Genetic analysis of pattern formation in the Zebrafish neural plate

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 62, Issue , 1997, Pages 523-534

  Driever, W ^d   Solnica Krezel, L ^a   Abdelilah, S ^b   Meyer, D ^d   Stemple, D ^c  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN REGION; CONFERENCE PAPER; DEVELOPMENTAL GENETICS; GENE MUTATION; GENETIC ANALYSIS; MESENCEPHALON; MESODERM; NERVOUS SYSTEM DEVELOPMENT; NEUROECTODERM; NONHUMAN; PRIORITY JOURNAL; RHOMBENCEPHALON; ZEBRA FISH; ARTICLE; CELL DIFFERENTIATION; CEREBELLUM; DIENCEPHALON; EMBRYO; EMBRYO PATTERN FORMATION; FOREBRAIN; GASTRULA; MARKER GENE; MESENCEPHALIC TISSUE; MOTONEURON; NERVE CELL DIFFERENTIATION; NEURAL TUBE; NEUROMERE; NEURULATION; NOTOCHORD; REGULATOR GENE; TECTUM; TELENCEPHALON;

DANIO RERIO; VERTEBRATA;

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 8; OSTEOGENIC PROTEIN 1; RETINOIC ACID; SONIC HEDGEHOG PROTEIN;

EID: 0031448180     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1997.062.01.059     Document Type: Conference Paper

References (102)

1. Abdelilah S., Mountcastle-Shah E., Harvey M., Solnica-Krezel L., Schier A.F., Stemple D.L., Malicki J., Neuhauss S.C.F., Zwartkruis F., Stainier D.Y.R., Rangini Z., and Driever W. 1996. Mutations affecting neural survival in the zebrafish, Danio rerio. Development 123: 217.
2. Adelmann H.B. 1932. The development of the prechordal plate and mesoderm of amblystoma punctatum. J. Morphol. 54: 1.
3. _. 1936. The problem of cyclopia, part II. Q. Rev. Biol. 11: 284.
4. Baier H., Klostermann S., Trowe T., Karlstrom R.O., Nüsslein-Volhard C., and Bonhoeffer F. 1996. Genetic dissection of the retinotectal projection. Development 123: 415.
5. Bally-Cuif L. and Wassef M. 1994. Ectopic induction and reorganization of Wnt-1 expression in quail/chick chimeras. Development 120: 3379.
6. Brand M., Heisenberg C.P., Jiang Y.-J., Beuchle D., van-Eeden F.J.M., Furutani-Seiki M., Granato M., Haffter P., Hammerschmidt M., Kane D.A., Kelsh R.N., Mullins M.C., Odenthal J., and Nüsslein-Volhard C. 1996a. Mutations in two zebrafish genes affect the formation of the boundary between midbrain and hindbrain. Development 123: 179.
7. Brand M., Heisenberg C.-P., Warga R.M., Pelegri F., Karlstrom R.O., Beuchle D., Picker A., Jiang Y.J., Furutani-Seiki M., van-Eeden F.J.M., Granato M., Haffter P., Hammerschmidt M., Kane D.A., Kelsh R.N., Mullins M.C., Odenthal J., and Nüsslein-Volhard C. 1996b. Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development 123: 129.
8. Brockerhoff S.E., Hurley J.B., Janssenbienhold U., Neuhauss S.C.F., Driever W., and Dowling J.E. 1995. A behavioral screen for isolating zebrafish mutants with visual system defects. Proc. Natl. Acad. Sci. 92: 10545.
9. Chiang C., Litingtung Y., Lee E., Young K.E., Cordon J.L., Westphal H., and Beachy P.A. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383: 407.
10. Cho K.W.Y., Blumberg B., Steinbeisser H., and De Robertis E.M. 1991. Molecular nature of Spemann's organizer: The role of the Xenopus homeobox gene goosecoid. Cell 67: 1111.
11. Cox W.G. and Hemmati-Brivanlou A. 1995. Caudalization of neural fate by tissue recombination and bFGF. Development 121: 4349.
12. Crossley P.H., Martinez S., and Martin G.R. 1996. Midbrain development induced by FGF8 in the chick embryo. Nature 380: 66.
13. Danielian P.S. and McMahon A.P. 1996. Engrailed-1 as a target of the Wnt-1 signaling pathway in vertebrtae midbrain development. Nature 383: 332.
14. Doniach T. 1995. Basic FGF as an inducer of anteroposterior neural pattern. Cell 83: 1067.
15. Driever W. and Nüsslein-Volhard C. 1988a. The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner. Cell 54: 95.
16. _. 1988b. A gradient of bicoid protein in Drosophila embryos. Cell 54: 83.
