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Volumn 7, Issue 5, 1996, Pages 279-289

Genes in the RB pathway and their knockout in mice

Author keywords

Cell cycle regulators; Gene knockout; RB; Tumor suppressor genes

Indexed keywords

REGULATOR PROTEIN;

EID: 0030265327     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.1996.0036     Document Type: Review
Times cited : (32)

References (73)
  • 1
    • 0028170806 scopus 로고
    • The retinoblastoma protein: More than a tumor suppressor
    • 1. Riley DJ, Lee EY-HP, Lee W-H (1994) The retinoblastoma protein: more than a tumor suppressor. Annu Rev Cell Biol 10:1-29
    • (1994) Annu Rev Cell Biol , vol.10 , pp. 1-29
    • Riley, D.J.1    Lee, E.Y.-H.P.2    Lee, W.-H.3
  • 2
    • 0029894254 scopus 로고    scopus 로고
    • RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila
    • 2. Du W, Vidal M, Xie J-E, Dyson N (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes and Dev 10:1206-1218
    • (1996) Genes and Dev , vol.10 , pp. 1206-1218
    • Du, W.1    Vidal, M.2    Xie, J.-E.3    Dyson, N.4
  • 3
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • 3. Sherr CJ, Roberts JM (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9:1149-1163
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 4
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • 4. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 5
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • 5. Nevins JR (1992) E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 6
    • 0027219918 scopus 로고
    • Signals and genes in the control of cell-cycle progression
    • 6. Muller R, Mumberg D, Lucibello FC (1993) Signals and genes in the control of cell-cycle progression. [Review]. Biochim Biophys Acta 1155:151-179
    • (1993) Biochim Biophys Acta , vol.1155 , pp. 151-179
    • Muller, R.1    Mumberg, D.2    Lucibello, F.C.3
  • 9
    • 0029026176 scopus 로고
    • The pRB-related protein p107 contains two growth suppression domains: Independent interactions with E2F and cyclin/ cdk complexes
    • 9. Zhu L, Enders G, Lees JA, Beijersbergen RL, Bernards R, Harlow E (1995) The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/ cdk complexes. EMBO J 14:1904-1913
    • (1995) EMBO J , vol.14 , pp. 1904-1913
    • Zhu, L.1    Enders, G.2    Lees, J.A.3    Beijersbergen, R.L.4    Bernards, R.5    Harlow, E.6
  • 10
    • 0029026176 scopus 로고
    • The pRB-related protein p107 contains two growth suppression domains: Independent interactions with E2F and cyclin/ cdk complexes
    • 10. Zhu L, Enders G, Lees JA, Beijersbergen RL, Bernards R, Harlow E (1995) The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/ cdk complexes. EMBO J 14:1904-1913
    • (1995) EMBO J , vol.14 , pp. 1904-1913
    • Zhu, L.1    Enders, G.2    Lees, J.A.3    Beijersbergen, R.L.4    Bernards, R.5    Harlow, E.6
  • 11
    • 0027986982 scopus 로고
    • DP and E2F proteins: Coordinating transcription with cell cycle progression
    • 11. Lam EW, La TN (1994) DP and E2F proteins: coordinating transcription with cell cycle progression. [Review]. Curr Opin Cell Biol 6:859-866
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 859-866
    • Lam, E.W.1    La, T.N.2
  • 15
    • 0028131540 scopus 로고
    • Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
    • 15. Lee EY-HP, Hu N, Yuan S-SF, Cox LA, Bradley A, Lee W-H, Herrup K (1994) Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev 8:2008-2021
    • (1994) Genes Dev , vol.8 , pp. 2008-2021
    • Lee, E.Y.-H.P.1    Hu, N.2    Yuan, S.-S.F.3    Cox, L.A.4    Bradley, A.5    Lee, W.-H.6    Herrup, K.7
  • 16
    • 0028988697 scopus 로고
    • Effects of heterozygosity for the Rb-1t19neo allele in the mouse
    • 16. Harrison DJ, Hooper ML, Armstrong JF, Clarke AR (1995) Effects of heterozygosity for the Rb-1t19neo allele in the mouse. Oncogene 10:1615-1620
    • (1995) Oncogene , vol.10 , pp. 1615-1620
