Nuclear import and export of proteins in plants: A tool for the regulation of signalling

Planta

Volumn 213, Issue 4, 2001, Pages 499-517

  Merkle, Thomas ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Arabidopsis (signal transduction); Nuclear export import; Nucleo cytoplasmic partitioning; Protein (nuclear export import); Signal transduction

Indexed keywords

CELL NUCLEUS; GENETIC REGULATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA KARYOPHERINS; AMINO ACID SEQUENCE; ARABIDOPSIS; CELL NUCLEUS; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; PLANTS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

ARABIDOPSIS;

EID: 0034850972     PISSN: 00320935     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004250100621     Document Type: Review

References (191)

1. A small nuclear GTP-binding protein from tomato suppresses a Schizosaccharomyces pombe cell cycle mutant
2. + which encodes a 115-kD protein preferentially localized in the nucleus and at its periphery
3. HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor
4. Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development
5. Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B
6. Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm
7. Homodimeric and heterodimeric leucine zipper proteins and nuclear factors from parsley recognize diverse promoter elements with ACGT cores
8. Nuclear localization signal binding protein from Arabidopsis mediates nuclear import of Agrobacterium VirD2 protein
9. Photoreceptors of higher plants
10. The Ran/TC4 GTPase-binding domain: Identification by expression cloning and characterization of a conserved sequence motif
11. I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: A mechanism for cytoplasmic retention
12. RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors
13. Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
14. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
15. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1
16. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export
17. NXT1 is necessary for the terminal step of Crm1-mediated nuclear export
18. Definition of a consensus Transportin-specific nucleocytoplasmic transport signal
19. Karyopherin β2 mediates nuclear import of a mRNA binding protein
20. Photoreceptors in plant photomorphogenesis to date. Five phytochromes, two cryptochromes, one phototropin, and one superchrome
21. Developmentally regulated activity of CRM1/XPO1 during early Xenopus embryogenesis
22. Protein degradation in signaling
23. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
24. Cryptochromes: Blue light receptors for plants and animals
25. Arabidopsis bZIP protein HY5 directly interacts with light-responsive promoters in mediating light control of gene expression
26. Combinatorial interaction of light-responsive elements plays a critical role in determining the response characteristics of light-regulated promoters in Arabidopsis
27. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
28. NK-kappa B subunit-specific regulation of the I kappa B alpha promoter
29. Autoregulation of I kappa B alpha activity
30. Arabidopsis NPH1: A flavoprotein with the properties of a photoreceptor for phototropism
31. The Drosophila embargoed gene is required for larval progression and encodes the functional homolog of Schizosaccharomyces Crm1
32. Plant nuclei can contain extensive grooves and invaginations
33. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha
34. Nucleocytoplasmic transport of macromolecules
35. Plants contain a novel multi-member family of heat shock factors without transcriptional activator potential
36. Parsley protoplasts retain differential responsiveness to UV light and fungal elicitor
37. cop1: A regulatory locus involved in light-controlled development and gene expression in Arabidopsis
38. β homologous domain
39. Fungal elicitor triggers rapid, transient, and specific protein phosphorylation in parsley cell suspension cultures
40. Role of AHA motifs for the activator function of tomato heat stress transcription factors HsfA1 and HsfA2
41. Early nuclear events in plant defence signalling: Rapid gene activation by WRKY transcription factors
42. A leptomycin B-sensitive homologue of human CRM1 promotes nuclear export of nuclear export sequence-containing proteins in Drosophila cells
43. The HIV1 Rev activation domain is a nuclear export pathway used by specific cellular RNAs
44. The human homologue of yeast CRM1 is in dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
45. CRM1 is an export receptor for leucine-rich nuclear export signals
46. CRM1 is responsible for intracellular transport mediated by the nuclear export signal
47. I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding
48. Photocontrol of subcellular partitioning of phytochrome-B:GFP fusion protein in tobacco seedlings
49. Matrix attachment region binding protein MFP1 is localized in discrete domains at the nuclear envelope
50. MAF1, a novel plant protein interacting with matrix attachment region binding protein MFP1, is located at the nuclear envelope
51. Transport between the cell nucleus and the cytoplasm
52. Isolation of a protein that is essential for the first step of nuclear protein import
53. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope
54. A 41 amino acid motif in importin-α confers binding to importin-β and hence transit into the nucleus
55. Identification of different roles for RanGDP and RanGTP in nuclear protein import
56. A novel class of RanGTP binding proteins
57. Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity
58. The Arabidopsis blue light receptor cryptochrome 2 is a nuclear protein regulated by a blue light-dependent post-transcriptional mechanism
59. Nuclear export of proteins in plants: AtXPO1 is the export receptor for leucine-rich nuclear export signals in Arabidopsis thaliana
