Neural Induction in Amphibians

Current Topics in Developmental Biology

Volumn 35, Issue C, 1997, Pages 191-228

  Crunz, Horst ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIBIA; ANIMAL; ECTODERM; EMBRYO DEVELOPMENT; EMBRYO INDUCTION; GASTRULA; GENE EXPRESSION REGULATION; GENETICS; MORPHOGENESIS; NERVOUS SYSTEM; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW;

AMPHIBIA; ANIMALS; BODY PATTERNING; ECTODERM; EMBRYONIC DEVELOPMENT; EMBRYONIC INDUCTION; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; NERVOUS SYSTEM;

EID: 0030629797     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0070-2153(08)60260-4     Document Type: Article

References (247)

1. F. Aberger, Schüren G. Lepperdinger H. Grunz K. Richter 1997 Induction of anterior neural fate by a novel cement gland-specific gene in Xenopus. Submitted.
2. Albers, B., Competence as the main factor determining the size of the neural plate. Develop. Growth and Differ. 29 (1987), 535–545.
3. Amaya, E., Kroll, K.L., A method for generating transgenic frog embryos. Sharpe, Paul., Mason, Ivor., (eds.) Methods in Molecular Biology: Methods and Protocols, 1997, Humana Press, Totowa, N.J. in press.
4. Amaya, E., Stein, P.A., Musci, T.J., Kirschner, M.W., FGF signalling in the early specification of mesoderm in Xenopus. Development 118 (1993), 477–487.
5. Ancel, P., Vintemberger, P., Recherches sur le déterminisme de la symétrie bilaterale dans l'oeuf des amphibiens. Bull. Biol. France et Belg.(suppl. 31), 1948, 1–182.
6. Arüzumi, T., Asashima, M., Head and trunk-tail organizing effects of the gastrula ectoderm of Cynops pyrrhogaster after treatment with activin-A. Roux's Arch. Dev. Biol. 204 (1995), 427–435.
7. Arüzumi, T., Sawamura, K.-I., Uchiyama, H., Asashima, M., Dose- and time-dependent mesoderm induction and outgrowth formation by activin-A in Xenopus laevis. Int. J. Dev. Biol. 35 (1991), 407–414.
8. Asashima, M., Review: Mesoderm induction during early amphibian development. Develop. Growth Differ. 36 (1994), 343–355.
9. Asashima, M., Nakano, H., Shimada, K., Knoshita, K., Ishii, K., Shibai, H.U., Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor). Roux's Arch. Dev. Biol. 198 (1990), 330–335.
10. Asashima, M., Nakano, H., Uchiyama, H., Sugino, H., Nakamura, T., Eto, Y., Ejima, D., Davids, M., Plessow, S., Cichocka, I., Kinoshita, K., Follistatin inhibits the mesoderm-inducing activity of activin-A and the vegetalizing factor from chicken embryo. Roux's Arch. Dev. Biol. 200 (1991), 4–7.
11. Asashima, M., Uchiyama, H., Nakano, H., Eto, Y., Ejima, D., Sugino, H., Davids, M., Plessow, S., Born, J., Hoppe, P., Tiedemann, H., Tiedemann, H., The vegetalizing factor from chicken embryos: Its EDF (activin-A)-like activity. Mech. Development 34 (1991), 135–141.
12. Ault, K.T., Dirksen, M.L., Jamrich, M., A novel homeobox gene PVI mediates induction of ventral mesoderm in Xenopus embryos. Proc. Natl. Acad. Sci. USA. 93 (1996), 6415–6420.
13. Bauer, D.V., Best, D.W., Hainski, A.M., Moody, S.A., A contact-dependent animal-to-vegetal signal biases neural lineages during Xenopus cleavage stages. Dev. Biol. 178 (1996), 217–228.
14. Bautzmann, H., Holtfreter, J., Spemann Mangold, H., Versuche zur analyse der induktionsmittel in der embryonalentwicklung. Naturwissenschaften 20 (1932), 971–974.
15. Baxevanis, A.D., Landsman, D., The HMG-1 box protein family: Classification and functional relationships. Nucleic Acids Res. 23 (1995), 1604–1613.
16. Becker, U., Tiedemann, H., Tiedemann, H., Versuche zur determination von embryonalen amphibiengewebe durch induktionsstoffe in Lösung. Z. Naturforschg. 14b (1959), 608–609.
17. Behrens, J., von Kries, J.P., Kuril, M., Bruhn, L., Wedlich, D., Grosschedl, R., Birchmeier, W., Functional interaction of β-catenin with the transcription factor LEF-1. Nature 382 (1996), 638–642.
18. Blitz, I.L., Cho, K.W.Y., Anterior neurectoderm is progressively induced during gastrulation: The role of the Xenopus homeobox gene orthodenticle. Development 121 (1995), 993–1004.
19. Blumberg, B., Wright, C.V.E., De Robertis, E.M., Cho, K.W.Y., Organizer-specific homeobox genes in Xenopus-laevis embryos. Science 253 (1991), 194–196.
20. Born, J., Hoppe, P., Janeczek, J., Tiedemann, H., Tiedemann, H., Covalent coupling of neuralizing factors from Xenopus to sepharose beads: No decrease of inducing activity. Cell Diff. 19 (1986), 97–101.
21. Born, J., Janeczek, J., Schwarz, W., Tiedemann, H., Tiedemann, H., Activation of masked neural determinants in amphibian eggs and embryos and their release from the inducing tissue. Cell Diff. Develop. 27 (1989), 1–7.
22. Bouwmeester, T., Kim, S.H., Sasai, Y., Lu, B., De Robertis, E.M., cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382 (1996), 595–601.
23. Cardellini, P., Reversal of dorsoventral polarity in Xenopus laevis embryos by 180° rotation of the animal micromeres at the eight-cell stage. Dev. Biol. 128 (1988), 428–434.
24. Cho, K.W.Y., Blumberg, B., Steinbeisser, H., De Robertis, E.M., Molecular nature of Spemann's organizer—The role of the Xenopus homeobox gene goosecoid. Cell 67 (1991), 1111–1120.
