Microcirculation of the islets of Langerhans: Long Beach Veterans Administration Regional Medical Education Center Symposium

Diabetes

Volumn 45, Issue 4, 1996, Pages 385-392

  Brunicardi, F Charles ^a,b   Stagner, John ^a   Bonner Weir, Susan ^a   Wayland, Harold ^a   Kleinman, Robert ^a   Livingston, Edward ^a   Guth, Paul ^a   Menger, Michael ^a   McCuskey, Robert ^a   Intaglietta, Marcos ^a   Charles, Arthur ^a   Ashley, Stanley ^a   Cheung, Anthony ^a   Ipp, Eli ^a   Gilman, Stewart ^a   Howard, Thomas ^a   Passaro Jr , Edward ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFERENCE PAPER; HUMAN; MICROCIRCULATION; NONHUMAN; PANCREAS BLOOD FLOW; PANCREAS ISLET; PANCREAS SECRETION; PRIORITY JOURNAL; SPECIES DIFFERENCE; TISSUE PERFUSION;

EID: 0004808355     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.4.385     Document Type: Conference Paper

References (84)

1. Murakami T, Fujita T, Miyake T, Ohtsuka A, Taguchi T, Kikuta A: The insulo-acinar portal and insulo-venous drainage systems in the pancreas of the mouse, dog, monkey and certain other animals: a scanning electron microscopic study of corrosion casts. Arch Histol Cytol 56:127-147, 1993
2. Bonner-Weir S: The microcirculation of the islet of Langerhans In The Endocrine Pancreas. Samols E, Ed. New York, Raven, 1994
3. Bonner-Weir S, Orci L: New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 31:883-889, 1982
4. Liu Y, Guth PH, Kaneko K, Livingston EH, Brunicardi FC: Dynamic in vivo observation of rat islet microcirculation Pancreas 8:15-21, 1993
5. Goldstein MB, Davis EA Jr: The three dimensional architecture of the islets of Langerhans. Acta Anat 71:161-171, 1968
6. Orci L: Macro- and micro-domains in the endocrine pancreas Diabetes 31:538-566, 1982
7. Murakami T, Fujita T: Microcirculation of the rat pancreas, with special reference to the insulo-acinar portal and insulo-venous drainage systems: a further scanning electron microscope study of corrosion casts. Arch Histol Cytol 55:453-476, 1992
8. Ohtani O, Ushiki T, Kanazawa H, Fujita T: Microcirculation of the pancreas in the rat and rabbit with special reference to the insuli-acinar portal system and enussary vein of isler. Arch Histol Jpn 49:45-60, 1986
9. Ohtani O: Microcirculation of the pancreas: a correlative study of intravital microscopy with scanning electron microscopy of vascular corrosion casts Arch Histol Jpn 46:315-325, 1983
10. Ohtani O: Review of scanning electron and light microscopic methods in microcirculalion research and their application to pancreatic studies. Scanning Electron Microsc 2:653-661, 1984
11. Nagata K, Nishhino H, Iwasaki T, Kobayashi R, Omasa R, Yoshigoe F, Hirano Y, Kuriyama K, Tamura T, Watanabe Y. Microcirculatory dynamics and microvasoular structure of pancreas in the rat-with special reference to endocrine-endocrine relationship in the pancreas. In Intravital Observation of Organ Microcirculation. Tsuchiya M, Wayland H, Oda M, Okazaki I, Eds. Princeton, NJ, Excerpta Medica, 1983, p 139-157
12. Miyake T, Murakami T, Ohtsuka A: Incomplete vascular casting for a scanning electron microscope study of the microcirculatory patterns in the rat pancreas. Arch Histol Cytol 55:397-406, 1992
13. Fujita T: Insulo-acinar portal system in the horse pancreas. Arch Histol Jpn 35:161-170, 1973
14. Fujita T, Murakami T: Microcirculation of monkey pancreas with special reference to the insulo-acinar portal system: a scanning electron microscope study of vascular casts. Arch Histol Jpn 35:255-263, 1973
15. Ohtani O, Fujita T: Microcirculation of the pancreas with special reference to periductular circulation a scanning electron microscope study of vascular casts. Biomed Res 1:130-140, 1980
16. Ohtani O, Kikuta A, Ohtsuka A, Taguchi T, Murakami T: Microvascular as studied by the microvascular corrosion casting/scanning electron microscope method. I. Endocrine and digestive system. Arch Histol Jpn 46:315-325, 1983
