Transport of peptidomimetic thrombin inhibitors with a 3-amidino-phenylalanine structure: Permeability and efflux mechanism in monolayers of a human intestinal cell line (Caco-2)

Pharmaceutical Research

Volumn 18, Issue 8, 2001, Pages 1110-1118

  Kamm, W ^a,b   Hauptmann, J ^c   Behrens, I ^a   Sturzebecher J ^c   Dullweber, F ^a   Gohlke, H ^a   Stubbs, M ^a   Klebe, G ^a   Kissel, T ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

3 amidino phenylalanine amides; Caco 2 cells; Efflux; Oxamidine promoiety; Structure transport relationship; Thrombin inhibitors

Indexed keywords

AMIDINE; AMINE; CARBOXYLIC ACID DERIVATIVE; CREMOPHOR; INDOMETACIN; NALPHA (2 NAPHTHYLSULFONYL) 3 AMIDINOPHENYLALANINE; NIPECOTIC ACID; PIPERIDINE DERIVATIVE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; VALSPODAR;

ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TRANSPORT; ELECTRIC RESISTANCE; ENANTIOMER; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE;

AMIDINES; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPITHELIAL CELLS; HEMOSTATICS; HUMANS; INDICATORS AND REAGENTS; INTESTINAL ABSORPTION; MOLECULAR MIMICRY; PHENYLALANINE; SOLUBILITY; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; THROMBIN;

EID: 0034807548     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010966708181     Document Type: Article

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