The nuclear pore complex

Plant Molecular Biology

Volumn 38, Issue 1-2, 1998, Pages 145-162

  Heese Peck, Antje ^a   Raikhel, Natasha V ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Nuclear envelope; Nuclear import; Nuclear import receptor; Nuclear pore complex; Nucleoporin; O linked GlcNAc modification

Indexed keywords

CELL NUCLEUS; MEMBRANE PERMEABILITY; MITOSIS; PROTEIN STRUCTURE;

EUKARYOTA; VERTEBRATA;

EID: 0032169763     PISSN: 01674412     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-94-011-5298-3_8     Document Type: Article

References (141)

1. Ach RA, Gruissem W: A small nuclear GTP-binding protein from tomato suppresses a Schizosaccharomyces pombe cell-cycle mutant. Proc Natl Acad Sci USA 91: 5863-5867 (1994).
2. Adam SA, Sterne-Marr R, Gerace L: Nuclear protein import in permeabilized cells requires soluble cytoplasmic factors. J Cell Biol 111: 807-16 (1990).
3. Adam SA, Sterne-Marr R, Gerace L: Nuclear protein import using digitonin-permeabilized cells. Meth Enzymol 219: 97-110 (1992).
4. Aitchison JD, Rout MP, Marelli M, Blobel G, Wozniak RW: Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p. J Cell Biol 131: 1133-1148 (1995).
5. Aitchison JD, Blobel G, Rout MP: Nup120: a yeast nucleoporin required for NPC distribution and mRNA export. J Cell Biol 131: 1659-1675 (1995).
6. Aitchison JD, Blobel G, Rout MP: Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274: 624-627 (1996).
7. Akey CW: Structural plasticity of the nuclear pore complex. J Mol Biol 248: 273-293 (1995).
8. Akey CW, Rademacher MP: Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryoelectron microscopy. J Cell Biol 122: 1-19 (1993).
9. Ballas N, Citovsky V: Nuclear localization signal binding protein from Arabidopsis mediates nuclear import of Agrobacterium VirD2 protein. Proc Natl Acad Sci USA 94: 10723-10728 (1997).
10. Bastos R, Lin A, Enarson M, Burke B: Targeting and function in mRNA export of nuclear pore complex protein Nup153. J Cell Biol 134: 1141-1156 (1996).
11. Bastos R, de Pouplana LR, Enarson M, Bodoor K, Burke B: Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex. J Cell Biol 137: 989-1000 (1997).
12. Belanger KD, Kenna MA, Wei S, Davis LI: Genetic and physical interaction between Srp1 and nuclear pore complex proteins Nup1p and Nup2p. J Cell Biol 126: 619-630 (1994).
13. Bucci M, Wente SR: In vivo dynamics of nuclear pore complexes in yeast. J Cell Biol 136: 1185-1199 (1997).
14. Buss F, Stewart M: Macromolecular interaction in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62. J Cell Biol 128: 251-261 (1995).
15. Buss F, Kent H, Stewart M, Bailer SM, Hanover JA: Role of different domains in self-association of rat nucleoporin p62. J Cell Sci 107: 631-638 (1994).
16. Byrd DA, Sweet DJ, Panic N, Konstantinov KN, Guan T, Saphire AC, Mitchell PJ, Cooper CS, Aebi U, Gerace L: Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. J Cell Biol 127: 1515-1526 (1994).
17. Carmo-Fonseca M, Kern H, Hurt EC: Human nucleoporin p62 and essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization. Eur J Cell Biol 55: 17-30 (1991).
18. Carrington JC, Kasschau KD, Mahajan SK, Schaad MC: Cell-to-cell and long distance transport of viruses in plants. Plant Cell 8: 1669-1681 (1996).
19. Corbett AH, Silver PA: Nucleocytoplasmic transport of macromolecules. Microbiol Mol Biol Rev 61: 193-211 (1997).
20. Cordes VI, Waizenegger I, Krohne G: Nuclear pore complex glycoprotein p62 from Xenopus laevis and mouse: cDNA cloning and identification of its glycosylation region. Eur J Cell Biol 55: 31-47 (1991).
21. Cordes VC, Reidenbach S, Rackwitz HR, Franke WW: Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. J Cell Biol 136: 515-529 (1997).