    • Harrison, D.J.1    Hooper, M.L.2    Armstrong, J.F.3    Clarke, A.R.4
  • 18
    • 0028339957 scopus 로고
    • Reversal of terminal differentiation mediated by p107 in Rb-/ -muscle cells
    • 18. Schneider JW, Gu W, Zhu L, Mahdavi V, Nadal GB (1994) Reversal of terminal differentiation mediated by p107 in Rb-/ -muscle cells. Science 264:1467-1471
    • (1994) Science , vol.264 , pp. 1467-1471
    • Schneider, J.W.1    Gu, W.2    Zhu, L.3    Mahdavi, V.4    Nadal, G.B.5
  • 19
    • 0029869443 scopus 로고    scopus 로고
    • Molecular cloning and developmental expression of mouse p130, a member of the retinoblastoma gene family
    • 19. Chen G, Guy CT, Chen H-W, Hu N, Lee EY-HP, Lee W-H (1996) Molecular cloning and developmental expression of mouse p130, a member of the retinoblastoma gene family. J Biol Chem 271:9567-9572
    • (1996) J Biol Chem , vol.271 , pp. 9567-9572
    • Chen, G.1    Guy, C.T.2    Chen, H.-W.3    Hu, N.4    Lee, E.Y.-H.P.5    Lee, W.-H.6
  • 24
    • 0027336491 scopus 로고
    • Mammalian G1 cyclins
    • 24. Sherr C (1993) Mammalian G1 cyclins. Cell 73:1059-1065
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.1
  • 26
    • 0028274940 scopus 로고
    • Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene
    • 26. Bodrug SE, Warner BJ, Bath ML, Lindeman GJ, Harris AW, Adams JM (1994) Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO J 13:2124-2130
    • (1994) EMBO J , vol.13 , pp. 2124-2130
    • Bodrug, S.E.1    Warner, B.J.2    Bath, M.L.3    Lindeman, G.J.4    Harris, A.W.5    Adams, J.M.6
  • 27
    • 0028049592 scopus 로고
    • Cyclin D1/ bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice
    • 27. Lovec H, Grzeschiczek A, Kowalski MB, Moroy T (1994) Cyclin D1/ bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice. EMBO J 13:3487-3495
    • (1994) EMBO J , vol.13 , pp. 3487-3495
    • Lovec, H.1    Grzeschiczek, A.2    Kowalski, M.B.3    Moroy, T.4
  • 29
    • 0028074603 scopus 로고
    • Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
    • 29. Li R, Waga S, Hannon GJ, Beach D, Stillman B (1994) Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371:534-537
    • (1994) Nature , vol.371 , pp. 534-537
    • Li, R.1    Waga, S.2    Hannon, G.J.3    Beach, D.4    Stillman, B.5
  • 30
  • 32
    • 0030067581 scopus 로고    scopus 로고
    • Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration
    • 32. Wu H, Wade M, Krall L, Grisham J, Xiong Y, Van DT (1996) Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration. Genes Dev 10:245-260
    • (1996) Genes Dev , vol.10 , pp. 245-260
    • Wu, H.1    Wade, M.2    Krall, L.3    Grisham, J.4    Xiong, Y.5    Van, D.T.6
  • 33
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/ WAF1 undergo normal development, but are defective in G1 checkpoint control
    • 33. Deng C, Zhang P, Harper JW, Elledge SJ, Leder P (1995) Mice lacking p21CIP1/ WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:675-684
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 37
    • 0029996726 scopus 로고    scopus 로고
    • Resistance to apoptosis conferred by cdk inhibitors during myocyte differentiation
    • 37. Wang J, Walsh K (1996) Resistance to apoptosis conferred by cdk inhibitors during myocyte differentiation. Science 273:359-361
    • (1996) Science , vol.273 , pp. 359-361
    • Wang, J.1    Walsh, K.2
  • 41
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retina dysplasia, and pituitary tumors
    • 41. Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, Shishido N, Horii I, Loh DY, Nakayama K (1996) Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retina dysplasia, and pituitary tumors. Cell 85:707-720
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1    Ishida, N.2    Shirane, M.3    Inomata, A.4    Inoue, T.5    Shishido, N.6    Horii, I.7    Loh, D.Y.8    Nakayama, K.9
  • 43
    • 0029664461 scopus 로고    scopus 로고
    • Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