25. Christian, J.L., Moon, R.T., Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. Genes Develop. 7 (1993), 13–28.
26. Chuang, H.-H., Spezifische induktionsleistungen von leber und niere im explantationsver-such. Biol. Zbl. 58 (1938), 472–480.
27. Chuang, H.-H., Induktionsleistungen von frischen und gekochten organteilen (niere, leber) nach ihrer verpfianzung in explantate und verschiedene wirtsregionen von tritonkeimen. Arch. EnlwMech. Org. 139 (1939), 556–638.
28. Clement, J.H., Fettes, P., Knöchel, S., Lef, J., Knochel, W., Bone morphogenetic protein 2 (BMP-2) in the early development of Xenopus laevis. Mech. Develop. 52 (1995), 357–370.
29. Cui, Y.Z., Brown, J.D., Moon, R.T., Christian, J.L., Xwnl-8b: A maternally expressed Xenopus Wnl gene with a potential role in establishing the dorsoventral axis. Development 121 (1995), 2177–2186.
30. Dalcq, A., Pasteels, J., Potential morphogénétique, regulation et “axial gradients” de Child. Mireau point des bases physiologiques de la morphogénése. Bull. Acad. Med. Belg. 6:Ser. 3 (1938), 261–308.
31. Dale, L., Howes, G., Price, B.M.J., Smith, J.C., Bone morphogenetic protein-4—A ventralizing factor in early Xenopus development. Development 115 (1992), 573–585.
32. Davids, M., Protein kinases in amphibian ectoderm induced for neural differentiation. Roux's Arch. Dev. Biol. 197 (1988), 339–344.
33. Davids, M., Loppnow, B., Tiedemann, H., Tiedemann, H., Neural differentiation of amphibian gastrula ectoderm exposed to phorbol ester. Roux's Arch. Dev. Biol. 196 (1987), 137–140.
34. Dawid, I.B., Taira, M., Axis determination in Xenopus: Gradients and signals. Bio-essays 16 (1994), 385–386.
35. De Robertis, E.M., Morita, E.A., Cho, K.W.Y., Gradient fields and homeobox genes. Development 112 (1991), 669–678.
36. Ding, X.-Y., McKeehan, W.L., Xu, J., Grunz, H., Spatial and temporal localization of FGF receptors in Xenopus laevis. Roux's Arch. Dev. Biol. 201 (1992), 334–339.
37. Dirksen, M.L., Jamrich, M., A novel, activin-inducible, òlastopore lip-specific gene of Xenopus-laevis contains a fork head DNA-binding domain. Genes Develop. 6 (1992), 599–608.
38. Doniach, T., Induction of anteroposterior neural pattern in Xenopus by planar signals. Development, 1992, 183–193.
39. Doniach, T., Basic FGF as an inducer of anteroposterior neural pattern. Cell 83 (1995), 1067–1070.
40. Doniach, T., Phillips, C.R., Gerhart, J.C., Planar induction of anteroposterior pattern in the developing central nervous system of Xenopus laevis. Science 257 (1992), 542–545.
41. 2+ channel during early embryogenesis in Xenopus laevis. Int. J. Dev. Biol. 39 (1995), 1027–1032.
42. Fainsod, A.S., Steinbeisser, H., De Robertis, E.M., On the function of BmP-4 in patterning the marginal zone of the Xenopus embryo. EMBO J. 13 (1994), 5015–5025.
43. Frohnhöfer, H.G., Nüsslein-Volhard, C., Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid. Nature 324 (1986), 120–125.
44. Fujisue, M., Kobayakawa, Y., Yamana, K., Occurrence of dorsal axis-inducing activity around the vegetal pole of an uncleaved Xenopus egg and displacement to the equatorial region by cortical rotation. Development 118 (1993), 163–170.
45. Fukui, A., Asashima, M., Control of cell differentiation and morphogenesis in Amphibian development. Int. J. Dev. Biol. 38 (1994), 257–266.
46. Funayama, N., Fagotto, F., McCrea, P., Gumbiner, B.M., Embryonic axis induction by the armadillo repeat domain of beta-catenin: Evidence for intracellular signaling. J. Cell Biol. 128 (1995), 959–968.
47. Gallagher, B.C., Hainski, A.M., Moody, S.A., Autonomous differentiation of dorsal axial structures from an animal cap cleavage stage blastomere in Xenopus. Development 112 (1991), 1103–1114.
48. Gawantka, V., Delius, H., Hirschfeld, K., Blumenstock, C., Niehrs, C., Antagonizing the Spemann organizer: Role of the homeobox gene Xvent-1. EMBO J. 14 (1995), 6268–6279.
49. Gebhardt, D.O.E., Nieuwkoop, P.D., The influence of lithium on the competence of the ectoderm of Ambystoma mexicanum. J. Embryol. Exp, Morph. 12 (1964), 317–331.
50. Gerhart, J., Danilchik, M., Doniach, T., Roberts, S., Rowning, B., Stewart, R., Cortical rotation of the Xenopus egg: Consequences for the anteroposterior pattern of embryonic dorsal development. Development 107:Suppl. (1989), 37–51.
51. Gilbert, S.F., Saxén, L., Spemann organizer—Models and molecules. Mech. Develop. 41 (1993), 73–89.
52. Godsave, S.F., Slack, J.M.W., Clonal analysis of mesoderm induction in Xenopus laevis. Dev. Biol. 134 (1989), 486–490.
53. Goetschy, J.F., Letourneur, O., Cerletti, N., Horisberger, M.A., The unglycosylated extracellular domain of type-II receptor for transforming growth factor-beta—A novel assay for characterizing ligand affinity and specificity. Eur. J. Biochem. 241 (1996), 355–362.
54. Gont, L.K., Fainsod, A., Kim, S.H., De Robertis, E.M., Overexpression of the homeobox gene Xnot-2 leads to notochord formation in Xenopus. Dev. Biol. 174 (1996), 174–178.
55. Graff, J.M., Thies, R.S., Song, J.J., Celeste, A.J., Melton, D.A., Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79 (1994), 169–179.
