메뉴 건너뛰기




Volumn 187, Issue 10, 1998, Pages 1647-1657

Protective immunity does not correlate with the hierarchy of virus- specific cytotoxic T cell responses to naturally processed peptides

Author keywords

Adoptive transfer; Antiviral protection; Cytotoxic T cell; Lymphocytic choriomeningitis virus; Peptide elution

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

EID: 0032543212     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.10.1647     Document Type: Article
Times cited : (245)

References (57)
  • 1
    • 0022483534 scopus 로고
    • The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
    • Townsend, A., J. Rothbard, F.M. Gotch, G. Bahadur, D. Wraith, and A.J. McMichael. 1986. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell. 44:959-968.
    • (1986) Cell , vol.44 , pp. 959-968
    • Townsend, A.1    Rothbard, J.2    Gotch, F.M.3    Bahadur, G.4    Wraith, D.5    McMichael, A.J.6
  • 2
    • 0023001973 scopus 로고
    • H-2 restricted cytolytic T cells specific for HLA can recognize a synthetic HLA peptide
    • Maryanski, J.L., P. Pala, G. Corradin, B.R. Jordan, and J.C. Cerottini. 1986. H-2 restricted cytolytic T cells specific for HLA can recognize a synthetic HLA peptide. Nature. 324:578-579.
    • (1986) Nature , vol.324 , pp. 578-579
    • Maryanski, J.L.1    Pala, P.2    Corradin, G.3    Jordan, B.R.4    Cerottini, J.C.5
  • 3
    • 0026764311 scopus 로고
    • Proteolysis, proteosomes and antigen presentation
    • Goldberg, A.L., and K.L. Rock. 1992. Proteolysis, proteosomes and antigen presentation. Nature. 357:375-379.
    • (1992) Nature , vol.357 , pp. 375-379
    • Goldberg, A.L.1    Rock, K.L.2
  • 6
    • 0027214605 scopus 로고
    • Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteosomes
    • Gaczynska, M., K.L. Rock, and A.L. Goldberg. 1993. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteosomes. Nature. 365:264-267.
    • (1993) Nature , vol.365 , pp. 264-267
    • Gaczynska, M.1    Rock, K.L.2    Goldberg, A.L.3
  • 7
    • 0027223877 scopus 로고
    • MHC-linked LMP gene products specifically alter peptidase activities of the proteosome
    • Drisscoll, J., M.G. Brown, D. Finley, and J.J. Monaco. 1993. MHC-linked LMP gene products specifically alter peptidase activities of the proteosome. Nature. 365:262-264.
    • (1993) Nature , vol.365 , pp. 262-264
    • Drisscoll, J.1    Brown, M.G.2    Finley, D.3    Monaco, J.J.4
  • 9
    • 0027424659 scopus 로고
    • Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner
    • Androlewicz, M.J., K.S. Anderson, and P. Cresswell. 1993. Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. Proc. Natl. Acad. Sci. USA. 90:9130-9134.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9130-9134
    • Androlewicz, M.J.1    Anderson, K.S.2    Cresswell, P.3
  • 11
    • 0027239749 scopus 로고
    • Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter
    • Neefjes, J.J., F. Momburg, and G.J. Hammerling. 1993. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science. 261:769-771.
    • (1993) Science , vol.261 , pp. 769-771
    • Neefjes, J.J.1    Momburg, F.2    Hammerling, G.J.3
  • 13
    • 0026500826 scopus 로고
    • Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer
    • Spies, T., V. Cerundolo, M. Colonna, P. Cresswell, A. Townsend, and R. DeMars. 1992. Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer. Nature. 355:644-646.
    • (1992) Nature , vol.355 , pp. 644-646
    • Spies, T.1    Cerundolo, V.2    Colonna, M.3    Cresswell, P.4    Townsend, A.5    DeMars, R.6
  • 15
    • 0024345149 scopus 로고
    • Specificity pockets for the side chains of peptide antigens in HLA-Aw68
    • Garrett, T., M.A. Saper, P.J. Bjorkman, J.L. Strominger, and D.C. Wiley. 1989. Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature. 342:692-696.
    • (1989) Nature , vol.342 , pp. 692-696
    • Garrett, T.1    Saper, M.A.2    Bjorkman, P.J.3    Strominger, J.L.4    Wiley, D.C.5
  • 16
    • 0026794581 scopus 로고
    • The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC
    • Madden, D.R., J.C. Gorga, J.L. Strominger, and D.C. Wiley. 1992. The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC. Cell. 70:1035-1048.
    • (1992) Cell , vol.70 , pp. 1035-1048
    • Madden, D.R.1    Gorga, J.C.2    Strominger, J.L.3    Wiley, D.C.4
