A search for susceptibility loci for anorexia nervosa: Methods and sample description

Biological Psychiatry

Volumn 47, Issue 9, 2000, Pages 794-803

  Kaye, Walter H ^a   Lilenfeld, Lisa R ^b   Berrettini, Wade H ^c   Strober, Michael ^d   Devlin, Bernie ^a   Klump, Kelly L ^a   Goldman, David ^e   Bulik, Cynthia M ^f   Halmi, Katherine A ^g   Fichter, Manfred M ^h   Kaplan, Allan ⁱ   Woodside, D Blake ⁱ   Treasure, Janet ^j   Plotnicov, Katherine H ^a   Pollice, Christine ^a   Rao, Radhika ^a   McConaha, Claire W ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c Pennsylvania State Univ Univ P   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^f VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

^h Hospital for Behavioral Medicine   (Germany)

ⁱ UNIVERSITY HEALTH NETWORK   (Canada)

^j KING'S COLLEGE LONDON   (United Kingdom)

more..

Author keywords

Affected relative pairs; Anorexia nervosa; Bulimia nervosa; Eating disorders; Genetics; Linkage analysis

Indexed keywords

ANOREXIA NERVOSA; ARTICLE; GENE LOCUS; GENE TRANSFER; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADULT; ANOREXIA NERVOSA; BODY MASS INDEX; BULIMIA; FEMALE; GENOME, HUMAN; GENOTYPE; HUMANS; INTERVIEW, PSYCHOLOGICAL; MALE; PSYCHIATRIC STATUS RATING SCALES; QUALITY CONTROL; RISK ASSESSMENT; SELF ASSESSMENT (PSYCHOLOGY);

EID: 0034192406     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00240-1     Document Type: Article

References (75)

1. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. 1994;American Psychiatric Press, Washington, DC.
2. Amos C.I., Krushkal J., Thiel T.J., Young A., Zhu D.K., Boerwinkle E., et al. Comparison of model-free linkage mapping strategies for the study of a complex trait. Genet Epidemiol. 14:1997;743-748.
3. Blangero J., Almasy L. Multipoint oligogenetic linkage analysis of quantitative traits. Genet Epidemiol. 14:1997;959-964.
4. Boehnke M., Cox N.J. Accurate inference of relationships in sib-pair linkage studies. Am J Hum Genet. 61:1997;423-429.
5. Brewerton T.D., Hand L.D., Bishop E.R. The Tridimensional Personality Questionnaire in eating disorder patients. Int J Eat Disord. 14:1993;213-218.
6. Bulik C.M., Sullivan P.F., Fear J., Pickering A. Predictors of the development of bulimia nervosa in women with anorexia nervosa. J Nerv Ment Dis. 185:1997;704-707.
7. Bulik C.M., Sullivan P.F., Weltzin T.E., Kaye W.H. Temperament in eating disorders. Int J Eating Dis. 17:1995;251-261.
8. Campbell D.A., Sundaramurthy D., Markham A.F., Pieri L.F. Lack of association between 5-HT2A gene promoter polymorphism and susceptibility to anorexia nervosa. Lancet. 351:1998;499.
9. Carey G., Gottesman I.I. Twin and family studies of anxiety, phobi, and obsessive-compulsive disorder. Klein D.F., Rabkin J. Anxiety New Research and Changing Concepts . 1981;117-136 Raven Press, New York.
10. Cloninger C.R., Przybeck T.R., Svrakic D.M. The Tridimensional Personality Questionnaire U.S. normative data . Psychol Rep. 69:1991;1047-1057.
11. Cloninger C.R., Svrakic D.M., Przybeck T.R. A psychobiological model of temperament and character. Arch Gen Psychiatry. 50:1993;975-990.
12. Collier D.A., Arranz M.J., Li T., Mupita D., Brown N., Treasure J. Association between 5-HT2A gene promoter polymorphism and anorexia nervosa. Lancet. 351:1997;412.
13. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923.
14. Davies J.L., Kawaguchi Y., Bennett S.T., Copeman J.B., Cordell H.J., Pritchard L.E., et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature. 371:1994;130-136.
15. Elston R.C., Guo X., Williams L.V. Two-stage global search designs for linkage analysis using pairs of affected relatives. Genet Epidemiol. 13:1996;535-558.
16. Enoch M.A., Kaye W.H., Rotondo A., Greenberg B.D., Murphy D.L., Goldman D. 5-HT2A promoter polymorphism-1438GÅ, anorexia nervosa, and obsessive-compulsive disorder. Lancet. 351:1998;1785-1786.
17. Fichter M.M., Herpetz S., Quadflieg N., Herpertz-Dahlmann B. Structured interview for anorexic and bulimic disorders for DSM-IV and ICD-10 Updated (third) revision . Int J Eat Disord. 24:1998;227-249.
18. Frost R.O., Marten P., Lahart C., Rosenblate R. The dimensions of perfectionism. Cognitive Ther Res. 14:1990;449-468.
19. Garner DM (1990): Eating Disorder Inventory-2 Professional Manual. Odessa, FL: Psychological Assessment Resources.
20. Garner D.M., Olmsted M.P., Polivy J. Development and validation of a multidimensional eating disorder inventory for anorexia and bulimia nervosa. Int J Eating Dis. 2:1983;15-34.
21. Gershon E.S., Schreiber J.L., Hamovit J.R., Dibble E.D., Kaye W., Nurnberger J.I. Jr, et al. Clinical findings in patients with anorexia nervosa and affective illness in their relatives. Am J Psychiatry. 141:1984;1419-1422.
22. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., et al. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) 1. development, use and reliability . Arch Gen Psychiatry. 46:1989;1006-1011.
23. Hauser E.R., Boehnke M., Guo S.-W., Risch N. Affected sib-pair interval mapping and exclusion of complex genetic traits Sampling consideration . Genet Epidemiol. 13:1996;117-136.
24. Heath A.C., Cloninger C.R., Martin N.G. Testing a model for the genetic structure of personality A comparison of the personality systems of Cloninger and Eysenck . J Pers Soc Psychol. 66:1994;762-775.
25. Hinney A., Ziegler A., Nothen M., Remschmidt H., Hebebrand J. 5-HT2A receptor gene polymorphisms, anorexia nervosa, and obesity. Lancet. 350:1998;1724-1725.