17. Driever W., Solnica-Krezel L., Schier A.F., Neuhauss S.C.F., Malicki J., Stemple D.L., Stainier D.Y.R., Zwartkruis F., Abdelilah S., Rangini Z., Belak J., and Boggs C. 1996. A genetic screen for mutations affecting embryogenesis in zebrafish. Development 123: 37.
18. Echelard Y., Epstein D.J., St-Jacques B., Shen L., Mohler J., McMahon J.A., and McMahon A.P. 1993. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75: 1417.
19. Figdor M.C. and Stern C.D. 1993. Segmental organization of embryonic diencephalon. Nature 363: 630.
20. Fisher S., Amacher S., and Halpern M.E. 1996. Loss of cerebum function ventralizes the zebrafish embryo. Development 124: 1301.
21. Fjose A., Izpisúa-Belmonte J.C., Fromental-Ramain C., and Duboule D. 1994. Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development. Development 120: 71.
22. Furutani-Seiki M., Jiang Y.-J., Brand M., Heisenberg C.P., Houart C., Beuchle D., van-Eeden F.J.M., Granato M., Haffter P., Hammerschmidt M., Kane D.A., Kelsh R.N., Mullins M.C., Odenthal J., and Nüsslein-Volhard C. 1996. Neural degeneration mutants in the zebrafish Danio rerio. Development 123: 229.
23. Gaul U. and Jäckle H. 1987. Pole region-dependent repression of the Drosophila gap gene Krüppel by maternal gene products. Cell 51: 549.
24. _. 1991. Role of gap genes in early Drosophila development. Adv. Genet. 27: 239.
25. Granato M., van-Eeden F.J.M., Schach U., Trowe T., Brand M., Furutani-Seiki M., Haffter P., Hammerschmidt M., Heisenberg C.-P., Jiang Y.-J., Kane D.A., Kelsh R.N., Mullins M.C., Odenthal J.J., and Nüsslein-Volhard C. 1996. Genes controlling and mediating locomotion behavior of the zebrafish embryo. Development 123: 399.
26. Haffter P., Granato M., Brand M., Mullins M.C., Hammerschmidt M., Kane D.A., Odenthal J., van-Eeden F.J.M., Jiang Y.-J., Heisenberg C.-P., Kelsh R.N., Furutani-Seiki M., Warg R.M., Vogelsang E., Beuchle D., Schach U., Fabian C., and Nüsslein-Volhard C. 1996. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123: 1.
27. Halpern M.E., Ho R.K., Walker C., and Kimmel C.B. 1993. Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation. Cell 75: 99.
28. Halpern M.E., Hatta K., Amacher S.L., Talbot W.S., Yan Y.-L., Thisse B., Thisse C., Postlethwait J.H., and Kimmel C.B. 1997. Genetic interactions in the zebrafish midline. Dev. Biol. 187: 154.
29. Hammerschmidt M., Serbedzija G.N., and McMahon A.P. 1996a. Genetic analysis of dorsoventral pattern formation in the zebrafish: Requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev. 10: 2452.
30. Hammerschmidt M., Pelegri F., Kane D.A., Mullins M.C., Serbedzija G., van-Eeden F.J.M., Granato M., Brand M., Furutani-Seiki M., Haffter P., Heisenberg C.P., Jiang Y.-J., Kelsh R.N., Odenthal J., Warga R.M., and Nüsslein-Volhard C. 1996b. dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development 123: 95.
31. Hatta K., Bremiller R., Westerfield M., and Kimmel C.B. 1991a. Diversity of expression of engrailed-like antigens in zebrafish. Development 112: 821.
32. Hatta K., Kimmel C.B., Ho R.K., and Walker C. 1991b. The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system. Nature 350: 339.
33. Heisenberg C.P. and Nüsslein-Volhard C. 1997. The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Dev. Biol. 184: 85.
34. Heisenberg C.P., Brand M., Jiang Y.-J., Warga R.M., Beuchle, F.J.M. van-Eeden, M. Furutani-Seiki, M. Granato, P. Haffter D., Hammerschmidt M., Kane D.A., Kelsh D.A., Mullins M.C., Odenthal J., and Nüsslein-Volhard C. 1996. Genes involved in forebrain development in the zebrafish. Danio rerio. Development 123: 191.
35. Henion P.D., Raible D.W., Beattie C.E., Stoesser K.L., Weston J.A., and Eisen J.S. 1996. Screen tor mutations affecting development of zebrafish neural crest. Dev. Genet. 18: 11.
