Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 19, 1999, Pages 2837-2842

  Rewinkel, J B M ^a   Lucas, H ^a   Smit, M J ^a   Noach, A B J ^a   Van Dinther, T G ^a   Rood, A M M ^a   Jenneboer, A J S M ^a   Van Boeckel, C A A ^a  

^a NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BENZAMIDINE DERIVATIVE; ORG 37476; PIPERIDINE DERIVATIVE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL MODEL; CELL MEMBRANE PERMEABILITY; CHEMICAL MODIFICATION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG INHIBITION; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; INTESTINE ABSORPTION; MEMBRANE TRANSPORT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANTICOAGULANTS; ANTITHROMBINS; BICYCLO COMPOUNDS, HETEROCYCLIC; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; HUMANS; ISOQUINOLINES; MOLECULAR STRUCTURE; PIPERIDINES; SERINE PROTEINASE INHIBITORS; THROMBIN;

EID: 0033523711     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00483-7     Document Type: Article

References (23)

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