Inhibition of transcription factor NF-κB by sesquiterpene lactones: A proposed molecular mechanism of action

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 11, 1999, Pages 2343-2352

  Rüngeler, Peter ^a   Castro, Victor ^b   Mora, Gerardo ^b   Gören, Nezhun ^c   Vichnewski, Walter ^d   Pahl, Heike L ^e   Merfort, Irmgard ^a   Schmidt, Thomas J ^f  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c MATERIALS INSTITUTE   (Turkey)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e UNIVERSITY OF FREIBURG   (Germany)

^f Inst Pharmazeut Biol Heinrich H   (Germany)

Author keywords

Anti inflammatory activity; Mechanism of action; Molecular modelling; NF B; Sesquiterpene lactones

Indexed keywords

AMINO ACID; CYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SESQUITERPENE LACTONE; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR; TYROSINE;

ALKYLATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; CROSS LINKING; DNA BINDING; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOLECULAR MODEL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; HUMANS; JURKAT CELLS; LACTONES; MODELS, MOLECULAR; NF-KAPPA B; PLANT EXTRACTS; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038809627     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00195-9     Document Type: Article

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