Pluripotent cells (stem cells) and their determination and differentiation in early vertebrate embryogenesis

Development Growth and Differentiation

Volumn 43, Issue 5, 2001, Pages 469-502

  Tiedemann, H ^a,e   Asashima, M ^b   Grunz, H ^c   Knochel W ^d  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d UNIVERSITY OF TOKYO   (Japan)

^e NONE   (Germany)

Author keywords

Early differentiation; Ethical problem; Human stem cell; Stem cell; Vertebrate embryo

Indexed keywords

ACTIVIN; BETA CATENIN; FIBROBLAST GROWTH FACTOR; FOLLISTATIN; NUCLEAR FACTOR; PROTEOGLYCAN; SMAD PROTEIN; TRANSCRIPTION FACTOR;

BLASTOCYST; CELL DIFFERENTIATION; ECTODERM; EMBRYO DEVELOPMENT; ENDODERM; FETUS (ANATOMY); GASTRULA; GENE ACTIVATION; GENE REPRESSION; INNER CELL MASS; MESODERM; NERVOUS SYSTEM DEVELOPMENT; NEUROECTODERM; NONHUMAN; PRIMORDIAL GERM CELL; REVIEW; STEM CELL; XENOPUS LAEVIS;

AMPHIBIA; MAMMALIA; VERTEBRATA; XENOPUS LAEVIS;

EID: 0034797086     PISSN: 00121592     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-169X.2001.00599.x     Document Type: Review

