Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-κB and enzymes of the arachidonic acid pathway as targets

Planta Medica

Volumn 64, Issue 7, 1998, Pages 588-593

  Rüngeler, Peter ^a   Lyß, Guido ^a   Castro, Victor ^b   Mora, Gerardo ^b   Pahl, Heike L ^c   Merfort, Irmgard ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Anti inflammatory activity; Asteraceae; Cyclooxygenase 1; NF B; Phospholipase A2; Sesquiterpene lactones; Tithonia diversifolia

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 1; DIVERSIFOLIN; DIVERSIFOLIN METHYL ETHER; LACTONE DERIVATIVE; PHOSPHOLIPASE A2; SESQUITERPENE LACTONE DERIVATIVE; TIROTUNDIN; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; COSTA RICA; DRUG ISOLATION; DRUG MECHANISM; DRUG PURIFICATION; HUMAN; HUMAN CELL; INFLAMMATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTERACEAE; CYCLOOXYGENASE 1; ENZYME INHIBITORS; HUMANS; ISOENZYMES; JURKAT CELLS; LACTONES; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; NF-KAPPA B; PHOSPHOLIPASES A; PLANTS, MEDICINAL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SESQUITERPENES;

ASTERACEAE; BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); TITHONIA DIVERSIFOLIA;

EID: 0031726866     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-957527     Document Type: Article

References (24)

1. Morton, J. (1981) Atlas of Medicinal Plants of Middle America, Bahamas to Yucatan, C. Thomas, Springfield, 973-974.
2. Ciccio, J. F., Castro, V., Calzada, J. G. (1979) Rev. Latinoam. Quim. 10, 134-135.
3. Baruah, N. C., Sharma, R. P., Madhusudanan, K. P., Thyagarajan, G., Herz, W., Murari. R. (1979) J. Org. Chem. 44, 1831-1835.
4. Schuster, A., Stokes, S., Papastergiou, Castro, V., Poveda, L., Jakupovic, J. (1992) Phytochemistry 31, 3139-3141.
5. Baeuerle, P. A., Henkel, T. (1994) Annu. Rev. Immunol. 12, 141-179.
6. Baeuerle, P. A., Baltimore, D. (1996) Cell 87, 13-20.
7. Barnes, P. J., Karin, M. (1997) N. Engl. J. Med. 1066-1071.
8. Lehr, M. (1995) Pharm. Pharmacol. Lett. 5, 37-40.
9. Müller-Jakic, B., Breu, W., Pröbstle, A., Redl, K., Greger, H., Bauer, R. (1994) Planta Med. 60, 37-40.
10. Burkhardt, F. (1992) Mikrobiologische Diagnostik, Georg Thieme Verlag, Stuttgart, pp. 721-726.
11. Pahl, H. L., Baeuerle, P. A. (1995) EMBO J. 14, 2580-2588.
12. Pahl, H. L., Krauß, B., Schulze-Osthoff, K., Decker, T., Traenckner, E. B.-M., Vogt, M., Myers, C., Parks, T., Warring, P., Mühlbacher, A., Czernilofsky, A.-P., Baeuerle, P. (1996) J. Exp. Med. 1829-1840.
13. Baeuerle, P., Baltimore, D. (1988) Cell 53, 211-217.
14. Kupchan, S. M., Fessler, D. C., Eakin, M. A., Giacobbe, T. J. (1970) Science 168, 376-378.
15. Matthews, J. R., Wakasugi, N., Virelizier, J.-L., Yodoi, J., Hay, R. T. (1992) Nucl. Acids Res. 20, 3821-3830.
16. Kumar, S., Rabson, A. B., Gélinas, C. (1992) Mol. Cell. Biol. 12, 3094-3106.
17. Ghosh, G., Van Duyne, G., Ghosh, S., Sigler, P. S. (1995) Nature 373, 303-310.
18. Toledano, M. B., Leonhard, W. J. (1991) Proc. Natl. Acad. Sci. 88, 4328-4332.
19. Hall, I. H., Starnes, C. O., Lee, K.-H., Waddell, T. G. (1980) J. Pharm. Sci. 69, 537-543.
20. Marles, R. J., Pazos-Sanou, L., Compadre, C. M., Pezzuto, J. M., Bloszyk, E., Arnason, J. T. (1995) in: Phytochemistry of Medicinal Plants, (Arnason, J. T. ed.), Plenum Press, New York, pp. 333-356.
21. Ysrael, M. C., Croft, K. C. (1990) Planta Med. 56, 268-270.
22. Rüngeler, P., Thesis, University of Freiburg, in preparation.
23. Lyss, G., Schmidt, T. J., Merfort, I., Pahl, H. L. (1997) Biol. Chem. 378, 951-961.
24. Kopp, E., Ghosh, S. (1994) Science 265, 956-959.