Sulfobetaine zwitterionic inhibitors of squalene synthase

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 21, 1996, Pages 2585-2588

  Shechter, Ishaiahu ^a   Gu, Peide ^a   Jiang, Guojian ^a   Onofrey, Thomas J ^b   Cann, Reginald O ^b   Castro, Alfredo ^b   Spencer, Thomas A ^b  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b Lamont Doherty Earth Observatory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOLYTE; ENZYME INHIBITOR; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR; SULFOBETAINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

EID: 0030571280     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00485-4     Document Type: Article

References (10)

1. 1. Biller, S. A.; Neuenschwander, K.; Ponpipom, M. M.; Poulter, C. D. Current Pharmaceutical Design 1996, 2, 1.
2. 2. (a) Magnin, D. R.; Biller, S. A.; Dickson, J. K., Jr.; Logan, J. V.; Lawrence, R. M.; Chen, V.; Sulsky, R. B.; Ciosek, C. P., Jr.; Harrity, T. W.; Jolibois, K. G.; Kunselman, L. K.; Rich, L. C.; Slusarchyk, D. A. J. Med. Chem. 1995, 38, 2596;
3. (b) Castro, A.; Erickson, S. K.; Shechter, I.; Spencer, T. A. Bioorg. Chem. 1996 in press.
4. 3. Ernst, R.; Miller, E. J., Jr. In Amphoteric Surfactants (Surfactant Science Series); Bluestein, B. R.; Hilton, C. L. Eds.; Marcel Dekker, Inc.: New York, 1982, Vol 12, pp 71-183.
5. 4. Norman, S. M.; Poling, S. M.; Maier, V. P.; Nelson, M. D. Agr. Bio. Chem. 1985, 49, 2893.
6. 5. Shechter, I.; Klinger, E.; Rucker, M. L.; Engstrom, R. G.; Spirito, J. A.; Islam, M. A.; Boettcher, B. R.; Weinstein, D. B. J. Biol. Chem. 1992, 267, 8628.
7. 6. Biller, S. A.; Sofia, M. J.; DeLange, B.; Forster, C.; Gordon, E. M.; Harrity, T.; Rich, L. C.; Ciosek, C. P., Jr.; J. Am. Chem. Soc. 1991, 113, 8522.
8. 7. Hey, D. H.; Wilkinson, R. J. Chem. Soc. 1940, 1030.
9. 8. Lee, G. C. M.; Syage, E. T.; Harcourt, D. A.; Holmes, J. M.; Garst, M. E. J. Org. Chem. 1991, 56, 7007.
10. 9. Umbreit, M. A.; Sharpless, K. B. J. Am. Chem. Soc. 1977, 99, 5526.