Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

Genes and Development

Volumn 12, Issue 1, 1998, Pages 95-106

  Sellers, William R ^a   Novitch, Bennett G ^a   Miyake, Satoshi ^a   Heith, Agnieszka ^a   Otterson, Gregory A ^b   Kaye, Frederic J ^b   Lassar, Andrew B ^a   Kaelin Jr , William G ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

E2F; Retinoblastoma; Transcription; Tumorigenesis

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; GENE MUTATION; GROWTH INHIBITION; HIGH RISK POPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RETINOBLASTOMA; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ANIMALIA;

EID: 0031930466     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.1.95     Document Type: Article

References (59)

1. Adams, P.D. and W.G. Kaelin. 1995. Transcriptional control by E2F. Cancer Biol. 6: 99-108.
2. Adnane, J., Z. Shao, and P.D. Robbins. 1995. The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter. J. Biol. Chem. 270: 8837-8843.
3. γ induces cell cycle withdrawl: Inhibition of E2F/DP DNA-binding activity via a down-regulation of PP2A. Genes & Dev. 11: 1987-1998.
4. Asahina, I., T.K. Sampath, and P.V. Hauschka. 1996. Human Osteogenic Protein-1 induces chondroblastic, osteoblastic, and/or adipocyte differentiation of clonal murine target cells. Exp. Cell Res. 222: 38-47.
5. Baker, S.J., S. Markowitz, E. Fearon, B. Willson, and B. Vogelstein. 1990. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249: 912-915.
6. Botz, J., K. Zerfass-Thome, D. Spitkovsky, H. Delius, B. Vogt, M. Eilers, A. Hatzigergiou, and P. Jansen-Dürr. 1996. Cell cycle regulation of the murine Cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell Biol. 16: 3401-3409.
7. Bremner, R., B.L. Cohen, M. Sopta, P.A. Hamel, C.J. Ingles, B.G. Gallie, and R.A. Phillips. 1995. Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol Cell Biol. 15: 3256-3265.
8. Cao, L., B. Faha, M. Dembski, L.-H. Tsai, E. Harlow, and N. Dyson. 1992. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature 355: 176-179.
9. Chen, C. and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7: 2745-2752.
10. Chen, P.-L., D.J. Riley, Y. Chen, and W.-H. Lee. 1996a. Retinoblastoma protein postively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes & Dev. 10: 2794-2804.
11. _. 1996b. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc. Natl. Acad. Sci. 93: 465-469.
12. Clarke, A.R., E.R. Maandag, M. van Roon, N.M.T. van der Lugt, M. van der Valk, M.L. Hooper, A. Berns, and H. Riele. 1992. Requirement for a functional Rb-1 gene in murine development. Nature 359: 328-330.
13. Claudio, P.P., C.M. Howard, A. Baldi, A. De Luca, Y. Fu, G. Condorelli, Y. Sun, N. Colburn, B. Calabretta, and A. Giordano. 1994. p130/pRb2 has growth suppression properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res. 54: 5556-5560.
14. Cobrinik, D., M.-H. Lee, G. Hannon, G. Mulligan, R.T. Bronson, N. Dyson, E. Harlow, D. Beach, R.A. Weinberg, and T. Jacks. 1996. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes &. Dev. 10: 1633-1644.
15. Dryja, T.P., J. Rapaport, T.L. McGee, T.M. Nork, and T.L. Schwartz. 1993. Molecular etiology of low-penetrance retinoblastoma in two pedigrees. Am. J. Hum. Genet. 52: 1122-1128.
16. Geng, Y., E.N. Eaton, M. Picon, J.M. Roberts, A.S. Lundberg, A. Gifford, C. Sardet, and R.A. Weinberg. 1996. Regulation of cyclin E transcription by E2Fs and the retinoblastoma protein. Oncogene 12: 1173-1180.