22. r 68,000 pore complex glycoprotein interfere with nuclear protein uptake in Xenopus oocytes. Chromosoma 97: 193-197 (1988).
23. Dabauvalle M-C, Loos K, and Scheer U: Identification of a soluble precursor complex essential for nuclear pore assembly in vitro. Chromosoma 100: 56-66 (1990).
24. Davis LI: The nuclear pore complex. Annu Rev Biochem 64: 865-896 (1995).
25. Davis LI, Blobel G: Identification and characterization of a nuclear pore complex protein. Cell 45: 699-709 (1986).
26. Davis LI, Fink GR: The NUP1 gene encodes an essential component of the yeast nuclear pore complex. Cell 61: 965-978 (1990).
27. Dingwall C, Laskey R: The nuclear membrane. Science 258: 942-947 (1992).
28. Dingwall C, Kandelslewis S, Seraphin B: A family of Ran binding proteins that includes nucleoporins. Proc Natl Acad Sci USA 92: 7525-7529 (1995).
29. D'Onofrio M, Starr CM, Park MK, Holt GD, Haltiwanger RS, Hart GW, Hanover JA: Partial cDNA sequence encoding a nuclear pore protein modified by O-linked N-acetylglucosamine. Proc Natl Acad Sci USA 85: 9595-9599 (1988).
30. Doye V, Hurt EC: Genetic approaches to nuclear pore structure and function. Trends Genet 11: 235-241 (1995).
31. Doye V, Hurt E: From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol 9: 401-411 (1997).
32. + RNA transport and nuclear pore distribution. EMBO J 13: 6062-6075 (1994).
33. Duverger E, Pellerin-Mendes C, Mayer R, Roche A-C, and Monsigny M: Nuclear import of glycoconjugates is distinct from the classical NLS pathway. J Cell Sci 108: 1325-1332 (1995).
34. Fabre E, Boelens WC, Wimmer C, Mattaj IW, Hurt EC: Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif. Cell 78: 275-289 (1994).
35. Featherstone C, Darby MK, Gerace L: A monoclonal antibody against the nuclear pore complex inhibits nucleocytoplasmic transport of protein and RNA in vivo. J Cell Biol 107: 1289-1297 (1988).
36. Finlay DR, Forbes DJ: Reconstitution of biochemically altered nuclear pores: Transport can be eliminated and restored. Cell 60: 17-29 (1990).
37. Finlay DR, Newmeyer DD, Price TM, Forbes DJ: Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores. J Cell Biol 104: 189-200 (1987).
38. Finlay DR, Meier E, Bradley P, Horecka J, Forbes DJ: A complex of nuclear pore proteins required for pore function. J Cell Biol 114: 169-183 (1991).
39. Forbes DJ: Structure and function of the nuclear pore complex. Annu Rev Cell Biol 8: 495-527 (1992).
40. Franke WW: Isolated nuclear membranes. J Cell Biol 31: 9-623 (1966).
41. Gerace L, Foisner R: Integral membrane proteins and dynamic organization of the nuclear envelope. Trends Cell Biol 4: 127-131 (1994).
42. Gerace L, Ottaviano Y, Kondor-Koch C: Identification of a major polypeptide of the nuclear pore complex. J Cell Biol 95: 826-837 (1982).
43. Goldberg MW, Allen TD: High resolution scanning electron microscopy of the nuclear envelope: demonstration of a new, regular, fibrous lattice attached to the baskets of the nucleoplasmic face of the nuclear pores. J Cell Biol 119: 1429-1440 (1992).
44. Goldberg MW, Allen TD: The nuclear pore complex: three-dimensional surface structure revealed by field emission, inlens scanning electron microscopy, with underlying structure uncovered by proteolysis. J Cell Sci 106: 261-274 (1993).
45. Goldberg MW, Allen T: Structural and functional organization of the nuclear envelope. Curr Opin Cell Biol 7: 301-309 (1995).
46. Goldberg MW, Allen TD: The nuclear pore complex and lamina: three-dimensional structures and interaction determined by field emission in-lens scanning electron microscopy. J Mol Biol 257: 848-865 (1996).
