TPEN, a Zn2+/Fe2+ chelator with low affinity for Ca2+, inhibits lamin assembly, destabilizes nuclear architecture and may independently protect nuclei from apoptosis in vitro

Cell Calcium

Volumn 23, Issue 2-3, 1998, Pages 151-164

  Shumaker, Dale K ^a   Vann, Lewis R ^a,c   Goldberg, Martin W ^b   Allen, Terence D ^b   Wilson, Katherine L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CALCIUM ION; CHELATING AGENT; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FERROUS ION; LAMIN; MANGANESE; ZINC ION; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; CALCIUM; DRUG DERIVATIVE; EGTAZIC ACID; ETHYLENEDIAMINE DERIVATIVE; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE; NUCLEAR PROTEIN; ZINC;

ANIMAL CELL; APOPTOSIS; BINDING AFFINITY; CELL NUCLEUS MEMBRANE; CHANNEL GATING; CHROMATIN; CONTROLLED STUDY; DNA REPLICATION; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SCANNING ELECTRON MICROSCOPY; SHORT SURVEY; ANIMAL; CELL NUCLEUS; DRUG EFFECT; METABOLISM; REVIEW; ULTRASTRUCTURE; XENOPUS;

ANIMALIA;

ANIMALS; APOPTOSIS; CALCIUM; CELL NUCLEUS; CHELATING AGENTS; DNA REPLICATION; EGTAZIC ACID; ETHYLENEDIAMINES; FERROUS COMPOUNDS; LAMINS; NUCLEAR PROTEINS; XENOPUS; ZINC;

EID: 0031596834     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0143-4160(98)90114-2     Document Type: Review

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