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266. Protein kinase C mediates neural induction in Xenopus laevis
267. Cell culture. Progenitor cells from human brain after death
268. The Spemann organizer-expressed zinc finger gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction pathway
269. The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions
270. Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
271. The head inducer cerberus is a multifunctional antagonist of nodal, BMP and Wnt signals
272. Cleavage of chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity
273. Dorso-ventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
274. Expression of the guanine nucleotide-binding protein Go correlates with the state of neural competence in the amphibian embryo
275. Activation of Pax6 depends on somitogenesis in the chick embryo cervical spinal cord
276. Activin A inhibits Pax6 expression and perturbs cell differentiation in the developing spinal cord in vitro
277. Patterning cascades in the neural tube. Neural development
278. Isolation of a vegetalizing inducing factor after extraction with acid ethanol. Concentration-dependent inducing activity of the factor
279. cDNA sequence of Xenopus laevis bone morphogenetic protein 2 (BMP-2)
280. Transcriptional regulation of Xvent homeobox genes
281. Expression of activin transcripts in follicle cells and oocytes of Xenopus laevis
282. Cyclops encodes a nodal-related factor involved in midline signaling
283. Transcriptional regulation of the Xlim-1 gene by activin is mediated by an element in intron I
284. Long-term proliferation of mouse primordial germ cells in culture
285. Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
286. Increase in circulating stem cells following chemotherapy in man
287. Diffusion controlled reactions in spheroidal geometry: Application to repressor-operator association and membrane bound enzymes
288. Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: Developmentally regulated expression of myogenic determination genes and functional expression of ionic currents
289. Primordial germ cell-derived mouse embryonic germ cells in vitro resemble undifferentiated stem cells with respect to differentiation capacity and cell cycle distribution
290. Mesoderm induction in amphibians: The role of TGF-β2-like factors
291. Mix 1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos
292. Retinoic acid modifies mesodermal patterning in early Xenopus embryos
293. Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryos
294. Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: Involvement in the development of the neural axis
295. Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps
296. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus
297. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
298. The specification of heart mesoderm occurs during gastrulation in Xenopus laevis
299. Transfilter neural induction of amphibian ectoderm
300. Determination of the dorsal-ventral axis in eggs of Xenopus laevis. Rescue of UV impaired eggs by obligue orientation before first cleavage
301. Nodal signalling in vertebrate development
302. An unusual feature revealed by the crystal structure at 2.2 Ä resolution of human transforming growth factor β
303. Wnt antagonism initiates cardiogenesis in Xenopus laevis
304. Mesoderm formation in response to Brachyury requires FGF signaling
305. Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg 1 and activin: Does activin play a role in mesoderm induction?
306. High performance gel permeation chromatography of proteins
307. Human embryonic germ cell derivatives express a broad reange of developmentally distinct markers and proliferate extensively in vitro
308. Derivation of pluripotent stem cells from cultured human primordial germ cells
309. Requirement for Lim1 in head-organizier function
310. The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation
311. Developmental biology of the pancreas
312. Mesoderm induction in early Xenopus embryos by heparin-binding growth factors
313. Culture and differentiation of embryonic stem cells
314. Expression of a Xenopus homolog of brachyury (T) is an immediate-early response to mesoderm induction
315. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A
316. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
317. Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm
318. Changes in the state of commitment of single animal pole blastomeres of Xenopus laevis
319. Analysis of dishevelled signalling pathways during Xenopus development
320. Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1)
321. Two Pax-binding sites are required for early embryonic brain expression of an engrailed-2-transgene
322. Purification and characterization of mouse hematopoietic stem cells
323. Úber die determination der ersten organ-anlagen des amphibienembryos
324. Úber die induktion von embryonalanlagen durch immplantation artfremder organisatoren
325. Self renewal and differentiation of interlerleukin-3-dependent multipotent stem cells are modulated by stromal cells and serum factors
326. Differential expression of VegT and Antipodean protein isoforms in Xenopus
327. The role of retinal pigment cells in regenerating neural retinae of adult salamander eyes
328. Initiation of neural induction by FGF signaling before gastrulation
329. Derrière: A TGF-β family member required for posterior development in Xenopus
330. Differential induction of regulatory genes during mesoderm formation in Xenopus laevis embryos
331. Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus
332. Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center
333. Localized synthesis of the Vg1 protein during early Xenopus development
334. Differenzierungs- und induktionsleistungen verschiedener abschnitte der medullarplatte und des urdarmdaches von triton im kombinat
335. Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo
336. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
337. Processed Vg1 protein is an axial mesoderm inducer in Xenopus
338. Embryonic stem cell lines derived from human blastocysts
339. Entwicklung und differenzierung höherer organismen
340. The mechanism of neural induction: Neural differentiation of Triturus ectoderm exposed to hepes buffer
341. Test of embryonic inducing factors: Advantages and disadvantages of different procecdures
342. Mesoderm differentiation in early amphibian embryos depends on the animal cap
343. Determination, induction and pattern formation in early amphibian embryos
344. Neural induction in embryos
345. Biological activity of vegetalizing and neuralizing inducing factors after binding to BAC-Cellulose and CNBr-Sepharose
346. Molecular mechanisms of tissue determination and pattern formation in amphibian embryos
347. Basic fibroblast growth factor can induce exclusively neural tissue in Triturus ectoderm explants
348. The vegetalizing factor - A member of the evolutionarily highly conserved activin family
349. 2 in gefurchte und ungefurchte eihälften und in verschiedene entwicklungsstadien von triturus
350. Versuche zur chemischen kennzeichnung von embryonalen induktionsstoffen
351. Isolierung von ribonucleinsäure und nucleotiden aus embryonalextrakt und leber und ihr verhalten im induktionsversuch
352. Das induktionsvermögen gereinigter induktionsfaktoren im kombinationsversuch
353. Neural inducing factors from Xenopus laevis eggs and embryos
354. Polyvinylsulfate: Interaction with complexes of morphogenetic factors and their natural inhibitors
355. Die selbstdifferen-zierungsfähigkeit medianer und lateraler teile der rumpf-medullarplatte bei urodelen
356. Morphogenetic interaction of presumptive neural and mesodermal cells mixed in different ratios
357. The LIM class homeobox gene lim 5: Implied role in CNS patterning in Xenopus and Zebrafish
358. Nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
359. Subcortical rotation in Xenopus eggs: An early step in embryonic axis specification
360. DNA sequences mediating the transcriptional response of the Mix 2 homeobox gene to mesoderm induction
361. The C-terminal trans-activation domain of β-catenin is necessary and sufficient for signaling by the LEF-1/β-catenin complex in Xenopus laevis
362. Implantation von indifferentem embryonalen gewebe in die leibeshöhle erwachsener molche
363. Die induktionsfähigkeit der gehirn-platte bei urodelen und ihr median-laterales gefälle
364. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8
365. Molecular mechanisms of Spemann's organizer formation: Conserved growth factor synergy between Xenopus and mouse
366. A role for GATA5 in Xenopus endoderm specification
367. Stem cells: Units of development, units of regeneration and units of evolution
368. Smads and early developmental signaling by the TGF-β superfamily
369. Viable offspring derived from fetal and adult mammalian cells
370. Induction of epidermis and inhibition of neural fate by Bmp-4
371. Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: The role of maternal activin
372. Characterization of pluripotent stem cells line derived from a mouse embryo
373. Molecular biology of the bone morphogenetic proteins
374. Maternal β-catenin establishes a 'dorsal signal' in early Xenopus embryos
375. Vegetal pole cells and commitment to form endoderm in Xenopus laevis
376. Allostenic effects in hemoglobin
377. Beeinflussung der differenzierungsleistung des isolierten mesoderms von molchkeimen durch zugefügtes chorda- und neuralmaterial
378. Direct evidence for transformation of differentiated iris epithelial cells into lens cells
379. Expression of BMP-2, 4 genes during early development in Xenopus
380. Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
381. A two-step model for the fate determination of presumptive endodermal blastomeres in Xenopus embryos
382. The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis
383. The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
384. The homeobox-containing gene XANF-1 may control development of the Spemann organizer
385. The role of maternal VegT in establishing the primary germ layers in Xenopus embryos
386. Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation
387. Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro
388. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4