56. Granato, M., Nüsslein-Volhard, C., Fishing for genes controlling development. Curr. Opin. Gen. Develop. 6 (1996), 461–468.
57. Green, J.B.A., Smith, J.C., Growth factors as morphogens—Do gradients and thresholds establish body plan?. Trends Genetics 7 (1991), 245–250.
58. Green, J.B.A., Smith, J.C., Gerhart, J.C., Slow emergence of a imultithreshold response to activin requires cell-contact-dependent sharpening but not prepattern. Development 120 (1994), 2271–2278.
59. Grunz, H., Experimentelle untersuchungen über die kompetenzverhältnisse früher entwicklungsstadien des amphibien-ektoderms. Roux's Arch. Dev. Biol. 160 (1968), 344–374.
60. Grunz, H., Hemmung der reaggregation dissoziierter amphibienzellen durch inhibitoren der RNS und Proteinsynthese. Roux's Arch. Dev. Biol. 163 (1969), 184–196.
61. Grunz, H., The differentiation of the four animal and the four vegetal blastomeres of the eight-cell stage of Triturus alpestris. Roux's Arch. Dev. Biol. 181 (1977), 267–277.
62. Grunz, H., Change of the differentiation pattern of amphibian ectoderm after the increase of the initial cell mass. Roux's Arch. Dev. Biol. 187 (1979), 49–57.
63. Grunz, H., Change in the differentiation pattern of Xenopus laevis ectoderm by variation of the incubation time and concentration of vegetalizing factor. Roux's Arch. Dev. Biol. 192 (1983), 130–137.
64. Grunz, H., Homoiogenetic neural inducing activity of the presumptive neural plate of Xenopus-laevis. Develop. Growth Differen. 32 (1990), 583–589.
65. Grunz, H., Suramin changes the fate of Spemann's organizer and prevents neural induction in Xenopus-laevis. Mech. Develop. 38 (1992), 133–142.
66. Grunz, H., The dorsalization of Spemann's organizer takes place during gastrulation in Xenopus laevis embryos. Develop. Growth Differ. 35 (1993), 21–28.
67. Grunz, H., Factors controlling the determination of the body plan in the amphibian embryo. Acta Biologiae Experimentalis Sinica 26 (1993), 317–341.
68. Grunz, H., The four animal blastomeres of the eight-cell stage of Xenopus laevis are intrinsically capable of differentiating into dorsal mesodermal derivatives. Int. J. Devel. Biol. 38 (1994), 69–76.
69. Grunz, H., Factors responsible for the establishment of the body plan in the amphibian embryo. Int. J. Devel. Biol. 40 (1996), 279–289.
70. Grunz, H., Staubach, J., Cell contacts between chorda-mesoderm and the overlaying neuroectoderm (presumptive central nervous system) during the period of primary embryonic induction in amphibians. Cell Diff. 14 (1979), 59–65.
71. Grunz, H., Tacke, L., The inducing capacity of the presumptive endoderm of Xenopus laevis studied by transfilter experiments. Roux's Arch. Dev. Biol. 195 (1986), 467–473.
72. Grunz, H., Tacke, L., Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer. Cell Differen. Develop. 28 (1989), 211–218.
73. Grunz, H., Tacke, L., Extracellular matrix components prevent neural differentiation of disaggregated Xenopus ectoderm cells. Cell Differen. Develop. 32 (1990), 117–124.
74. Grunz, H., Tiedemann, H., Influence of cyclic nucleotides on amphibian ectoderm. Roux's Arch. Dev. Biol. 181 (1977), 261–265.
75. Grunz, H., Born, J., Tiedemann, H., Tiedemann, H., The activation of a neuralizing factor in the neural plate is correlated with its homoiogenetic-inducing activity. Roux's Arch. Dev. Biol. 195 (1986), 464–466.
76. Grunz, H., McKeehan, W.L., Knöchel, W., Born, J., Tiedemann, H., Tiedemann, H., Induction of mesodermal tissue by acidic and basic heparin binding growth factors. Cell Diff. 22 (1987), 183–190.
77. Grunz, H., Schüren, C., Richter, K., The role of vertical and planar signals during the early steps of neural induction. Int. J. Dev. Biol. 39 (1995), 539–543.
78. Gualandris, L., Duprat, A.M., A rapid experimental method to study primary induction. Differentiation 20 (1981), 270–273.
79. Gumbiner, B.M., Signal-transduction by β-catenin. Curr. Opin. Cell. Biol. 7 (1995), 634–640.
80. Gurdon, J.B., A community effect in animal development. Nature 336 (1988), 772–774.
81. Gurdon, J.B., The generation of diversity and pattern in animal development. Cell 68 (1992), 185–199.
82. Gurdon, J.B., Harger, P., Mitchell, A., Lemaire, P., Activin signalling and response to a morphogen gradient. Nature 371 (1994), 487–492.
83. Gurdon, J.B., Mitchell, A., Ryan, K., An experimental system for analyzing response to a morphogen gradient. Proc. Nat. Acad. Sci. USA. 93 (1996), 9334–9338.
84. Haffter, P., Nüsslein-Volhard, C., Large-scale genetics in a small vertebrate, the zebrafish. Int. J. Dev. Biol. 40 (1996), 221–227.
85. Hamburger, V., The Heritage of Experimental Embryology: Hans Spemann and the Organizer., 1988, Oxford University Press, New York.
86. Harger, P.L., Gurdon, J.B., Mesoderm induction and morphogen gradients. Sem. Cell Dev. Biol. 7 (1996), 87–93.
87. He, X., Saint-Jeannet, J.P., Woodgett, J.R., Varmus, H.E., Dawid, I.B., Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature 374 (1995), 617–622.
88. Hemmati-Brivanlou, A., Melton, D.A., A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature 359 (1992), 609–614.
89. Hemmati-Brivanlou, A., Melton, D.A., Inhibition of activin receptor signaling promotes neuralization in Xenopus. Cell 77 (1994), 273–281.