    • 43. Coats S, Flanagan WM, Nourse J, Roberts JM (1996) Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272:877-880
    • (1996) Science , vol.272 , pp. 877-880
    • Coats, S.1    Flanagan, W.M.2    Nourse, J.3    Roberts, J.M.4
  • 44
    • 0028988159 scopus 로고
    • p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
    • 44. Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ (1995) p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev 9:650-662
    • (1995) Genes Dev , vol.9 , pp. 650-662
    • Matsuoka, S.1    Edwards, M.C.2    Bai, C.3    Parker, S.4    Zhang, P.5    Baldini, A.6    Harper, J.W.7    Elledge, S.J.8
  • 47
    • 0029587551 scopus 로고
    • Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • 47. Quelle DE, Zindy F, Ashmun RA, Sherr CJ (1995) Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83:993-1000
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 48
    • 0028172926 scopus 로고
    • Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB
    • 48. Otterson GA, Kratzke RA, Coxon A, Kim YW, Kaye FJ (1994) Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene 9:3375-3378
    • (1994) Oncogene , vol.9 , pp. 3375-3378
    • Otterson, G.A.1    Kratzke, R.A.2    Coxon, A.3    Kim, Y.W.4    Kaye, F.J.5
  • 50
    • 0030031542 scopus 로고    scopus 로고
    • E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes
    • 50. Guy CT, Zhou W, Kaufman S, Robinson MO (1996) E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes. Molec Cell Biol 16:685-693
    • (1996) Molec Cell Biol , vol.16 , pp. 685-693
    • Guy, C.T.1    Zhou, W.2    Kaufman, S.3    Robinson, M.O.4
  • 54
    • 0025943945 scopus 로고
    • Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein
    • 54. Shi Y, Seto E, Chang LS, Shenk T (1991) Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67:377-388
    • (1991) Cell , vol.67 , pp. 377-388
    • Shi, Y.1    Seto, E.2    Chang, L.S.3    Shenk, T.4
  • 55
    • 0030008768 scopus 로고    scopus 로고
    • Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
    • 55. Wu CL, Classon M, Dyson N, Harlow E (1996) Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Molec Cell Biol 16:3698-3706
    • (1996) Molec Cell Biol , vol.16 , pp. 3698-3706
    • Wu, C.L.1    Classon, M.2    Dyson, N.3    Harlow, E.4
  • 56
    • 0028298169 scopus 로고
    • DNA-binding and trans-activation properties of Drosophila E2F and DP proteins
    • 56. Dynlacht BD, Brook A, Dembski M, Yenush L, Dyson N (1994) DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc Nat Acad Sci USA 91:6359-6363
    • (1994) Proc Nat Acad Sci USA , vol.91 , pp. 6359-6363
    • Dynlacht, B.D.1    Brook, A.2    Dembski, M.3    Yenush, L.4    Dyson, N.5
  • 57
    • 0028218873 scopus 로고
    • Functional properties of a Drosophila homolog of the E2F1 gene
    • 57. Ohtani K, Nevins JR (1994) Functional properties of a Drosophila homolog of the E2F1 gene. Mol Cell Biol 14:1603-1612
    • (1994) Mol Cell Biol , vol.14 , pp. 1603-1612
    • Ohtani, K.1    Nevins, J.R.2
  • 58
    • 0029044951 scopus 로고
    • The transcription factor E2F is required for S phase during Drosophila embryogenesis
    • 58. Duronio RJ, O'Farrell PH, Xie J-E, Brook A, Dyson N (1995) The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 9:1445-1455
    • (1995) Genes Dev. , vol.9 , pp. 1445-1455
    • Duronio, R.J.1    O'Farrell, P.H.2    Xie, J.-E.3    Brook, A.4    Dyson, N.5
  • 59
    • 0029050533 scopus 로고
    • Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F responsive genes, and apoptosis
    • 59. Almasan A, Yin Y, Kelly RE, Lee EY-HP, Bradley A, Li W, Bertino JR, Wahl GM (1995) Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F responsive genes, and apoptosis. Proc Nat Acad Sci USA 92:5436-5440
    • (1995) Proc Nat Acad Sci USA , vol.92 , pp. 5436-5440
    • Almasan, A.1    Yin, Y.2    Kelly, R.E.3    Lee, E.Y.-H.P.4    Bradley, A.5    Li, W.6    Bertino, J.R.7    Wahl, G.M.8
