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Current Pharmaceutical Design

Volumn 7, Issue 13, 2001, Pages 1277-1290

The epothilones, eleutherobins, and related types of molecules

(3) Stachel, S J a Biswas, K a Danishefsky, S J a

a MEMORIAL SLOAN KETTERING CANCER CENTER (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12,13 DESOXYEPOTHILONE B; ANTINEOPLASTIC AGENT; DISCODERMOLIDE; ELEUTHEROBIN; EPOTHILONE A; EPOTHILONE B; EPOTHILONE DERIVATIVE; LAULIMALIDE; PACLITAXEL; UNCLASSIFIED DRUG; WS 9885 B;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGY; CANCER; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG INDUSTRY; DRUG POTENTIATION; DRUG RESEARCH; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; LABORATORY; MICROTUBULE ASSEMBLY; MOLECULE; MULTIDRUG RESISTANCE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; DITERPENES; EPOTHILONES; EPOXY COMPOUNDS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0034857182 PISSN: 13816128 EISSN: None Source Type: Journal
DOI: 10.2174/1381612013397410 Document Type: Article

Times cited : (72)

References (89)

1
- 0003931691
- 'Cancer Chemotherapeutic Agents'. Ed. W. O. Foye, American Chemical Society, Washington, D.C.
- (1995)

2
- 0000467248
- (1979) Nature , vol.277 , pp. 665
- Horwitz, S.B.¹ Fant, J.² Schiff, P.B.³

3
- 0004112137
- Wiley-Liss: New York
- (1993) Microtubules
- Hyams, J.F.¹ Loyd, C.W.²

4
- 0031027531
- (1997) J. Biol. Chem. , vol.272 , pp. 2534
- Kowalski, R.J.¹ Giannakakou, P.² Hamel, E.³

5
- 0003855343
- (1993) Cell. Pharmacol. , vol.1
- Timashiff, S.¹ Andreu, J.² Gorbunoff, M.³ Medranot, F.⁴ Prakash, V.⁵

6
- 0027461876
- (1993) Biochemistry , vol.32 , pp. 1285
- Toso, R.J.¹ Jordan, M.A.² Farrell, K.W.³ Matsumoto, B.⁴ Wilson, L.⁵

7
- 0026328348
- (1991) Pharmacol. Ther. , vol.51 , pp. 377
- Hastie, S.B.¹

8
- 0021686169
- (1984) Nature , vol.312 , pp. 237
- Mitchison, T.¹ Kirschner, M.W.²

9
- 0022919318
- (1986) Cell , vol.45 , pp. 329
- Kirschner, M.W.¹ Mitchison, T.²

10
- 0023052498
- (1986) Nature , vol.324 , pp. 621
- Kirschner, M.W.¹ Mitchison, T.²

11
- 0027330403
- (1993) Pharmacol. Ther. , vol.59 , pp. 163
- Sackett, D.L.¹

12
- 0003797139
- (1997) Semin. Oncol. , vol.24 , pp. 29
- Natale, R.B.¹

13
- 0003926409
- Taxol is a registered trademark of Bristol-Myers Squibb.

14
- 0018387446
- (1979) Nature , vol.277 , pp. 665
- Schiff, P.B.¹ Fant, J.² Horwitz, S.B.³

15
- 0033550167
- (1999) J. Org. Chem. , vol.64 , pp. 8434
- Harris, C.R.¹ Danishefsky, S.J.²

16
- 0001084425
- (1998) Angew. Chem., Int. Ed. Engl. , vol.37 , pp. 2015
- Nicolaou, K.C.¹ Roschanger, F.² Vourloumis, D.³

17
- 0030018666
- (1996) J. Antibiot. , vol.49 , pp. 560
- Gerth, K.¹ Bedorf, N.² Hofle, G.³ Irschik, H.⁴ Reichenbach, H.⁵

18
- 0029776766
- (1996) Angew. Chem., Int. Ed. Engl. , vol.35 , pp. 1567
- Hofle, G.¹ Bedorf, N.² Steinmetz, H.³ Schomburg, D.⁴ Gerth, K.⁵ Reichenbach, H.⁶

19
- 0003792821
- Reichenbach (GBF), DE-B 4138042. [Chem. Abstr. 1993, 120, 52841].
- (1993)
- Hofle, G.¹ Bedorf, K.² Gerth, H.³

