Candidate gene polymorphisms in eating disorders

European Journal of Pharmacology

Volumn 410, Issue 2-3, 2000, Pages 147-159

  Hinney, Anke ^a   Remschmidt, Helmut ^a   Hebebrand, Johannes ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

5 HT2A receptor; Association; Dopamine; Estrogen receptor; Genome screening; Leptin; Transmission disequilibrium

Indexed keywords

ANTIOBESITY AGENT;

ANOREXIA NERVOSA; ARTICLE; BODY WEIGHT; BULIMIA; DNA POLYMORPHISM; EATING DISORDER; GENETIC SUSCEPTIBILITY; HUMAN; PHARMACOGENETICS; PRIORITY JOURNAL;

ANIMALS; EATING DISORDERS; GENOME, HUMAN; HUMANS; NEUROTRANSMITTER AGENTS; POLYMORPHISM, GENETIC; RECEPTORS, NEUROTRANSMITTER;

EID: 0034723056     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00812-8     Document Type: Article

References (136)

1. Manhattan versus Reykjavik
2. Hypothalamic neuropeptide Y and its gene expression: Relation to light/dark cycle and cirulating corticosterone
3. Meta-analysis of the association of the Trp64Arg polymorphism in the beta3 adrenergic receptor with body mass index
4. Neurotransmitter transporters: Recent progress
5. 2A receptor gene polymorphism is associated with food and alcohol intake in obese people
6. Anatomy of an endogenous antagonist: Relationship between Agouti-related protein and proopiomelanocortin in brain
7. On the role of dopamine in the pathophysiology of anorexia nervosa
8. 3-adrenoceptor mRNA in human tissues
9. Serotonin and the biology of feeding
10. Serotonin, eating behavior, and fat intake
11. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
12. Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1
13. Independent and additive effects of central POMC and leptin pathways on murine obesity
14. Studies of serotonin function in anorexia nervosa
15. Serum leptin levels increase rapidly after initiation of clozapine therapy
16. Lack of association between anorexia nervosa and D3 dopamine receptor gene
17. Twin studies of eating disorders: A review
18. 2C receptor (HTR2C) in bulimia nervosa and binge eating disorder
19. 2A gene promoter polymorphism and susceptibility to anorexia nervosa
20. Association between a marker in the UCP-2/UCP-3 gene cluster and genetic susceptibility to anorexia nervosa
21. Genome-wide search for genes related to the fat-free body mass in the Quebec family study
22. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
23. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
24. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
25. Food deprivation and hypothalamic neuropeptide gene expression: Effects of strain background and the diabetes mutation
26. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
27. 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity
28. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
29. 2A gene promoter polymorphism and anorexia nervosa
30. The relationship between premorbid body weight, weight loss, and weight at referral in adolescent patients with anorexia nervosa
31. Involvement of the medial preoptic area in the anorectic action of estrogens
32. Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa
33. Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern
34. 2A promoter polymorphism -1438 G/A, anorexia nervosa, and obsessive-compulsive disorder
35. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
36. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropetide Y
37. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
38. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
39. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
40. Reduced body fat in long-term followed-up female patients with anorexia nervosa
41. Meta-analysis of the association of Trp64Arg polymorphism of beta 3-adrenergic receptor gene with body mass index
42. A receptor subtype involved in neuropeptide-Y-induced food intake
43. Clinical findings in patients with anorexia nervosa and affective illness in their relatives
44. Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis
45. Amenorrhea in anorexia nervosa. Neuroendocrine control of hypothalamic dysfunction
46. Neuropeptide Y effector systems: Perspectives for drug development
47. Separate systems for serotonin and leptin in appetite control
48. No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism
49. Anorexia nervosa viewed as an extreme weight condition: Genetic implications
50. Plasma concentrations of obese protein in anorexia nervosa
51. Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration
52. Allelic variation of human serotonin transporter gene expression
53. Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa
54. Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa
55. 2A receptor gene polymorphisms, anorexia nervosa, and obesity
56. Systematic mutation screening of the pro-opiomelanocortin gene: Identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes
57. No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: Identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region
58. No evidence for an involvement of alleles of polymorphisms in the serotonin1Dbeta and 7 receptor genes in obesity, underweight or anorexia nervosa
59. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
60. No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity
