The role of protein kinase C in the desensitization of rat pancreatic islets to cholinergic stimulation

Journal of Endocrinology

Volumn 159, Issue 2, 1998, Pages 287-295

  Verspohl, E J ^a   Wienecke, A ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CARBACHOL; ISOENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAUROSPORINE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CHOLINERGIC STIMULATION; DESENSITIZATION; ENZYME INHIBITION; FEMALE; INSULIN RELEASE; INSULIN RESPONSE; MALE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT;

EID: 0031743065     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1590287     Document Type: Article

References (58)

1. 2+ channels. Journal of Biological Chemistry 269 2743-2749.
2. Barr AJ & Watson SP 1994 Protein kinase C mediates delayed inhibitory feedback regulation of human neurokinin type 1 receptor activation of phospholipase C in UC11 astrocytoma cells. Molecular Pharmacology 46 266-273.
3. Benovic JL & Gomez J 1993 Molecular cloning and expression of GRK 6. A new member of the G protein-coupled receptor kinase family. Journal of Biological Chemistry 268 19521-19527.
4. Benya RV, Kusui T, Battey JF & Jensen RT 1995 Chronic desensitization and down-regulation of the gastrin-releasing peptide receptor are mediated by a protein kinase C-dependent mechanism. Journal of Biological Chemistry 270 3346-3352.
5. Berrie CP & Elliott AC 1994 Activation of protein kinase C does not cause desensitization in rat and rabbit mandibular acinar cells. European Journal of Physiology 428 163-172.
6. Birchall AM, Bishop J, Bradshaw D, Cline A, Coffey J, Elliot LH, Gibson VM, Greenham A, Hallam TJ, Harris W, Hill CH, Hutchings A, Lamont AG, Lawton G, Lewis EJ, Maw A, Nixon JS, Pole D, Wadsworth J & Wilkinson SE 1994 RO 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. Journal of Pharmacology and Experimental Therapeutics 268 922-929.
7. Bruns RF, Miller FD, Merriman RL, Howbert JJ, Heath WF, Kobayashi E, Takahashi I, Tamaoki T & Nakano H 1991 Inhibition of protein kinase C by calphostin C is light-dependent. Biochemical and Biophysical Research Communications 176 288-293.
8. Chuang TT, LeVine III H & DeBlasi A 1995 Phosphorylation and activation of β-adrenergic receptor kinase by protein kinase C. Journal of Biological Chemistry 270 18660-18665.
9. Conklin BR, Brann MR, Buckley NJ, Ma AL, Bonner TI & Axelrod J 1988 Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells. Proceedings of the National Academy of Sciences of the USA 85 8698-8702.
10. Debburman SK, Kunapuli P, Benovic JL & Hosey MM 1995 Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases. Molecular Pharmacology 47 224-233.
11. 1-receptors and ATP-receptors in the smooth muscle cell line, DDT(1)MF-2. The role of protein kinase C. British Journal of Pharmacology 110 1449-1456.
12. Doi R, Chowdhurya P & Rayford P 1993 Agonist-regulated alteration of the affinity of pancreatic muscarinic cholinergic receptors. Journal of Biological Chemistry 268 22436-22443.
13. Fabiato A & Fabiato F 1979 Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. Journal of Physiology 75 463-505.
14. Frankel A & Viallet J 1993 Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells. Experimental Cell Research 209 398-401.
15. Gao ZY, Gilon P & Henquin JC 1994 The role of protein kinase C in signal transduction through vasopressin and acetylcholine receptors in pancreatic B-cells from normal mouse. Endocrinology 135 191-199.
16. Guillemain I & Rossignol B 1994 Receptor-and phorbol ester-mediated phospholipase D activation in rat parotid involves two different pathways. American Journal of Physiology 266 C692-C699.
17. Guma A, Munoz P, Camps M, Testar X, Palacin M & Zorzano A 1992 Inhibitors such as staurosporin, H-7 or polymyxin B cannot be used in skeletal muscle to prove the role of protein kinase C on insulin action. Bioscience Reports 12 413-424.
