Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus

Journal of Virology

Volumn 74, Issue 22, 2000, Pages 10304-10311

  Bartholdy, C ^a   Christensen, J P ^a   Wodarz, D ^a   Thomsen, A R ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; IMMUNE RESPONSE; IMMUNITY; IMMUNOGLOBULIN DEFICIENCY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MATHEMATICAL MODEL; MEMORY CELL; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION; VIRUS LOAD; VIRUS REPLICATION;

ANIMALS; CHRONIC DISEASE; INTERFERON TYPE II; KINETICS; LUNG; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033760676     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.22.10304-10311.2000     Document Type: Article

References (51)

1. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence
2. Changes in cell adhesion molecule expression on T cells associated with systemic virus infection
3. + T cells
4. Virus-induced non-specific signals cause cell cycle progression of primed CD8(+) T cells but do not induce cell differentiation
5. + T-cell-deficient mice
6. + cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection
7. The role of CD4-T cells in cell-mediated immunity to LCMV: Studies in MHC class I and class II deficient mice
8. T-cell-mediated immunity to lymphocytic choriomeningitis virus in β2-integrin (CD18) and ICAM-1 (CD54)-deficient mice
9. Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice
10. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
11. Establishment and persistence of virus-specific CD4- and CD8+ T cell memory
12. In vivo proliferation of naive and memory influenza-specific CD8(+) T cells
13. Optimal lymphocytic choriomeningitis virus sequences restricted by H 2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes
14. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptide
15. Immune response in mice that lack the interferon-gamma receptor
16. HLA alleles determine human T lymphotropic virus I (HTLV-I) proviral and the risk of HTLV-I-associated myelopathy
17. Different roles for cytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses
18. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
19. Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: Interferron gamma, but not tumour necrosis factor alpha, displays antiviral activity in vivo
20. Interferon-gamma is not an antiviral, but a growth-promoting factor for T lymphocytes
21. Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice
22. Studies on cell-mediated immunity to lymphocytic choriomeningitis virus in mice
23. Selection of CD8+ T cells with highly focused specificity during viral persistence in the central nervous system
24. + cytotoxic T-cell reponses during chronic viral infection
25. A new look at T cells
26. Role of virus and host variables in virus persis or immunopathological disease caused by a non-cytolytic virus
27. MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice
28. Virus persisted in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
29. Functional role of type I and type II interferons in antiviral defense
30. Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus
31. A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers
32. A case for cytokines as effector molecules in the resolution of virus infection
33. Cytokines and immunity to viral infections
34. Major histocompatibility complex-dependent T cell epitopes of lymphocytic choriomeningitis virus nucleo-protein and their protective capacity against viral disease
35. Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection
36. Exhaustion of CTL memory and recrudence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice
37. MHC and non-MHC genes regulate elimination of lymphocytic choriomeningitis virus and antiviral cytotoxic lymphocyte and delayed-type hypersensitivity mediating T lymphocyte activity in parallel
38. CD40 ligand is pivotal to efficient control of virus replication m mice infected with lymphocytic choriomeningitis virus
39. An essential role for type 1 interferon-gamma in terminating persistent viral infection
40. CD8+ T cells clear influenza virus by perforin or Fas-dependent processes
41. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
42. Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors
43. The provocation of latent lymphocytic choriomeningitis virus infections in mice by treatment with antilymphocytic serum
44. Low-affinity cytotoxic T-lymphocytes require IFN-gamma to clear an acute viral infection
45. Immune function in mice lacking the perform gene
46. Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomengitis virus-infected mice with anti-interferon-gamma monoclonal antibody blocks generation of virus-specific cytotoxic T lymphocytes and virus elimination
47. Immune responses and viral phenotype: Do replication rate and cytopathogenicity influence viral load?
48. The dynamics of HTLV-I and the CTL response
49. Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule
50. In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection
51. Viral immune evasion due to persistence of activated T cells without effector function