  • 17
    • 0026621224 scopus 로고
    • Atomic structure of a human MHC molecule presenting an influenza virus peptide
    • Silver, M.L., H.-C. Guo, J.L. Strominger, and D.C. Wiley. 1992. Atomic structure of a human MHC molecule presenting an influenza virus peptide. Nature. 360:367-369.
    • (1992) Nature , vol.360 , pp. 367-369
    • Silver, M.L.1    Guo, H.-C.2    Strominger, J.L.3    Wiley, D.C.4
  • 18
    • 0026673724 scopus 로고
    • Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb
    • Fremont, D.H., M. Matsumura, E.A. Stura, P.A. Peterson, and I.A. Wilson. 1992. Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Science. 257:919-927.
    • (1992) Science , vol.257 , pp. 919-927
    • Fremont, D.H.1    Matsumura, M.2    Stura, E.A.3    Peterson, P.A.4    Wilson, I.A.5
  • 20
    • 0025855156 scopus 로고
    • Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
    • Falk, K., O. Roetzschke, S. Stevanovic, G. Jung, and H.G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature. 351:290-296.
    • (1991) Nature , vol.351 , pp. 290-296
    • Falk, K.1    Roetzschke, O.2    Stevanovic, S.3    Jung, G.4    Rammensee, H.G.5
  • 21
    • 0028922319 scopus 로고
    • Chemistry of peptides associated with MHC class I and class II molecules
    • Rammensee, H.-G. 1995. Chemistry of peptides associated with MHC class I and class II molecules. Curr. Opin. Immunol. 7:85-96.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 85-96
    • Rammensee, H.-G.1
  • 23
    • 0028960613 scopus 로고
    • b major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes
    • b major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes. J. Virol. 69:2297-2305.
    • (1995) J. Virol. , vol.69 , pp. 2297-2305
    • Gairin, J.E.1    Mazarguil, H.2    Hudrisier, D.3    Oldstone, M.B.A.4
  • 24
    • 0025114152 scopus 로고
    • Vaccination and protection from a lethal viral infection: Identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope
    • Klavinskis, L.S., J.L. Whitton, E. Joly, and M.B.A. Oldstone. 1990. Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope. Virology. 178:393-400.
    • (1990) Virology , vol.178 , pp. 393-400
    • Klavinskis, L.S.1    Whitton, J.L.2    Joly, E.3    Oldstone, M.B.A.4
  • 26
    • 0023692994 scopus 로고
    • Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes
    • Oldstone, M., J.L. Whitton, H. Lewicki, and A. Tishon. 1988. Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes. J. Exp. Med. 168:559-570.
    • (1988) J. Exp. Med. , vol.168 , pp. 559-570
    • Oldstone, M.1    Whitton, J.L.2    Lewicki, H.3    Tishon, A.4
  • 27
    • 0024542303 scopus 로고
    • Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunisation with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein
    • Hany, M., S. Oehen, M. Schulz, H. Hengartner, M. Mackett, D. Bishop, and R.M. Zinkernagel. 1989. Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunisation with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein. Eur. J. Immunol. 19:417-424.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 417-424
    • Hany, M.1    Oehen, S.2    Schulz, M.3    Hengartner, H.4    Mackett, M.5    Bishop, D.6    Zinkernagel, R.M.7
  • 28
    • 0023840826 scopus 로고
    • Analysis of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus
    • Whitton, J.L., P.J. Southern, and M.B.A. Oldstone. 1988. Analysis of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus. Virology. 162:321-327.
    • (1988) Virology , vol.162 , pp. 321-327
    • Whitton, J.L.1    Southern, P.J.2    Oldstone, M.B.A.3
  • 30
    • 0002046199 scopus 로고
    • Lymphocytic choriomeningitis virus
    • Lehmann-Grube, F. 1971. Lymphocytic choriomeningitis virus. Virol. Monogr. 10:1-173.
    • (1971) Virol. Monogr. , vol.10 , pp. 1-173
    • Lehmann-Grube, F.1
  • 31
    • 0022004801 scopus 로고
    • Complete sequence of the S RNA of lymphocytic choriomeningitis virus (WE strain) compared to that of pichinde arenavirus
    • Romanowski, V., Y. Matsuura, and D. Bishop. 1985. Complete sequence of the S RNA of lymphocytic choriomeningitis virus (WE strain) compared to that of pichinde arenavirus. Virus Res. 3:101-114.
    • (1985) Virus Res. , vol.3 , pp. 101-114