60. Isolation and sequence analysis of a genomic clone of the nuclear export receptor AtXPO1 (AtCRM1) from Arabidopsis thaliana
61. Characterization of proteins that interact with the GTP-bound form of the regulatory GTPase Ran in Arabidopsis
62. Light-regulated modification and nuclear translocation of cytosolic G-box binding factors (GBFs) in parsley (Petroselinum crispum L.)
63. The balance of nuclear import and export determines the intracellular distribution and function of tomato heat stress transcription factor HsfA2
64. The nuclear pore complex
65. Plant nuclear pore complex proteins are modified by novel oligosaccharides with terminal N-acetylglucosamine
66. Determination of the functional domain organization of the importin alpha nuclear import factor
67. GTP hydrolysis by Ran is required for nuclear envelope assembly
68. Nuclear import in permeabilized protoplasts from higher plants has unique features
69. At-PHH1, a novel gene from Arabidopsis thaliana related to microbial photolyases and plant blue light photoreceptors
70. Cse1p is required for export of Srp1p/importin-α from the nucleus in Saccharomyces cerevisiae
71. A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes
72. Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure
73. Plant importin alpha binds nuclear localization sequences with high affinity and can mediate nuclear import independent of importin beta
74. Cryptochrome nucleocytoplasmic distribution and gene expression are regulated by light quality in the fern Adiantum capillus-veneris
75. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
76. Functional characterization of a plant importin alpha homologue. Nuclear localization signal (NLS)-selective binding and mediation of nuclear import of NLS proteins in vitro
77. In vitro characterization of rice importin beta 1: Molecular interaction with nuclear transport factors and mediation of nuclear protein import
78. Molecular cloning of a novel importin alpha homologue from rice, by which Constitutive Photomorphogenesis 1 (COP1) nuclear localization signal (NLS)-protein is preferentially nuclear imported
79. An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha
80. Regulation of nuclear localisation: A key to a door
81. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus
82. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121
83. The Ran GTPase regulates mitotic spindle assembly
84. The COP9 signalosome: From light signalling to general developmental regulation and back
85. Light-induced nuclear import of phytochrome-A:GFP fusion proteins is differentially regulated in transgenic tobacco and Arabidopsis
86. Light quality-dependent nuclear import of the plant photoreceptors phytochrome-A and B
87. Nuclear import of the parsley bZIP transcription factor CPRF2 is regulated by phytochrome photoreceptors
88. Nuclear localization of the Arabidopsis blue light receptor cryptochrome 2
89. Evidence for distinct substrate specificities of importin a family members in nuclear protein import
90. Roles of phosphorylation sites in regulating activity of the transcription factor Pho4
91. Cse1p functions as the nuclear export receptor for importin α in yeast
92. Dominant-negative mutants of importin-β block multiple pathways of import and export through the nuclear pore complex
93. Export of importin α from the nucleus is mediated by a specific nuclear transport factor
94. Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts
95. Receptor-mediated activation of a MAP kinase in pathogen defense of plants
96. CRY2: A second member of the Arabidopsis cryptochrome gene family
97. Intracellular distribution and identification of the nuclear localization signals of two heat-stress transcription factors
98. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
99. Functional interaction of phytochrome B and cryptochrome 2
100. Phytochrome gene diversity
101. Nucleocytoplasmic transport: The soluble phase
102. Isolation and characterization of two importin-beta genes from rice
103. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
104. A novel link between Ran signal transduction and nuclear envelope proteins in plants
105. MFP1, a novel plant filament-like protein with affinity for matrix attachment region DNA
106. Nuclear import of proteins: Putative import factors and development of in vitro import systems in higher plants
107. Phenotype of the fission yeast cell cycle regulatory mutant pim1-46 is suppressed by a tobacco cDNA encoding a small, Ran-like GTP-binding protein
108. A plant in vitro system for the nuclear import of proteins
109. A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway
110. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
111. Purification of a Ran-interacting protein that is required for protein import into the nucleus
112. The direction of transport through the nuclear pore can be inverted
113. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly
114. Control of nuclear import and phytochromes
115. Nucleo-cytoplasmic partitioning of the plant photoreceptors phytochromes
116. Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis
117. Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain
118. Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis
119. The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
120. High affinity binding of a fungal oligopeptide elicitor to parsley plasma membranes triggers multiple defense responses
121. Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran
122. Evidence for a role of CRM1 in signal-mediated nuclear protein export
123. RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro
124. Multiple photoreceptors mediate the light-induced reduction of GUS-COP1 from Arabidopsis hypocotyl nuclei
125. Targeted destabilization of HY5 during light-regulated development of Arabidopsis