18. Haga K, Haga T & Ichiyama A 1990 Phosphorylation by protein kinase C of the muscarinic acetylcholine receptor. Journal of Neurochemistry 54 1639-1644.
19. Hishinuma S, Matsumoto Y, Uchida MK & Kurokawa M 1993 Novel regulation of muscarinic receptors and their coupling with G proteins in smooth muscle: transient resensitization during the desensitizing process. British Journal of Pharmacology 109 330-335.
20. Jonas JC, Plant TD, Gilon P, Detimary P, Nenquin M & Henquin JC 1995 Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets. British Journal of Pharmacology 114 872-880.
21. 2+-induced protein phosphorylation. Biochemical Journal 285 973-978.
22. Kachintorn U, Vongkovit P, Vajanaphanich M, Dinh S, Barrett KE & Dharmsathaphorn K 1992 Dual effects of a phorbol ester on calcium-dependent chloride secretion by T84 epithelial cells. American Journal of Physiology 262 C15-C22.
23. Karlsson S & Ahrėn B 1991 Cholecystokinin-stimulated insulin secretion and protein kinase C in rat pancreatic islets. Acta Physiologica Scandinavica 142 397-403.
24. Kase H, Iwahashi K, Nakanishi S, Matsuda Y, Yamada K, Takahashi M, Murakata C, Sato A & Kaneko M 1987 K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochemical and Biophysical Research Communications 142 436-440.
25. Kuo WN, Hods D & Kuo FN 1973 Adenylate cyclase in islets of Langerhans. Journal of Biological Chemistry 248 2705-2711.
26. 1B-adrenergic receptor. Journal of Biological Chemistry 269 22887-22893.
27. Lee MH & Bell RM 1986 The lipid binding regulatory domain of protein kinase C: a 32-kDa fragment contains the calcium-and phosphatidyl serine-dependent phorbol diester binding activity. Journal of Biological Chemisty 261 14867-14870.
28. Lin CR, Chen WS, Lazar CS, Carpenter CD, Gill GN, Evans RM & Rosenfeld MG 1986 Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms. Cell 44 839-848.
29. Lin W-W & Chuang D-M 1993 Agonist-induced desensitization of ATP receptor-mediated phosphoinositide turnover in C6 glioma cells: comparison with the negative-feedback regulation by protein kinase C. Neurochemistry International 23 53-60.
30. 2+ mobilization. Journal of Biological Chemistry 271 23711-23717.
31. McGlynn E, Liebetanz J, Reutener S, Wood J, Lydon NB, Hofstetter H, Vanek M, Meyer T & Fabbro D 1992 Expression and partial characterization of rat protein kinase C-d and protein kinase C-z in insect cells using recombinant baculovirus. Journal of Cellular Biochemistry 49 239-250.
32. Maruyama Y 1989 Activation and desensitization mechanisms of muscarinic current response in single pancreatic acinar cells of rats. Journal of Physiology 417 343-359.
33. Mizuno K, Saido TC, Ohno S, Tamaoki T & Suzuki K 1993 Staurosporin-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC. Proceedings of the Meeting of the Federation of European Biochemical Societies 350 114-116.
34. Nixon JS, Bishop J, Bradshaw D, Davis PD, Hill CH, Elliott LH, Kumar H, Lawton G, Lewis EJ, Mulqueen M, Westmacott D, Wadswoth J & Wilkinson SE 1992 The design and biological properties of potent and selective inhibitors of protein kinase C. Biochemical Society Transactions 20 419-425.
35. Persaud SJ & Jones PM 1994 Inhibition of insulin release by staurosporin and Ro 31-8220: a role for protein kinase C? Biochemical Society Transactions 22 208S.
36. Penaud SJ, Jones PM, Sugden D & Howell SL 1989 Translocation of protein kinase C in rat islets of Langerhans. Effects of a phorbol ester, carbachol and glucose. FEBS Letters 245 80-84.
37. Potter LR & Garbers DL 1994 Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation. Journal of Biological Chemistry 269 14636-14642.