90. Hemmati-Brivanlou, A., Kelly, O.G., Melton, D.A., Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell 77 (1994), 283–295.
91. Hogan, B.L.M., Bone morphogenetic proteins in development. Curr. Opin. Genet. Develop. 6 (1996), 432–438.
92. Hollemann, T., Beilefroid, E., Stick, R., Pieler, T., Zinc finger proteins in early Xenopus development. Int. J. Dev. Biol. 40 (1996), 291–295.
93. T. Hollemann T. Pieler H. Grunz 1997 Vertical versus planar signals during early neural induction in Xenopus and Triturus alpestris. In preparation.
94. Holley, S.A., Jackson, P.D., Sasai, Y., Lu, B., De Robertis, E.M., Hoffmann, F.M., Ferguson, E.L., A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin. Nature 376 (1995), 249–253.
95. Holtfreter, J., Nachweis der induktionsfahigkeit abgetoteter keimteile isolations—und transplantations—versuche. Arch. Entw. Mech. Org. 128 (1933), 584–633.
96. Holtfreter, J., Die totale exogastrulation, eine selbstablosung des ektoderms von entomesoderm Entwicklung und funktionelles verhalten nervenloser organe. Arch. Entw. Mech. Org. 129 (1933), 669–793.
97. Holtfreter, J., Der einfluss thermischer, mechanischer und chemischer eingriffe auf die induzierfähigkeit von triton-keimteilen. Roux's Arch. Dev. Biol. 132 (1934), 225–306.
98. Holtfreter, J., Neural induction in explants which have passed through a sublethal cytolysis. J. Exp. Zool. 106 (1947), 197–222.
99. Hoppler, S., Brown, J.D., Moon, R.T., Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos. Genes Develop. 10 (1996), 2805–2817.
100. Hopwood, N.D., Gurdon, J.B., Activation of muscle genes without myogenesis by ectopic expression of MyoD in frog embryo cells. Nature 347 (1990), 197–200.
101. Houliston, E., Microtubule translocation and polymerization during cortical rotation in Xenopus eggs. Development 120 (1994), 1213–1220.
102. Houliston, E., Elinson, R.P., Evidence for the involvement of microtubules, ER, and kinesin in the cortical rotation of fertilized frog eggs. J. Cell Biol. 114 (1991), 1017–1028.
103. Huber, O., Bierkamp, C., Kemler, R., Cadherins and catenins in development. Curr. Opin. Cell Biol. 8 (1996), 685–691.
104. Huber, O., Korn, R., McLaughlin, J., Ohsugi, M., Herrmann, B.G., Kemler, R., Nuclear localization of beta-catenin by interaction with transcription factor LEF-1. Mech. Develop. 59 (1996), 3–10.
105. Itoh, K., Tang, T.L., Neel, B.G., Sokol, S.Y., Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase. Development 121 (1995), 3979–3988.
106. Janeczek, J., John, M., Born, M., Tiedemann, H., Tiedemann, H., Inducing activity of subcellular fractions from amphibian embryos. Roux's Arch. Dev. Biol. 193 (1984), 1–12.
107. Janeczek, J., Born, J., Hoppe, P., Tiedemann, H., Partial characterization of neural-inducing factors from Xenopus-gaslrulae-Evidence for a larger protein complex containing the factor. Roux's Arch. Dev. Biol. 201 (1992), 30–35.
108. John, M., Janeczek, J., Born, J., Hoppe, P., Tiedemann, H., Tiedemann, H., Neural induction in amphibians Transmission of a neuralizing factor. Roux's Arch. Dev. Biol. 192 (1983), 45–47.
109. John, M., Born, J., Tiedemann, H., Tiedemann, H., Activation of a neuralizing factor in amphibian ectoderm. Roux's Arch. Dev. Biol. 193 (1984), 13–18.
110. Johnston, D.S., Nüsslein-Volhard, C., The origin of pattern and polarity in the Drosophila embryo. Cell 68 (1992), 201–219.
111. Jones, C.M., Lyons, K.M., Lapan, P.M., Wright, C.V.E., Hogan, B.L.M., DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development 115 (1992), 639–647.
112. Jones, C.M., Kuehn, M.R., Hogan, B.L.M., Smith, J.C., Wright, C.V.E., Nodalrelated signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development 121 (1995), 3651–3662.
113. Jones, C.M., Dale, L., Hogan, B.L.M., Wright, C.V.E., Smith, J.C., Bone morphogenetic protein 4 (BMP-4) exerts its ventralizing effects on embryonic mesoderm during gastrula stages in Xenopus development. Development, 122, 1996, 1545 1544.
114. Kageura, H., Yamana, K., Pattern regulation in isolated halves and blastomeres of early Xenopus laevis. J. Embryol. Exp. Morph. 74 (1983), 221–234.
115. Kageura, H., Yamana, K., Pattern regulation in defect embryos of Xenopus laevis. Dev. Biol. 101 (1984), 410–415.
116. Kao, K.R., Elinson, R.P., The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos. Dev. Biol. 127 (1988), 64–77.
117. Kao, K.R., Masui, Y., Elinson, R.P., Lithium-induced respecification of pattern in Xenopus laevis embryos. Nature 322 (1986), 371–373.
118. Kato, K., Gurdon, J.B., An inhibitory effect of Xenopus gastrula ectoderm on muscle cell differentiation and its role for dorsoventral patterning of mesoderm. Dev. Biol. 163 (1994), 222–229.
119. Kernler, R., From cadherins to catenins: Cytoplasmic protein interactions and regulation of cell adhesion. TIG 9 (1993), 317–321.
120. Kengaku, M., Okamoto, H., Basic fibroblast growth factor induces differentiation of neural tube and neural crest lineages of cultured ectoderm cells from Xenopus gastrula. Development 119 (1993), 1067–1078.
121. Kengaku, M., Okamoto, H., bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus. Development 121 (1995), 3121–3130.
122. Kessler, D.S., Melton, D.A., Induction of dorsal mesoderm by soluble, mature vgl protein. Development 121 (1995), 2155–2164.
