First-pass elimination of a peptidomimetic thrombin inhibitor is due to carrier-mediated uptake by the liver: Interaction with bile acid transport systems

Biochemical Pharmacology

Volumn 52, Issue 1, 1996, Pages 85-96

  Eckhardt, Uta ^a   Stüber, Werner ^b   Dickneite, Gerhard ^b   Reers, Martin ^b   Petzinger, Ernst ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Behringwerke AG   (Germany)

Author keywords

Bile elimination; Bioavailability; Blood coagulation; CRC 220; Hepatocyte; Membrane transport

Indexed keywords

AMPHOPHILE; ASPARTAME; BILE ACID; BROMSULFOPHTHALEIN; BUMETANIDE; CHENODEOXYCHOLIC ACID; CHOLIC ACID; CHOLINE; CRC 220; CRC 294; CRC 369; CRC 569; CRC 572; CRC 584; DEOXYCHOLIC ACID; DRUG CARRIER; GLYCOCHOLIC ACID; LITHIUM; LITHOCHOLIC ACID; N ALPHA (2 NAPHTHYLSULFONYLGLYCYL) 4 AMIDINOPHENYLALANYLPIPERIDINE; PEPTIDE DERIVATIVE; RADIOISOTOPE; SODIUM ION; TAUROCHOLIC ACID; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; BILIARY EXCRETION; CELL LINE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DIFFUSION; DRUG ELIMINATION; DRUG UPTAKE; ENERGY; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; LIVER CELL; MALE; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; TEMPERATURE;

ADOLESCENT; ANIMALS; ANTITHROMBINS; BILE; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CHLORIDES; DIPEPTIDES; ENERGY METABOLISM; HUMANS; LIVER; MALE; PIPERIDINES; RATS; RATS, WISTAR; SODIUM; SULFOBROMOPHTHALEIN; TEMPERATURE; THROMBIN;

EID: 0029891673     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00141-4     Document Type: Article

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