47. Goldfarb DS: Whose finger is on the switch? Science 276: 1814-1816 (1997).
48. Goldstein AL, Snay CA, Heath CV, Cole CN: Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p. Mol Biol Cell 7: 917-934 (1996).
49. Görlich D: Nuclear protein import. Curr Opin Cell Biol 9: 412-419 (1997).
50. Görlich D, Mattaj IW: Nucleocytoplasmic transport. Science 271: 1513-1518 (1996).
51. Görlich D, Kraft R, Kostka S, Vogel F, Hartmann E, Laskey RA, Mattaj IW, Izaurraide E: Importin provides a link between nuclear protein import and U snRNA export. Cell 87: 21-32 (1996).
52. Gorsch LC, Dockendorff TC, Cole CN: A conditional allele of the novel-repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes. J Cell Biol 129: 939-955 (1995).
53. Grandi P, Schlaich N, Tekotte H, Hurt EC: Functional interaction of Nic96p with a core nucleoporin complex consisting of Nsplp, Nup49p and a novel protein Nup57p. EMBO J 14: 76-87 (1995).
54. Greber UF, Gerace L: Nuclear protein import is inhibited by an antibody to a lumenal epitope of a nuclear pore complex glycoprotein. J Cell Biol 116: 15-30 (1992).
55. Greber UF, Senior A, Gerace L: A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. EMBO J 9: 1495-1502 (1990).
56. Haizel T, Merkle T, Pay A, Fejes E, Nagy F: Characterization of proteins that interact with the GTP-bound form of the regulatory GTPase Ran in Arabidopsis. Plant J 11: 93-103 (1997).
57. Hallberg E, Wozniak RW, Blobel G: An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region. J Cell Biol 122: 513-521 (1993).
58. Haltiwanger RS, Kelly WG, Roquemore EP, Blomberg MA, Dong L-YD, Kreppel L, Chou T-Y, Hart GW: Glycosylation of nuclear and cytoplasmic proteins is ubiquitous and dynamic. Biochem Soc Trans 20: 264-269 (1992).
59. Hanover JA, Cohen CK, Willingham MC, Park MK: O-linked N-acetylglucosamine is attached to proteins of the nuclear pore. J Biol Chem 262: 9887-9894 (1987).
60. Hart GW: Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins. Annu Rev Biochem 66: 315-335 (1997).
61. Harter K, Kircher S, Frohnmeyer H, Krenz M, Nagy F, Schäfer E: Light-regulated modification and nuclear translocation of cytosolic G-box binding factors in parsley. Plant Cell 6: 545-559 (1994).
62. Heese-Peck A, Raikhel NV: A glycoprotein modified with terminal N-acetylglucosamine and localized at the nuclear periphery shows sequence similarity to aldose-1-epimerases. Plant Cell, in press (1998).
63. Heese-Peck A, Cole RN, Borkhsenious ON, Hart GW, Raikhel NV: Plant nuclear pore complex proteins are modified by novel oligosaccharides with terminal N-acetylglucosamine. Plant Cell 7: 1459-1471 (1995).
64. Hicks GR, Raikhel NV: Specific binding of nuclear localization sequences to plant nuclei. Plant Cell 5: 983-994 (1993).
65. Hicks GR, Raikhel NV: Protein import into the nucleus: an integrated view. Annu Rev Cell Devel Biol 11: 155-188 (1995).
66. Hicks GR, Raikhel NV: Nuclear localization signal binding proteins in higher plant nuclei. Proc Natl Acad Sci USA 92: 734-738 (1995).
67. Hicks GR, Smith HMS, Shieh M, Raikhel NV: Three classes of nuclear import signals bind to plant nuclei. Plant Physiol 107: 1055-1058 (1995).
68. Hicks GR, Smith HMS, Lobreaux S, Raikhel NV: Nuclear import in permeabilized protoplasts from higher plants has unique features. Plant Cell 8: 1337-1352 (1996).
69. Hinshaw JE, Carragher BO, Milligan RA: Architecture and design of the nuclear pore complex. Cell 69: 1133-1141 (1992).
70. Holt GD, Snow CM, Senior A, Haltiwanger RS, Gerace L, Hart GW: Nuclear pore complex glycoproteins contain cytoplasmically disposed O-linked N-acetylglucosamine. J Cell Biol 104: 1157-1164 (1987).