61. Anorexia nervosa: A study of 34 twin pairs and one set of triplets
62. Anorexia nervosa: Evidence for a genetic basis
63. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior
64. Targeted disruption of the melanocortin-4 receptor results in obesity in mice
65. Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes
66. The neurobiology of eating disorders
67. Altered cerebrospinal fluid neuropeptide Y and peptide YY immunoreactivity in anorexia and bulimia nervosa
68. Alterations in serotonin activity and psychiatric symptoms after recovery from bulimia nervosa
69. Altered dopamine activity after recovery from restricting-type anorexia nervosa
70. Anorexia and bulimia nervosa
71. A search for susceptibility loci for anorexia nervosa: Methods and sample description
72. Genetic factors in anorexia nervosa
73. The uncoupling protein UCP: A membranous mitochondrial ion carrier exclusively expressed in brown adipose tissue
74. 3-adrenergic receptor mRNA in man
75. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
76. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice
77. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
78. Coexistence of three β-adrenergic receptor subtypes in white fat cells of various mammalian species
79. Gonadal steroids and hypothalamic galanin and neuropeptide Y: Role in eating behavior and body weight control in female rats
80. Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter
81. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
82. Role of the Y5 neuropeptide Y receptor in feeding and obesity
83. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
84. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin
85. Congenital leptin deficiency is associated with severe early-onset obesity in humans
86. ER beta: Identification and characterization of a novel human estrogen receptor
87. The therapeutic potential of neuropeptide Y
88. 2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa
89. Molecular characterization of the mouse beta 3-adrenergic receptor: Relationship with the atypical receptor of adipocytes
90. Human dopamine D4 receptor gene: Frequent occurrence of a null allele and observation of homozygosity
91. Differential distribution and regulation of estrogen receptor-alpha and-beta mRNA within the female rat brain
92. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
93. Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding
94. Searching for genetic determinants in the new millennium
95. The future of genetic studies of complex human diseases
96. Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: Identification of several genetic variants
97. Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extremes
98. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine
99. Of mice and MEN: What transgenic models tell us about hypothalamic control of energy balance
100. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
101. The distribution of estrogen receptor-β mRNA in the rat hypothalamus
102. Serotonergic control of the organization of feeding and satiety
103. Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene
104. Drastic and selective hyperinnervation of central serotonergic neurons in a lethal neurodevelopmental mouse mutant, Anorexia (anx)
105. 2A promoter polymorphism in anorexia nervosa
106. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
107. 2A receptor binding in anorexia nervosa and bulimia nervosa
108. Neuropeptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus
109. A leptin missense mutation associated with hypogonadism and morbid obesity
110. Family-genetic studies of eating disorders
111. Controlled family study of anorexia nervosa and bulimia nervosa: Evidence of shared liability and transmission of partial syndromes
112. Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa
113. 2C serotonin receptors
114. Dopamine receptor subtype agonists and feeding behavior
115. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
116. A frameshift mutation in human MC4R is associated with a dominant form of obesity
117. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
118. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
119. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
120. Gonadal effects on food intake and adiposity. A metabolic hypothesis
121. Neurobiological aspects of feeding disorders
122. 3-adrenergic-receptor gene
123. Anorexia nervosa and anorexic-like syndromes in a population-based female twin sample
124. Bulimia nervosa and major depression: A study of common genetic and environmental factors
125. 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns
126. Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of obese (ob/ob) mouse
127. Brain serotonin, carbohydrate-craving, obesity and depression
128. Increased food intake and body weight gain after lateral hypothalamic dopaminergic cell implantation
129. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
130. A frameshift mutation in MC4R associated with dominantly inherited human obesity
131. Estrogen and the etiology of anorexia nervosa
132. Positional cloning of the mouse obese gene and its human homologue
133. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
134. 2A gene promoter polymorphism and susceptibility to eating disorders and a meta-analysis pertaining to anorexia nervosa