    • Romanowski, V.1    Matsuura, Y.2    Bishop, D.3
  • 32
    • 0022718930 scopus 로고
    • Impaired assembly and transport of HLA-A and -B antigens in a mutant T×B cell hybrid
    • Salter, R.D., and P. Cresswell. 1986. Impaired assembly and transport of HLA-A and -B antigens in a mutant T×B cell hybrid. EMBO (Eur. Mol. Biol. Organ.) J. 5:943-949.
    • (1986) EMBO (Eur. Mol. Biol. Organ.) J. , vol.5 , pp. 943-949
    • Salter, R.D.1    Cresswell, P.2
  • 33
    • 0025195567 scopus 로고
    • Restoration of H-2b expression and processing of endogenous antigen in the MHC class I pathway by fusion of a lymphoma mutant to L cells of the H-2k haplotype
    • Ohlen, C., J. Bastin, H.G. Ljunggren, S. Imreh, G. Klein, A.R. Townsend, and K. Kärre. 1990. Restoration of H-2b expression and processing of endogenous antigen in the MHC class I pathway by fusion of a lymphoma mutant to L cells of the H-2k haplotype. Eur. J. Immunol. 20:1873-1876.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1873-1876
    • Ohlen, C.1    Bastin, J.2    Ljunggren, H.G.3    Imreh, S.4    Klein, G.5    Townsend, A.R.6    Kärre, K.7
  • 34
    • 0022624298 scopus 로고
    • Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus
    • Baenziger, J., H. Hengartner, R.M. Zinkernagel, and G.A. Cole. 1986. Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus. Eur. J. Immunol. 16:387-393.
    • (1986) Eur. J. Immunol. , vol.16 , pp. 387-393
    • Baenziger, J.1    Hengartner, H.2    Zinkernagel, R.M.3    Cole, G.A.4
  • 35
    • 0022295840 scopus 로고
    • Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D
    • Zinkernagel, R.M., T.P. Leist, H. Hengartner, and A. Althage. 1985. Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D. J. Exp. Med. 162:2125-2141.
    • (1985) J. Exp. Med. , vol.162 , pp. 2125-2141
    • Zinkernagel, R.M.1    Leist, T.P.2    Hengartner, H.3    Althage, A.4
  • 36
    • 0021035910 scopus 로고
    • Lymphocytic choriomeningitis virus. VI. Isolation of a glycoprotein mediating neutralization
    • Bruns, M., J. Cihak, G. Müller, and F. Lehmann-Grube. 1983. Lymphocytic choriomeningitis virus. VI. Isolation of a glycoprotein mediating neutralization. Virology. 130:247-251.
    • (1983) Virology , vol.130 , pp. 247-251
    • Bruns, M.1    Cihak, J.2    Müller, G.3    Lehmann-Grube, F.4
  • 37
    • 0021934271 scopus 로고
    • Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice
    • Lehmann-Grube, F., U. Assmann, C. Loliger, D. Moskophidis, and J. Lohler. 1985. Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice. J. Immunol. 134:608-615.
    • (1985) J. Immunol. , vol.134 , pp. 608-615
    • Lehmann-Grube, F.1    Assmann, U.2    Loliger, C.3    Moskophidis, D.4    Lohler, J.5
  • 38
    • 0025175893 scopus 로고
    • Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells
    • Rötzschke, O., K. Falk, K. Deres, H. Schild, M. Norda, J. Metzger, G. Jung, and H.G. Rammensee. 1990. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature. 348:252-254.
    • (1990) Nature , vol.348 , pp. 252-254
    • Rötzschke, O.1    Falk, K.2    Deres, K.3    Schild, H.4    Norda, M.5    Metzger, J.6    Jung, G.7    Rammensee, H.G.8
  • 39
    • 0025740521 scopus 로고
    • Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast
    • Falk, K., O. Roetzschke, K. Deres, J. Metzger, G. Jung, and H.G. Rammensee. 1991. Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast. J. Exp. Med. 174:425-434.
    • (1991) J. Exp. Med. , vol.174 , pp. 425-434
    • Falk, K.1    Roetzschke, O.2    Deres, K.3    Metzger, J.4    Jung, G.5    Rammensee, H.G.6
  • 40
    • 0010424474 scopus 로고
    • Arenaviruses and their replication
    • B.N. Fields, D.M. Knipe, R.M. Chanock, M.S. Hirsch, J.L. Melnick, T.P. Monath, and B. Roizman, editors. Raven Press, Ltd., New York
    • Bishop, D.H.L. 1990. Arenaviruses and their replication. In Virology. 2nd ed. B.N. Fields, D.M. Knipe, R.M. Chanock, M.S. Hirsch, J.L. Melnick, T.P. Monath, and B. Roizman, editors. Raven Press, Ltd., New York. 1231-1267.
    • (1990) Virology. 2nd Ed. , pp. 1231-1267
    • Bishop, D.H.L.1
  • 41
    • 0029965055 scopus 로고    scopus 로고
    • Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy
    • Alexander-Miller, M.A., G.R. Leggatt, and J.A. Berzofsky. 1996. Selective expansion of high-or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA. 93:4102-4107.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4102-4107
    • Alexander-Miller, M.A.1    Leggatt, G.R.2    Berzofsky, J.A.3
  • 42
    • 0027400357 scopus 로고
    • Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection
    • Ohashi, P.S., R.M. Zinkernagel, I. Leuscher, H. Hengartner, and H.P. Pircher. 1993. Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection. Int. Immunol. 5:131-138.
    • (1993) Int. Immunol. , vol.5 , pp. 131-138
    • Ohashi, P.S.1    Zinkernagel, R.M.2    Leuscher, I.3    Hengartner, H.4    Pircher, H.P.5
  • 45
    • 0029920909 scopus 로고    scopus 로고
    • The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4
    • Levitsky, V., Q.-J. Zhang, J. Levitskaya, and M.G. Masucci. 1996. The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4. J. Exp. Med. 183:915-926.
    • (1996) J. Exp. Med. , vol.183 , pp. 915-926
    • Levitsky, V.1    Zhang, Q.-J.2    Levitskaya, J.3    Masucci, M.G.4
  • 46
    • 0028067568 scopus 로고
    • Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1
    • Tsomides, T.J., A. Aldovini, R.P. Johnson, B.D. Walker, R.A. Young, and H.N. Eisen. 1994. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J. Exp. Med. 180:1283-1293.
    • (1994) J. Exp. Med. , vol.180 , pp. 1283-1293
    • Tsomides, T.J.1    Aldovini, A.2    Johnson, R.P.3    Walker, B.D.4    Young, R.A.5    Eisen, H.N.6
  • 47
    • 0028345099 scopus 로고
    • Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope
    • Pamer, E.G. 1994. Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope. J. Immunol. 152:686-694.
    • (1994) J. Immunol. , vol.152 , pp. 686-694
    • Pamer, E.G.1
  • 48
    • 0031110168 scopus 로고    scopus 로고
    • Immunodominant and subdominant CTL responses to Listeria monocytogenes infection
    • Vijh, S., and E.G. Pamer. 1997. Immunodominant and subdominant CTL responses to Listeria monocytogenes infection. J. Immunol. 158:3366-3371.
    • (1997) J. Immunol. , vol.158 , pp. 3366-3371
    • Vijh, S.1    Pamer, E.G.2
  • 49
    • 0025286210 scopus 로고
    • Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation
    • Harding, C.V., and E.R. Unanue. 1990. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature. 346:574-576.
    • (1990) Nature , vol.346 , pp. 574-576
    • Harding, C.V.1    Unanue, E.R.2
  • 50
    • 0025182003 scopus 로고
    • The minimal number of class II MHC-antigen complexes needed for T cell activation
    • Demotz, S., H.M. Grey, and A. Sette. 1990. The minimal number of class II MHC-antigen complexes needed for T cell activation. Science. 248:1028-1030.
    • (1990) Science , vol.248 , pp. 1028-1030
    • Demotz, S.1    Grey, H.M.2    Sette, A.3
  • 51
    • 0030176270 scopus 로고    scopus 로고
    • Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
    • Sykulev, Y., M. Joo, I. Vturina, T.J. Tsomides, and H.N. Eisen. 1996. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity. 4:565-571.
    • (1996) Immunity , vol.4 , pp. 565-571
    • Sykulev, Y.1    Joo, M.2    Vturina, I.3    Tsomides, T.J.4    Eisen, H.N.5
  • 54
    • 0028817871 scopus 로고
    • b major histocompatibility complex class I molecule to alloreactive T cells
    • b major histocompatibility complex class I molecule to alloreactive T cells. J. Exp. Med. 182:1739-1750.
    • (1995) J. Exp. Med. , vol.182 , pp. 1739-1750
    • Malarkannan, S.1    Afkarian, M.2    Shastri, N.3
  • 55
    • 0029037210 scopus 로고
    • Serial triggering of many T-cell receptors by a few peptide-MHC complexes
    • Valitutti, S., S. Müller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature. 375:148-151.
    • (1995) Nature , vol.375 , pp. 148-151
    • Valitutti, S.1    Müller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 56
    • 0028961573 scopus 로고
    • Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton
    • Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181:577-584.
    • (1995) J. Exp. Med. , vol.181 , pp. 577-584
    • Valitutti, S.1    Dessing, M.2    Aktories, K.3    Gallati, H.4    Lanzavecchia, A.5
  • 57
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science. 273:104-106.
    • (1996) Science , vol.273 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.