Radioligand-binding assay employing P-glycoprotein-overexpressing cells: Testing drug affinities to the secretory intestinal multidrug transporter

Pharmaceutical Research

Volumn 15, Issue 7, 1998, Pages 1001-1006

  Döppenschmitt, Stephan ^a,b   Spahn Langguth, Hildegard ^a   Regårdh, Carl Gunnar ^b   Langguth, Peter ^b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

3H verapamil; Binding affinity; Drug efflux; Drug secretion; P glycoprotein; Radiligand binding assay

Indexed keywords

2' DEOXYTUBERCIDIN; ATENOLOL; BACLOFEN; CAFFEINE; CALCEIN; CELIPROLOL; CHLORPROMAZINE; CIMETIDINE; DOXORUBICIN; FLUOROURACIL; GLYCOPROTEIN P; INDOMETACIN; MONOCLONAL ANTIBODY; N METHYLNICOTINAMIDE; OUABAIN; PARACETAMOL; PHENOBARBITAL; PINDOLOL; PROBENECID; QUINIDINE; QUININE; RHODAMINE 123; TALINOLOL; TESTOSTERONE; TETRYLAMMONIUM; TRANYLCYPROMINE; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE; VINBLASTINE SULFATE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN 3T3; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE CELL; INTESTINE SECRETION; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; PRIORITY JOURNAL; RECEPTOR DENSITY; REPRODUCIBILITY; TECHNIQUE;

ADRENERGIC BETA-ANTAGONISTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING, COMPETITIVE; CACO-2 CELLS; CALCIUM CHANNEL BLOCKERS; FLUORESCENT DYES; HUMANS; KINETICS; P-GLYCOPROTEIN; PROPANOLAMINES; RADIOLIGAND ASSAY; REPRODUCIBILITY OF RESULTS; RHODAMINE 123; RHODAMINES; TRITIUM; VERAPAMIL; VINBLASTINE;

EID: 0031818952     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011965707998     Document Type: Article

References (25)

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