38. Simpson PB, Challiss RAJ & Nahorski SR 1994 Chronic activation of muscarinic and metabotropic glutamate receptors down-regulates type I inositol 1,4,5-trisphosphate receptor expression in cerebellar granule cells. Journal of Neurochemistry 63 2369-2372.
39. Tamaoki T, Nomoto H, Takahashi I, Kato Y, Morimoto M & Tomita F 1986 Staurosporin, a potent inhibitor of phospholipid/ Ca-dependent protein kinase. Biochemical and Biophysical Research Communications 135 397-402.
40. Tan YP & Marty A 1991 Protein kinase C-mediated desensitization of the muscarinic response in rat lacrimal gland cells. Journal of Physiology 433 357-371.
41. Tang H, Shirai H & Inagami T 1995 Inhibition of protein kinase C prevents rapid desensitization of type 1B angiotensin II receptor. Circulation Research 77 239-248.
42. Tobin AB, Keys B & Nahorski SR 1993 Phosphorylation of a phosphoinositidase C-linked muscarinic receptor by a novel kinase distinct from β-adrenergic receptor kinase. Proceedings of the Meeting of the Federation of European Biochemical Societies 335 353-357.
43. Ueda H, Miyamae T, Hayashi C, Watanabe S, Fukushima N, Sasaki Y, Iwamura T & Misu Y 1995 Protein kinase C involvement in homologous desensitization of delta-opioid receptor coupled to Gi1-phospholipase C activation in Xenopus oocytes. Journal of Neuroscience 15 7485-7499.
44. Verspohl EJ & Ammon HPT 1980 Evidence for presence of insulin receptors in rat islets of Langerhans. Journal of Clinical Investigation 65 1230-1237.
45. Verspohl EJ & Herrmann K 1996 Involvement of G proteins in the effect of carbachol and cholecystokinin in rat pancreatic islets. American Journal of Physiology 271 E65-E72.
46. Verspohl EJ, Tacke R, Mutschler E & Lambrecht G 1990 Muscarinic receptor subtypes in rat pancreatic islets: binding and functional studies. European Journal of Pharmacology 178 303-311.
47. Verspohl EJ, Tollkühn B & Kloss H 1995 Role of tyrosine kinase in insulin release in an insulin secreting cell line (INS-1). Cellular Signalling 7 505-512.
48. Verspohl EJ, Kaiserling-Buddemeier I & Wienecke A 1997 Introducing specific antibodies into electropermeabilized cells is a valuable tool for knocking out specific cell functions, e.g. G-protein function. Cell Biochemistry and Function 115 127-134.
49. Wilkinson SE, Parker PJ & Nixon JS 1993 Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochemical Journal 294 335-337.
50. 2+ mobilization in pancreatic acinar cells: evidence for a regulatory role of protein kinase C by a mechanism involving the transition of high-affinity receptors to a low-affinity state. Pflügers Archiv 424 171-182.
51. Wojcikiewicz RJH, Tobin AB & Nahorski SR 1993 Desensitization of cell signalling mediated by phosphoinositidase C. Trends in Pharmacological Sciences 14 279-285.
52. Wojcikiewicz RJH, Furuichi T, Nakade S, Mikoshiba K & Nahorski SR 1994 Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation. Journal of Biological Chemistry 269 7963-7969.
53. Wollheim CB & Regazzi R 1990 Protein kinase C in insulin releasing cells. Putative role in stimulus secretion coupling. FEBS Letters 268 376-380.
54. 2+ concentration. Journal of Biological Chemistry 264 2455-2462.
55. Yamatani T, Chiba T, Kadowaki S, Hishikawa R, Yamaguchi A, Inui T, Fujita T & Kawazu S 1988 Dual action of protein kinase C activation in the regulation of insulin release by muscarinic agonist from rat insulinoma cell line (RINr). Endocrinology 122 2826-2832.
56. Yaseen MA, Pedley KC & Howell SL 1982 Regulation of insulin secretion from islets of Langerhans rendered permeable by electric discharge. Biochemical Journal 206 81-87.
57. 1-receptor-stimulated inositol phosphate production and calcium mobilisation in GT1-7 neuronal cells is independent of protein kinase C. Journal of Neurochemistry 65 160-169.
58. Zawalich WS & Kelley GG 1995 The pathogenesis of NIDDM: the role of the pancreatic beta cell. Diabetologia 38 986-991.