123. King, M.L., Molecular basis for Cytoplasmic localization. Develop. Gen. 19 (1996), 183–189.
124. Klein, P.S., Melton, D.A., A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. USA. 93 (1996), 8455–8459.
125. Kloc, M., Etkin, L.D., Delocalization of vgl mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA. Science 265 (1994), 1101–1103.
126. Kloc, M., Etkin, L.D., Two distinct pathways for the localization of RNAs at the vegetal cortex in Xenopus oocytes. Development 121 (1995), 287–297.
127. Knöchel, S., Lef, J., Clement, J., Klocke, B., Hille, S., Köster, M., Knöchel, W., actvin-A-induced expression of a fork head related gene in posterior chordamesoderm (noto-chord) of Xenopus laevis embryos. Mech. Devel. 38 (1992), 157–165.
128. Knöchel, W., Bom, J., Hoppe, P., Loppnow-Blinde, B., Tiedemann, H., Tiedemann, H., McKeehan, W., Grunz, H., Mesoderm inducing factors: Their possible relationship to heparin-binding growth factors and transforming growth factor-β. Naturwissenschafien 74 (1987), 604–606.
129. Kobel, H.R., Du Pascier, L., Genetics of polyploid Xenopus. Trends Genet. 2 (1986), 310–315.
130. Köster, M., Plessow, S., Clement, J.H., Lorenz, A., Tiedemann, H., Knöchel, W., Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus-laevis—Analysis of mesoderm inducing activity. Mech. Develop. 33 (1991), 191–200.
131. Kroll, K.L., Amaya, E., Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation. Development 122 (1996), 3173–3183.
132. Kühl, M., Wedlich, D., Xenopus cadherins: Sorting out types and functions in embryo-genesis. Dev. Dynam. 207 (1996), 121–134.
133. Kuusi, T., Über die chemische natur der induktionsstoffe mit besonderer berücksichtigung der rolle der proteine und der nuklein-säuren. Diss., Helsinki. Ann. Soc. Zool.-Bot. Fenn. Vanarno 14:4 (1951), 1–98.
134. Kuusi, T., Über die chemische natur der induktionsstoffe im implantatversuch bei triton. Experientia 7 (1951), 299–300.
135. Ladher, R., Mohun, T.J., Smith, J.C., Snape, A.M., Xom: A Xenopus homeobox gene that mediates the early effects of BMP-4. Development 122 (1996), 2385–2394.
136. Larabell, C.A., Torres, M., Rowning, B.A., Yost, C., Miller, J.R., Wu, M., Kimelman, D., Moan, R.T., Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. J. Cell. Biol. 136 (1997), 1123–1136.
137. Laudet, V., Stehelin, D., Clevers, H., Ancestry and diversity of the HMG box super-family. Nucleic Acids Res. 21 (1993), 2493–2501.
138. Lemaire, P., Garrett, N., Gurdon, J.B., Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae is able to induce a complete secondary axis. Cell 81 (1995), 85–94.
139. Li, S.H., Mao, Z.R., Van, S.Y., Grunz, H., Isolated dorsal animal blastomeres of Xenopus laevis are capable to form mesodermal derivatives, while the ventral animal blastomeres differentiate into ciliated epidermis only. Zool. Sci. 13 (1996), 125–131.
140. London, C., Akers, R., Phillips, C., Expression of Epi 1, an epidermis-specific marker in Xenopus laevis embryos, is specified prior to gastrulation. Dev. Biol. 129 (1988), 380–389.
141. Lopashov, G.V., Seller, H., Montenarh, M., Knochel, W., Grunz, H., Tiedemann, H., Tiedemann, H., Neural inducing factors in neuroblastoma and retinoblastoma cell lines—Extraction with acid ethanol. Naturwissenschaften 79 (1992), 365–367.
142. Lustig, K.D., Kroll, K., Sun, E., Ramos, R., Elmendorf, H., Kirschner, M.W., Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation. Development 122 (1996), 3275–3282.
143. Maéno, M., Ong, R.C., Kung, H.F., Positive and negative regulation of the differentiation of ventral mesoderm for erythrocytes in Xenopus-laevis. Develop. Growth Diff. 34 (1992), 567–577.
144. Maéno, M., Ong, R.C., Suzuki, A., Ueno, N., Kung, H.F., A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: Roles of animal pole tissue in the development of ventral mesoderm. Proc. Acad. Sci. USA 91 (1994), 10260–10264.
145. Maéno, M., Ong, R.C., Xue, Y., Nishimatsu, S., Ueno, N., Kung, H.F., Regulation of primary erythropoiesis in the ventral mesoderm of Xenopus gastrula embryo—Evidence for the expression of a stimulatory factor(s) in animal pole tissue. Dev. Biol. 161 (1994), 522–529.
146. Mangold, O., Über die induktionsfähigkeit der verschiedenen bezirke der neurula von urodelen. Naturwissenschaften 21 (1933), 761–766.
147. Mangold, O., Spemann, H., Über die induktion von medullarplatte durch medullar-platte beim jüngeren keim, ein beispiel homoiogenetischer oder assimilatorischer induktion. Roux's Arch. Entw. Mech. Org. 109 (1927), 599–638.
148. Massagué, J., Weis-Garcia, F., Serine/threonine kinase receptors: Mediators of transforming growth factor beta family signals. Cancer Surve. 27 (1996), 41–64.
149. Masui, Y., Mesodermal and endodermal differentiation of the presumptive ectoderm of Triturus gastrula through influence of lithium ion. Experientia (Basel) 17 (1961), 458–459.
150. Mikhailov, A.T., Gorgolyuk, N.A., Biochemistry of embryonic induction: Identification and characterization of morphogenetic factors. Sov. Sci. Rev. F. Physiol. Gen. Biol. 1 (1987), 267–306.
