Endotoxin, tumor necrosis factor, and interleukin-1 decrease hepatic squalene synthase activity, protein, and mRNA levels in Syrian hamsters

Journal of Lipid Research

Volumn 38, Issue 8, 1997, Pages 1620-1629

  Memon, Riaz A ^a   Shechter, Ishaiahu ^b   Moser, Arthur H ^a   Shigenaga, Judy K ^a   Grunfeld, Carl ^a   Feingold, Kenneth R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Acute phase response; Cholesterol feeding; Cholesterol metabolism; Colestipol feeding; Cytokines; HMG CoA reductase

Indexed keywords

ENDOTOXIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INTERLEUKIN 1; MESSENGER RNA; MEVALONIC ACID; SQUALENE SYNTHASE; TUMOR NECROSIS FACTOR;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DIETARY INTAKE; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME SUBSTRATE; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECEPTOR UPREGULATION;

ANIMALS; ANTILIPEMIC AGENTS; CHOLESTEROL, DIETARY; COLESTIPOL; CRICETINAE; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; LIVER; MALE; MESOCRICETUS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030823967     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Kaufmann, R. L., C. F. Matson, and W. R. Beisel. 1976. Hypertriglyceridemia produced by endotoxin: role of impaired triglyceride disposal mechanisms. J. Infect. Dis. 133: 548-555.
2. Bagby, G. J., C. B. Corll, and R. R. Martinez. 1987. Triacylglycerol kinetics in endotoxic rats with suppressed lipoprotein lipase activity. Am. J. Physiol. 253: E59-E64.
3. Sammalkorpi, K., V. Valtonen, Y. Kerttula, E. Nikkila, and M. R. Taskinen. 1988. Changes in serum lipoprotein pattern induced by acute infections. Metabolism. 37: 859-865.
4. Lanza-Jacoby, S., and A. Tabares. 1990. Triglyceride kinetics, tissue lipoprotein lipase, and liver lipogenesis in septic rats. Am. J. Physiol. 258: E678-685.
5. Lanza-Jacoby, S., S. H. Wong, A. Tabares, D. Baer, and T. Schneider. 1992. Disturbances in the composition of plasma lipoproteins during gram negative sepsis in the rat. Biochim. Biophys. Acta. 1124: 233-240.
6. Feingold, K. R., I. Staprans, R. A. Memon, A. H. Moser, J. K. Shigenaga, W. Doerrler, C. A. Dinarello, and C. Grunfeld. 1992. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J. Lipid Res. 33: 1765-1776.
7. Memon, R. A., K. R. Feingold, A. H. Moser, W. Doerrler, S. Adi, C. A. Dinarello, and C. Grunfeld. 1992. Differential effects of interleukin-1 and tumor necrosis factor on ketogenesis. Am. J. Physiol. 263: E301-E309.
8. Memon, R. A., C. Grunfeld, A. H. Moser, and K. R. Feingold. 1993. Tumor necrosis factor mediates the effects of endotoxin on cholesterol and triglyceride metabolism in mice. Endocrinology. 132: 2246-2253.
9. Vasconcelos, P. R. L., M. G. W. Kettlewell, G. F. Gibbons, and D. H. Williamson. 1989. Increased rates of hepatic cholesterogenesis and fatty acid synthesis in septic rats in vivo: evidence for the possible involvement of insulin. Clin. Sci. 76: 205-211.
10. Feingold, K. R., I. Hardardottir, R. A. Memon, E. J. T. Krul, A. H. Moser, J. M. Taylor, and C. Grunfeld. 1993. Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters. J Lipid Res. 34: 2147-2158.
11. Hardardottir, I., S. T. Kunitake, A. H. Moser, W. Doerrler, J. H. Rapp, C. Grunfeld, and K. R. Feingold. 1994. Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (Clusterin) in Syrian hamsters. J. Gin. Invest. 94: 1304-1309.
12. Feingold, K. R., A. S. Pollock, A. H. Moser, J. K. Shigenaga, and C. Grunfeld. 1995. Discordant regulation of protein of cholesterol metabolism during the acute phase response. J. Lipid Res. 36: 1474-1482.
13. Feingold, K. R., D. K. Spady, A. S. Pollock, A. H. Moser, and C. Grunfeld. 1996. Endotoxin, TNF, and IL-1 decrease cholesterol 7-α hydroxylase mRNA levels and activity. J. Lipid Res. 37: 223-228.
14. Goldstein, J. L., and M. S. Brown. 1990. Regulation of mevalonate pathway. Nature. 343: 425-430.
15. Grunler, J., J. Ericsson, and G. Dallner. 1994. Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. Biochim. Biophys. Acta. 1212: 259-277.