26. Hoek H.W. Lack of relation between culture and anorexia nervosa-results of an incidence study in Curaco. N Engl J Med. 338:1998;1231-1232.
27. Holland A.J., Hall A., Murray R., Russell G.F.M., Crisp A.H. Anorexia nervosa a study of 34 twin pairs . Br J Psychiatry. 145:1984;414-419.
28. Holland A.J., Sicotte N., Treasure J. Anorexia nervosa Evidence for a genetic basis . J Psychosom Res. 32:1988;561-571.
29. Kaye WH, Frank GKW, McConaha C (in press): Altered dopamine activity after recovery from restricting-type anorexia nervosa. Neuropsychopharmacol.
30. Kaye W.H., Greeno C.G., Moss H., Fernstrom J., Fernstrom M., Lilenfeld L.R., et al. Alterations in serotonin activity and psychiatric symptomatology after recovery from bulimia nervosa. Arch Gen Psychiatry. 55:1998;927-935.
31. Kaye W.H., Gwirtsman H.E., George D.T., Ebert M.H. Altered serotonin activity in anorexia nervosa after long-term weight restoration Does elevated cerebrospinal fluid 5-hydroxy indoleacetic acid level correlate with rigid and obsessive behavior? Arch Gen Psychiatry. 48:1991;556-562.
32. Kaye W.H., Strober M. Neurobiology of eating disorders. Charney D.E., Nestler E.J., Bunney B.S. Neurobiological Foundations of Mental Illness. 1999;891-906 Oxford University Press, New York.
33. Kaye W.H., Weltzin T.E., Hsu L.K.G. Relationship between anorexia nervosa and obsessive and compulsive behaviors. Psychiatric Ann. 23:1993;365-373.
34. Kendler K.S., MacLean C., Neale M., Kessler R., Heath A., Eaves L. The genetic epidemiology of bulimia nervosa. Am J Psychiatry. 148:1991;1627-1637.
35. Kleifield E.I., Sunday S., Hurt S., Halmi K.A. The Tridimensional Personality Questionnaire An exploration of personality traits in eating disorders . J Psychiatric Res. 28:1993;413-423.
36. Klump KL, McGue M, Iacono WG (in press): Age differences in genetic and environmental influences on eating attitudes and behaviors in preadolescent and adolescent twins. J Abnorm Psychol.
37. Kong A., Cox N.J. Allele-sharing models LOD scores and accurate linkage tests . Am J Hum Genet. 61:1997;1179-1188.
38. Kruglyak L., Daly M.J., Reeve-Daly M.J., Lander E.S. Parametric and nonparametric linkage analysis A unified multipoint approach . Am J Hum Genet. 58:1996;1347-1363.
39. Lahiri D.K., Nurnberger J.I. Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 19:1991;5444.
40. Lilenfeld L.R., Kaye W.H., Greeno C.G., Merikangas K.R., Plotnicov K., Pollice C., et al. A controlled family study of anorexia nervosa and bulimia nervosa. Arch Gen Psychiatry. 55:1998;603-610.
41. Lilenfeld L.R., Kaye W.H., Strober M. Genetics and family studies of anorexia nervosa and bulimia nervosa. Jimerson D.C., Kaye W.H. Bailliere's Clinical Psychiatry, vol. 3 Eating Disorders . 1997;177-197 Bailliere Tindall, London.
42. Martin E.R., Kaplan N.L., Weir B.S. Tests for linkage and association in families. Am J Hum Genet. 61:1997;439-448.
43. Mazure C.M., Halmi K.A., Sunday S.R., Romano S.J., Einhorn A.M. The Yale-Brown-Cornell Eating Disorder Scale Development, use, reliability and validity . J Psychiatr Res. 28:1994;425-445.
44. O'Dwyer A.M., Lucey J.V., Russell G.F.M. Serotonin activity in anorexia nervosa after long-term weight restoration Response to D-fenfluramine challenge . Psychol Med. 26:1996;353-359.
45. Pato M.T., Eisen J., Pato C.N. Rating scales for obsessive compulsive behavior. Hollander E., Zohar J., Marassati D., Olivier B. Current Insights in Obsessive Compulsive Disorder. 1994;77-91 John Wiley and Sons, New York.
46. Pericak-Vance M.A., Bebout J.L., Gaskell P.C. Jr, Yamaoka L.H., Hung W.-Y., Alberts J.M., et al. Linkage studies in familial Alzheimer's disease Evidence for chromosome 19 linkage . Am J Hum Genet. 49:1991;1034-1050.
47. Risch N. The effects of reduced fertility, method of ascertainment, and a second unlinked locus on affected sib-pair marker allele sharing. Am Med Genet. 6:1983;243-259.
48. Risch N. Linkage strategies for genetically complex traits. I. Multilocus traits. Am J Hum Genet. 46:1990;222-228.
49. Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet. 46:1990;229-241.