17. Giguere, V., S. Hollenberg, M. Rosenfeld, and R. Evans. 1986. Functional domains of the human glucocorticoid receptor. Cell 46: 645-652.
18. Ginsberg, D., G. Vairo, T. Chittenden, Z.-X. Xiao, G. Xu, K.L. Wydner, J.A. DeCaprio, J.B. Lawrence, and D.M. Livingston. 1994. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes & Dev. 8: 2665-2679.
19. Gu, W., J.W. Schneider, G. Condorelli, S. Kaushal, V. Mahdavi, and B. Nadal-Ginard. 1993. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72: 309-324.
20. Harlow, E. and D. Lane. 1988. Antibodies - A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
21. Hinds, P.W., S. Mittnacht, V. Dulic, A. Arnold, S.I. Reed, and R.A. Weinberg. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70: 993-1006.
22. Huang, H.-J.S., J.-K. Yee, J.-Y. Shew, P.-L. Chen, R. Bookstein, T. Friedmann, E.Y.-H.P. Lee, and W.-H. Lee. 1988. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 242: 1563-1566.
23. Hurst, H.C., N. Masson, N.C. Jones, and K.A.W. Kee. 1990. The cellular transcription factor CREB corresponds to activating factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43. Mol. Cell Biol. 10: 6192-6203.
24. Jacks, T., A. Fazeli, E.M. Schmitt, R.T. Bronson, M.A. Goodell, and R.A. Weinberg. 1992. Effects of an Rb mutation in the mouse. Nature 359: 295-300.
25. Jaynes, J.J., J. Johnson, C. Buskin, C. Gartside, and S. Hauschka. 1988. The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle specific enhancer. Mol. Cell. Biol. 8: 62-70.
26. Kratzke, R.A., G.A. Otterson, A. Hogg, A.B. Coxon, J. Geradts, J.K. Cowell, and F.J. Kaye. 1994. Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors. Oncogene 9: 1321-1326.
27. Krek, W., D.M. Livingston, and S. Shirodkar. 1993. Binding to DNA and retinoblastoma gene product promoted by complex formation of different E2F family members. Science 262: 1557-1560.
28. La Thangue, N.B. 1994. DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19: 108-114.
29. Lee, E.Y.-H.P., C.-Y. Chang, N. Hu, Y.-C.J. Wang, C.-C. Lai, K. Herrup, W.-H. Lee, and A. Bradley. 1992. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359: 288-294.
30. Lee, E.Y.-H.P., N. Hu, S.-S.F. Yuan, L.A. Cox, A. Bradley, W.-H. Lee, and K. Herrup. 1994. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes & Dev. 8: 2008-2021.
31. Lee, M.-H., B.O. Williams, G. Mulligan, S. Mukai, R.T. Bronson, N. Dyson, E. Harlow, and T. Jacks. 1996. Targeted disruption of p107: Functional overlap between p107 and Rb. Genes & Dev. 10: 1621-1632.
32. Lohmann, D.R., B. Brandt, W. Hopping, E. Passarge, and B. Horsthemke. 1994. Distinct RB1 gene mutations with low penetrance in hereditary retinoblastoma. Hum. Genet. 94: 349-354.
33. Neuman, E., E.K. Flemington, W.R. Sellers, and W.G. Kaelin. 1994. Transcription of the E2F1 gene is rendered cell-cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 14: 6607-6615.
34. +/- mice. Genes & Dev. 10: 1870-1879.
35. Novitch, B.G., G.J. Mulligan, T. Jacks, and A.B. Lassar. 1996. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J. Cell Biol. 135: 441-456.
36. Ohtani, K., J. DeGregori, and J.R. Nevins. 1995. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. 92: 12146-12150.
37. Onadim, Z., A. Hogg, P.N. Baird, and J.K. Cowell. 1992. Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotype. Proc. Natl. Acad. Sci. 89:6177-6181.
38. Qin, X.-Q., T. Chittenden, D.M. Livingston, and W.G. Kaelin. 1992. Identification of a growth suppression domain within the retinoblastoma gene product. Genes & Dev. 6: 953-964.