36. Ho, R. 1992. Axis formation in the embryo of the zebrafish Brachydanio rerio. Semin. Dev. Biol. 3: 53.
37. Jiang Y.-J., Brand M., Heisenberg C.-P., Beuchle D., van-Eeden F.J.M., Furutani-Seiki M., Granato M., Haffter P., Hammerschmidt M., Kane D.A., Kelsh R.N., Mullins M.C., Odenthal J., and Nüsslein-Volhard C. 1996. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development 123: 205.
38. Johnson S.L., Gates M.A., Johnson M., Talbot W.S., Horne S., Baik K., Rude, S. Wong J.R., and Postlethwait J.H. 1996. Half-tetrad analysis in zebrafish II: Centromere-linkage analysis and consolidation of the zebrafish genetic map. Genetics 142: 1277.
39. Joyner A.L. 1996. Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development. Trends Genet. 12: 15.
40. Karlstrom R.O., Trowe T., Brand M., Baier H., Crawford A., Grunewald B., Haffter P., Hammerschmidt M., Hoffman H., Klostermann S., Meyer S., Richter F.J.M., van-Eeden E., Vogelsang S., Nüsslein-Volhard C., and Bonhoeffer F. 1996. Zebrafish mutations affecting retinotectinal axon pathfinding. Development 123: 427.
41. Kelly G.M. and Moon R.T. 1995. Involvement of WntI and Pax2 in the formation of the midbrain-hindbrain boundary in the zebrafish gastrula. Dev. Genet. 17: 129.
42. Kimmel C.B., Ballard W.W., Kimmel S.R., Ullmann B., and Schilling T.F. 1995. Stages of embryonic development of the zebrafish. Dev. Dyn. 203: 253.
43. Kishimoto Y., Lee K., Zon L., Hammerschmidt M., and Schulte-Merker S. 1997. The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Developmant 124: 4457.
44. Knapik E.W., Goodmann A., Atkinson S., Roberts C.T., Shiozawa M., Sim C.U., Weksler-Zangen S., Trolliet M., Futrell C., Innes B.A., Koike G., McLaughlin M.G., Pierre L., Simson J.S., Vilallonga E., Roy M., Chiang P., Fishman M.C., Driever W., and Jacob H.J. 1996. A reference cross for zebrafish (Danio rerio). Development 123: 451.
45. Krauss S., Johansen T., Korzh V., and Fjose A. 1991. Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis. Development 113: 1193.
46. Krauss S., Maden M., Holder N., and Wilson S.W. 1992. Zebrafish pax[b] is involved in the formation of the midbrain-hindbrain boundary. Nature 360: 87.
47. Lawrence P.A. 1992. The making of a fly: The genetics of animal design. Blackwell, Oxford, United Kingdom.
48. Liem K.F., Tremmi G., Roelink H., and Jessell T.M. 1995. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82: 969.
49. Lumsden A. and Krumlauf R. 1996. Patterning the vertebrate neuraxis. Science 274: 1109.
50. Macdonald R., Xu Q., Barth K.A., Mikkola I., Holder N., Fjose A., Krauss S., and Wilson S.W. 1994. Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain. Neuron 13: 1039.
51. Malicki J., Neuhauss S.C.F., Schier A.F., Solnica-Krezel L., Stainier D.Y.R., Stemple D.L., Abdelilah S., and Driever W. 1996a. Mutations affecting development of the zebrafish retina. Development 123: 263.
52. Malicki, J., Schier A., Solnica-Krezel L., Stemple D.L., Neuhauss S.C.F., Stainier D.Y.R., Abdelilah S., Rangini Z., Zwartkruis F., and Driever W. 1996b. Patterning mutations of the zebrafish ear. Development 123: 275.
53. Marin F. and Puelles L. 1994. Patterning the embryonic avian midbrain after experimental inversions: A polarizing activity from the isthmus. Dev. Biol. 163: 19.
54. Mathers P.H., Miller A., Doniach T., Dirksen M.-L., and Jamrich M. 1995. Initiation of anterior head-specific gene expression in uncommitted ectoderm of Xenopus laevis by ammonium chloride. Dev. Biol. 171: 641.
55. - mice results from stepwise deletion of engrailed-expression cells by 9.5 days post coitum. Cell 69: 581.
56. Mizuno T., Yamaha E., Wakahara M., Kuroiwa A., and Takeda H. 1996. Mesoderm induction in zebrafish. Nature 383: 131.
57. Moens C.B., Yan Y.-L., Appel B., Force A.G., and Kimmel C.B. 1996. valentino: A zebrafish gene required for normal hindbrain segmentation. Development 122: 3981.