17. Bonner-Weir S: The microvasculature of the pancreas, with emphasis on that of the islets of Langerhans: anatomy and functional implications. In The Pancreas: Biology, Pathobiology and Disease. Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA, Eds. New York, Raven, 1903, p. 759-708
18. McCuskey RT, Chapman TM: Microscopy of the living pancreas in situ. Am J Anat 126:395-406, 1969
19. Williams JA, Goldfine ID: The insulin-pancreatic acinar axis. Diabetes 34:980-986, 1985
20. Samols E, Stagner JI: Intraislet and islet-acinar portal systems and their signiflcance. In The Endocrine Pancreas. Samols E, Ed. New York, Raven, 1993, p 93-124
21. Orel L: The microanatomy of the islets of Langerhans. Metabolism 25:1303-1313, 1976
22. Orci L, Baetens D, Ravazzola M, Stefan Y, Malaisse-Lagae F: Pancreatic polypeptide and glucagon: non-random distribution in pancreatic islets. Life Sci 19 1811-1816, 1976
23. Orci L, Unger RH: Functional subdivision of islets of Langerhans and possible role of D-cells. Lancet ii: 1243-1244, 1975
24. Brelje TC, Scharp DW, Sorenson RL: Three-dimensional imaging of intact isolated islets of Langerhans with confocal microscopy. Diabetes 38:808-814, 1989
25. Kleinman R, Gingerich R, Wong H, Walsh J, Lloyd K, Ohning G, DeGiorgio R, Sternini C, Brunicardi FC: Use of the Fab fragment for immunoneutralization of somatostatin in the isolated perfused human pancreas. Am J Surg 167:114-119, 1994
26. Erlandsen SL, Hegre OD, Parsons JA, McEvory RC, Elde RP: Pancreatic islet cell hormones distribution of cell types in the islet and evidence for the presence of somatostatin and gastrin within the D cell. J Histochem Cytochem 24:883-897, 1976
27. Grube D, Eckert I, Speck PT, Wagner H-J: Immunohistochemistry and microanatomy of the islets of Langerhans. Biomed Res 4 (Suppl. 46):25, 1983
28. Jones CW, Reynolds WA, Hoganson GE: Streptozotocin in the monkey. plasma levels of glucose, insulin, glucagon, and somatostatin with corresponding morphometric analysis of islet endocrine cells. Diabetes 29:536-546, 1980
29. Girod C, Durand N, Raccurt M: Immunostaining of a cell type in the islets of Langerhans of the monkey macaca irus by antibodies against S-100 protein Cell Tissue Res 247:11-16, 1987
30. Wolfe-Coote SA, Du Toit DF: Distribution of cell types of the islets of Langerhans throughout the pancreas of the chacma baboon. Anal Rec 217:172-177, 1987
31. Menger MD, Hammersen F, Messmer K: The microcirculation of the islets of Langerhans. state of the art. In Gastrointestinal Microcircuation. Vol 17. Messiner K, Hammersen F, Eds. Basel, Karger, p. 192-215, 1990
32. Menger MD, Vajloczy P, Beger C, Messmer K: Orientation of microvascular blood flow in pancreatic islet isografts. J Clin Invest 93:2280-2285, 1994
33. Samols E, Stagner JI, Ewart RBL, Marks V The order of microvascular cellular perfusion is B-A-D in the perfused rat pancreas. J Clin Invest 82:350-354, 1988
34. Samols E, Stagner JI: Intra-isiet regulation. Am J Med 85:31-35, 1988
35. Stagner JI, Samols E, Bonner-Weir S; B-A-D pancreatic islet cellular perfusion in dogs Diabetes 41:1715-1721, 1988
36. Stagner JI, Samols E, Marks V: Anterograde and retrograde infusion of glucagon antibodies suggests the A cells are vascularly perfused before D cells within the rat islet. Diabetologia 32:203-206, 1989
37. Stagner JI, Samols E, Koerker DJ, Goodner CJ: Perfusion with anti-insulin gamma globulin indicates a B to A to D cellular perfusion sequence in the pancreas of the rhesus monkey, macaca mulatta. Pancreas 7:26-29, 1992
38. Stagner JI, Samols E. The vascular order of islet cellular perfusion in the human pancreas. Diabetes 41:93-97, 1992
39. Stagner JI, Samols E: Retrograde perfusion as a method for testing the relative effects of glucose on the A cell. J Clin Incest. 77:1034-1037, 1986
40. Stagner JI, Samols E: A test of concepts of islet blood flow and compartmentalization (Abstract). Diabetes 33:145A, 1984
