Glucagon-like peptide-1 stimulates insulin secretion but not phosphoinositide hydrolysis from islets desensitized by prior exposure to high glucose or the muscarinic agonist carbachol

Metabolism: Clinical and Experimental

Volumn 45, Issue 2, 1996, Pages 273-278

  Zawalich, Walter S ^a   Zawalich, Kathleen C ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C;

ANIMAL CELL; ARTICLE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HYDROLYSIS; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT; SECOND MESSENGER;

EID: 0030012196     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90066-9     Document Type: Article

References (22)

1. +, cAMP and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev 67:1185-1248, 1987
2. +, cAMP and diacylglycerol. Mol Cell Endocrinol 70:119-137, 1990
3. Drucker DJ, Philippe J, Mojsov S, et al: Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci USA 84:3434-3441, 1987
4. Bolaffi JL, Heldt A, Lewis LD, et al: The third phase of in vitro insulin secretion. Evidence for glucose insensitivity. Diabetes 35:370-373, 1986
5. 3H]inositol alter the subsequent responses of these islets to a high glucose concentration. Biochem J 259:743-749, 1989
6. Zawalich WS, Kelley GG: The pathogenesis of NIDDM: The role of the pancreatic beta cell. Diabetologia 38:986-991, 1995
7. Zawalich WS: Multiple effects of increases in phosphoinositide hydrolysis on islets and their relationship to changing patterns of insulin secretion. Diabetes Rev 13:101-111, 1990
8. Rasmussen H, Zawalich KC, Ganesan S, et al: Physiology and pathophysiology of insulin secretion. Diabetes Care 13:655-666, 1990
9. Grodsky GM, Bolaffi JL: Desensitization of the insulin-secreting beta cell. J Cell Biol 48:3-11, 1992
10. Zawalich WS, Zawalich KC: Phosphoinositide hydrolysis and insulin release from isolated perifused rat islets. Studies with glucose. Diabetes 37:1294-1300, 1988
11. Zawalich WS, Diaz VA, Zawalich KC: Role of phosphoinositide metabolism in induction of memory in isolated perifused rat islets. Am J Physiol 254:E609-E616, 1988
12. Hallcher LM, Sherman WR: The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J Biol Chem 255:10896-10901, 1980
13. Berridge MJ, Dawson RMC, Downes CP, et al: Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J 212:473-482, 1983
14. Zawalich WS, Takuwa N, Takuwa Y, et al: Interactions of cholecystokinin and glucose in rat pancreatic islets. Diabetes 36:426-433, 1987
15. 45Ca efflux profile patterns. J Membr Biol 68:37-46, 1982
16. Wiedenkeller DE, Sharp GWG: Effects of forskolin on insulin release and cAMP content in rat pancreatic islets. Endocrinology 113:2311-2313, 1983
17. Ebert R, Creutzfeldt W: Gastro-intestinal peptides and insulin secretion. Diabetes Metab Rev 3:1-26, 1987
18. Orskov C, Wettergren A, Holst JJ: Biological effects and metabolic rates of glucagonlike peptide-17-36 amide and glucagon-like peptide-1 7-37 in healthy subjects are indistinguishable. Diabetes 42:658-661, 1993
19. Zawalich WS: Phosphoinositide hydrolysis and insulin secretion in response to glucose stimulation are impaired in isolated rat islets by prolonged exposure to the sulfonylurea tolbutamide. Endocrinology 125:281-286, 1989
20. Zawalich WS, Zawalich KC: Forskolin-induced desensitization of pancreatic β-cell insulin secretory responsiveness: Possible involvement of impaired information flow in the inositol-lipid cycle. Endocrinology 126:2307-2312, 1990
21. Zawalich WS, Zawalich KC: Glucosamine-induced desensitization of beta-cell responses: possible involvement of impaired information flow in the phosphoinositide cycle. Endocrinology 130:3135-3142, 1992
22. Mosjov S, Weir GC, Habener JF: Insulinotropin: Glucagon-like peptide (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 79:616-619, 1987