Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulation

Journal of Biological Chemistry

Volumn 273, Issue 20, 1998, Pages 12526-12535

  Guan, Guimin ^a   Dai, Peihua ^a   Shechter, Ishaiahu ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SQUALENE SYNTHASE;

ARTICLE; CHOLESTEROL SYNTHESIS; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MUTAGENESIS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032524628     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.20.12526     Document Type: Article

References (30)

1. McKenzie, T. L., Jiang, G., Straubhaar, J. R., Conrad, D. G., and Shechter, I. (1992) J. Biol. Chem. 267, 21368-21374
2. Shechter, I., Klinger, E., Rucker, M. L., Engstrom, R. G., Spirito, J. A., Islam, M. A., Boettcher, B. R., and Weinstein, D. B. (1992) J. Biol. Chem. 267, 8628-8635
3. Goldstein, J. L., and Brown, M. S. (1990) Nature 343, 425-430
4. Clarke, C. F., Tanaka, R., Svenson, K., Walmsley, M., Fogelman, A. M., and Edwards, P. A. (1987) Mol. Cell. Biol. 7, 3138-3146
5. Metherall, J. E., Goldstein, J. L., Luskey, K. L., and Brown, M. S. (1989) J. Biol. Chem. 264, 15634-15641
6. Smith, J. R., Osborne, T. F., Goldstein, J. L., and Brown, M. S. (1990) J. Bid. Chem. 265, 2306-2310
7. Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., and Brown, M. S. (1993) Cell 78, 187-197
8. Ericsson, J., Jackson, S. M., Lee, B. C., and Edwards, P. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 945-950
9. Magana, M. M., and Osborne, T. F. (1996) J. Biol. Chem. 271, 32689-32694
10. Sanchez, H. B., Yieh, L., and Osborne, T. F. (1995) J. Biol. Chem. 270, 1161-1169
11. Yieh, L., Sanchez, H. B., and Osborne, T. F. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 6102-6106
12. Bennett, M. K., Lopez, J. M. Sanchez, H. B., and Osborne, T. F. (1995) J. Biol. Chem. 270, 25578-25583
13. Lopez, J. M., Bennett, M. K. Sanchez, H. B. Rosenfeld, J. M., and Osborne. T. F. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1049-1053
14. Hua, X., Yokoyama, C., Wu, C. J., Briggs, M. R., Brown, M. S., and Goldstein, J. L. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 11603-11607
15. Sato, R., Inoue, J., Kawabe, Y., Kodama, T. Takano, T., and Maeda, M. (1996) J. Biol. Chem. 271, 26461-26464
16. Hua, X., Sakai, J., Ho, Y. K., Goldstein, J. L., and Brown, M. S. (1995) J. Biol. Chem. 270, 29422-29427
17. Wang, X., Sato, R., Brown, M. S., Hua, X., and Goldstein, J. L. (1994) Cell 77, 53-62
18. Hua, X., Sakai, J., Brown, M. S., and Goldstein, J. L. (1996) J. Biol. Chem. 271, 10379-10384
19. Sakai, J., Duncan, E. A., Rawson, R. B., Hua, X., Brown, M. S., and Goldstein, J. L. (1996) Cell 85, 1037-1046
20. Yang, J., Brown, M. S., Ho, Y. K., and Goldstein, J. L. (1995) J. Biol. Chem. 270, 12152-12161
21. Sheng, Z., Otani, H., Brown, M. S., and Goldstein, J. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 935-938
22. Sudhof, T. C., Van der Westhuyzen, D. R., Goldstein, J. L., Brown, M. S., and Russell, D. W. (1987) J. Biol. Chem. 262, 10773-10779
23. Kawabe, Y., Sato, R., Matsumoto, A., Honda, M., Wada, Y., Yazaki, Y., Endo, A., Takano, T., Itakura, H., and Kodama, T. (1996) Biochem. Biophys. Res. Commun. 219, 515-520
24. Jackson, S. M., Ericsson, J., Osborne, T. F., and Edwards, P. A. (1995) J. Biol. Chem. 270, 21445-21448
25. Guan, G., Dai, P.-H., Osborne, T. F., Kim, J. B., and Shechter, I. (1997) J. Biol. Chem. 272, 10295-10302
26. Ericsson, J., Jackson, S. M., and Edwards, P. A. (1996) J. Biol. Chem. 271, 24359-24364
27. Smith, J. R., Osborne, T. F., Brown, M. S., Goldstein, J. L., and Gil, G. (1988) J. Biol. Chem. 263, 18480-18487
28. Jiang, G., McKenzie, T. L., Conrad, D. G., and Shechter, I. (1993) J. Biol. Chem. 268, 12818-12824
29. Guan, G., Jiang, G., Koch, R. L., and Shechter, I (1995) J. Biol. Chem. 270, 21958-21965
30. Tontonoz, P., Kim, J. B., Graves, R. A., and Spiegelman, B. M. (1993) Mol. Cell. Biol 13, 4753-4759