1997. Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68. J. Virol. 71:3916-21
57. Dutia BM, Clarke CJ, Allen DJ, Nash AA. 1997. Pathological changes in the spleens of gamma interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells. J. Virol. 71:4278-83
58. Cantin E, Tanamachi B, Openshaw H, Mann J, Clarke K. 1999. Gamma interferon (IFN-gamma) receptor null-mutant mice are more susceptible to herpes simplex virus type 1 infection than IFN-gamma ligand null-mutant mice. J. Virol. 73:5196-5200
59. + cells in resolution of rotavirus infection and protection against reinfection in mice. Virology 214:387-97
60. Franco MA, Greenberg HB. 1995. Role of B cells and cytotoxic T lymphocytes in clearance of and immunity to rotavirus infection in mice. J. Virol. 69:7800-6
61. + T-cell immunity to murine rotavirus in the absence of perform, fas, and gamma interferon. J. Virol. 71:479-86
62. Lohman BL, Welsh RM. 1998. Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice. J. Virol. 72:7815-21
63. Tishon A, Lewicki H, Rall G, Von HM, Oldstone MB. 1995. An essential role for type 1 interferon-gamma in terminating persistent viral infection. Virology 212: 244-50
64. Bhardwaj V, Kanagawa O, Swanson PE, Unanue ER. 1998. Chronic Listeria infection in SCID mice: requirements for the carrier state and the dual role of T cells in transferring protection or suppression. J. Immunol. 160:376-84
65. Parra B, Hinton DR, Marten NW, Bergmann CC, Lin MT, Yang CS, Stohlman SA. 1999. IFN-gamma is required for viral clearance from central nervous system oligodendroglia. J. Immunol. 162: 1641-47
66. Torres C, Arangurz I, Rubio N. 1995. Expression of interferon-gamma receptors on murine oligodendrocytes and its regulation by cytokines and mitogens. Immunology. 86:250-55
67. Chisari FV. 1997. Cytotoxic T cells and viral hepatitis. J. Clin. Invest. 99:1472-77
68. Guidotti LG, Ishikawa T, Hobbs MV, Matzke B, Schreiber R, Chisari FV. 1996. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4:25-36
69. Guidotti LG, Borrow P, Hobbs MV, Matzke B, Gresser I, Oldstone MB, Chisari FV. 1996. Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. Proc. Natl. Acad. Sci., USA 93:4589-94
70. Cavanaugh VJ, Guidotti LG, Chisari FV. 1998. Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice. J. Virol. 72:2630-37
71. Guidotti LG, Rochford R, Chung J, Shapiro M, Purcell R, Chisari FV. 1999. Viral clearance without destruction of infected cells during acute HBV infection. Science 284:825-29
72. McMichael AJ, Phillips RE. 1997. Escape of human immunodeficiency virus from immune control. Annu. Rev. Immunol. 15:271-96
73. + lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234:1563-66
74. Bates, P. 1996. Chemokine receptors and HIV-1: an attractive pair? Cell 86:1-3
75. + T cells. Science 270:1811-15
76. + cells from HIV-infected individuals can suppress productive infection of macrophages independent of beta-chemokines. Proc. Natl. Acad. Sci. USA 95:1725-29
77. + T cell-mediated suppression of HIV replication: beta-chemokine-dependent and -independent effects. AIDS Res. Hum. Retrovirus 13:63-9
78. Bach EA, Aguet M, Schreiber RD. 1997. The IFN-gamma receptor: a paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 15:563-91
79. Ashkenazi A, Dixit VM. 1998. Death receptors: signaling and modulation. Science 281:1305-8
80. Suzuki Y, Remington JS. 1988. Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+,L3T4+ T cells in mice. J. Immunol. 140:3943
81. Weiss WR, Berzofsky JA, Houghten RA, Sedegah M, Hollindale M, Hoffman SL. 1992. A T cell clone directed at the circumsporozoite protein which protects mice against Plasmodium yoelii and Plasmodium berghei. J. Immunol. 149: 2103-9
82. + T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc. Natl. Acad. Sci. USA 85:573-76
83. Romero P, Maryanski JL, Corradin G, Nussenzweig RS, Nussenzweig V, Zavala F. 1989. Cloned cytotoxic T cells recognize an eptiope in the circumsporozoite protein and protect against malaria. Nature 341:323-26
84. Tarleton RL, Koller BH, Latour A, Postan M. 1992. Susceptibility of b2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature 356:338-40
