The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation

Developmental Biology

Volumn 213, Issue 1, 1999, Pages 202-206

  Simpson, Eleanor H ^a   Johnson, Dabney K ^b   Hunsicker, Pat ^b   Suffolk, Ruth ^a   Jordan, Siobhán A ^a   Jackson, Ian J ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN CER1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; EMBRYO PATTERN FORMATION; GENE ACTIVITY; GENE FUNCTION; GENE INDUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPUS;

ANIMALIA; CERBERUS; MAMMALIA; XENOPUS CERBERUS;

EID: 0033199854     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1999.9372     Document Type: Article

References (28)

1. -/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 121:1995;3279-3290.
2. Ang S.-L., Conlon R. A., Jin O., Rossant J. Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development. 120:1994;2979-2989.
3. Ang S.-L., Jin O., Rhinn M., Daigle N., Stevenson L., Rossant J. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development. 122:1996;243-252.
4. Bell J. A., Rinchik E. M., Raymond S., Suffolk R., Jackson I. J. A high resolution map of the brown (b, Tyrp1) deletion complex of mouse chromosome 4. Mamm. Genome. 6:1995;389-395.
5. Belo A. J., Bouwmeester T., Leyns L., Kertesz N., Gallo M. F., De Robertis E. M. Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech. Dev. 68:1997;45-57.
6. Biben C., Stanley E., Fabri L., Kotecha S., Rhinn M., Drinkwater C., Lah M., Wang C.-C., Nash A., Hilton D., Ang S., Mohun T., Harvey R. Murine Cerberus homologue mCer-1: A candidate anterior patterning molecule. Dev. Biol. 194:1998;135-151.
7. Bouwmeester T., Kim S., Sasai Y., Lu B., De Robertis E. M. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature. 382:1996;595-601.
8. Davis A. P., Justice M. J. An Oak Ridge legacy: The specific-locus test and its role in mouse mutagenesis. Genetics. 148:1998;7-12.
9. Ferguson C. A., Tucker A. S., Christensen L., Lau A. L., Matzuk M. M. Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev. 12:1998;2636-2649.
10. Hammond K. L., Hanson I. M., Brown A. G., Lettice L. A., Hill R. E. Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb. Mech. Dev. 74:1998;121-131.
11. Hecksher-Sorensen J., Hill R. E., Lettice L. Double labeling for whole-mount in situ hybridization in mouse. Biotechniques. 24:1998;914-916.
12. Hsu D. R., Economides A. N., Wang X., Eimon P. M., Harland R. M. The Xenopus dorsalising factor Gremlin identifies a novel family of secreted proteins that antagonise BMP activities. Mol. Cell. 1:1998;673-683.
13. Irving C., Nieto M. A., DasGupta R., Charnay P., Wilkinson D. G. Progressive spatial restriction of Sek-1 and Krox-20 gene expression during hindbrain segmentation. Dev. Biol. 173:1996;26-38.
14. Matsuo I., Kuratani S., Kimura C., Takeda N., Aizawa S. Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 9:1995;2646-2658.
15. Matzuk M. M., Kumar T. R., Vassalli A., Bickenbach J. R., Roop D. R. Functional analysis of activins during mammalian development. Nature. 374:1995;354-356.
16. Minabe-Saegusa C., Saegusa H., Tsukahara M., Noguchi S. Sequence and expression of a novel mouse gene PRDC (protein related to DAN and Cerberus) identified by a gene trap approach. Dev. Growth Differ. 40:1998;343-353.
17. Piccolo S., Agius E., Leyns L., Bhattacharyya S., Grunz H., Bouwmeester T., De Robertis E. M. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and wnt signals. Nature. 397:1999;707-710.
18. Rinchik E. M. Molecular genetics of the brown (b)-locus region of mouse chromosome 4. II. Complementation analyses of the lethal brown deletions. Genetics. 137:1994;855-865.
19. Rinchik E. M., Bell J. A., Hunsicker P. R., Friedman J. M., Jackson I. J., Russell L. B. Molecular genetics of the brown (b)-locus region of mouse chromosome 4. I. Origin and molecular mapping of radiation- and chemical-induced lethal brown deletions. Genetics. 137:1994;845-854.
20. Rivera-Perez J. A., Mallo M., Gendron-Maguire M., Gridley T., Behringer R. R. Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development. Development. 121:1995;3005-3012.
21. Russell L. B. Functional and structural analysis of the mouse genomic regions screened by the morphological specific-locus test. Mutat. Res. 212:1989;23-32.
22. Russell W. L. X-ray induced mutations in mice. Cold Spring Harbor Symp. Quant. Biol. 16:1951;327-336.
23. Shawlot W., Deng J. M., Behringer R. R. Expression of the mouse Cerberus-related gene Cerr1 suggests a role in anterior neural induction and somitogenesis. Proc. Natl. Acad. Sci. USA. 95:1998;6198-6203.
24. Stanley E., Gilbert N. A., Jenkins N. G., Harvey R. P. Murine Cerberus homologue cer1 maps to chromosome 4. Genomics. 49:1998a;337-338.
25. Stanley E., Biben C., Kotecha S., Fabri L., Tajbakhsh S., Wang C. C., Hatzistavrou T., Roberts B., Drinkwater C., Lah M., Buckingham M., Hilton D., Nash A., Mohun T., Harvey R. P. DAN is a secreted glycoprotein related to Xenopus cerberus. Mech. Dev. 77:1998b;173-184.
26. Vassalli A., Matzuk M. M., Gardner H. A., Lee K. F., Jaenisch R. Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 8:1994;414-427.
27. Wilkinson D. G., Bhatt S., Charvier P., Bravo R., Charnay P. Segment-specific expression of a zinc finger gene in the developing nervous system of the mouse. Nature. 337:1989;461-464.
28. Yamada G., Mansouri A., Torres M., Stuart E. T., Blum M. Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death. Development. 121:1995;2917-2922.