The RING finger domain: A recent example of a sequence-structure family

Current Opinion in Structural Biology

Volumn 6, Issue 3, 1996, Pages 395-401

  Borden, Katherine L B ^a   Freemont, Paul S ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ZINC; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN MODIFICATION; PROTEIN STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; ZINC FINGERS;

EID: 0029977716     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(96)80060-1     Document Type: Article

References (49)

1. Freemont PS, Hanson IM, Trowsdale J: A novel cysteine-rich sequence motif. Cell 1991, 64:483-484.
2. Sternberg MJE: PROMOT: a FORTRAN program to scan protein sequences against a library of known motifs. CABIOS 1991, 7:257-260.
3. Freemont PS: The RING finger: a novel protein sequence motif related to the zinc finger. Ann NY Acad Sci 1993, 684:174-192.
4. Saurin AJ, Borden KLB, Boddy MN, Freemont PS: Does this have a familar RING? Trends Biochem Sci 1996, in press.
5. Schwabe JWR, Klug A: Zinc mining for protein domains. Nat Struct Biol 1994, 1:345-349.
6. Gill GN: The enigma of LIM domains. Structure 1995, 3:1285-1289.
7. Aasland R, Gibson TJ, Stewart AF: The PHD-finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci 1995, 20:56-59.
8. Saha V, Chaplin T, Gregorini A, Ayton P, Young BD: The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10 and MLLT6 protein. Proc Natl Acad Sci USA 1995, 92:9737-9741.
9. Weiss K, Rambaud S, Lavau C, Jansen J, Carvalho T, Carmo-Fonseca M, Lamond A, Dejean A: Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukaemia cells. Cell 1994, 76:345-356.
10. Koken MHM, Puvion-Dutilleul F, Guillemin MC, Viron A, Linares-Cruz G, Stuurman N, De Jong L, Szostecki C, Calvo F, Chomienne C et al.: The t(15:17) retranslocation alters a nuclear body in a retinoic acid reversible fashion. EMBO J 1994, 13:1073-1 083.
11. Dyck JA, Maul GG, Miller WH, Chen DJ, Kakizuka A, Evans RM: A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 1994, 76:333-343.
12. Le Dourain B, Zechel C, Gamier J-M, Lutz Y, Tora L, Pierrat B, Heery D, Gronemeye H, Chambon P, Losson R: The N-terminal part of TIF1, a putative mediator of the ligand dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protien T18. EMBO J 1995, 14:2020-2033.
13. Tagawa M, Sakamoto T, Shigemoto K, Matsubara H, Tamura Y, Ito T, Nankmura I, Okitsu A, Imai K, Taniguchi M: Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. J Biol Chem 1991, 265:20021-20026.
14. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman •• K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W et al.: A strong candidate for the breast and ovarian cancer suseptibility gene BRCA1. Science 1994, 266:66-71. This report of the sequence of the breast cancer susceptibility gene showed that there was a RING domain in the coding sequence. Furthermore, a number of mutations within the RING-finger region have been identifed in patients.
15. Reddy BA, Etkin LD: A unique bipartite cysteine-histidine motif defines a sub family of potential zinc-finger proteins. Nucleic Acids Res 1991, 19:6330.
16. Reddy BA, Etkin LD, Freemont PS: A novel zinc finger coiled-coil domain in a family of nuclear proteins. Trends Biochem Sci 1992, 17:344-345.
17. Borden KLB, Martin SR, O'Reilly N, Lally JM, Reddy BA, Etkin LD, Freemont PS: Characterisation of a novel cysteine/histidine-rich metal binding domain from Xenopus nuclear factor XNF7. FEBS Lett 1993, 335:255-260.
18. Borden KLB, Lally JM, Martin SR, O'Reilly NJ, Etkin LD, Freemont PS: Novel topology of a zinc-binding domain from a protein involved in regulating early Xenopus development EMBO J 1995, 14:5947-5956.
19. Boddy MN, Freemont PS, Borden KLB: The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger. Trends Biochem Sci 1994, 19:198-199.
20. Régnier CH, Tomasetto C, Moog-Lutz C, Chenard M-P, Wendling C, Basset P, Rio M-C: Presence of a new conserved domain in CART1, a novel member of the tumour necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. J Biol Chem 1995, 270:25715-25721.
21. Everett RD, Barlow P, Milner A, Luisi B, Orr A, Hope G, Lyon D: A novel arrangement of zinc-binding residues and secondary structure in the C3HC4 motif of an alpha herpes virus protein family. J Mol Biol 1993, 234:1038-1047.
22. Lovering R, Hanson IM, Borden KLB, Martin S, O'Reilly N, Evan G, Rahman D, Pappin DJC, Trowsdale J, Freemont PS: Identification and preliminary characterization of a protein motif related to the zinc finger. Proc Natl Acad Sci USA 1993, 90:2112-2116.
23. Von Arnim AG, Deng X-W: Ring finger motif of Arabidopsis thaliana COP1 defines a new class of zinc-binding domain. J Biol Chem 1993, 268:19626-19631.
24. 1H-nuclear magnetic resonance spectroscopy. J Mol Biol 1994, 237:201-211. This paper describes the structure of a RING domain from the equine herpes virus protein IEEHV. This is the first reported structure of a RING domain and shows the cross-brace motif which appears to be unique to the family.