41. Samols E, Stagner JI: Flow versus compartmentalization in the determination of intra-islet hormone interactions (Abstract). Clin Res 34:387A, 1986
42. Samols E, Stagner JI: Intra-islet and islot-acinar portal systems and their significance. In The Endocrine Pancreas. Samols E, Ed. New York, Raven, 1991, p. 93-124
43. Nakagawa A, Stagner JI, Samols E: In situ binding of islet hormones in the isolated rat pancreas: evidence for local high concentrations of islet hormones in the islet-acinar axis. Diabetologia 38:262-268, 1996
44. Nakagawa A, Stagner JI, Samols E: Suppression of the islet-acinar axis in the perfused rat pancreas. Gastroenterol 105:868-875, 1993
45. Nakagawa A, Samols E, Stagner JI: Interstitial acinar islet hormone concentrations in the dog pancreas. Am J Physiol 264:G728-G734, 1993
46. Stagner JI, Samols E, Nakagawa A: The role of the islet-acinar portal system in the regulation of exocrine function. In Gastrointestinal Tract and Endocrine System. Singer MV, Ziegler R, Rohr G, Eds. Lancaster, U.K, Kluwer, 1995, p. 518-536
47. Rippe B, Harldsson B: Transport of macromolecules across microvascular walls: the two pore theory Physiol Rev 74:163-219, 1994
48. Kvietys PR, Perry MA, Granger DN: Permeability of pancreatic capillaries to small molecules. Am J Physiol 245:G519-G524, 1983
49. Maruyama H, Hisatomi A, Orci L, Grodsky GM, Unger RH: Insulin within islets is a physiological glucagon release inhibitor. J Clin Invest 74:2296-2299, 1984
50. Samols E, Stagner JI: Reinterpretation of the effects of haloperidol and ethanol on insulin secretion. Diabetologia 19:81-83, 1980
51. Stagner JI, Mokshaguntiam S, Samols E- Hormone secretion from transplanted islets is dependent upon changes in islet revascularization and islet architecture. Transplant Proc 27:3251-3254, 1995
52. Weir GC, Samols E, Loo S, Patel YC, Gabbay KH: Somatostatin and pancreatic polypeptide secretion: effects of glucagon, insulin and arginine. Diabetes 28:35-40, 1979
53. Asplin CM, Paquete TL, Palmer JP: In vivo inhibition of glucagon secretion by paracrine beta cell activity in man. J Clin Invent 68:314-318, 1981
54. Kleinman R, Ohning G, Wong H, Watt P, Walsh J, Brunicardi FC: The regulatory role of intraislet somatostatin on insulin secretion in the isolated perfused human pancreas. Pancreas 9:172-178, 1993
55. Kleinman R, Gingerich R, Ohning G, Wong H, Olthoff K, Walsh J, Brunicardi FC: The influence of somatostatin on glucagon and pancreatic polypeptide secretion in the isolated perfused human pancreas. Int J Pancreatol 15:51-57, 1995
56. Brunicardi FC, Druck P, Seymour NE, Sun YS, Elahi D, Andersen DK: Selective neurohormonal interactions in islet cell secretion in the isolated perfused human pancreas. J Surg Res 48:273-278, 1990
57. Brunicardi FC, Sun YS, Druck P, Goulet RJ, Elahi D, Andersen DK: Splanchnic neural regulation of insulin and glucagon secretion in the isolated perfused human pancreas. Am J Surg 153:34-40, 1987
58. Moldovan S, Livingston E, Zhang RS, Kleinman R, Guth P, Brunicardi FC: Glucose induced islet hyperemia is mediated by nitric oxide. Am J Surg 171:16-20, 1996
59. Aharinejad S, MacDonald IC, Schmidt BE, Bock P, Hagen D, Groom AC: Scanning and transmission electron microscopy and high resolution intravital videomicroscopy of capillaries in the mouse exocrine pancreas, with special emphasis on endothelial cells. Anat Rec 237:163-177, 1993
60. McCuskey RS: Sphincters in the microvascular system Microvasc Res 2428-433, 1971
61. Jansson L, Hellerstrom C: Stimulation by glucose of the blood flow to the pancreatic islets of the rat. Diabetologia 25:45-50, 1983
62. Jansson L, Hellerstrom C: Glucose-induced changes in pancreatic islet blood flow mediated by central nervous system Am J Physiol 251:E644-E647, 1986
63. Jansson L: Influence of adrenaline on blood perfusion and vascular conductance of the whole pancreas and the islets of Langerhans in the rat. Arch lut Pharmacodyn 313:90-97, 1991
