CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

Journal of Virology

Volumn 70, Issue 2, 1996, Pages 1072-1079

  Von Herrath, Matthias G ^a   Yokoyama, Masayuki ^a   Dockter, Janel ^a   Oldstone, Michael B A ^a   Lindsay Whitton, J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; HOST RESISTANCE; IMMUNIZATION; IMMUNOREGULATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VACCINIA VIRUS; VIRUS INFECTION; VIRUS RECOMBINANT;

EID: 0030053663     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.2.1072-1079.1996     Document Type: Article

References (57)

1. + T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses. J. Virol. 62:2102-2106.
2. Ahmed, R., J. A. Byrne, and M. B. A. Oldstone. 1984. Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains. J. Virol. 51:34-41.
3. Baldridge, J. R., and M. J. Buchmeier. 1992. Mechanisms of antibody-mediated protection against lymphocytic choriomeningitis virus infection: mother-to-baby transfer of humoral protection. J. Virol. 66:4252-4257.
4. + T-cell-deficient mice. J. Virol. 68:4700-4704.
5. Borrow, P., C. Evans, and M. B. A. Oldstone. 1995. Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J. Virol. 69:1059-1070.
6. Borrow, P., A. Tishon, and M. B. A. Oldstone. 1991. Infection of lymphocytes by a virus that aborts CTL activity and establishes persistent infection. J. Exp. Med. 174:203-212.
7. Doherty, P. C., S. Hou, and P. J. Southern. 1993. Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I MHC glycoproteins. J. Neuroimmunol. 46:11-17.
8. Eichelberger, M., W. Allan, M. Zijlstra, R. Jaenisch, and P. C. Doherty. 1991. Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J. Exp. Med. 174:875-880.
9. Good, R. A., and S. J. Zak. 1956. Disturbance in gamma-globulin synthesis as "experiments of nature." Pediatrics 18:109-149
10. Gray, D. 1994. Regulation of immunological memory. Curr Opin. Immunol. 6:425-430.
11. Gray, M. M., I. M. Hann, S. Glass, O. B. Eden, P. M. Jones, and R. F. Stevens. 1987. Mortality and morbidity caused by measles in children with malignant disease attending four major treatment centres: a retrospective review. Br. Med. J. Clin. Res. 295:19-22.
12. Horvat, B., J. A. Loukides, L. Anandan, E. Brewer, and P. M. Flood. 1991. Production of interleukin 2 and interleukin 4 by immune CD4-CD8+ and their role in the generation of antigen-specific cytotoxic T cells. Eur. J. Immunol. 21:1863-1871.
13. Hou, S., P. C. Doherty, M. Zijlstra, R. Jaenisch, and J. M. Katz. 1992. Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells J. Immunol 149:1319-1325.
14. Hou, S., L. Hyland, K. W. Ryan, A. Portner, and P. C. Doherty. 1994. Virus-specific CD8+ T-cell memory determined by clonal burst size. Nature (London) 369:652-654.
15. Jennings, S. R., R. H. Bonneau, P. M. Smith, R. M. Wolcott, and R. Chervenak. 1991. CD4-positive T lymphocytes are required for the generation of the primary but not the secondary CD8-positive cytolytic T lymphocyte response to herpes simplex virus in C57BL/6 mice. Cell Immunol. 133:234-252.
16. Jonjic, S., M. del Val, G. M. Keil, M. J. Reddehase, and U. H. Koszinowski. 1988. A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection J Virol. 62:1653-1658
17. Kasaian, M. T., K. A. Leite-Morris, and C. A. Biron. 1991 The role of CD4+ cells in sustaining lymphocyte proliferation during lymphocytic choriomeningitis virus infection J. Immunol. 146:1955-1963.