71. Hu T, Guan T, Gerace L: Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins. J Cell Biol 134: 589-601 (1996).
72. Hurt EC: A novel nucleoskeletal-like protein located at the nuclear periphery is required for the life cycle of Saccharomyces cerevisiae. EMBO J 7: 323-4334 (1988).
73. + RNA export. J Cell Biol 130: 1275-1281 (1995).
74. Iovine MK, Wente SR: A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup16p and Nup100p. J Cell Biol 1374: 797-811 (1997).
75. Iovine MK, Watkins JL, Wente SR: The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor. J Cell Biol 131: 1699-1713 (1995).
76. Izaurralde E, Jarmolowski A, Beisel C, Mattaj I, Dreyfuss G, Fischer U: A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol 137: 27-35 (1997).
77. Izaurralde E, Kutay U, Mattaj IW, Görlich D: The asymmetric distribution of the constituents of the Ran system is essential for transport in and out of the nucleus. EMBO J 16: 6535-6547 (1997).
78. Jarnik M, Aebi U: Towards a more complete 3D structure of the nuclear pore complex. J Struct Biol 107: 291-308 (1991).
79. Jordan EG, Timmis JN, Trewavas AJ: The plant nucleus. In: Tolbert NE (ed), The Biochemistry of Plants, vol 1, pp. 490-588. Academic Press, New York (1980).
80. Kalinich JF, Douglas MG: In vitro translocation through the yeast nuclear envelope: signal dependent transport requires ATP and calcium. J Cell Biol 264: 17979-17989 (1989).
81. Kenna MA, Petranka JG, Reilly JL, Davis LI: Yeast N1e3p/Nup170p is required for normal stoichiometry of FG nucleoporins within the nuclear pore complex. Mol Cell Biol 16: 2025-2036 (1996).
82. Kraemer D, Wozniak RW, Blobel G, Radu A: The human CAN protein, a putative oncogene product associated with myloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. Proc Natl Acad Sci USA 91: 1519-1523 (1994).
83. Kraemer DC, Strambio-de-Castilla C, Blobel G, Rout MP: The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrates. J Biol Chem 270: 19017-19021 (1995).
84. Kutay U, Izaurrralde E, Bischoff FR, Mattaj IW, Görlich D: Dominant-negative mutants of importin-β block multiple pathways of import and export through the nuclear pore complex. EMBO J 16: 1153-1163 (1997).
85. Loeb JD, Davis LI, Fink GR: NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex. Mol Biol Cell 4: 209-222 (1993).
86. Mattaj IW, Boelens W, Izaurralde E, Jarmolowski A, Kambach C: Nucleocytoplasmic transport and snRNP assembly. Mol Biol Reports 18: 79-83 (1993).
87. Matunis MJ, Blobel G: Biochemical and molecular analysis of the mammalian nuclear pore complex and the regulation of nuclear transport. Mol Biol Cell (Supp 7): 95a (1996).
88. Meier E, Miller BR, Forbes DJ: Nuclear pore complex assembly studied with a biochemical assay for annulate lamellae formation. J Cell Biol 129: 1459-1472 (1995).
89. Merkle T, Haizel T, Matsumoto T, Harter K, Dallmann G, Nagy F: Phenotype of the fission yeast cell cycle regulatory mutant pim1-46 is suppressed by a tobacco cDNA encoding a small, Ran-like GTP-binding protein. Plant J 6: 555-565 (1994).
90. Merkle T, Leclerc D, Marshallsay C, Nagy F: A plant in vitro system for the nuclear import of proteins. Plant J 10: 1177-1186 (1996).
91. Miller MW, Hanover JA: Functional nuclear pores reconstituted with β-1,4 galactose-modified O-linked N-acetylglucosamine glycoproteins. J Biol Chem 269: 9289-9297 (1994).
92. 2 subunit binds nuclear localization signal and β subunit interacts with peptide repeat-containing nucleoporins. Proc Natl Acad Sci USA 92: 6532-6536 (1995).