20
- 0029049468
- (1995) Cancer Res. , vol.55 , pp. 2325
- Bollag, D.M.¹ McQueney, P.A.² Zhu, J.³ Hensens, O.⁴ Koupal, L.⁵ Liesch, J.⁶ Goetz, M.⁷ Lazarides, E.⁸ Woods, C.M.⁹

21
- 0000429459
- (1995) Mol. Biol. Cell , vol.6 , pp. 2137
- Kowalski, R.J.¹ Terhaar, E.² Longley, R.E.³ Gunasekera, S.P.⁴ Lin, C.M.⁵ Day, B.V.⁶ Hamel, E.⁷

22
- 0030761974
- (1997) Cancer Res. , vol.57 , pp. 3344
- Muhlradt, P.F.¹ Sasse, F.²

23
- 0030669587
- (1997) J. Am. Chem. Soc. , vol.119 , pp. 10073
- Meng, D.¹ Bertinato, P.² Balog, A.³ Su, D.-S.⁴ Kamenecka, T.⁵ Sorensen, E.J.⁶ Danishefsky, S.J.⁷

24
- 0030514018
- (1996) Angew. Chem. Int. Ed. Engl. , vol.35 , pp. 2801
- Balog, A.¹ Meng, D.² Kameneka, T.³ Bertinato, P.⁴ Su, D.-S.⁵ Sorensen, E.J.⁶ Danishefsky S., J.⁷

25
- 0032541259
- and references therein. For recent chemical syntheses of epothilone B. see:
- (1998) Angew. Chem. Int. Ed. Engl. , vol.37 , pp. 2014
- Nicolaou, K.C.¹ He, Y.² Vourloumis, D.³ Vallberg, H.⁴ Yang, Z.⁵

26
- 0034327638
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 10521
- Sawada, D.¹ Kanai, M.² Shibasaki, M.³

27
- 0034602349
- (2000) J. Org. Chem. , vol.65 , pp. 7456
- Mulzer, J.¹ Mantoulidis, A.² Ohler, E.³

28
- 0033525108
- (1999) J. Org. Chem. , vol.64 , pp. 684
- White, J.D.¹ Carter, R.G.² Sundermann, K.F.³

29
- 0032493824
- (1998) Chem. Comm. , pp. 1597
- May, S.A.¹ Grieco, P.A.²

30
- 0030669587
- (1997) J. Am. Chem. Soc. , vol.119 , pp. 10073
- Meng, D.¹ Bertinato, P.² Balog, A.³ Su, D.-S.⁴ Kamenecka, T.⁵ Sorensen, E.J.⁶ Danishefsky, S.J.⁷

31
- 1542763298
- For a review of ring-closing olefin metathesis see:
- (1995) Acc. Chem. Res. , vol.28 , pp. 446
- Grubbs, R.H.¹ Miller, S.J.² Fu, G.C.³

32
- 33750239613
- (1995) Angew. Chem. Int. Ed. Engl. , vol.34 , pp. 1833
- Schmalz, H.-G.¹

33
- 33750283011
- (1989) J. Am. Chem. Soc. , vol.111 , pp. 314
- Miyaura, N.¹ Ishiyama, T.² Sasaki, H.³ IshiKawa, M.⁴ Satoh, M.⁵ Suzuki, A.⁶

34
- 2042507954
- For an excellent review see:
- (1995) Chem Rev. , vol.95 , pp. 2457
- Miyaura, N.¹ Suzuki, A.²

35
- 0001616071
- (1979) Bull. Chem. Soc. Jpn. , vol.52 , pp. 1989
- Yamaguchi, M.¹ Inanaga, J.² Hirata, K.³ Saeki, H.⁴ Katsuki, T.⁵

36
- 0026547995
- (1992) Synthesis , pp. 215
- Mulzer, J.¹ Mareski, P.A.² Buschmann, J.³ Luger, P.⁴

37
- 0030889136
- (1997) J. Am. Chem. Soc. , vol.119 , pp. 2733
- Meng, D.¹ Su, D.-S.² Balog, A.³ Bertinato, P.⁴ Sorensen, E.J.⁵ Danishefsky, S.J.⁶ Zheng, Y.-H.⁷ Chou, T.-C.⁸ He, L.⁹ Horwitz, S.B.¹⁰

38
- 33746236970
- (1995) Angew. Chem. Int. Ed. Engl. , vol.34 , pp. 2039
- Schwab, P.¹ France, M.B.² Ziller, J.W.³ Grubbs, R.H.⁴