18. Kernahan, J., J. McQuillin, and A. W. Craft. 1987. Measles in children who have malignant disease. Br. Med. J Clin. Res. 295:15-18.
19. Killeen, N., S. Sawada, and D. R. Littman. 1993. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4 EMBO J. 12:1547-1553
20. Kirberg, J., L. Bruno, and H. von Boehmer. 1993. CD4+8- help prevents rapid deletion of CD8+ cells after a transient response to antigen Eur. J Immunol 23:1563-1967.
21. Klavinskis, L. S., M. B. A. Oldstone, and J. L. Whitton. 1989. Designing vaccines to induce cytotoxic T lymphocytes: protection from lethal viral infection, p. 485-489. In F. Brown, R. Chanock, H. Ginsberg, and R. Lerner (ed.), Vaccines 89 Modern approaches to new vaccines including prevention of AIDS. Cold Spring Harbor Laboratory. Cold Spring Harbor, N.Y.
22. Klavinskis, L. S., J. L. Whitton, E. Joly, and M. B. A. Oldstone. 1990 Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope Viroloey 178:393-400.
23. Klavinskis, L. S., J. L. Whitton, and M. B. A. Oldstone. 1989. Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection. J Virol. 63:4311-4316.
24. Kyburz, D., D. Speiser, T. Aebischer, H. Hengartner, and R. M. Zinkernagel. 1993. Virus-specific CTL mediated lysis of lymphocytes in vitro and in vivo, J. Immunol. 150:5051-5058
25. Lau, L. L., B. D. Jamieson, T. Somasundaram, and R. Ahmed. 1994. Cytotoxic T-cell memory without antigen. Nature (London) 369:648-652.
26. + T lymphocytes because of disruption of the 32-microglobulin gene. J. Virol. 67:332-339.
27. Leist, T. P., M. Kohler, and R. M. Zinkernagel. 1989. Impaired generation of anti-viral cytotoxicity against lymphocytic choriomeinngitis and vaccinia virus in mice treated with CD4-specific monoclonal antibody. Scand. J. Immunol 30:679-686.
28. Liu, Y., and A. Mullbacher. 1989. The generation and activation of memory class I MHC restricted cytotoxic T cell responses to influenza A virus in vivo do not require CD4+ T cells. Immunol. Cell Biol. 67:413-120.
29. + cytotoxic T-cell responses during chronic viral infection. J Virol. 68:8056-8063
30. Matzinger, P. 1994. Memories are made of this? Nature (London) 369:605-606.
31. McDonald, H. R., J. C. Cerottini, J.-E. Ryser, J. L. Maryanski, C. Taswell, M. Widmer, and K. T. Brunner. 1980. Quantitation and cloning of CTL and their precursors. Immunol Rev 51:93-123.
32. Mercadal, C. M., S. Martin, and B. T. Rouse. 1991. Apparent requirement for CD4+ T cells in primary anti-herpes simplex virus cytotoxic T-lymphocyte induction can be overcome by optimal antigen presentation. Viral Immunol 4:177-156.
33. Mossman, K., C. Upton, R. M. Buller, and G. McFadden. 1995. Species specificity of ectromelia virus and vaccinia virus interferon-gamma binding proteins. Virology 208:762-769.
34. Nahmias, A. J., D. Griffith, C. Salsbury, and K. Yoshida. 1967. Thymic aplasia with lymphopenia, plasma cells, and normal immunoglobulins. Relation to measles virus infection. JAMA 201:729-734.
35. Oldstone, M. B. A., P. Blount, P. J. Southern, and P. W. Lampert. 1986. Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature (London) 321:239-243
36. Oldstone, M. B. A., M. Salvato, A. Tishon, and H. Lewicki. 1988. Virus-lymphocyte interactions. III Biologic parameters of a virus variant the fails to generate CTL and establishes persistent infection in immunocompetent hosts. Virology 164:507-516.
37. Oldstone, M. B. A., J. L. Whitton, H. Lewicki, and A. Tishon. 1988 Fine dissection of a nine amino acid glycoprotein epitope a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes. J. Exp. Med. 168:559-570.
