메뉴 건너뛰기




Volumn 1529, Issue 1-3, 2000, Pages 49-62

Structure and regulation of mammalian squalene synthase

Author keywords

Cholesterol biosynthesis; Cytokine; Isoprenoid metabolism; Squalene synthase; Sterol regulatory element binding protein

Indexed keywords

ASPARTIC ACID; CHOLESTEROL; CYTOKINE; INTERLEUKIN 1BETA; ISOPRENOID; MESSENGER RNA; MEVINOLIN; PHENYLALANINE; PROTEIN; SQUALENE SYNTHASE; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; TYROSINE;

EID: 0034672674     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(00)00137-2     Document Type: Review
Times cited : (94)

References (91)
  • 2
    • 0002869606 scopus 로고
    • Biosynthesis of non-head-to-tail terpenes: formation of 1'-1 and 1'-3 linkages
    • (1990) Acc. Chem. Res. , vol.23 , pp. 70-77
    • Poulter, C.D.1
  • 3
    • 0007105377 scopus 로고    scopus 로고
    • I. Shechter, G. Guan, B. Boettcher, Squalene synthase, in: D. Barton, K. Nakanishi, O. Meth-Cohn, D.E. Cane (Eds.), Isoprenoids Including Carotenoids and Steroids, vol. 2, Elsevier, New York, 1999, pp. 245-266.
  • 6
    • 0007106565 scopus 로고    scopus 로고
    • P.A. Edwards, R. Davis, Isoprenoids, sterols and bile acids, in: D.E. Vance, J.E. Vance (Eds.), Biochemistry of Lipids, Lipoproteins, and Membranes, vol. 31, Elsevier, Amsterdam, 1996, pp. 341-362.
  • 7
    • 0019135838 scopus 로고
    • Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth
    • (1980) J. Lipid Res. , vol.21 , pp. 505-517
    • Brown, M.S.1    Goldstein, J.L.2
  • 22
    • 0032895029 scopus 로고    scopus 로고
    • HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells
    • (1999) J. Lipid Res. , vol.40 , pp. 24-38
    • Petras, S.F.1    Lindsey, S.2    Harwood H.J., Jr.3
  • 32
    • 0027717852 scopus 로고
    • Cloning, expression and characterization of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase
    • (1993) Gene , vol.136 , pp. 185-192
    • Summers, C.1    Karst, F.2    Charles, A.D.3
  • 39
    • 0027768770 scopus 로고
    • Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity
    • (1993) J. Biol. Chem. , vol.268 , pp. 26983-26989
    • Joly, A.1    Edwards, P.A.2
  • 41
    • 0032524330 scopus 로고    scopus 로고
    • Function-structure studies and identification of three enzyme domains involved in the catalytic activity in rat hepatic squalene synthase [published erratum appears in J. Biol. Chem. 273 (1998) 17296]
    • (1998) J. Biol. Chem. , vol.273 , Issue.1998 , pp. 12515-12525
    • Gu, P.1    Ishii, Y.2    Spencer, T.A.3    Shechter, I.4
  • 43
    • 0030043489 scopus 로고    scopus 로고
    • Cation-pi interactions in chemistry and biology: a new view of benzene. Phe, Tyr, and Trp
    • (1996) Science , vol.271 , pp. 163-168
    • Dougherty, D.A.1
  • 46
    • 0007054904 scopus 로고    scopus 로고
    • J. Pandit, D.E. Danley, G.K. Schulte, S.M. Mazzalupo, T.A. Pauly, C.M. Hayward, E.M. Hamanaka, J.F. Thompson, H.J. Harwood Jr., Crystal structure of human squalene synthase, a key enzyme in cholesterol biosynthesis, J. Biol. Chem. (2000) 30610-30617.
  • 54
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 60
    • 0031892148 scopus 로고    scopus 로고
    • Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y
    • (1998) J. Biol. Chem. , vol.273 , pp. 1349-1356
    • Dooley, K.A.1    Millinder, S.2    Osborne, T.F.3
  • 61
    • 0033605244 scopus 로고    scopus 로고
    • A critical role for cAMP response element-binding protein (CREB) as a co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter
    • (1999) J. Biol. Chem. , vol.274 , pp. 5285-5291
    • Dooley, K.A.1    Bennett, M.K.2    Osborne, T.F.3
  • 64
    • 0007100881 scopus 로고    scopus 로고
    • D. Rothwarf, M. Karin, The NF-κB activation pathway: a paradigm in information transfer from membrane to nucleus, Science Signal Transduction Knowledge Environment, 1999, www.stke.org/cgi/content/full/OC
  • 72
    • 0033551846 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
    • (1999) J. Biol. Chem. , vol.274 , pp. 23577-23583
    • Xu, J.1    Nakamura, M.T.2    Cho, H.P.3    Clarke, S.D.4
  • 79
    • 0032524628 scopus 로고    scopus 로고
    • Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulation
    • (1998) J. Biol. Chem. , vol.273 , pp. 12526-12535
    • Guan, G.1    Dai, P.2    Shechter, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.