85. + T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi. J. Immunol. 144:717-24
86. + T cell function to immune control of Trypanosoma cruzi. Parasite Immunol. 20:207-16
87. Denkers EY, Yap G, Scharton-Kersten T, Charest H, Butcher BA, Caspar P, Heiny S, Sher A. 1997. Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii. J. Immunol. 159:1903-8
88. + immune T cells against Toxoplasmosis in mice. J. Immunol. 144:1954-56
89. Renggli J, Hahne M, Matile H, Betschart B, Tschopp J, Corradin G. 1997. Elimination of P. berghei liver stages is independent of Fas (CD95/apo-I) or perforin-mediated cytotoxicity. Parasite Immunol. 19:145-48
90. + CTLs are essential for protective immunity against Encephalitozoon cuniculi infection. J. Immunol. 162:6086-91
91. + T cells in intracellular bacterial infections of mice. Res. Immunol. 147:519-24
92. Pamer EG, Sijts AJ, Villanueva MS, Busch DH, Vijh S. 1997. MHC class I antigen processing of Listeria monocytogenes proteins: implications for dominant and subdominant CTL responses. Immunol. Rev. 158:129-36
93. Lenz LL, Bevan MJ. 1997. CTL responses to H2-M3-restricted Listeria epitopes. Immunol. Rev. 158:115-21
94. Mielke ME, Ehlers S, Hahn H. 1988. T-cell subsets in delayed-type hypersensitivity, protection, and granuloma formation in primary and secondary Listeria infection in mice: superior role of Lyt-2+ cells in acquired Immunity Infect. Immun. 56:1920-25
95. Czuprynski CJ, Brown JF. 1990. Effects of purified anti-Lyt-2 mAb treatment on murine listeriosis: comparative roles of Lyt-2+ and L3T4+ cells in resistance to primary and secondary infection, delayed-type hypersensitivity and adoptive transfer of resistance. Immunology 71:107-12
96. Mielke ME, Niedobitek G, Stein H, Hahn H. 1989. Acquired resistance to Listeria monocytogenes is mediated by Lyt-2+ T cells independently of the influx of monocytes into granulomatous lesions. J. Exp. Med. 170:589-94
97. Roberts AD, Ordway DJ, Orme IM. 1993. Listeria monocytogenes infection in beta 2 microglobulin-deficient mice. Infect. Immun. 61:1113-16
98. Ladel CH, Flesch IE, Arnoldi J, Kaufmann SH. 1994. Studies with MHC-deficient knock-out mice reveal impact of both MHC I-and MHC II-dependent T cell responses on Listeria monocytogenes infection. J. Immunol. 153:3116-22
99. Fu YX, Roark CE, Kelly K, Drevets D, Campbell P, O'Brien R, Born W. 1994. Immune protection and control of inflammatory tissue necrosis by gamma delta T cells. J. Immunol. 153:3101-15
100. Czuprynski CJ, Brown JF. 1987. Dual regulation of anti-bacterial resistance and inflammatory neutrophil and macrophage accumulation by L3T4+ and Lyt 2+ Listeria-immune T cells. Immunology 60:287-93
101. Bishop DK, Hinrichs DJ. 1987. Adoptive transfer of immunity to Listeria monocytogenes. The influence of in vitro stimulation on lymphocyte subset requirements. J. Immunol. 139:2005-9
102. + T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo. J. Exp. Med. 175:1531-38
103. Lukacs K, Kurlander R. 1989. Lyt-2+ T cell-mediated protection against listeriosis. Protection correlates with phagocyte depletion but not with IFN-gamma production. J. Immunol. 142:2879-86
104. Harty JT, Bevan MJ. 1996. CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes. Infect. Immun. 64:3632-40
105. Bhardwaj V, Kanagawa O, Swanson PE, Unanue ER. 1998. Chronic Listeria infection in SCID mice: requirements for the carrier state and the dual role of T cells in transferring protection or suppression. J. Immunol. 160:376-84
106. Seaman MS, Perarnau B, Lindahl KF, Lemonneir FA, Forman J. 1999. Response to L. monocytogenes in mice lacking MHC class Ia molecules. J. Immunol. 162:5429-36
107. + T cells in antichlamydial immunity defined by Chlamydia-specific T-lymphocyte clones. Infect. Immun. 62:5195-97
108. Starnbach MN, Bevan MJ, Lampe MF. 1994. Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis. J. Immunol. 153:5183-89
109. Starnbach MN, Bevan MJ, Lampe MF. 1995. Murine cytotoxic T lymphocytes induced following Chlamydia trachomatis intraperitoneal or genital tract infection respond to cells infected with multiple serovars. Infect. Immun. 63: 3527-30
