The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κb by targeting the IκB kinase complex

Journal of Immunology

Volumn 163, Issue 10, 1999, Pages 5617-5623

  Hehner, Steffen P ^a   Hofmann, Thomas G ^a   Dröge, Wulf ^a   Schmitz, M Lienhard ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PARTHENOLIDE; PROTEIN INHIBITOR; SESQUITERPENE LACTONE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG TARGETING; HELA CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ENZYME ACTIVATION; HELA CELLS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; MAP KINASE KINASE KINASE 1; MAP KINASE KINASE KINASES; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SESQUITERPENES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033571108     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14: 649.
2. Huxford, T., D. B. Huang, S. Malek, and G. Ghosh. 1998. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation. Cell 95:759.
3. Jacobs, M. D., and S. C. Harrison. 1998. Structure of an IκBα/NF-κB complex. Cell 95:749.
4. Baichwal, V. R., and P. A. Baeuerle. 1997. Activate NF-κB or die? Curr. Biol. 7:R94.
5. 1-to-S-phase transition. Mol. Cell. Biol. 19:2690.
6. Kaltschmidt, B., C. Kaltschmidt, S. P. Hehner, W. Dröge, and M. L. Schmitz. 1999. Repression of NF-κB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators. Oncogene 18:3213.
7. Chen, Z. J., L. Parent, and T. Maniatis. 1996. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84:853.
8. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225.
9. Yamaoka, S., G. Courtois, C. Bessia, S. T. Whiteside, R. Weil, F. Agou, H. E. Kirk, R. J. Kay, and A. Israel. 1998. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93:1231.
10. Rothwarf, D. M., E. Zandi, G. Natoli, and M. Karin. 1998. IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 395:297.
11. Cohen, L., W. J. Henzel, and P. A. Baeuerle. 1998. IKAP is a scaffold protein of the IκB kinase complex. Nature 395:292.
12. Malinin, N. L., M. P. Boldin, A. V. Kovalenko, and D. Wallach. 1997. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385:540.
13. Ling, L., Z. Cao, and D. V. Goeddel. 1998. NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. USA 95:3792.
14. Lin, X., E. T. Cunningham Jr., Y. Mu, R. Geleziunas, and W. C. Greene. 1999. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases. Immunity 10:271.
15. Ninomiya-Tsuji, J., K. Kishimoto, A. Hiyama, J. Inoue, Z. Cao, and K. Matsumoto. 1999. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398:252.
16. Lee, F. S., R. T. Peters, L. C. Dang, and T. Maniatis. 1998. MEKK1 activates both IκB kinase α and IκB kinase β. Proc. Natl. Acad. Sci. USA 95:9319.
17. Nemoto, S., J. A. DiDonato, and A. Lin. 1998. Coordinate regulation of IκB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-κB-inducing kinase. Mol. Cell. Biol. 18:7336.
18. Lee, F. S., J. Hagler, Z. J. Chen, and T. Maniatis. 1997. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213.
19. Attar, R. M., J. Caamano, D. Carrasco, V. Iotsova, H. Ishikawa, R. P. Ryseck, F. Weih, and R. Bravo. 1997. Genetic approaches to study Rel/NF-κB/IκB function in mice. Semin. Cancer Biol. 8:93.
20. Dumont, A., S. P. Hehner, M. L. Schmitz, J.-Å. Gustafsson, J. Lidén, S. Okret, P. T. van der Saag, S. Wissink, B. van der Burg, P. Herrlich, G. Haegeman, K. De Bosscher, and W. Fiers. 1998. Cross-talk between steroids and NF-κB: what language? Trends Biochem. Sci. 23:233.
21. Yin, M. J., Y. Yamamoto, and R. B. Gaynor. 1998. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 396:77.
22. Bork, P. M., M. L. Schmitz, M. Kuhnt, C. Escher, and M. Heinrich. 1997. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-κB. FEBS Lett. 402:85.
23. Hehner, S. P., M. Heinrich, P. M. Bork,. M. Vogt, F. Ratter, V. Lehmann, K. Schulze-Osthoff, W. Dröge, and M. L. Schmitz. 1998. Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J. Biol. Chem. 273:1288.
24. De Bosscher, K., M. L. Schmitz, S. Plaisance, W. Vanden Berghe, W. Fiers, and G. Haegeman. 1997. Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation. Proc. Natl. Acad. Sci. USA 94:13504.
25. Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866.
26. Rothe, M., S. C. Wong, W. J. Henzel, and D. V. Goeddel. 1994. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78:681.
27. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. 1993. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:2135.
28. Tanaka, M., M. E. Fuentes, K. Yamaguchi, M. H. Durnin, S. A. Dalrymple, K. L. Hardy, and D. V. Goeddel 1999. Embryonic lethality, liver degeneration and impaired NF-κB activation in IKK-β-deficient mice. Immunity 10:421.
29. Li, Q., D. Van Antwerp, F. Mercurio, K. F. Lee, and I. M. Verma 1999. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284:321.
30. Karin, M., and M. Delhase. 1998. JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action? Proc. Natl. Acad. Sci. USA 95:9067.
31. Heinrich, M., M. Robles, J. E. West, B. R. Ortiz de Montellano, and E. Rodriguez. 1998. Ethnopharmacology of Mexican asteraceae (Compositae). Annu. Rev. Pharmacol. Toxicol. 38:539.
32. Lyss, G., A. Knorre, T. J. Schmidt, H. L. Pahl, and I. Merfort. 1998. The antiinflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65. J. Biol. Chem. 273:33508.
33. Woerdenbag, H. J., I. Merfort, C. M. Passreiter, T. J. Schmidt, G. Willuhn, W. van Uden, N. Pras, H. H. Kampinga, and A. W. Konings. 1994. Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines. Planta Med. 60:434.
34. Yin, M. J., L. B. Christerson, Y. Yamamoto, Y. T. Kwak, S. Xu, F. Mercurio, M. Barbosa, M. H. Cobb, and R. B. Gaynor. 1998. HTLV-I Tax protein binds to MEKK1 to stimulate IκB kinase activity and NF-κB activation. Cell 93:875.
35. Chu, Z. L., J. A. DiDonato, J. Hawiger, and D. W. Ballard. 1998. The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IκB kinases containing IKKα and IKKβ. J. Biol. Chem. 273:15891.
36. Geleziunas, R., S. Ferrell, X. Lin, Y. Mu, E. T. Cunningham Jr., M. Grant, M. A. Connelly, J. E. Hambor, K. B. Marcu, and W. C. Greene. 1998. Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase α (IKKα) and IKKβ cellular kinases. Mol. Cell. Biol. 18:5157.
37. Uhlik, M., L. Good, G. Xiao, E. W. Harhaj, E. Zandi, M. Karin, and S. C. Sun. 1998. NF-κB-inducing kinase and IκB kinase participate in human T-cell leukemia virus I Tax-mediated NF-κB activation. J. Biol. Chem. 273:21132.