16. Schechter, I., E. Klinger, M. L. Rucker, R. G. Engstrom, J. A. Spirito, M. A. Islam, B. R. Boettcher, and D. B. Weinstein. 1992. Solubilization, purification and characterization of a truncated form of rat hepatic squalene synthetase. J. Biol. Chem. 267: 8628-8635.
17. McKenzie, T. L., G. Jiang, J. R. Straubhaar, D. Conrad, and I. Shechter. 1992. Molecular cloning, expression and characterization of the cDNA for the rat hepatic squalene synthase. J. Biol. Chem. 267: 21368-21374.
18. Hardardottir, I., A. H. Moser, R. A. Memon, C. Grunfeld, and K. R. Feingold. 1994. Effects of TNF, IL-1, and the combination of both cytokines on cholesterol metabolism in Syrian hamsters. Lymphokine Cytokine Res. 13: 161-166.
19. Morrow, J. F., R. S. Steraman, C. G. Peltzman, and D. A. Potter. 1981. Induction of hepatic synthesis of serum amyloid A and actin. Proc. Natl. Acad. Sci. USA. 78: 4718-4722.
20. Cohen, L. H., A. M. Griffioen, R. J. A. Wanders, C. W. T. Van Roermund, C. M. G. Huysmans, and H. M. G. Princen. 1986. Regulation of squalene synthetase activity in rat liver: elevation by cholestyramine, but no diurnal variation. Biochem. Biophys. Res. Commun. 138: 335-341.
21. Keller, R. K., A. Cannons, F. Vilsaint, Z. Zhao, and G. C. Ness. 1993. Identification and regulation of rat squalene synthetase mRNA. Arch. Biochem. Biophys. 302: 304-306.
22. Stamellos, K. D., J. E. Shackelford, I. Shechter, G. Jiang, D. Conrad, G. Andre Keller, and S. K. Krisans. 1993. Subcellular localization of squalene synthase in rat hepatic cells: biochemical and immunochemical evidence. J. Biol. Chem. 268: 12825-12836.
23. Brown, M. S., and J. L. Goldstein. 1980. Multivalent feedback regulation of HMG-CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J. Lipid Res. 21: 505-517.
24. Rudling, M. 1992. Hepatic mRNA levels for the LDL receptor and HMG-CoA reductase show coordinate regulation in vivo. J. Lipid Res. 33: 493-501.
25. Roser, D. S., M. N. Ashby, J. L. Ellis, and P. A. Edwards. 1989. Coordinate regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and prenyltransferase synthesis but not degradation in HepG2 cells. J. Biol. Chem. 264: 12653-12656.
26. Ashby, M. N., and P. A. Edwards. 1989. Identification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthase. J. Biol. Chem. 264: 635-640.
27. Clarke, C. F., A. M. Fogelman, and P. A. Edwards. 1984. Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Biol. Chem. 259: 10439-10447.
28. Clarke, C. F., A. M. Fogelman, and P. A. Edwards. 1985. Transcriptional regulation of the 3-hydroxy-3methylglutaryl coenzyme A reductase gene in rat liver. J Biol. Chem. 260: 10363-10367.
29. Keller, R. K. 1986. The mechanism and regulation of dolichyl phosphate biosynthesis in rat liver. J. Biol. Chem. 261: 12053-12059.
30. Elmberger, P. G., A. Kalen, E. L. Appelkvist, and G. Dallner. 1987. In vitro and in vivo synthesis of dolichol and other main mevalonate products in various organs of the rat. Eur. J. Biochem. 168: 1-11.
31. Keller, R. K., and F. Vilsaint. 1993. Regulation of isoprenoid metabolism in rat liver: near constant chain lengths of dolichyl phosphate and ubiquinone are maintained during greatly altered rates of cholesterogenesis. Biochim. Biophys. Acta. 1170: 204-210.
32. Carrol, K. K., N. Guthrie, and K. Ravi. 1992. Dolichol: function, metabolism and accumulation in human tissues. Biochem. Cell. Biol. 70: 382-384.
33. Richards, C., J. Gauldie, and H. Baumann. 1991. Cytokine control of acute phase protein expression. Eur. Cytokine Netw. 2: 89-98.
34. Baumann, H., and J. Gauldie. 1994. The acute phase response. Immunol. Today. 15: 74-80.
35. Coolbear, T., and S. Mookerjea. 1981. Effects of turpentine-induced inflammation on the synthesis of dolichol-linked intermediates of N-glycosylation and the phosphorylation of dolichol by CTP-dependent dolichol kinase. J. Biol. Chem. 256: 4529-4535.
36. Vestal, D. J., R. A. Maki, and J. E. Buss. 1995. Induction of a prenylated 65-kD protein in macrophages by interferon or lipopolysaccharide. J. Leukocyte Biol. 58: 607-615.
37. Vestal, D. J., J. E. Buss, G. S. Kelner, D. Maciejewski, V. K. Asundi, and R. A. Maki. 1996. Rat p67 GBP is induced by interferon gamma and isoprenoid modified in macrophages. Biochem. Biophys. Res. Commun. 224: 528-534.