25. Borden KLB, Boddy MN, Lally J, O'Reilly NJ, Martin S, Howe K, •• Solomon E, Freemont PS: The solution structure of the RING finger domain from the acute promyelocytic leukaemia protooncoprotein PML. EMBO J 1995, 14:1532-1541. This paper describes the RING finger domain from the acute promyelocytic leukaemia protein PML. The structure is different to the IEEHV RING but has some conserved similarities, especially the use of the cross-brace ligation scheme. A comparison of these structures demonstrates the diverse nature of this family. This paper also indicates that the RING domain is necessary for PML-associated nuclear body formation.
26. Takahashi M, Inaguma Y, Hiai H, Hirose F: Developmentally regulated expression of a human 'Finger'-containing gene encoded by the 5' half of the ret transforming gene. Mol Cell Biol 1988, 8:1853-1856.
27. Kanno M, Hasegawa M, Ishida A, Isono K, Taniguchi M: Mel-18, • a polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J 1995, 14:101-107. This paper provides the first strong evidence for sequence-specific DNA binding by a RING finger-containing protein. However, no evidence is presented to suggest that the RING domain is directly mediating the DNA-binding activity. All of the transcriptional-repression and DNA-binding assays were performed using full length Mel-18 protein.
28. Borden KLB, Lally JM, Martin SR, O'Reilly NJ, Solomon E, Freemont PS: In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia proto-oncoprotein PML. Proc Natl Acad Sci USA 1996, 93:1601-1606.
29. Everett R, O'Hare P, O'Rouke D, Barlow P, Orr A: Point mutations • in the herpes-simplex virus type-1 vmw110 ring finger helix affect activation of gene-expression, viral growth and interaction with PML-containing nuclear-structures. J Virol 1995, 69:7339-7344. This paper uses the solution structure of the IEEHV RING finger to test point mutations of the amphipathic a helix of a related herpes virus (IE110) RING finger. The authors show that this region of the IE110 RING domain is important for virus growth and the normal interaction of IE110 with PML nuclear structures. It is interesting to note that this region appears to be absent in the PML RING domain.
30. Kalish JE, Theda C, Morrell JC, Berg JM,Gould SJ: Formation of the peroxisome lumen is abolished by loss of Pichia pastoris Pas7p, a zinc-binding integral membrane protein of the peroxisome. Mol Cell Biol 1995, 15:6406-6419.
31. Scotland PB, Colledge M, Melnikova I, Dai Z, Froehner SC: Clustering of the acetylcholine receptor by the 43-kD protein: involvement of the zinc finger domain J Cell Biol 1993, 123:719-728.
32. Frankel AD, Bredt DS, Pabo CO: Tat protein from human immunodeficiency virus forms a metal-linked dimer. Science 1988, 240:70-73.
33. Everett RD, Maul GG: HSV-1 IE protein Vmw110 causes redistribution of PML. EMBO J 1994, 13:5062-5069.
34. Everett RD, Maul GG, Orr A, Elliott M: The cellular RING finger protein PML is not a functional counterpart of the herpes-simplex virus type-1 RING finger protein Vmw110. J Gen Virol 1995, 76:791-798.
35. Stuurman N, De Graaf A, Floore A, Josso A, Humbel B, De Jong L, Van Driel R: A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies. J Cell Sci 1992, 101:773-784.
36. Ascoli CA, Maul GG: Identification of a novel nuclear domain. J Cell Biol 1991, 112:785-795.
37. Xhu ZM, Cai WZ, Schaffer PA: Cooperativity among herpes-simplex virus type1 immediate early regulatory proteins ICP4 and ICP27 affect the intracellular localisation of ICPO. J Virol 1994, 68:3027-3040.
38. Korioth F, Gieffers C, Maul GG, Frey J: Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. J Cell Biol 1995, 130:1-13.
39. Blake TJ, Heath KG, Langdon WY: The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. EMBO J 1993, 12:2017-2026.
40. Andoniou CE, Thien CBF, Langdon WY: Tumour induction by activated abl involves tyrosine phosphorylation of the product of cbl oncogene. EMBO J 1994, 13:4515-4523.
41. Rivero-Lezcano OM, Sameshima JH, Marcillar A, Robbins KC: Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. J Biol Chem 1994, 269:17363-17366.
42. Devault A, Martinex A-M, Fesquet D, Labbe J-C, Morin N, Tassan J-P, Nigg EA, Cavadore J-C, Doree M: MAT1 ('menage a trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK. EMBO J 1995, 14:5027-5036.
43. Fisher RP, Jin P, Chamberlin HM, Morgan DO: Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell 1995, 83:47-57.
44. Chen Y, Chen C-F, Riley DJ, Allred DC, Chen PL, Von Hoff D, Osborne CK, Lee W-H: Aberrant subcellular localization of BRCA1 in breast cancer. Science 1995, 270:789-792.
45. Patarca R, Scwartz J, Singh RP, Kong Q-T, Murphy E, Anderson Y, Sheng F-Y, Singh P, Johnson KA, Guarnagia SM et al.: Rpt-1, an intracellular protein from helper-inducer T cells that regulates gene expression of interleukin-2 receptor and human immunovirus type 1. Proc Natl Acad Sci USA 1988, 85:2733-2737.
46. Tsukamoto T, Shimozawa N, Fujiki Y: Peroxisome assembly factor 1 : nonsense mutation in a peroxisome deficient chinese hamster ovary cell mutant and deletion analysis. Mol Cell Biol 1994, 14:5458-5465.
47. Tsukamoto T, Miura S, Fujiki Y: Restoration by a 35K membrane protein of peroxisome assembly in a peroxisome deficient mammalian cell mutant. Science 1991, 350:77-81.
48. Rothe M, Wong SC, Henzel WJ, Goeddel DV: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 1994, 78:681-692.
49. Rothe M, Sarma V, Dixit VM, Goeddel DV: TRAF2-mediated activation of the NF-κB by TNF receptor 2 and CD40. Science 1995, 269:1424-1427.