39
- 0001077422
- (1990) J. Am. Chem. Soc. , vol.112 , pp. 3875
- Schrock, R.R.¹ Murdzek, J.S.² Bazan, G.C.³ Robbins, J.⁴ DiMare, M.⁵ O'Regan, M.⁶

40
- 0032483019
- (1998) J. Proc. Natl. Acad. Sci. , vol.95 , pp. 9642
- Chou, T.-C.¹ Zhang, X.-G.² Balog, A.³ Su, D.-S.⁴ Meng, D.⁵ Savin, K.⁶ Bertino, J.R.⁷ Danishefsky, S.⁸

41
- 0003931695
- MX-1 is a well characterized human mammary adenocarcinoma that has been used for many years as part of the National Cancer Institute's screening panel of experimental tumors

42
- 0032416734
- (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 15798
- Chou, T.-C.¹ Zhang, X.G.² Harris, C.R.³ Kuduk, S.D.⁴ Balog, A.⁵ Savin, K.⁶ Danishefsky, S.J.⁷

43
- 4243589929
- (2000) Clin. Cancer Res. , vol.6
- Calvert, P.M.¹ O'Neill, V.² Azzabi, A.³ Hughes, A.⁴ Plummer, R.⁵ Twelves, C.⁶ Robinson, A.⁷ Machan, M.A.⁸ Dimitrijevic, S.⁹ Moss, D.¹⁰ Rothermel, J.¹¹ Cohen, P.¹² Chen, T.¹³ Man, A.¹⁴ Calvert, A.H.¹⁵

44
- 0001136501
- (2000) J. Org. Chem. , vol.65 , pp. 6525
- Lee, C.B.¹ Chou, T.C.² Zhang, X.G.³ Wang, Z.G.⁴ Kuduk, S.D.⁵ Chappel, M.D.⁶ Stachel, S.J.⁷ Danishefsky, S.J.⁸

45
- 0034354340
- (2000) Chemia , vol.54 , pp. 612
- Altmann, K.-H.¹ Bold, G.² Caravatti, G.³ End, N.⁴ Florsheimer, A.⁵ Guagnano, V.⁶ O'Reilly, T.⁷ Wartmann, M.⁸

46
- 0033826818
- (2000) Chemistry & Biology , vol.7 , pp. 593
- Nicolaou, K.C.¹ Scarpelli, R.² Bollbuck, B.³ Werschkun, B.⁴ Pereira, M.M.A.⁵ Wartmann, M.⁶ Altmann, K.-H.⁷ Zaharevitz, D.⁸ Gussio, R.⁹ Giannakakou, P.¹⁰

47
- 0003797141
- Patent WO99/102514
- (1999)
- Vite, G.D.¹ Borzilleri, R.M.² Kim, S.-H.³ Johnson, J.A.⁴

48
- 0034692354
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 8890
- Borzilleri, R.M.¹ Zheng, X.² Schmidt, R.J.³ Johnson, J.⁴ Kim, S.-H.⁵ DiMarco, J.D.⁶ Fairchild, C.R.⁷ Gougoutas, J.Z.⁸ Lee, F.Y.F.⁹ Long, B.H.¹⁰ Vite, G.D.¹¹

49
- 0034601091
- (2000) Chembiochem , vol.1 , pp. 67
- Schinzer, D.¹ Altmann, K.H.² Stuhlmann, F.³ Bauer, A.⁴ Wartmann, M.⁵

50
- 0034199809
- (2000) Org. Lett. , vol.11 , pp. 1637
- Stachel, S.J.¹ Chappell, M.D.² Lee, C.B.³ Danishefsky, S.J.⁴ Chou, T.-C.⁵ He, L.⁶ Horwitz, S.B.⁷

51
- 0003903918
- U.S. patent 5,473,057
- (1995)
- Fenical, W.-H.¹ Jensen, P.R.² Lindel, T.³

52
- 0030984058
- (1997) J. Am. Chem. Soc. , vol.119 , pp. 8744
- Lindel, T.¹ Jensen, P.R.² Fenical, W.³ Long, B.H.⁴ Casazza, A.M.⁵ Carboni, J.⁶ Fairchild, C.R.⁷

53
- 0032520890
- (1998) Cancer Res. , vol.58 , pp. 1111
- Long, B.H.¹ Carboni, J.M.² Wasserman, A.J.³ Cornell, L.A.⁴ Casazza, A.M.⁵ Jensen, P.R.⁶ Lindel, T.⁷ Fenical, W.-H.⁸ Fairchild, C.R.⁹