126. The Arabidopsis HY5 gene encodes a bZIP protein that regulates stimulus-induced development of root and hypocotyl
127. CRM1-mediated recycling of snurportin 1 to the cytoplasm
128. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
129. A novel receptor-mediated nuclear protein import pathway
130. HSF3, a new heat shock factor from Arabidopsis thaliana, derepresses the heat shock response and confers thermotolerance when overexpressed in transgenic plants
131. Phytochrome-interacting factors
132. Kinetic analysis of translocation through nuclear pore complexes
133. NTF2 mediates nuclear import of Ran
134. The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy
135. Interaction of elicitor-induced DNA-binding proteins with elicitor response elements in the promoters of parsley PR1 genes
136. The nuclear pore complex: A protein machine bridging the nucleus and cytoplasm
137. RanBP2 associates with Ubc9p and a modified form of RanGAP1
138. Nuclear localization activity of phytochrome B
139. The tomato Hsf system: HsfA2 needs interaction with HsfA1 for efficient nuclear import and may be localized in cytoplasmic heat stress granules
140. Resistance response physiology and signal transduction
141. Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination
142. Heterodimerization between light-regulated and ubiquitously expressed Arabidopsis GBF bZIP proteins
143. DNA binding site preferences and transcriptional activation properties of the Arabidopsis transcription factor GBF-1
144. Characterization of four cDNAs encoding different importin alpha homologues from Arabidopsis thaliana, designated AtIMPa1-4
145. Regulation of the heat shock response
146. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
147. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins
148. Functional conservation of the Transportin nuclear import pathway in divergent organisms
149. Nuclear import of Ran is mediated by the transport factor NTF2
150. Importin alpha from Arabidopsis thaliana is a nuclear import receptor that recognizes three classes of import signals
151. A cDNA encoding an importin alpha homologue from Arabidopsis thaliana
152. Nuclear localization signal receptor importin alpha associates with the cytoskeleton
153. Cse1p is involved in export of yeast importin α from the nucleus
154. A novel motif mediates the targeting of the Arabidopsis COP1 protein to subnuclear foci
155. Discrete domains mediate the light-responsive nuclear and cytoplasmic localisation of Arabidopsis COP1
156. Modular domain structure of Arabidopsis COP1. Reconstitution of activity by fragment complementation and mutational analysis of a nuclear localisation signal in planta
157. Exportin 1 (Crm1p) is an essential nuclear export factor
158. The plant ER: A dynamic organelle composed of a large number of discrete functional domains
159. The nuclear pore complex: From molecular architecture to functional dynamics
160. NF-kappa B controls expression of inhibitor I kappa B alpha: Evidence for an inducible autoregulatory pathway
161. Intracellular localization of GBF proteins and blue light-induced import of GBF2 fusion proteins into the nucleus of cultured Arabidopsis and soybean cells
162. Clustal W: Improving sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
163. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli
164. Ring finger motif of Arabidopsis thaliana COP1 defines a new class of zinc-binding domain
165. Light inactivation of Arabidopsis photomorphogenic repressor COP1 involves a cell type specific modulation of its nucleocytoplasmic partitioning
166. Genetic and developmental control of nuclear accumulation of COP1, a repressor of photomorphogenesis in Arabidopsis
167. The conserved amino-terminal domain of hSRP1α is essential for nuclear protein import
168. Light-inducible and constitutively expressed DNA-binding proteins recognizing a plant promoter element with functional relevance in light responsiveness
169. UV irradiation in photomorphogenesis
170. Phosphorylation of the parsley bZIP transcription factor CPRF2 is regulated by light
171. Identification of a signal for rapid export of proteins from the nucleus
172. Role of importin-beta in coupling Ran to downstream targets in microtubule assembly
173. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran
174. Heat shock transcription factors: Structure and regulation
175. Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region
176. Identification of a plant cytoskeletal, cell cycle-related and polarity-related proteins using Schizosaccharomyces pombe
177. Nuclear transport factor p10/NTF2 functions as a Ran-GDP dissociation inhibitor (Ran-GDI)
178. Light-dependent translocation of a phytochrome B-GFP fusion protein to the nucleus in transgenic Arabidopsis
179. Protein nucleocytoplasmic transport and its light regulation in plants
180. Role of a COP1 interactive protein in mediating light-regulated gene expression in Arabidopsis
181. CIP4, a new COP1 target, is a nucleus-localized positive regulator of Arabidopsis photomorphogenesis
182. The C termini of Arabidopsis cryptochromes mediate a constitutive light response
183. Two distinct classes of Ran-binding sites on the nucleoporin Nup-358
184. A giant nucleopore protein that binds Ran/TC4
185. Nucleocytoplasmic protein traffic and its significance to cell function
186. Purified human I kappa B can rapidly dissociate the complex of the NF-kappa B transcription factor with its cognate DNA
187. Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts
188. Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system
189. NF-AT activation requires suppression of Crm1-dependent export by calcineurin
190. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1
191. Nucleoporins Nup98 and Nup214 participate in nuclear export of human immunodeficiency virus type 1