The spemann organizer and embryonic head induction

EMBO Journal

Volumn 20, Issue 4, 2001, Pages 631-637

  Niehrs, C ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIBIA; EMBRYO DEVELOPMENT; EMBRYO INDUCTION; EMBRYO PATTERN FORMATION; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; BONE MORPHOGENETIC PROTEINS; EMBRYONIC INDUCTION; HEAD; HUMANS; PROTO-ONCOGENE PROTEINS; WNT PROTEINS; ZEBRAFISH PROTEINS;

AMPHIBIA;

EID: 0035865340     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.4.631     Document Type: Review

References (78)

1. Neural induction in whole chick embryo cultures by FGF
2. The organizer factors Chordin and Noggin are required for mouse forebrain development
3. Organizer-specific homeobox genes in Xenopus laevis embryos
4. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
5. BMPs, Smads and metalloproteases: Extracellular and intracellular modes of negative regulation
6. Molecular nature of Spemann's organizer: The role of the Xenopus homeobox gene goosecoid
7. Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus
8. A gradient of BMP activity specifies dorsal-ventral fates in early Xenopus embryos
9. Bone morphogenetic protein 4: A ventralizing factor in early Xenopus development
10. A common plan for dorsoventral patterning in Bilateria
11. The establishment of Spemann's organizer and patterning of the vertebrate embryo
12. Anterior endoderm and head induction in early vertebrate embryos
13. The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer
14. Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus
15. Cluster analysis and display of genome-wide expression patterns
16. The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways
17. Conservation of dorsal-ventral paterning in arthropods and chordates
18. Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1′ in Xenopus embryos
19. Antagonizing the Spemann organizer: Role of the homeobox gene Xvent-1
20. Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning
21. Spemann's organizer: Models and molecules
22. Head induction by simultaneous repression of Bmp and wnt signalling in Xenopus
23. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
24. Formation and function of Spemann's organizer
25. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
26. Fish are like flies are like frogs: Conservation of dorsal-ventral patterning mechanisms
27. The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing dpp from activating its receptor
28. Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos
29. Establishment of a BMP-4 morphogen gradient by long-range inhibition
30. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction
31. Signalling by TGF-β family members: Short range effects of Xnr-2 and BMP-4 contrast with long-range effects of activin
32. Repressor activity of Headless/Tcf3 is essential for vertebrate head formation
33. Bone morphogenetic protein-4 (BMP-4), a member of the TGF-β family, in early embryos of Xenopus laevis: Analysis of mesoderm inducing activity
34. Xom: A Xenopus homeobox gene that mediates the early effects of BMP-4
35. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
36. Two distinct mechanisms for long-range patterning by decapentaplegic in the Drosophila wing
37. Frzb-1 is a secreted antagonist of wnt-signals expressed in the Spemann organizer
38. Genomics, gene expression and DNA arrays
39. TGF-β signal transduction
40. Activin as a morphogen in Xenopus mesoderm induction
41. The C-terminal domain of mad-like signal transducers is sufficient for biological activity in vivo and transcriptional activation
42. Regulation of dorsal gene expression in Xenopus by the ventralizing homeodomain gene Vox
43. Patterning the early zebrafish by the opposing actions of bozozok and vox/vent
44. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation
45. Direct and long-range action of a dpp morphogen gradient
46. Morphogens and pattern formation
47. Gene-expression screens in vertebrate embryos: More than meets the eye
48. Head in the Wnt - The molecular nature of Spemann's head organizer
49. Ectopic expression of a homeobox gene changes cell fate in Xenopus embryos in a position-specific manner
50. Synexpression groups in eukaryotes
51. The homeobox gene goosecoid controls cell migration in Xenopus embryos
52. Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid
53. Short historical survey of pattern formation in the endo-mesoderm and the neural anlage in the vertebrates: The role of vertical and planar inductive actions
54. The Xvent-2 homeobox gene is part of the BMP-4 signaling pathway controling dorsoventral patterning of Xenopus mesoderm
55. Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm
56. Silencing of TGF-β signalling by the pseudoreceptor BAMBI
57. A Xenopus gene, Xbr-1, defines a novel class of homeobox genes and is expressed in the dorsal ciliary margin of the eye
58. Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
59. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
60. Transcriptional regulation of Xvent homeobox genes
61. Competition between noggin and BMP-4 activities may regulate dorsalization during Xenopus development
62. Nodal signalling in vertebrate development
63. Regulation of dorsal-ventral patterning: The ventralizing effects of the novel Xenopus homeobox gene Vox
64. The homeodomain transcription factor Xvent-2 mediates auto-catalytic regulation of BMP-4 expression in Xenopus embryos
65. Mesoderm-inducing factors in early vertebrate development
66. Initiation of neural induction by FGF signalling before gastrulation
67. Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4
68. Wnt-3a regulates somite and tailbud formation in the mouse embryo
69. Systematic determination of genetic network architecture
70. Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction
71. A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos
72. Molecular mechanisms of tissue determination and pattern formation in amphibian embryos
73. DNA-binding specificity and embryological function of Xom (Xvent-2)
74. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8
75. An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo
76. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein-4