In vitro and in vivo evaluations of intestinal barriers for the zwitterion L-767,679 and its carboxyl ester prodrug L-775,318: Roles of efflux and metabolism

Drug Metabolism and Disposition

Volumn 26, Issue 6, 1998, Pages 520-527

  Prueksaritanont, Thomayant ^a   Deluna, Polly ^b   Gorham, Lynn M ^b   Ma, Bennett ^b   Cohn, Dosinda ^b   Pang, Jianmei ^b   Xu, Xin ^b   Leung, Kwan ^b   Lin, Jiunn H ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 ETHYNYL N [[1,2,3,4 TETRAHYDRO 1 OXO 7 (1 PIPERAZINYL) 2 ISOQUINOLINYL]ACETYL] BETA ALANINE; 3 ETHYNYL N [[1,2,3,4 TETRAHYDRO 1 OXO 7 (1 PIPERAZINYL) 2 ISOQUINOLINYL]ACETYL] BETA ALANINE BENZYL ESTER; AMPHOLYTE; FIBRINOGEN RECEPTOR ANTAGONIST; ISOQUINOLINE DERIVATIVE; N [[7 (PIPERAZIN 1 YL) 3,4 DIHYDRO 1(1H) ISOQUINOLINONE 2 YL]ACETYL]ETHYNYL BETA ALANINE; OIL; PRODRUG; QUINIDINE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG TRANSPORT; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; INTESTINE SECRETION; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS;

ANIMALS; BETA-ALANINE; CACO-2 CELLS; HUMANS; INTESTINES; MALE; P-GLYCOPROTEIN; PIPERAZINES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PRODRUGS; QUINIDINE; RATS; RATS, SPRAGUE-DAWLEY; VERAPAMIL;

EID: 0031793032     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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