58. Müller M., von Weizsäcker E., and Campos-Ortega J.A. 1996. Transcription of a zebrafish gene of the hairy-Enhancer of split family delineates the midbrain anlage in the neural plate. Dev. Genes Evol. 206: 153.
59. Mullins M.C., Hammerschmidt M., Kane D.A., Brand M., van Eeden F.J.M., Furutani-Seiki M., Granato M., Haffter P., Heisenberg C.-P., Jiang Y.-J., Kelsh R.N., Odenthal J., Warga R.M., and Nüsslein-Volhard C. 1996. Genes establishing dorsal-ventral pattern formation in the zebrafish embryo: The ventral specifying genes. Development 123: 81.
60. Nadeau J.H. 1989. Maps of linkage and synteny homologies between mouse and man. Trends Genet. 5: 82.
61. Nieuwkoop P.D., Boterenbrood E.C., Kremer A., Bloesma F.F.S.N., Hiessels E.L.M.J., Meyer G., and Verheyen F.J. 1952. Activation and organization of the central nervous system in amphibians. J. Exp. Zool. 120: 1.
62. Nüsslein-Volhard C. and Wieschaus E. 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287: 795.
63. Oppenheimer J. 1936a. Transplantation experiments on developing teleosts (Fundulus and Perca). J. Exp. Zool. 72: 409.
64. _. 1936b. Structures developed in amphibians by implantation of living fish organizers. Proc. Soc. Exp. Biol. Med. 34: 461.
65. Pankratz M.J. and Jäckle H. 1993. Blastoderm segmentation. In The development of Drosophila melanogaster (ed. M. Bate and A. Martinez Arias), p. 467. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
66. Papalopulu N. and Kintner C. 1996. A posteriorising factor, retinoic acid, reveals that anteroposterior patterning controls the timing of neuronal differentiation in Xenopus neuroectoderm. Development 122: 3409.
67. Papan C. and Campos-Ortega J.A. 1994. On the formation of the neural keel and neural tube in the zebrafish Danio (Brachydanio) Rerio. Roux's Arch. Dev. Biol. 203: 178.
68. Piccolo S., Sasai Y., Lu B., and De Robertis E.M. 1996. Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 86: 589.
69. Postlethwait J.H. and Talbot W.S. 1997. Zebrafish genomics: From mutants to genes. Trends Genet. 13: 183.
70. Postlethwait J.H., Johnson S.L., Midson C.N., Talbot W.S., Gates M., Ballinger E.W., Africa D., Andrews R., Carl T., Eisen J.S., Horne S., Kimmel C.B., Hutchinson M., Johnson M., and Rodriguez A. 1994. A genetic linkage map for the zebrafish. Science 264: 699.
71. Puelles L. and Rubenstein J. 1993. Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization. Trends Neurosci. 16: 472.
72. Riddle R.D., Johnson R.L., Laufer E., and Tabin C. 1993. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75: 1401.
73. Roelink H., Porter J.A., Chiang C., Tanabe Y., Chang D.T. Beachy P.A., and Jessell T.M. 1995. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81: 445.
74. Roelink H., Augsburger A., Heemskerk J., Korzh V., Norlin S., Ruiz i Altaba A., Tanabe Y., Placzek M., Edlund T., Jessell T.M., and Dodd J. 1994. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 76: 761.
75. Rubenstein J., Martinez S., Shimamura K., and Puelles L. 1993. The embryonic vertebrate forebrain: The prosomeric model. Science 266: 578.
76. Schier. A.F., Neuhauss S.C.F., Helde K.A., Talbot W.S., and Driever W. 1997. The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail. Development 124: 327.
77. Schier A.F., Neuhauss S.C.F., Harvey M., Malicki J., Solnica-Krezel L., Stainier D.Y.R., Zwartkruis F., Abdelilah S., Stemple D.L., Rangini Z., Yang H., and Driever W. 1996. Mutations affecting the development of the embryonic zebrafish brain. Development 123: 165.
78. Schulte-Merker S., Lee K.J., McMahon A.P., and Hammerschmidt M. 1997. The zebrafish organizer requires chordino. Nature 387: 862.
79. Schulte-Merker, S., Van Eeden F.J.M., Halpern M.E., Kimmel C.B., and Nüsslein-Volhard C. 1994. no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development 120: 1009.
80. Shin J. and Fraser S.E. 1996. Characterizing the zebrafish organizer: Microsurgical analysis at the early-shield stage. Development 122: 1313.