54
- 0031470265
- (1997) Angew. Chem. Int. Ed. Engl. , vol.36 , pp. 2520
- Nicolaou, K.C.¹ van Delft, F.L.² Ohshima, T.³ Vourloumis, D.⁴ Xu, J.Y.⁵ Hosokawa, S.⁶ Pfefferkorn, J.⁷ Kim, S.⁸ Li, T.⁹

55
- 0032475452
- (1998) J. Am. Chem. Soc. , vol.120 , pp. 8674
- Nicolaou, K.C.¹ Ohshima, T.² Hosokawa, S.³ van Delft, F.L.⁴ Vourloumis, D.⁵ Xu, J.Y.⁶ Pfefferkorn, J.⁷ Kim, S.⁸

56
- 0031882649
- (1998) Angew. Chem. Int. Ed. Engl. , vol.37 , pp. 185
- Chen, X.-T.¹ Gutteridge, C.E.² Bhattacharya, S.K.³ Zhou, B.⁴ Pettus, T.R.R.⁵ Haskall, T.⁶ Danishefsky, S.J.⁷

57
- 0031924818
- (1998) Angew. Chem. Int. Ed. Engl. , vol.37 , pp. 789
- Chen, X.-T.¹ Zhou, B.² Bhattacharya, S.K.³ Gutteridge, C.E.⁴ Pettus, T.R.R.⁵ Danishefsky, S.J.⁶

58
- 0033591877
- (1999) J. Am. Chem. Soc. , vol.121 , pp. 6563
- Chen, X.-T.¹ Bhattacharya, S.K.² Zhou, B.³ Gutteridge, C.E.⁴ Pettus, T.R.R.⁵ Danishefsky, S.J.⁶

59
- 0032890262
- (1999) Tetrahedron Lett. , vol.40 , pp. 153
- Ceccarelli, S.¹ Piarulli, U.² Gennari, C.³

60
- 0033601389
- (1999) Tetrahedron Lett. , vol.40 , pp. 9321
- Baron, A.¹ Caprio, V.² Mann, J.³

61
- 0034705399
- (2000) Tetrahedron , vol.56 , pp. 4367
- Carter, R.¹ Hodgetts, K.² Mckenna, J.³ Magnus, P.⁴ Wren, S.⁵

62
- 0032988620
- (1999) Cancer Chemother. Pharmacol. , vol.44 , pp. 131
- McDaid, H.M.¹ Bhattacharya, S.K.² Chen, X.-T.³ He, L.⁴ Shen, H.-J.⁵ Gutteridge, C.E.⁶ Horwitz, S.B.⁷ Danishefsky, S.J.⁸

63
- 0032576190
- (1998) J. Am. Chem. Soc. , vol.120 , pp. 10814
- Nicolaou, K.C.¹ Winssinger, D.² Vourloumis, D.³ Ohshima, T.⁴ Kim, S.⁵ Pfefferkorn, J.⁶ Xu, J.-Y.⁷ Li, T.⁸

64
- 0025160288
- (correction: J. Org. Chem. 1991, 56, 1346).
- (1990) J. Org. Chem. , vol.55 , pp. 4912
- Gunasekara, S.P.¹ Gunasekara, M.² Longley, R.E.³

65
- 0025942924
- (1991) Transplatation , vol.52 , pp. 650
- Longley, R.E.¹ Caddigan, D.² Harmody, D.³ Gunasekara, M.⁴ Gunasekara, S.P.⁵

66
- 0030039669
- (1996) Biochemistry , vol.35 , pp. 243
- Terhaar, E.¹ Kowalski, R.J.² Hamel, E.³ Lin, C.M.⁴ Longley, R.E.⁵ Gunasekara, S.P.⁶ Rosenkrantz, H.S.⁷ Day, B.W.⁸

67
- 0030113284
- (1996) Chem. Biol. , vol.3 , pp. 287
- Hung, D.T.¹ Chen, J.² Schreiber, S.L.³

68
- 0027858856
- (1993) J. Am. Chem. Soc. , vol.115 , pp. 12621
- Nerenberg, J.B.¹ Hung, D.T.² Somers, P.K.³ Schreiber, S.L.⁴

69
- 0029619410
- (1995) J. Am. Chem. Soc. , vol.117 , pp. 12011
- Smith, A.B.¹ Qui, Y.² Jones, D.R.³ Kobayashi, K.⁴