151. Mikhailov, A.T., Gorgolyuk, N.A., Embryonic brain derived neuralizing factor. Cell Diff. Dev. 27 (1989), 70–80.
152. Mikhailov, A.T., Gorgolyuk, N.A., Tacke, L., Mykhoyan, M.M., Grunz, H., Partially purified factor from embryonic chick brain can provoke neuralization of Rana temporaria and Trirurus alpestris but not Xenopus laevis early gastrual ectoderm. Int. J. Dev. Biol. 39 (1995), 317–325.
153. Miller, J.R., Moon, R.T., Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes Develop. 10 (1996), 2527–2539.
154. Minuth, M., Grunz, H., The formation of mesodermal derivates after induction with vegetalizing factor depends on secondary cell interactions. Cell Diff. 3 (1980), 229–238.
155. Molenaar, M., Van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destree, O., Clevers, H., Xtcf-3 transcription factor mediates β- catenin-induced axis formation in Xenopus embryos. Cell 86 (1996), 391–399.
156. Moos, M., Wang, S.W., Krinks, M., Anti-dorsalizing morphogenetic protein is a novel TGF-beta homolog expressed in the Spemann organizer. Development 121 (1995), 4293–4301.
157. 2+ mediates neural induction in the amphibian embryo. Proc. Nat. Acad. Sci. USA 91 (1994), 12639–12643.
158. Nakamura, O., Toivonen, S., (eds.) Organizer. A milestone of a half-century from Spemann., 1978, Elsevier/North-Holland Biomedical Press, New York.
159. Nakamura, T., Takio, K., Eto, Y., Hiroshiro, S., Titani, K., Sugino, H., Activin-binding protein from rat ovary is follistatin. Science 247 (1990), 836–838.
160. Nascone, N., Mercola, M., An inductive role for the endoderm in Xenopus cardiogenesis. Development 121 (1995), 515–523.
161. Needham, J., Waddington, C.H., Needham, D.M., Physico-chemical experiments on the amphibian organizer. Proc. R. Soc. Lond., Ser. B. 114 (1934), 393–422.
162. Nieuwkoop, P.D., The formation of the mesoderm in urodelean amphibians I. Induction by the endoderm. Roux's Arch. Dev. Biol. 162 (1969), 341–373.
163. Nieuwkoop, P.D., Faber, J., Normal table of Xenopus laevis (Daudin)., 1956, North Holland, Amsterdam.
164. Nieuwkoop, P.D., Koster, K., Vertical versus planar induction in amphibian early development. Develop. Growth Diff. 37 (1995), 653–668.
165. Nieuwkoop, P.D., Boterenbrood, E.C., Kremer, A., Bloemsma, F.F.S.N., Hoesseis, E.L.M.J., Meyer, G., Verheyen, F.J., Activation and organization of the central nervous system in amphibians I. Induction and activation. II. Differentiation and organization. III. Synthesis of a new working hypothesis. J. Exp. Zool. 120 (1952), 1–108.
166. Nieuwkoop, P.D., Johnen, A., Albers, B., The Epigenetic Nature of Early Chordate Development. Inductive Interaction and Competence., 1985, Cambridge University Press, New York.
167. Niu, M.C., Twitty, V.C., The differentiation of gastrula ectoderm in medium conditioned by axial mesoderm. Proc. Nat. Acad. Sci. USA 39 (1953), 985–989.
168. Nüsslein-Volhard, C., Of flies and fishes. Science 266 (1994), 572–574.
169. Nüsslein-Volhard, C., Gradients that organize embryo development. Scientific American, 275, 1996, 54.
170. Nüsslein-Volhard, C., Frohnhöfer, H.G., Lehmann, R., Determination of antero-posterior polarity in Drosophila. Science 238 (1987), 1675–1681.
171. Okada, T.S., Experimental studies on the differentiation of endodermal organs in amphibians II. Differentiation potencies of the presumptive endoderm in the presence of the mesodermal tissue. Mem. Coll. Sci. Univ. Kyoto Ser. B. 21 (1954), 7–14.
172. Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C., Niehrs, C., The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling dorsoventral patterning of Xenopus mesoderm. Development 122 (1996), 3045–3053.
173. Oschwald, R., Clement, J.H., Knöchel, W., Grunz, H., suramin prevents transcription of dorsal marker genes in Xenopus-laevis embryos, isolated dorsal blastopore lips and activin-A induced animal caps. Mech. Dev. 43 (1993), 121–133.
174. Otte, A.P., Koster, C.H., Snoek, G.T., Durston, A.J., Protein kinase C mediates neural induction in Xenopus laevis. Nature 334 (1988), 618–620.
175. Otte, A.P., RunVan, P., Heideveld, M., vanDriel, R., Durston, A.J., Neural induction is mediated by cross-talk between the protein kinase C and cyclic AMP pathways. Cell 58 (1989), 641–648.
176. Otte, A.P., Kramer, I.M., Durston, A.J., Protein kinase C and regulation of the local competence of Xenopus Ectoderm. Science 251 (1991), 570–573.
177. Pannese, M., Polo, C., Andreazzoli, M., Vignali, R., Kablar, B., Barsacchi, G., Boncinelli, E., The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions. Development 121 (1995), 707–720.
178. Papalopulu, N., Kintner, C., A Xenopus gene, Xbr-1, defines a novel class of homeobox genes and is expressed in the dorsal ciliary margin of the eye. Dev. Bioi. 174 (1996), 104–114.
179. R. Penzel R. Oschwald R. Chen L. Tacke H. Grunz 1997 Characterization and early embryonic expression of a neural specific transmission factor xSox3 in Xenopus. Submitted.
180. Piccolo, S., Sasai, Y., Lu, B., De Robertis, E., Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direkt binding of chordin to BMP-4. Cell 86 (1996), 1–20.
181. Pierandrei-Amaldi, P., Amaldi, F., Aspects of regulation of ribosomal protein synthesis in Xenopus laevis—Review. Genetica 94 (1994), 181–193.
182. Reilly, K.M., Melton, D.A., Short-range signaling by candidate morphogens of the TGF beta family and evidence for a relay mechanism of induction. Cell 86 (1996), 743–754.
