Nodal signalling in vertebrate development

Nature

Volumn 403, Issue 6768, 2000, Pages 385-389

  Schier, Alexander F ^a   Shen, Michael M ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; ENDODERM; GASTRULATION; MESODERM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; VERTEBRATE; XENOPUS;

ANIMALS; BODY PATTERNING; EMBRYONIC INDUCTION; FORECASTING; MESODERM; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; CERBERUS; VERTEBRATA;

EID: 0034719512     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35000126     Document Type: Article

References (71)

1. Harland, R. & Gerhart, J. Formation and function of Spemann's organizer. Annu. Rev. Cell Dev. Biol. 13, 611-667 (1997).
2. Matzuk, M. M. et al. Functional analysis of activins during mammalian development. Nature 374, 354-356 (1995).
3. Hawley, S. H. et al. Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes Dev. 9, 2923-2935 (1995).
4. Kessler, D. S. & Melton, D. A. Induction of dorsal mesoderm by soluble, mature Vgl protein. Development 121, 2155-2164 (1995).
5. Schulte-Merker, S., Smith, J. C. & Dale, L. Effects of truncated activin and FGF receptors and of follistation on the inducing activities of BVgl and activin: does activin play a role in mesoderm induction? EMBO J. 13, 3533-3541 (1994).
6. Sun, B. I. et al. derriere: a TGF-β family member required for posterior development in Xenopus. Development 126, 1467-1482 (1999).
7. Dyson, S. & Gurdon, J. B. Activin signalling has a necessary function in Xenopus early development. Curr. Biol. 7, 81-84 (1997).
8. Hemmati-Brivanlou, A. & Melton, D. A. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature 359, 609-614 (1992).
9. Hemmati-Brivanlou, A. & Thomsen, G. H. Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4. Dev. Genet. 17, 78-89 (1995).
10. Meno, C. et al. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of Nodal signaling during vertebrate gastrulation. Mol. Cell 4, 287-298 (1999).
11. Joseph, E. M. & Melton, D. A. Mutant Vgl ligands disrupt endoderm and mesoderm formation in Xenopus embryos. Development 125, 2677-2685 (1998).
12. Zhou, X., Zasaki, H., Lowe, L., Hogan, B. L. & Kuehn, M. R. Nodal is a novel TGF-β like gene expressed in the mouse node during gastrulation. Nature 361, 543-547 (1993).
13. Conlon, F. L. et al. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120, 1919-1928 (1994).
14. Smith, W. C., McKendry, R., Ribisi, S. J. & Harland, R. M. A nodal-related gene defines a physical and functional domain within the Spemann organizer. Cell 82, 37-46 (1995).
15. Jones, C. M., Kuehn, M. R., Hogan, B. L., Smith, J. C. & Wright, C. V. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development 121, 3651-3662 (1995).
16. Levin, M., Johnson, R. L., Stern, C. D., Kuehn, M. & Tabin, C. A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 82, 803-814 (1995).
17. Rebagliati, M. R., Toyama, R., Fricke, C., Haffter, P. & Dawid, I. B. Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Dev. Biol. 199, 261-272 (1998).
18. Rebagliate, M. R., Toyama, R., Haffter, P. & Dawid, I. B. cyclops encodes a nodal-related factor involved in midline signaling. Proc. Natl Acad, Sci. USA 95, 9932-9937 (1998).
19. Erter, C. L., Solnica Krezel, L. & Wright, C. V. Zebrafish nodal-related 2 encodes an early mesendodermal inducer signalling from the extraembryonic yolk syncytial layer. Dev. Biol. 204, 361-372 (1998).
20. Sampath K., et al. Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature 395, 183-189 (1998).
21. Feldman, B., et al. Zebrafish organizer development and germ-layer formation nodal-related signals. Nature 395, 181-185 (1998).
22. Joseph, E. M., & Melton, D. A. Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer. Dev. Biol. 184, 367-372 (1997).
23. Kimelman, D. & Griffin, K. J. Mesoderm induction: a postmodern view. Cell 94, 419-421 (1998).
24. Zhang, J. et al. The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. Cell 94, 515-524 (1998).
25. Kotron, M. et al. Mesoderm induction in Xenopus in a zygotic event regulated by maternal VegT via TGF-β growth factors. Development 126, 5759-5770 (1999).
26. Yasuo, H. & Lemaire, P. A two step model for the fate determination of presumptive endodermal blastomeres in Xenopus embryos. Curr. Biol. 9, 869-879 (1999).
27. Clements, D., Friday, R. V. & Woodland, H. R. Mode of action of VegT in mesoderm and endoderm formation. Development 126, 4903-4911 (1991).
28. Shen, M. M., Wang, H. & Leder, P. A defferential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. Development 124, 429-442 (1997).
29. Zhang, L., Tafbot, W. S. & Schier, A. F. Posititonal cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation. Cell 92, 241-251 (1998).
30. Salomon, D. S., Bianco, C. & De Santis, M. Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia. Bioessays 21, 61-70 (1999).
31. Gritsman, K. et al. The EGF-CFC protein one-eyed pinhead is essential for nodal signalling. Cell 97, 121-132 (1999).
32. Ding F. et al. Gripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature 395, 702-707 (1998).