50. Risch N. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affective relative pairs. Am J Hum Genet. 46:1990;242-253.
51. Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
52. Rutherford J., McGuffin P., Katz R., Murray R. Genetic influences on eating attitudes in a normal female population. Psychol Med. 23:1993;425-436.
53. Schaid D.J. General score tests for associations of genetic markers with disease using cases and their parents. Genetic Epidemiol. 13:1996;423-449.
54. Smith K.A., Fairburn C.G., Cowen P.J. Symptomatic relapse in bulimia nervosa following acute tryptophan depletion. Arch Gen Psychiatry. 56:1999;171-176.
55. Sohlberg S., Strober M. Personality in anorexia nervosa An update and theoretical integration . Acta Psychiatr Scand. 89:1994;1-15.
56. Sorbi S., Nacmias B., Tedde A., Ricca V., Mezzani B., Rotella C. 5-HT2A promoter polymorphism in anorexia nervosa. Lancet. 351:1998;1785.
57. Spielberger C.D., Gorsuch R.L., Lushene R.E. STAI Manual for the State Trait Anxiety Inventory. 1970;Consulting Psychologists Press, Palo Alto, CA.
58. Spielman R.C., Ewens W.J. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet. 59:1996;983-989.
59. Spielman R.C., McGinnis R.E., Ewens W.J. Transmission test for linkage disequilibrium The insulin gene region and insulin-dependent diabetes mellitus (IDDM) . Am J Hum Genet. 52:1993;506-516.
60. Srinivasagam N.M., Plotnicov K.H., Greeno C., Weltzin T.E., Rao R., Kaye W.H. Persistent perfectionism, symmetry, and exactness in anorexia nervosa after long-term recovery. Am J Psychiatry. 11:1995;1630-1634.
61. Strober M. Personality and symptomatological features in young, nonchronic anorexia nervosa patients. J Psychosom Res. 24:1980;353-359.
62. Strober M. Family-genetic studies of eating disorders. J Clin Psychiatry. 52:1991;9-12.
63. Strober M. Family-genetic perspectives on anorexia nervosa and bulimia nervosa. Brownell K.E., Fairburn C.G. Eating Disorders and Obesity A Comprehensive Handbook . 1995;212-218 The Guilford Press, New York.
64. Strober M, Freeman R, Lampert C, Diamond J, Kaye W (in press): A controlled family study of anorexia nervosa and bulimia nervosa: Evidence of shared liability and transmission of partial syndromes. Am J Psychiatry.
65. Strober M., Freeman R., Morrell W. The long-term course of severe anorexia nervosa in adolescents Survival analysis of recovery, relapse, and outcome predictors over 10-15 years in a prospective study . Int J Eating Dis. 22:1997;339-360.
66. Strober M., Lampert C., Morrell W., Burroughs J., Jacobs C. A controlled family study of anorexia nervosa Evidence of familial aggregation and lack of shared transmission with affective disorders . Int J Eating Dis. 9:1990;239-253.
67. Sunday S.R., Halmi K.A., Einhorn A. The Yale-Brown-Cornell Eating Disorder Scale A new scale to assess eating disorder symptomatology . Int J Eating Dis. 18:1995;237-245.
68. Thomson G. Mapping disease genes Family-based association studies . Am J Hum Genet. 57:1995;487-498.
69. Treasure J., Holland A.J. Genetic vulnerability to eating disorders Evidence from twin and family studies . Remschmidt H., Schmidt M.H. Child and Youth Psychiatry European Perspectives . 1989;59-68 Hogrefe and Huber, New York.
70. Tsai M.S., Tangalos E.G., Petersen R.C., Smith G.E., Schaid D.J., Kokmen E., et al. Apolipoprotein E Risk for Alzheimer disease . Am J Hum Genet. 54:1994;643-649.
71. Vitousek K., Manke F. Personality variables and disorders in anorexia nervosa and bulimia nervosa. J Abnorm Psychol. 1:1994;137-147.
72. Von Ranson KM, Kaye W, Weltzin TE, Rao R, Matsunaga H (in press). Obsessive-compulsive disorder symptoms before and after recovery from bulimia nervosa. Am J Psychiatry.
73. Wade T., Martin N., Tiggemann M. Genetic and environmental risk factors for the weight and shape concerns characteristic of bulimia nervosa. Psychol Med. 28:1998;761-771.
74. Walters E.E., Kendler K.S. Anorexia nervosa and anorexic-like syndromes in a population-based twin sample. Am J Psychiatry. 152:1995;64-71.
75. Weeks D.E., Lathrop G.M. Polygenic disease Methods for mapping complex disease traits . Trends Genet. 11:1995;513-519.