183. Roux, W., Beiträge zur entwicklungsmechanik des Embryo, III. über die bestimmung der hauptrichtungen des froschembryo im ei und über die erste teilung des froscheies. Breslauärztl. Z., Ges. Abh. II (1885), 277–343.
184. Roux, W., Beiträge zur entwicklungsmechanik des embryo, IV. Die bestimmung der medianebene des froschembryo durch die copulationsrichtung des ei-kernes und des spermakernes. Arch. mikrosk. Anat. 29 (1887), 344–418.
185. Ruiz i Altaba, A., Planar and vertical signals in the induction and patterning of the Xenopus nervous system. Development 115 (1992), 67–80.
186. Ruiz i Altaba, A., Jessell, T.M., Pintallavis, a gene expressed in the organizer and midline cells of frog embryos—Involvement in the development of the neural axis. Development 116 (1992), 81–93.
187. Saha, M.S., Grainger, R.M., A labile period in the determination of the anterior-posterior axis during early neural development in Xenopus. Neuron 8 (1992), 1003–1014.
188. Sargent, T.D., Jamrich, M., Dawid, I.B., Cell interactions and the control of gene activity during early development of Xenopus laevis. Dev. Biol. 114 (1986), 238–246.
189. Sasai, Y., Lu, B., Steinbeisser, H., Geissert, D., Gont, L.K., De Robertis, E.M., Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes. Cell 79 (1994), 779–790.
190. Sasai, Y., Lu, B., Steinbeisser, H., De Robertis, E.M., Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature 376 (1995), 333–336.
191. Sater, A.K., Jacobson, A.G., The role of the dorsal lip in the induction of heart mesoderm in Xenopus laevis. Development 108 (1990), 461–470.
192. Sato, S.M., Sargent, T.D., Localized and inducible expression of Xenopus-posterior (Xpo), a novel gene active in early frog embryos, encoding a protein with a CCHC finger domain. Development 112 (1991), 747–753.
193. Saxén, L., Transfilter neural induction of amphibian ectoderm. Develop. Biol. 3 (1961), 140–152.
194. Saxén, L., Neural induction. Int. J. Dev. Biol 33 (1989), 21–48.
195. Saxén, L., Toivonen, S., The two-gradient hypothesis in primary induction The combined effect of two types of inductors mixed in different ratios. J. Embryol. Exp. Morph. 9 (1961), 514–533.
196. Saxén, L., Toivonen, S., Newth, D.R., Abercrombie, H., Brent, L., Mynard Smith, J., (eds.) Primary embryonic induction., 1962, Logos Press/Academic Press, London.
197. Saxén, L., Toivonen, S., Vainio, T., Initial stimulus and subsequent interactions in embryonic induction. J. Embryol. Exp. Morph. 12 (1964), 333–338.
198. Scharf, S.R., Gerhart, J.C., Determination of the dorsal—ventral axis in eggs of Xenopus laevis: Complete rescue of UV-impaired eggs by oblique orientation before first cleavage. Dev. Biol. 79 (1980), 181–198.
199. Schmidt, J.E., Suzuki, A., Ueno, N., Kimelman, D., Localized BMP-4 mediates dorsal-ventral patterning in the early Xenopus embryo. Dev. Biol. 169 (1995), 37–50.
200. von Schmidt, J.E., Dassow, G., Kimelman, D., Regulation of dorsal-ventral patterning: The ventralizing effects of the novel Xenopus homeobox gene. Vox. Development 122 (1996), 1711–1721.
201. Schneider, S., Steinbeisser, H., Warga, R.M., Hausen, P., Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. Mech. Develop. 57 (1996), 191–198.
202. Sive, H.L., The frog prince-ss—A molecular formula for dorsoventral patterning in Xenopus. Genes Develop. 7 (1993), 1–12.
203. Sive, H.L., Bradley, L., A sticky problem: The Xenopus cement gland as a paradigm for anteroposterior patterning. Dev. Dynam. 205 (1996), 265–280.
204. Slack, J.M.W., Darlington, B.G., Heath, J.K., Godsave, S.F., Mesoderm induction in early Xenopus embryos by heparin-binding growth factors. Nature 326 (1987), 197–200.
205. Smith, J.C., A mesoderm-inducing factor is produced by a Xenopus cell line. Devel. 99 (1987), 3–14.
206. Smith, J.C., Price, B.M.J., Van Nimmen, K., Huylebroeck, D., Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin-A. Nature 345 (1990), 729–731.
207. Smith, W.C., Harland, R.M., Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell 67 (1991), 753–765.
208. Smith, W.C., Harland, R.M., Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell 70 (1992), 829–840.
209. Smith, W.C., McKendry, R., Ribisi, S., Harland, R.M., A nodal-related gene defines a physical and functional domain within the Spemann organizer. Cell 82 (1995), 37–46.
210. Sokol, S., Melton, D.A., Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin. Nature 351 (1991), 409–411.
211. Sokol, S., Christian, L., Moon, R.T., Melton, D.A., Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell 67 (1991), 741–752.
212. Spemann, H., Mangold, H., Über induktion von embryonalanlagen durch implantation artfremder organisatoren. Roux's Arch. Dev. Biol. 100 (1924), 599–638.
213. Steinbeisser, H., Fainsod, A., Niehrs, C., Sasai, Y., Derobertis, E.M., The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: A loss-of-function study using antisense RNA. EMBO J. 14 (1995), 5230–5243.
214. Stern, C.D., Ireland, G.W., HGF-SF—a neural inducing molecule in vertebrate embryos, hepatocyte growth factor—scatter factor (Hgf-Sf), and the C-Met receptor. Experientia Supplement 65 (1993), 369–380.
215. Suzuki, A., Thies, R.S., Yamaji, N., Song, J.J., Wozney, J.M., Murakami, K., Ueno, N., A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in early Xenopus embryo. Proc. Acad. Sci. USA 91 (1994), 10255–10259.
216. Tacke, L., Grunz, H., Close juxtaposition between inducing chordamesoderm and reacting neuroectoderm is a prerequisite for neural induction in Xenopus laevis. Cell. Diff. 24 (1988), 33–44.