81. Solnica-Krezel L., Stemple D.L., Mountcastle-Shah E., Rangini Z., Neuhauss S.C.F., Malicki J., Schier A., Stainier D.Y.R., Zwartkruis F., Abdelilah S., and Driever W. 1996. Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development 123: 67.
82. Spemann H. 1938. Embryonic development and induction. Yale University Press, New Haven, Connecticut.
83. Stemple D.L., Solnica-Krezel L., Zwartkruis F., Neuhauss S.C.F., Schier A.F., Malicki J., Stainier D.Y.R., Abdelilah S., Rangini Z., Mountcastle-Shah E., and Driever W. 1996. Mutations affecting development of the notochord in zebrafish. Development 123: 117.
84. Talbot W.S., Trevarrow B., Halpern M.E., Melby A.E., Farr G., Postlethwait J.H., Jowett T., Kimmel C.B., and Kimelman D. 1995. A homeobox gene essential for zebrafish notochord development. Nature 378: 150.
85. Thisse C., Thisse B., Halpern M.E., and Postlethwait J.H. 1994. goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Dev. Biol. 164: 420.
86. Thomas K.R. and Capecchi M.R. 1990. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346: 847.
87. Thomas P. and Beddington R. 1996. Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo. Curr. Biol. 5: 1487.
88. Trowe T., Klostermann S., Baier H., Grunewald B., Hoffmann H., Granato M., Haffter P., Hammerschmidt M., van-Eeden F.J.M., Vogelsang. Meyer S., Crawford A., Stroh T., Richter S., Nüsslein-Volhard C., and Bonhoeffer F. 1996. Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish. Danio rerio. Development 123: 439.
89. Urbanek P., Wang Z.Q., Fetka I., Wagner E.F., and Busslinger M. 1994. Complete block of early B-cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79: 901.
90. van Baer K. 1828. Über die Entwicklungsgeschichte der Thiere. Borntráger, Königsberg.
91. van Straaten H.W.M., Hekking J.W.M., Beursgens J.P.W.M., Terwindt-Rouwenhoorst E., and J. Drukker. 1989. Effect of the notochord on proliferation and differentiation in the neural tube of the chick embryo. Development 107: 793.
92. Viehbahn C., Mayer B., and Hrabe de Angelis M. 1995. Signs of the principlal body axis prior to primitive streak formation in the rabbit embryo. Anat. Embryol. 192: 159.
93. von Kupfer K. 1906. Die Morphogenie des Central Nerven Systems. In Handbuch der vergleichenden und experimentellen Entwicklungslehre der Wirbeltiere (ed. O. Hertwigs), vol.2 (part 3), p. 1. Fischer Verlag, Jena.
94. von Weizsacker E. 1994. Molekulargenetische Untersuchungen an sechs Zebrafisch-Genen mit Homologie zur Enhancer of split Gen-Familie von Drosophila. Ph.D thesis, University of Cologne, Germany.
95. Vos P., Hogers R., Bleeker M., Reijans M., van de Lee T., Hornes M., Frijters A., Pot J., Peleman J., Kuiper M., and Zabeau M. 1995. AFLP: A new technique for DNA finger-printing. Nucleic Acids Res. 23: 4407.
96. Whitfield T., Granato M., van-Eeden F.J.M., Schach U., Brand M. Furutani-Seiki M., Haffter P., Hammerschmidt M., Heisenberg C.-P., Jiang Y.-J., Kane D.A., Kelsh R.N., Mullins M.C., Odenthal J., and Nüsslein-Volhard C. 1996. Mutations affecting development of the zebrafish inner ear and lateral line. Development 123: 241.
97. Woo K. and Fraser S. 1995. Order and coherence in the fatemap of the zebrafish nervous system. Development 121: 2595.
98. _. 1997. Specification of the zebrafish nervous system by nonaxial signals. Science 277: 254.
99. Wurst W., Auerbach A.B., and Joyner A.L. 1994. Multiple developmental defects in Engrailed-1 mutant mice: An early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120: 2065.
100. Yamada T., Placzek M., Tanaka H., Dodd J., and Jessell T.M. 1991. Control of cell pattern in the developing nervous system: Polarizing activity of floor plate and notochord. Cell 64: 635.
101. Zaraisky A.G., Ecochard V., Kazanskaya O.V., Lukyanov S.A., Fresnko I.V., and Duprat A.-M. 1995. The homeobox-containing gene XANF1 may control development of the Spemann organizer. Development 121: 3839.
102. Zimmerman L.B., De Jesús-Escobar J.M., and Harland R. 1996. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 85: 599.