110. Magee DM, Williams DM, Smith JG, Bleicker CA, Grubbs BG, Schachter J, Rank RG. 1995. Role of CD8 T cells in primary Chlamydia infection. Infect. Immun. 63:516-21
111. De Libero G, Flesch I, Kaufmann SH. 1988. Mycobacteria-reactive Lyt-2+ T cell lines. Eur. J. Immunol. 18:59-66
112. Winter N, Lagranderie M, Gangloff S, Leclerc C, Gheorghiu M, Gicquel B. 1995. Recombinant BCG strains expressing the SIVmac251nef gene induce proliferative and CTL responses against nef synthetic peptides in mice. Vaccine 13:471-78
113. Stover CK, de la Cruz VF, Fuerst TR, Burlein JE, Benson LA, Bennet LT, Bansal GP, Young JF, Lee MH, Hatfull GF, Snapper SB, Barletta RG, Jacobs WR Jr, Bloom BR. 1991. New use of BCG for recombinant vaccines. Nature 351:456-60
114. Aldovini A, Young RA. 1991. Humoral and cell-mediated immune responses to live recombinant BCG-HIV vaccines. Nature 351:479-82
115. + T lymphocytes specific for Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 95:270-75
116. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, Modlin RL. 1995. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269:227-30
117. Mazzaccaro RJ, Stenger S, Rock KL, Porcelli SA, Brenner MB, Modlin RL, Bloom BR. 1998. Cytotoxic T lymphocytes in resistance to tuberculosis. Adv. Exp. Med. Biol. 452:85-101
118. Orme IM. 1987. The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis. J. Immunol. 138:293-98
119. Hubbard RD, Flory CM, Collins FM. 1991. Memory T cell-mediated resistance to Mycobacterium tuberculosis infection in innately susceptible and resistant mice. Infect. Immun. 59:2012-16
120. Kawamura I, Tsukada H, Yoshikawa H, Fujita M, Nomoto K, Mitsuyama M. 1992. IFN-gamma-producing ability as a possible marker for the protective T cells against Mycobacterium bovis BCG in mice. J. Immunol. 148:2887-93
121. Silva CL, Silva MF, Pietro RCLR, Lowrie DB. 1994. Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65. Immunology. 83:341-46
122. + alpha/beta T cells with specificity for the mycobacterial 65 kd heat shock protein. Internat. Immunol. 2:279-84
123. Zugel U, Schoel B, Yamamoto S, Hengel H, Morein B, Kaufmann SH. 1995. Crossrecognition by CD8 T cell receptor alpha beta cytotoxic T lymphocytes of peptides in the self and the mycobacterial hsp60 which share intermediate sequence homology. Eur. J. Immunol. 25:451-58
124. Flynn JL, Goldstein MM, Triebold KJ, Koller B, Bloom BR. 1992. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA. 89:12013-17
125. Behar SM, Dascher CC, Grusby MJ, Wang C-R, Brenner MB. 1999. Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J. Exp. Med. 189:1973-80
126. Portnoy DA, Chakraborty T, Goebel W, Cossart P. 1992. Molecular determinants of Listeria monocytogenes pathogenesis. Infect. Immun. 60:1263-67
127. Barry RA, Bouwer HG, Portnoy DA, Hinrichs DJ. 1992. Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread. Infect. Immun. 60:1625-32
128. + T cells requires secretion of hemolysin and intracellular bacterial growth. J. Immunol. 145:3540-46
129. Tilney LG, Portnoy DA. 1989. Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes. J. Cell Biol. 109:1597-1608
130. Tilney LG, Connelly PS, Portnoy DA. 1990. Actin filament nucleation by the bacterial pathogen, Listeria monocytogenes. J. Cell Biol. 111:2979-88
131. Welch MD, Iwamatsu A, Mitchison TJ. 1997. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. Nature 385: 265-69
132. Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ. 1998. Interaction of Human Arp2/3 Complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science 281:105-8
133. Kocks C, Gouin E, Tabouret M, Berche P, Ohayon H, Cossart P. 1992. L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein. Cell 68:521-31
134. Brundage RA, Smith GA, Camilli A, Theriot JA, Portnoy DA. 1993. Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells. Proc. Natl. Acad. Sci. USA 90:11890-94
135. Smith GA, Portnoy DA. 1993. The role of two phospholipases in the pathogenicity of Listeria monocytogenes. Infect. Agent. Dis. 2:183-85