70
- 0003935850
- (1997) J. Org. Chem. , vol.62 , pp. 6908
- Harried, S.S.¹ Yang, G.² Strawn, M.A.³ Myles, D.C.⁴

71
- 0032582745
- (1998) J. Org. Chem. , vol.63 , pp. 7885
- Marshall, J.A.¹ Johns, B.A.²

72
- 0033518052
- (1999) Org. Lett. , vol.1 , pp. 1823
- Smith, A.B.¹ Kaufman, M.D.² Beauchamp, T.J.³ LaMarche, M.J.⁴ Arimoto, H.⁵

73
- 0029860912
- (1996) J. Am. Chem. Soc. , vol.118 , pp. 11054
- Hung, D.T.¹ Nerenberg, J.B.² Schreiber, S.L.³

74
- 18844469806
- (2000) Clin. Cancer Res. , vol.6 , pp. 1978
- Martello, L.A.¹ McDaid, H.M.² Regl, D.L.³ Yang, C.P.⁴ Meng, D.⁵ Pettus, T.R.R.⁶ Kaufman, M.D.⁷ Arimoto, H.⁸ Danishefsky, S.J.⁹ Smith, A.B.¹⁰ Horwitz, S.B.¹¹

75
- 33845278737
- (1988) J. Org. Chem. , vol.53 , pp. 3642
- Quinoa, E.¹ Kakou, Y.² Crews, P.³

76
- 0023710155
- (1988) J. Org. Chem. , vol.53 , pp. 3644
- Corley, D.G.¹ Herb, R.² Moore, R.E.³ Scheuer, P.J.⁴ Paul, V.J.⁵

77
- 0030068561
- (1996) Tetrahedron Lett. , vol.37 , pp. 159
- Jefford, C.W.¹ Bernardinelli, G.² Tanaka, J.-I.³ Higa, T.⁴

78
- 0002792091
- (1996) Chem. Lett. , pp. 255
- Tanaka, J.-I.¹ Higa, T.² Bernardinelli, G.³ Jefford, C.W.⁴

79
- 0033083045
- (1999) Cancer Res. , vol.59 , pp. 653
- Moorberry, S.L.¹ Tien, G.² Hernandez, A.H.³ Plubrukarn, A.⁴ Davidson, B.S.⁵

80
- 0033991982
- (2000) Tetrahedron Lett. , vol.41 , pp. 33
- Mulzer, J.¹ Hanbauer, M.²

81
- 0034175522
- (2000) Tetrahedron Lett. , vol.41 , pp. 2319
- Ghosh, A.K.¹ Wang, Y.²

82
- 0034659844
- (2000) Tetrahedron Lett. , vol.41 , pp. 4705
- Ghosh, A.K.¹ Wang, Y.²

83
- 0034623543
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 11027
- Ghosh, A.K.¹ Wang, Y.²

84
- 0003855345
- 40th Symposium on the Chemistry of Natural Products, Fukuoka, Japan, paper 83
- (1998) , pp. 487
- Muramatsu, H.¹ Miyauchi, M.² Sato, B.³ Yoshimura, S.⁴

85
- 0031027531
- (1997) J. Biol. Chem. , vol.272 , pp. 2534
- Kowalski, R.J.¹ Giannakakou, P.² Hamel, E.³

86
- 0000429459
- (1995) Mol. Biol. Cell. , vol.6
- Kowalski, R.J.¹ Ter Haar, E.² Longley, R.E.³ Gunasekara, S.P.⁴ Lin, C.M.⁵ Day, B.W.⁶ Hamel, E.⁷

87
- 0033551046
- (1999) J. Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 4256
- Ojima, I.¹ Chakravarty, S.² Inoue, T.³ Lin, S.⁴ He, L.⁵ Horwitz, S.B.⁶ Kuduk, S.D.⁷ Danishefsky, S.⁸

88
- 12944277104
- (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 2904
- Giannakakou, P.¹ Gussion, R.² Nogales, E.³ Downing, K.H.⁴ Zaharevitz, D.⁵ Bolbuck, B.⁶ Poy, G.⁷ Sackett, D.⁸ Nicolaou, K.C.⁹ Fojo, T.¹⁰

89
- 0034636084
- (2000) Biochemistry , vol.39 , pp. 3972
- He, L.¹ Jagtap, P.G.² Kingston, D.G.³ Shen, H.J.⁴ Orr, G.A.⁵ Horwitz, S.B.⁶

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