  • 60
    • 0029863840 scopus 로고    scopus 로고
    • Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in RB-deficient fibroblasts
    • 60. Herrera RE, Sah VP, Williams BO, Makela TM, Weinberg RA, Jacks T (1996) Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in RB-deficient fibroblasts. Molec Cell Biol 16:2402-2407
    • (1996) Molec Cell Biol , vol.16 , pp. 2402-2407
    • Herrera, R.E.1    Sah, V.P.2    Williams, B.O.3    Makela, T.M.4    Weinberg, R.A.5    Jacks, T.6
  • 61
    • 0027351577 scopus 로고
    • Developmental mechanisms that generate precise patterns of neuronal connectivity
    • 61. Goodman CS, Shatz CJ (1993) Developmental mechanisms that generate precise patterns of neuronal connectivity. [Review]. Cell 72(S):77-98
    • (1993) Cell , vol.72 , Issue.S , pp. 77-98
    • Goodman, C.S.1    Shatz, C.J.2
  • 62
    • 0027934570 scopus 로고
    • p53-Dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • 62. Morgenbesser SD, Williams BO, Jacks T, DePinho RA (1994) p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371:72-74
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    DePinho, R.A.4
  • 63
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
    • 63. Pan H, Griep AE (1994) Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev 8:1285-1299
    • (1994) Genes Dev , vol.8 , pp. 1285-1299
    • Pan, H.1    Griep, A.E.2
  • 64
    • 0028227260 scopus 로고
    • Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
    • 64. Howes KA, Ranson N, Papermaster DS, Lasudry JGH, Albert DM, Windle JL (1994) Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes Dev 8:1300-1310
    • (1994) Genes Dev , vol.8 , pp. 1300-1310
    • Howes, K.A.1    Ranson, N.2    Papermaster, D.S.3    Lasudry, J.G.H.4    Albert, D.M.5    Windle, J.L.6
  • 66
    • 0027499060 scopus 로고
    • Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
    • 66. Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B (1993) Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72:309-324
    • (1993) Cell , vol.72 , pp. 309-324
    • Gu, W.1    Schneider, J.W.2    Condorelli, G.3    Kaushal, S.4    Mahdavi, V.5    Nadal-Ginard, B.6
  • 67
    • 0027215522 scopus 로고
    • RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development
    • 67. Chen J, Lansford R, Stewart V, Young F, Alt FW (1993) RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Nat Acad Sci USA 90:4528-4532
    • (1993) Proc Nat Acad Sci USA , vol.90 , pp. 4528-4532
    • Chen, J.1    Lansford, R.2    Stewart, V.3    Young, F.4    Alt, F.W.5
  • 68
    • 0029316784 scopus 로고
    • Genome engineering: The new mouse genetics
    • 68. Rossant J, Nagy A (1995) Genome engineering: the new mouse genetics. [Review]. Nature Medicine 1:592-594
    • (1995) Nature Medicine , vol.1 , pp. 592-594
    • Rossant, J.1    Nagy, A.2
  • 69
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • 69. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. [Review]. Cell 61:759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 71
    • 0029818753 scopus 로고    scopus 로고
    • Time-sensitive reversal of hyperplasia in transgenic mice expressing SV 40 T antigen
    • 71. Ewald D, Li M, Efrat S, Auer G, Wall RJ, Furth PA, Hennighausen L (1996) Time-sensitive reversal of hyperplasia in transgenic mice expressing SV 40 T antigen. Science 273:1384-1386
    • (1996) Science , vol.273 , pp. 1384-1386
    • Ewald, D.1    Li, M.2    Efrat, S.3    Auer, G.4    Wall, R.J.5    Furth, P.A.6    Hennighausen, L.7
  • 72
    • 0028937476 scopus 로고
    • Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin
    • 72. Harvey M, Vogel H, Lee EY-HP, Bradley A, Donehower LA (1995) Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. Cancer Res 55:1146-1151
    • (1995) Cancer Res , vol.55 , pp. 1146-1151
    • Harvey, M.1    Vogel, H.2    Lee, E.Y.-H.P.3    Bradley, A.4    Donehower, L.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.