39. Qin, X.-Q., D.M. Livingston, M. Ewen, W.R. Sellers, Z. Arany, and W.G. Kaelin, Jr. 1995. The transcription factor E2F1 is a downstream target of Rb action. Mol. Biol. Cell. 15: 742-755.
40. Schwarz, J.K., S.H. Devoto, E.J. Smith, S.P. Chellappan, L. Jakoi, and J.R. Nevins. 1993. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO J. 12: 1013-1020.
41. Sellers, W.R. and W.G. Kaelin, Jr. 1996. RB as a modulator of transcription. Biochim. Biophys. Acta 1288: M1-M5.
42. Sellers, W.R., J.W. Rodgers, and W.G. Kaelin Jr. 1995. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl. Acad. Sci. 92: 11544-11548.
43. Shirodkar, S., M. Ewen, J.A. DeCaprio, J. Morgan, D.M. Livingston, and T. Chittenden. 1992. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 68: 157-166.
44. Singh, P., J. Coe, and W. Hong. 1995. A role for retinoblastoma protein in potentiating protein transcriptional activation by the glucocorticoid receptor. Nature 374: 562-565.
45. Skapek, S.X., J. Rhee, D.E. Spicer, and A.B. Lassar. 1995. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science 267: 1022-1024.
46. Strauss, M., J. Lukas, and J. Bartek. 1995. Unrestricted cell cycling and cancer. Nature Med. 1: 1245-1246.
47. Taya, Y. 1997. RB kinases and RB-binding proteins: New points of view. [Review] [50 refs]. Trends Biochem. Sci. 22: 14-17.
48. Tedder, T.F. and C.M. Isaacs. 1989. Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. J. Immnnol. 143: 712-717.
49. Templeton, D.J., S.H. Park, L. Lanier, and R. Weinberg. 1991. Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc. Natl. Acad. Sci. 88: 3033-3037.
50. Vairo, G., D.M. Livingston, and D. Ginsberg. 1995. Functional Interaction between E2F4 and p130: Evidence for distinct mechanisms underlying growth suppression by different Rb family members. Genes & Dev. 9: 869-881.
51. Weinberg, R.A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
52. Weintraub, S.J., C.A. Prater, and D.C. Dean. 1992. Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358: 259-261.
53. Weintraub, S., K. Chow, R. Luo, S. Zhang, S. He, and D. Dean. 1995. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375: 812-815.
54. Wilson, I.A., D.H. Haft, E.D. Getzoff, J.A. Tainer, R.A. Lerner, and S. Brenner. 1985. Identical short peptide sequences in unrelated proteins can have different confirmations: A testing ground for theories of immune recognition. Proc. Natl. Acad. Sci. 82: 5255-5259.
55. Yamasaki, L., T. Jacks, R. Bronson, E. Goillot, E. Harlow, and N.J. Dyson. 1996. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85: 537-548.
56. Yandell, D.W., T.A. Campbell, S.H. Dayton, R. Petersen, D. Walton, J.B. Little, A. McConkie-Rosell, E.G. Buckley, and T.P. Dryja. 1989. Oncogenic point mutations in the human retinoblastoma gene: Their application to genetic counseling. N. Engl. J. Med. 321: 1689-1695.
57. Zacksenhaus, E., Z. Jiang, D. Chung, J.D. Marth, R.A. Phillips, and B.L. Gallie. 1996. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes & Dev. 10: 3051-3064.
58. Zhu, L., S. van der Heuvel, K. Helin, A. Fattaey, M. Ewen, D. Livingston, N. Dyson, and E. Harlow. 1993. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes & Dev. 7: 1111-1125.
59. Zhu, L., G. Enders, J.A. Lees, R.L. Beijersbergen, R. Bernards, and E. Harlow. 1995. The pRB-related protein p107 contains two growth suppression domains: Independent interactions with E2F and cyclin/cdk complexes. EMBO J. 14: 1904-1913.