38. Palladino, G., P. A. Scherte, and W. Gerhard. 1991. Activity of CD4 T-cell clones of type 1 and type 2 in generation of influenza virus-specific cytotoxic responses in vitro. J. Virol. 65:6071-6076
39. Rahemtulla, A., W. P. Fung-Leung, M. W. Schilham, T. M. Kundig, S. R. Sambhara, A. Narendran, A. Arabian, A. Wakeham, C. J. Paige, and R. M. Zinkernagel. 1991. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature (London) 353:180-184.
40. Rahemtulla, A., T. M. Kundig, A. Narendran, M. F. Bachmann, M. Julius, C. J. Paige, P. S. Ohashi, R. M. Zinkernagel, and T. W. Mak. 1994. Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice. Eur. J. Immunol. 24:2213-2218.
41. Riviere, Y., and M. B. A. Oldstone. 1986. Genetic reassortants of lymphocytic choriomeningitis virus: unexpected disease and mechanism of pathogenesis. J. Virol. 59:363-368.
42. Schulz, M., P. Aichele, M. Vollenweider, F. W. Bobe, F. Cardinaux, H. Hengartner, and R. M. Zinkernagel. 1989. Major histocompatibility complex-dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease. Eur. J. Immunol 19:1657-1068.
43. Siegel, M. M., T. K. Walter, and A. R. Ablin. 1977. Measles pneumonia in childhood leukemia. Pediatrics 60:38-40.
44. Smith, G. L. 1993. Vaccinia virus glycoproteins and immune evasion The sixteenth Fleming Lecture. J. Gen Virol. 74:1725-1740.
45. Sparshott, S. M., and E. B. Bell. 1994. Membrane CD45R isoform exchange on CD4 T cells is rapid, frequent and dynamic in vivo. Eur. J Immunol. 24:2573-2578
46. Sprent, J. 1993. Lifespans of naive, memory and effector lymphocytes. Curr. Opin Immunol. 5:433-438.
47. Spriggs, M. K., D. E. Hruby, C. R. Maliszewski, D. J. Pickup, J. E. Sims. R. M. Buller, and J. VanSlyke. 1992. Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein. Cell 71:145-152.
48. Tishon, A., H. A. Lewicki, G. Rall, M. G. von Herrath, and M. B. A. Oldstone. 1995. An essential role for type I interferon-gamma in terminating persistent viral infection. Virology 212:244-250.
49. Ulmer, J. B., J. J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Feigner, V. J. Dwarki, S. H. Gromkowski, R. R. Deck, C. M. DeWitt, A. Friedman, L. A. Hawe, K. R. Leander, D. Martinez, H. C. Perry, J. W. Shiver, D. L. Montgomery, and M. A. Liu. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein Science 259:1745-1749.
50. von Herrath, M. G., J. Dockter, and M. B. Oldstone. 1994. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model Immunity 1:231-242.
51. Whitton, J. L. Unpublished data.
52. Whitton, J. L. 1990 Lymphocytic choriomeningitis virus CTL. Semin. Virol. 1:257-262.
53. Whitton, J. L. 1994 Induction of protective immunity using minigenes. Ann. N.Y. Acad. Sci 730:107-117
54. Whitton, J. L., N. Sheng, M. B. A. Oldstone, and T. A. McKee. 1993 A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge. J. Virol. 67:348-352.
55. Whitton, J. L., P. J. Southern, and M. B. A. Oldstone. 1988. Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus. Virology 162:321-327.
56. Whitton, J. L., A. Tishon, H. Lewicki, J. R. Gebhard, T. Cook, M. S. Salvato, E. Joly, and M. B. A. Oldstone. 1989. Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity. J. Virol. 63:4303-4310
57. Wright, K. E., and M. J. Buchmeier. 1991. Antiviral antibodies attenuate T-cell-mediated immunopathology following acute lymphocytic choriomeningitis virus infection. J. Virol. 65:3001-3006.