93. Nakielny S, Dreyfuss G: Nuclear export of proteins and RNAs. Curr Opin Cell Biol 9: 420-429 (1997).
94. Nehrbass U, Fabre E, Dihlman S, Herth W, Hurt EC: Analysis of nucleo-cytoplasmic transport of a thermosensitive mutant of nuclear pore protein Nsplp. Eur J Cell Biol 62: 1-12 (1993).
95. Nehrbass U, Rout MP, Maguire S, Blobel G, Wozniak RW: The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex. J Cell Biol 133: 1153-1162 (1996).
96. Newmeyer DD, Forbes DJ: Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation. Cell 52: 641-653 (1988).
97. Nigg EA: Nucleocytoplasmic transport: signals, mechanisms, and regulation. Nature 386: 779-787 (1997).
98. Panté N, Aebi U: The nuclear pore complex. J Cell Biol 122: 977-984 (1993).
99. Panté N, Aebi U: Sequential binding of import ligands to distinct nucleopore regions during their nuclear import. Science 273: 1729-1732 (1996).
100. Park MK, D'Onofrio M, Willingham MC, Hanover JA: A monoclonal antibody against a family of nuclear pore proteins (nucleoporins): O-linked acetylglucosamine is part of the immunodeterminant. Proc Natl Acad Sci USA 84: 6462-6466 (1987).
101. Pollard VW, Michael WM, Naldalny B, Slomi MC, Wang P, Dreyfuss G: A novel receptor mediated nuclear protein import pathway. Cell 88: 985-994 (1996).
102. Powers MA, Macaulay C, Masiarz FR, Forbes DF: Reconstituted nuclei depleted of a vertebrate GLFG nuclear pore complex protein, p97, import but are defective in nuclear growth and replication. J Cell Biol 128: 721-736 (1995).
103. Powers MA, Forbes DJ, Dahlberg JE, Lund E: The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathway. J Cell Biol 136: 241-250 (1997).
104. Radu A, Blobel G and Wozniak, RW: Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA. J Cell Biol 121: 1-9 (1993).
105. Radu A, Blobel G, Wozniak RW: Nup107 is a novel nuclear pore complex protein that contains a leucine zipper. J Biol Chem 269: 17600-17605 (1994).
106. Radu A, Blobel G, Moore MS: Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Natl Acad Sci USA 92: 1769-1773 (1995).
107. Radu A, Moore MS, Blobel G: The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell 81: 215-222 (1995).
108. Raikhel NV: Nuclear targeting in plants. Plant Physiol 100: 1627-1632 (1992).
109. Reichelt R, Holzenburg A, Buhle EL, Jarnik M, Engel A, Aebi U: Correlation between structure and mass distribution of the nuclear pore complex, and of distinct pore complex components. J Cell Biol 110: 883-894 (1990).
110. Rexach M, Blobel G: Protein import into nuclei: association and dissociation reactions involving transport substrate transport factors, and nucleoporins. Cell 83: 683-692 (1995).
111. Roberts K, Northcote DH: Structure of the nuclear pore in higher plants. Nature 228: 385-386 (1970).
112. Rout MP, Blobel G: Isolation of the yeast nuclear pore complex. J Cell Biol 123: 771-783 (1993).
113. Rout MP, Wente SR: Pores for thought: nuclear pore complex proteins. Trends Cell Biol 4: 357-365 (1994).
114. Saitoh H, Cooke CA, Burgess WH, Earnshaw WC, Dasso M: Direct and indirect association of the small GTPase Ran with nuclear pore proteins and soluble transport factors: studies in Xenopus laevis egg extract. Mol Biol Cell 7: 1319-1334 (1996).
115. Sanderfoot AA, Lazarowitz SG: Getting it together in plant virus movement: cooperative interactions between bipartite geminivirus movement proteins. Trends Cell Biol 6: 353-358 (1996).
116. Schlaich NL, Haner M, Lustig A, Aebi U, Hurt EC: In vitro reconstitution of a heterotrimeric nucleoporin complex consisting of recombinant Nsplp, Nup49p, and Nup57p. Mol Biol Cell 8: 33-46 (1997).
117. Schlenstedt G, Hurt E, Doye V, Silver PA: Reconstitution of nuclear protein transport with semi-intact yeast cells. J Cell Biol 123: 785-798 (1993).