33. Schier, A. F., Neuhauss, S. C. F., Helde, K. A., Talbot, W. S. & Driever, W. The one-eyed pinhead gene function in mesoderm and endoderm formation in zebrafish and interacts with no tail. Development 124, 327-342 (1997).
34. Strahle, U. et al. one-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube. Genes Funct. 1, 131-148 (1997).
35. Meno, C. et al. Left-right assymetric expression of the TGF β-family member lefty in mouse embryos.
36. Meno, C. et al. Two closely-related left-right assymetrically expressed genes, lefty-1 and lefty 2: their distinct expression domains, chromosomal linkage and direct neutralizing activity in Xenopus embryo. Genes Cell. 2, 513-524 (1997).
37. Thisse, C. & Thisse, B. Antivin, a novel and divergent member of the TGFbeta; superfamily, negatively regulates mesoderm induction. Development 126, 229-240 (1999).
38. Bisgrove, B. W., Essner J. J. & Yost, H. J. Regulation of midline development by antagonism of lefty and nodal signalling. Development 126, 3253-3262 (1999).
39. Cheng, A., Thisse, B., Thisse C. & Wright, C. V. E. The lefty-related factor Xatv acts as a feedback inhibitor of Nodal signaling in mesoderm induction and L-R axis development in Xynopus. Development (in the press).
40. Bouwineester, T., Kim, S., Sasai, Y., Lu, B. & De Robertis, E. M. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595-601 (1996).
41. Hsu, D. R., Economides, A. N., Wang, X., Eimon, P.M. & Harland, R. M. The Xenopus dorsalizing 1, 673-683 (1998).
42. Piccolo, S. et al. The head inducer Cerbecus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397, 707-710 (1999).
43. Rodriguez-Esteban, C. et al. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right assymetry. Nature 401, 243-251 (1999).
44. Simpson, E. H. et al. The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation. Dev. Biol. 213, 202-206 (1999).
45. Massagué, J. TGF-β signal transduction. Annu. Rev. Biochem. 67, 753-791 (1998).
46. Whitman, M. Smads and early developmental signaling by the TGFβ superfamily. Genes Dev. 12, 2445-2462 (1998).
47. Waldrip, W. R., Bikoff, E. K., Hoodless, P. A., Wrana, J. L. & Robertson, E. J. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92, 797-808 (1998).
48. Weinstein, M. et al. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc. Natl Acad. Sci. USA 95, 9378-9383 (1998).
49. Nomura, M. & Li, E. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 393, 786-790 (1998).
50. Gu, Z. et al. The type 1 activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. Genes Dev. 12, 844-857 (1998).
51. Song, J. et al. The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev. Biol. 213, 157-169 (1999).
52. Ramsdell, A. F. & Yost, H. J. Molecular mechanisms of vertebrate left-right development. Trends Genet. 14, 453-405 (1998).
53. Yan, Y.-T, et al. Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev. 13, 2527-2537 (1999).
54. Meno, C. et al. lefty-I is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94, 287-297 (1998).
55. Oh, S. P. & Li, E. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 11, 1812-1826 (1997).
56. Gurdon, J. B., Dyson, S. & St Johnston, D. Cells' perception of position in a concentration gradient. Cell 95, 159-162 (1998).
57. Gritsman, K., Talbot, W. S. & Schier, A. F. Nodal signaling patterns the organizer. Development (in the press).
58. Jones, C. M., Armes, N. & Smith, J. C. Signalling by TGF-β family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin. Curr. Biol. 6, 1468-1475 (1996).
59. Hatta, K., Kimmel, C. B., Ho, R. K. & Walker, C. The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system. Nature 350, 339-341 (1991).
60. Heisenberg, C. P. & Nüsslein-Volhard, C. The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Dev. Biol. 184, 85-94 (1997).
61. Matzuk, M. M., Kumar, T. R. & Bradley, A. Different phenotypes for mice deficient in either activins or activin receptor type II. Nature 374, 356-360 (1995).
62. Sirard, C. et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12, 107-119 (1990).
63. Yang, X., Li, C., Xu, X. & Deng, C. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc. Natl Acad. Sci. USA 95, 3667-3672 (1998).
64. Yokouchi, Y., Vogan, K. J., Pearse, R. V. 2nd & Tabin, C. J. Antagonistic, signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression. Cell 98, 573-583 (1999).
65. Zhu, L. et al. Cerberus regulates left-right asymmetry of the embryonic head and heart. Curr. Biol. 9, 931-938 (1999).
66. Rodaway, A. et al. Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-β family signals and discrimination of mesoderm and endoderm by FGF. Development 126, 3067-3078 (1999).
67. Thisse, B., Wright, C. V. E. & Thisse, B. Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature 403, 425-426 (2000).
68. Varlet, I., Collignon, J. & Robertson, E. J. nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development 124, 1033-1044 (1997).
69. Osada, S. I. & Wright, C. V. Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. Development 126, 3229-3240 (1999).
70. Beddington, R. S. P. & Robertson, E. J. Anterior patterning in mouse. Trends Genet. 14, 277-284 (1998).
71. Schauerte, H. E. et al. Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development 125, 2983-2993 (1998).