217. Taira, M., Jamrich, M., Good, P.J., Dawid, I.B., The LIM domain-containing homeo-box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Genes Develop. 6 (1992), 356–366.
218. Takeichi, M., Morphogenetic roles of classical cadherins. Curr. Opin. Cell Biol. 7 (1995), 619–627.
219. Thomsen, G.H., Melton, D.A., Processed vgl protein is an axial mesoderm inducer in Xenopus. Cell 74 (1993), 433–441.
220. Tiedemann, H., Mesoderm differentiation in early amphibian embryos depends on the animal cap. Roux's Arch. Dev. Biol. 203 (1993), 28–33.
221. Tiedemann, H., Tiedemann, H., Versuche zur chemischen kennzeichnung von embryonalen induktionsstoffen. Z. Physiol. Chem. 306 (1956), 7–32.
222. Tiedemann, H., Tiedemann, H., Das induktionsvermögen geeigneter induktionsfaktoren im kombinationsversuch. Rev. Suisse Zool. 71 (1964), 117–137.
223. Tiedemann, H., Grunz, H., McKeehan, W.L., Knöchel, W., Born, J., Hoppe, P., Loppnow-Blinde, B., Tiedemann, H., Volk, R., Mesoderm induction by heparin-binding growth factors and transforming growth factor-β. J. Cell Biochem., 12A, 1988, 159.
224. Tiedemann, H., Tiedemann, H., Grunz, H., Knöchel, W., Molecular mechanisms of tissue determination and pattern formation in amphibian embryos. Naturwissenschaften 82 (1995), 123–134.
225. Tiedemann, H., Asashima, M., Born, J., Grunz, H., Knöchel, W., Tiedemann, H., Determination, induction and pattern formation in early amphibian embryo. Develop. Growth Diff., 38, 1996, 575.
226. Toivonen, S., Spezifische induktionsleistungen von abnormen induktoren im implantationsversuch. Ann. Zool. Soc. Zool. Bot. Fenn. Vanamo 6 (1938), 1–8.
227. Toivonen, S., Saxén, L., The simultaneous inducing action of liver and bone-marrow of the guinea-pig in implantation and explanation experiments with embryos of Triturus. Exp. Cell Res (Suppl.) 3 (1955), 346–357.
228. Toivonen, S., Wartiovaara, J., Mechanisms of cell interaction during primary embryonic induction studied in transfilter experiments. Differentiation 5 (1976), 61–66.
229. Tonissen, K.F., Drysdale, T.A., Lints, T.J., Harvey, R.P., Krieg, P.A., Xnkx-2.5, a Xenopus gene related to Nkx-2.5 and Tinman-Evidence for a conserved role in cardiac development. Dev. Biol. 162 (1994), 325–328.
230. Townes, P.L., Holtfreter, J., Directed movements and selective adhesion of embryonic amphibian cells. J. Exp. Zool. 128 (1955), 53–120.
231. Ueno, N., Ling, N., Ying, S., Esch, F., Shimasaki, S., Guillemin, R., Isolation and partial characterization of follistatin: A single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone. Proc. Natl. Acad. Sci. USA 84 (1987), 8282–8286.
232. Vincent, J.P., Gerhart, J.C., Subcortical rotation in Xenopus eggs: An early step in embryonic axis specification. Dev. Biol. 123 (1987), 526–539.
233. Von Dassow, G., Schmidt, J.E., Kimelman, D., Induction of the Xenopus organizer—Expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. Genes Develop. 7 (1993), 355–366.
234. Vriz, S., Joly, C., Boulekbacke, H., Condamine, H., Zygotic expression of the zebra-fish Sox-19, an HMG box-containing gene, suggests an involvement in central nervous system development. Molec. Brain Res. 40 (1996), 221–228.
235. Weeks, D.L., Melton, D.A., A maternal mRNA localized to the animal pole of Xenopus eggs encodes a subunit of mitochondrial ATPase. Proc. Nat. Acad. Sci. USA 84 (1987), 2798–2802.
236. Wilson, P.A., Hemmati-Brivanlous, A., Induction of epidermis and inhibition of neural fate by BMP-4. Nature 376 (1995), 331–333.
237. Wilson, P.A., Melton, D.A., Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. Biol. 4 (1994), 676–686.
238. Wright, E.M., Snopek, B., Koopman, P., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res., 21, 1993, 744.
239. Wylie, C., Kofron, M., Payne, C., Anderson, R., Hosobuchi, M., Joseph, E., Heasman, J., Maternal beta-catenin establishes a “dorsal signal” in early Xenopus embryos. Development 122 (1996), 2987–2996.
240. Xu, R.H., Kim, J.B., Taira, M., Zhan, S.I., Sredni, D., Kung, H.F., A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm. Biochem. Biophys. Res. Comm. 212 (1995), 212–219.
241. Yamada, T., An extension of the double potential theory in morphogenesis. Zool. Mag. 57 (1947), 124–126.
242. Yamada, T., Regional differentiation of the isolated ectoderm of the Triturus gastrula induced through a protein extract. Embryologia 1 (1950), 1–20.
243. Yamada, T., Induction of specific differentiation by samples of proteins and nucleoproteins in the isolated ectoderm of Triturus-gastrulae. Experientia 14 (1958), 81–87.
244. Yang-Snyder, J., Miller, J.R., Brown, J.D., Lai, C.J., Moon, T.T., A frizzled homolog in a vertebrate Wnt signaling pathway. Curr. Biol. 6 (1996), 1302–1306.
245. Yost, C., Torres, M., Miller, R.R., Huang, E., Kimelman, D., Moon, R.T., The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Develop. 10 (1996), 1443–1454.
246. Zaraisky, A.G., Ecochard, V., Kazanskaya, O.V., Lukyanov, S.A., Fesenko, I.V., Duprat, A.M., The homeobox-containing gene XANF-1 may control development of the Spemann organizer. Development 121 (1995), 3839–3847.
247. Zhou, Y., King, M.L., RNA transport to the vegetal cortex of Xenopus oocytes. Dev. Biol. 179 (1996), 173–183.