118. Scofield GN, Seven AF, Shaw PJ, Doonan JH: Identification and localization of a nucleoporin-like protein component of the plant nuclear matrix. Planta 187: 414-420 (1992).
119. + RNA and nuclear pores. EMBO J 16: 3256-3271 (1997).
120. Sheng J, Citovsky V: Agrobacterium-plant cell DNA transport: have virulence proteins, will travel. Plant Cell 8: 1699-1710 (1996).
121. Shieh M, Wessler SR, Raikhel NV: Nuclear targeting of the maize R protein requires two localization sequences. Plant Physiol 101: 353-361 (1993).
122. Siniossoglou S, Wimmer C, Rieger M, Doye V, Tekotte H, Weise C, Emig S, Segref A, Hurt EC: A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell 26: 265-275 (1996).
123. Siomi H, Dreyfuss G: A nuclear localization domain in the hnRNP A1 protein. J Cell Biol 129: 551-560 (1995).
124. Smith HMS, Hicks GR, Raikhel NV: Importin α from Arabidopsis thaliana is a nuclear import receptor that recognizes three classes of import signals. Plant Physiol 114: 411-417 (1997).
125. Snow CM, Senior A, Gerace L: Monoclonal antibodies identify a group of nuclear pore complex glycoproteins. J Cell Biol 104: 1143-1156 (1987).
126. Soderqvist H, Hallberg E: The large C-terminal region of the integral pore membrane proteins, POM121, is facing the nuclear pore complex. Eur J Cell Biol 64: 184-191 (1994).
127. Sukegawa J, Blobel G: A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm. Cell 72: 29-38 (1993).
128. Terns MP, Dahlberg JE: Retention and 5′ cap trimethylation of U3 snRNA in the nucleus. Science 264: 959-961 (1994).
129. Ullman KC, Powers MA, Forbes DJ: Nuclear export receptors: from importin to exportin. Cell 90: 967-970 (1997).
130. Van Deursen J, Boer J, Kasper L, Grosveld G: G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214. EMBO J 15: 5574-5583 (1996).
131. Varagona MJ, Schmidt RJ, Raikhel NV: Nuclear localization signal(s) required for nuclear targeting of the maize regulatory protein Opaque-2. Plant Cell 4: 1213-1227 (1992).
132. Wente SR, Blobel G: NUP145 encodes a novel yeast glycine-leucine-phenylalanine-glycine (GLFG) nucleoporin required for nuclear envelope structure. J Cell Biol 125: 955-969 (1994).
133. Wente SR, Rout MP, Blobel G: A new family of yeast nuclear pore complex proteins. J Cell Biol 119: 705-723 (1992).
134. Whittaker G, Bui M, Helenius A: Nuclear trafficking of influenza virus ribonucleoproteins in heterokaryons. J Virol 70: 2743-2756 (1996).
135. Wilken N, Senecal J-L, Scheer U, Dabauvalle M-C: Localization of the Ran-GTP binding protein Ran-BP2 at the cytoplasmic side of the nuclear pore complex. Eur J Cell Biol 68: 211-219 (1995).
136. Wozniak RW, Bartnik E, Blobel G: Primary structure analysis of an integral membrane glycoprotein of the nuclear pore. J Cell Biol 108: 2083-2092 (1989).
137. Wozniak RW, Blobel G, Rout MP: POM 152 is an integral protein of the pore membrane domain of the yeast nuclear envelope. J Cell Biol 125: 31-42 (1994).
138. Wu J, Matunis MJ, Kraemer D, Blobel G, Coutavas E: Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J Biol Chem 270: 14209-14213 (1995).
139. Yokoyama N, Hayashi N, Seki T, Panté N, Ohba T, Nishii K, Kuma K, Hayashida T, Miyata T, Aebi U et al.: A giant nucleopore protein that binds Ran/TC4. Nature 376: 184-188 (1995).
140. Yoneda Y: How proteins are transported from cytoplasm to the nucleus. J Biochem 121: 811-817 (1997).
141. Zupan JR, Citovsky V, Zambryski P: Agrobacterium VirE2 protein mediates nuclear uptake of single-stranded DNA in plant cells. Proc Natl Acad Sci USA 93: 2392-2397 (1996).