64. De Giorgio R, Parodi JE, Brecha NC, Brunicardi FC, Becker JM, Go VL, Sternini C: Nitric oxide producing neurons in the monkey and human digestive system. J Comp Neurol 342:619-627, 1994
65. Corbett JA, Mikhael A, Shimizu J, Frederick K, Misko TP, McDaniel ML, Kanagawa O, Unanue ER: Nitric oxide production in islets from non-obese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. Proc Nat Acud Sci USA 90:8992-8995, 1993
66. Ekbad E, Alm P, Sundler F: Distribution, origin and projections of nitricoxide synthase-containing neurons in gut and pancreas. Neuroscience 63.233-248, 1994
67. Schmidt HW, Warner TD, Ishii K, Sheng H, Murad F: Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science 255:721-723, 1992
68. Svensson AM, Ostenson CG, Sandier S, Efendic S, Jansson L: Inhibition of nitric oxide synthase by NG-nitro-L-arginine causes a preferential decrease in pancreatic islet blood flow in normal rats and spontaneously diabetic GK rats. Endocrinology 135.849-853, 1994
69. Brown M, Rivier J, Vale W: Biological activity of somatostatin and somatostatin analogs on inhibition of arginine-induced insulin and glucagon release in the rat. Endocrinology 98:336-343, 1976
70. Santerre RF, Cook RA, Crisel RMD, Sharp, JD, Schmidt RJ, Williams DC, Wilson CP: Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells. Proc Natl Acad Sci USA 78:4339-4343, 1981
71. Schusdziarra V, Lawcki J, Ditschunheit HH, Lukas B, Meier V, Pfeiffer EF: Effect of low-dose somatostatin infusion on pancreatic and gastric endocrine function in lean and obese nondiabetic human subjects. Diabetes 34:595-601, 1081
72. Schusdziarra V, Zyznar E, Rouiller D, Boden G, Brown JC, Arimura A. Unger RH: Splanchnic somatostatin: a hormonal regulator of nutrient homeostasis. Science 207:530-532, 1980
73. Mortimer CH, Turnbridge WMG, Carr D, Yeomena L, Lind T, Coy DH, Schally AV, Drouin J, Ferland L, Beaulieu M, Labrie F: Somatostatin analogs which inhibit glucagon and growth hormone more than insuline release Biochem Biophys Res Commun 74.630-636, 1977
74. Reichlin S: Somatostatin. N Engl J Med 309:1495-1501, 1983
75. Patel YC, Wheatlet T, Ning C: Multiple forms of immunoreactive somatostatin: comparison of distribution in neural and nonneural tissues and portal plasma of the rat. Endocrinology 109:1943-1949, 1981
76. Amherdt M, Patel YC, Orci L: Selective binding of somatostatin-14 and somatostatin-28 to islet cells revealed by quantitative electron microscopic autoradiography. J Clin Invest 80:1455-1458, 1987
77. Taborsky GJ: Evidence of a paracrine role for pancreatic somatostatin in vivo. Am J Physiol 245:E598-E603, 1983
78. Itoh M, Mandarino L, Gerich JE: Antisomatostatin gamma globulin augments secretion of both insulin and glucagon in vitro: evidence for a physiologic role for endogenous somalostatin in the regulation of pancreatic A- and B- cell function. Diabetes 29:693-696, 1980
79. Wong HC, Walsh JH, Yang H, Tache Y, Buchan AM: A monoclonal antibody to somatostatin with potent in vivo immunoneutralizing actixity. Peptides 11:707-712, 1990
80. Samols E, Stagner JI: Intraislet and islet-acinar portal systems and their significance. In Comprehensive Endocrinology: The Endocrine Pancreas. Samols E, Ed. New York, Raven Press. 1991, p. 93-124
81. Ohning GV, Lloyd KCK, Granger DN, Walsh JH: Distribution of somatostatin monoclonal IgG and its Fab-1 fragment from plasma to intestinal lymph in rats (Abstract). Dig Dis 98:A510, 1991
82. Moldovan S, Atiya A, Adrian TE, Kleinman RM, Lloyd K, Olthoff K, Imagawa D, Shevlin L, Coy D, Walsh J, Brunicardi FC: Somatostatin inhibits insulin secretion by a type 2 receptor in the isolated perfused human pancreas. J Surg Ren 59:85-90, 1995
83. Intaglietta M: Arteriolar vasomotion: implications for tissue ischemia Blood Vessels 28:1-7, 1991
84. Colantuoni A, Bertuglia S, Intaglietta M: The effects of alpha or beta adrenergic receptor agonists and antagonists and calcium entry blockers on the spontaneous vasomotion Microvasc Res 28:143-158, 1984