136. Smith GA, Marquis H, Jones S, Johnston NC, Portnoy DA, Goldfine H. 1995. The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread. Infect. Immun. 63:4231-37
137. Sijts AJ, Villanueva MS, Pamer EG. 1996. CTL epitope generation is tightly linked to cellular proteolysis of a Listeria monocytogenes antigen. J. Immunol. 156:1497-1503
138. Pamer EG, Harty JT, Bevan MJ. 1991. Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature 353:852-55
139. Pamer EG. 1994. Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope. J. Immunol. 152:686-94
140. Schafer R, Portnoy DA, Brassell SA, Paterson Y. 1992. Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine. J. Immunol. 149:53-59
141. Shen H, Miller JF, Fan X, Kolwyck D, Ahmed R, Harty JT. 1998. Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective Immunity Cell 92:535-45
142. Gulden PH, Fischer PR, Sherman NE, Wang W, Engelhard VH, Shabanowitz J, Hunt DF, Pamer EG. 1996. A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule. Immunity 5:73-79
143. Lenz LL, Dere B, Bevan MJ. 1996. Identification of an H2-M3-restricted Listeria epitope: implications for antigen presentation by M3. Immunity 5:63-72
144. Princiotta MF, Lenz LL, Bevan MJ, Staerz UD. 1998. H2-M3 restricted presentation of a Listeria-derived leader peptide. J. Exp. Med. 187:1711-19
145. Teitelbaum R, Schubert W, Gunther L, Kress Y, Macaluso F, Pollard JW, McMurray DN, Bloom BR. 1999. The M cell as a portal of entry to the lung for the bacterial pathogen Mycobacterium tuberculosis. Immunity 10:641-50
146. Schlesinger LS. 1996. Entry of Mycobacterium tuberculosis into mononuclear phagocytes. Curr. Top. Microbiol. Immunol. 215:71-96
147. Russell DG. 1995. Of microbes and macrophages: entry, survival and persistence. Curr. Opin. Immunol. 7:479-84
148. + T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur. J. Immunol. 24:3068-72
149. Jensen ER, Glass AA, Clark WR, Wing EJ, Miller JF, Gregory SH. 1998. Fas (CD95)-Dependent cell-mediated immunity to Listeria monocytogenes. Infect. Immun. 66:4143-50
150. Czuprynski CJ, Brown JF. 1985. Phagocytes from flora-defined and germfree athymic nude mice do not demonstrate enhanced antibacterial activity. Infect. Immun. 50:425-30
151. + T cells: in vivo priming and antigen-specific immunity against Listeria monocytogenes. J. Immunol. 162:980-88
152. + T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha. J. Immunol. 160:898-905
153. Perry LL, Feilzer K, Hughes S, Caldwell HD. 1999. Clearance of Chlamydia trachomatis from the murine genital mucosa does not require perforin-mediated cytolysis or Fas-mediated apoptosis. Infect. Immun. 67:1379-85
154. Rottenberg ME, Gigliotti RA, Gigliotti D, Svanholm C, Bandholtz L, Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J. Immunol. 162:2829-36
155. Laochumroonvorapong P, Wang J, Liu CC, Ye WG, Moreira AL, Elkon KB, Freedman VH, Kaplan G. 1997. Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice. Infect. Immun. 65:127-32
156. Cooper AM, Dsouza C, Frank AA, Orme IM. 1997. The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin-or granzyme-mediated cytolytic mechanisms. Infect. Immun. 65:1317-20
157. Bancroft GJ, Schreiber RD, Unanue ER. 1991. Natural immunity: a T-cell-independent pathway of macrophage activation, defined in the SCID mouse. Immunol. Rev. 124:5-24
158. Portnoy DA, Schreiber RD, Connelly P, Tilney LG. 1989. Gamma interferon limits access of Listeria monocytogenes to the macrophage cytoplasm. J. Exp. Med. 170:2141-46
159. Fruh K, Yang Y. 1999. Antigen presentation by MHC class I and its regulation by interferon-γ. Curr. Opin. Immunol. 11:76-81
160. Tripp CS, Kanagawa O, Unanue ER. 1995. Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12. J. Immunol. 155:3427-32
161. Harty JT, Schreiber RD, Bevan MJ. 1992. CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion. Proc. Natl. Acad. Sci. USA 89:11612-16
162. Samsom JN, Langermans JA, Savelkoul HF, van Furth R. 1995. Tumour necrosis factor, but not interferon-gamma, is essential for acquired resistance to Listeria monocytogenes during a secondary infection in mice. Immunology 86:256-62
163. Harty JT, Bevan MJ. 1995. Specific immunity to Listeria monocytogenes in the absence of IFN gamma. Immunity 3:109-17
164. Huang S, Hendriks W, Althage A, Hemmi S, Bluethmann H, Kamijo R, Vilcek J, Zinkernagel RM, Aguet M. 1993. Immune response in mice that lack the interferon-gamma receptor. Science 259:1742-45
165. Dai WJ, Bartens W, Kohler G, Hufnagel M, Kopf M, Brombacher F. 1997. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice. J. Immunol. 158:5297-5304
166. Bancroft GJ, Sheehan KC, Schreiber RD, Unanue ER. 1989. Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in SCID mice. J. Immunol. 143:127-30
167. Havell EA. 1987. Production of tumor necrosis factor during murine listeriosis. J. Immunol. 139:4225-31
168. Nakane A, Minagawa T, Kato K. 1988. Endogenous tumor necrosis factor (cachectin) is essential to host resistance against Listeria monocytogenes infection. Infect. Immun. 56:2563-69
169. Pasparakis M, Alexopoulou L, Episkopou V, Kollias G. 1996. Immune and inflammatory responses in TNF-alpha-deficient mice-a critical requirement for TNF-alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184:1397-1411
170. Pfeffer K, Matsuyama T, Kundig TM, Wakeham A, Kishihara K, Shahinian A, Wiegmann K, Ohashi PS, Kronke M, Mak TW. 1993. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73:457-67
171. Endres R, Luz A, Schulze H, Neubauer H, Futterer A, Holland SM, Wagner H, Pfeffer K. 1997. Listeriosis in p47 (phox-/-) and TRp55-/-mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity 7:419-32
172. Ashkenazi A, Dixit VM. 1998. Death receptors: signalling and modulation. Science 281:1305-8
173. Henninger DD, Panes J, Eppihimer M, Russell J, Gerritsen M, Anderson DC, Granger DN. 1997. Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J. Immunol. 158:1825-32
174. Kondo S, Sauder DN. 1997. Tumor necrosis factor (TNF) receptor type 1 (p55) is a main mediator for TNF-alpha-induced skin inflammation. Eur. J. Immunol. 27:1713-18
175. Lukacs NW, Chensue SW, Strieter RM, Warmington K, Kunkel SL. 1994. Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1. J. Immunol. 152:5883-89
176. Samsom JN, Langermans JA, Savelkoul HF, van Furth R. 1995. Tumour necrosis factor, but not interferon-gamma, is essential for acquired resistance to Listeria monocytogenes during a secondary infection in mice. Immunology. 86:256-62
177. + T cells are a biologically relevant source of macrophage inflammatory protein-1 alpha in vivo. J. Immunol. 162:5423-28
178. Lampe MF, Wilson CB, Bevan MJ, Starnbach MN. 1998. Gamma Interferon production by cytotoxic T lymphocytes is required for resolution of Chlamydia trachomatis infection. Infect. Immun. 66:5457-61
179. Perry LL, Su H, Feilzer K, Messer R, Hughes S, Whitmire W, Caldwell HD. 1999. Differential sensitivity of distinct Chlamydia trachomatis isolates to IFN-gamma-mediated inhibition. J. Immunol. 162:3541-48
180. Kane CD, Byrne GI. 1998. Differential effects of gamma interferon on Chlamydia trachomatis growth in polarized and nonpolarized human epithelial cells in culture. Infect. Immun. 66:2349-51
181. Kane CD, Vena RM, Ouellette SP, Byrne GI. 1999. Intracellular tryptophan pool sizes may account for differences in gamma interferon-mediated inhibition and persistence of chlamydial growth in polarized and nonpolarized cells. Infect. Immun. 67:1666-71
182. Bancroft GJ, Schreiber RD, Bosma GC, Bosma MJ, Unanue ER. 1987. A T cell-independent mechanism of macrophage activation by interferon-gamma. J. Immunol. 139:1104-7
183. Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-54
184. Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schreibe RR, Mak TW, Bloom BR. 1995. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2:561-72
185. Stenger S, Mazzaccaro RJ, Uyemura K, Cho S, Barnes PF, Rosat J-P, Sette A, Brenner MB, Porcelli SA, Bloom BR, Modlin RL. 1997. Differentail effects of cytolytic T cell subsets on intracellular infection. Science 276:1684
186. Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melian A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL. 1998. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 282:121-25