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Volumn 1436, Issue 3, 1999, Pages 307-318

The physiological role of sterol regulatory element-binding protein-2 in cultured human cells

Author keywords

Cholesterol; Fatty acid; Sterol regulatory element binding protein

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; SQUALENE SYNTHASE; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN;

EID: 0033521699     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2760(98)00119-2     Document Type: Article
Times cited : (18)

References (31)
  • 1
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Nature. 343:1990;425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 2
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown M.S., Goldstein J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89:1997;331-340.
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 3
    • 0027490174 scopus 로고
    • SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
    • Yokoyama C., Wang X., Briggs M.R., Admon A., Wu J., Hua X., Goldstein J.L., Brown M.S. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell. 75:1993;187-197.
    • (1993) Cell , vol.75 , pp. 187-197
    • Yokoyama, C.1    Wang, X.2    Briggs, M.R.3    Admon, A.4    Wu, J.5    Hua, X.6    Goldstein, J.L.7    Brown, M.S.8
  • 4
    • 0027139362 scopus 로고
    • SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
    • Hua X., Yokoyama C., Wu J., Briggs M.R., Brown M.S., Goldstein J.L., Wang X. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. U.S.A. 90:1993;11603-11607.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 11603-11607
    • Hua, X.1    Yokoyama, C.2    Wu, J.3    Briggs, M.R.4    Brown, M.S.5    Goldstein, J.L.6    Wang, X.7
  • 5
    • 0027648820 scopus 로고
    • ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
    • Tontonoz P., Kim J.B., Graves R.A., Spiegelman B.M. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell Biol. 13:1993;4753-4759.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 4753-4759
    • Tontonoz, P.1    Kim, J.B.2    Graves, R.A.3    Spiegelman, B.M.4
  • 6
    • 0028225462 scopus 로고
    • SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
    • Wang X., Sato R., Brown M.S., Hua X., Goldstein J.L. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 77:1994;53-62.
    • (1994) Cell , vol.77 , pp. 53-62
    • Wang, X.1    Sato, R.2    Brown, M.S.3    Hua, X.4    Goldstein, J.L.5
  • 7
    • 0028820299 scopus 로고
    • Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection
    • Hua X., Sakai J., Ho Y.K., Goldstein J.L., Brown M.S. Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. J. Biol. Chem. 270:1995;29422-29427.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29422-29427
    • Hua, X.1    Sakai, J.2    Ho, Y.K.3    Goldstein, J.L.4    Brown, M.S.5
  • 8
    • 0030604717 scopus 로고    scopus 로고
    • Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
    • Sakai J., Duncan E.A., Rawson R.B., Hua X., Brown M.S., Goldstein J.L. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell. 85:1996;1037-1046.
    • (1996) Cell , vol.85 , pp. 1037-1046
    • Sakai, J.1    Duncan, E.A.2    Rawson, R.B.3    Hua, X.4    Brown, M.S.5    Goldstein, J.L.6
  • 9
    • 0011176887 scopus 로고    scopus 로고
    • A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
    • Vallett S.M., Sanchez H.B., Rosenfeld J.M., Osborne T.F. A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. J. Biol. Chem. 271:1996;12247-12253.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12247-12253
    • Vallett, S.M.1    Sanchez, H.B.2    Rosenfeld, J.M.3    Osborne, T.F.4
  • 10
    • 0030070645 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene
    • Ericsson J., Jackson S.M., Lee B.C., Edwards P.A. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. Proc. Natl. Acad. Sci. U.S.A. 93:1996;945-950.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 945-950
    • Ericsson, J.1    Jackson, S.M.2    Lee, B.C.3    Edwards, P.A.4
  • 11
    • 0030892083 scopus 로고    scopus 로고
    • Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene
    • Guan G., Dai P.H., Osborne T.F., Kim J.B., Shechter I. Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene. J. Biol. Chem. 272:1997;10295-10302.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10295-10302
    • Guan, G.1    Dai, P.H.2    Osborne, T.F.3    Kim, J.B.4    Shechter, I.5
  • 12
  • 13
    • 0028875426 scopus 로고
    • Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways
    • Bennett M.K., Lopez J.M., Sanchez H.B., Osborne T.F. Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways. J. Biol. Chem. 270:1995;25578-25583.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25578-25583
    • Bennett, M.K.1    Lopez, J.M.2    Sanchez, H.B.3    Osborne, T.F.4
  • 14
    • 0030904931 scopus 로고    scopus 로고
    • Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- And sterol regulatory element-binding protein-responsive gene
    • Ericsson J., Jackson S.M., Kim J.B., Spiegelman B.M., Edwards P.A. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene. J. Biol. Chem. 272:1997;7298-7305.
    • (1997) J. Biol. Chem. , vol.272 , pp. 7298-7305
    • Ericsson, J.1    Jackson, S.M.2    Kim, J.B.3    Spiegelman, B.M.4    Edwards, P.A.5
  • 15
    • 0029958652 scopus 로고    scopus 로고
    • Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2
    • Sato R., Inoue J., Kawabe Y., Kodama T., Takano T., Maeda M. Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2. J. Biol. Chem. 271:1996;26461-26464.
    • (1996) J. Biol. Chem. , vol.271 , pp. 26461-26464
    • Sato, R.1    Inoue, J.2    Kawabe, Y.3    Kodama, T.4    Takano, T.5    Maeda, M.6
  • 16
    • 0028960739 scopus 로고
    • Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13
    • Hua X., Wu J., Goldstein J.L., Brown M.S., Hobbs H.H. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. Genomics. 25:1995;667-673.
    • (1995) Genomics , vol.25 , pp. 667-673
    • Hua, X.1    Wu, J.2    Goldstein, J.L.3    Brown, M.S.4    Hobbs, H.H.5
  • 17
    • 0031568872 scopus 로고    scopus 로고
    • Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)
    • Miserez A.R., Cao G., Probst L.C., Hobbs H.H. Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2). Genomics. 40:1997;31-40.
    • (1997) Genomics , vol.40 , pp. 31-40
    • Miserez, A.R.1    Cao, G.2    Probst, L.C.3    Hobbs, H.H.4
  • 19
    • 0028839010 scopus 로고
    • Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver
    • Sheng Z., Otani H., Brown M.S., Goldstein J.L. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. U.S.A. 92:1995;935-938.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 935-938
    • Sheng, Z.1    Otani, H.2    Brown, M.S.3    Goldstein, J.L.4
  • 20
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • Shimomura I., Shimano H., Horton J.D., Goldstein J.L., Brown M.S. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 99:1997;838-845.
    • (1997) J. Clin. Invest. , vol.99 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 22
    • 0030907175 scopus 로고    scopus 로고
    • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
    • Shimano H., Horton J.D., Shimomura I., Hammer R.E., Brown M.S., Goldstein J.L. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Invest. 99:1997;846-854.
    • (1997) J. Clin. Invest. , vol.99 , pp. 846-854
    • Shimano, H.1    Horton, J.D.2    Shimomura, I.3    Hammer, R.E.4    Brown, M.S.5    Goldstein, J.L.6
  • 23
    • 0029797604 scopus 로고    scopus 로고
    • Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    • Shimano H., Horton J.D., Hammer R.E., Shimomura I., Brown M.S., Goldstein J.L. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J. Clin. Invest. 98:1996;1575-1584.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1575-1584
    • Shimano, H.1    Horton, J.D.2    Hammer, R.E.3    Shimomura, I.4    Brown, M.S.5    Goldstein, J.L.6
  • 24
    • 0030829812 scopus 로고    scopus 로고
    • Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
    • Shimano H., Shimomura I., Hammer R.E., Herz J., Goldstein J.L., Brown M.S., Horton J.D. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J. Clin. Invest. 100:1997;2115-2124.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2115-2124
    • Shimano, H.1    Shimomura, I.2    Hammer, R.E.3    Herz, J.4    Goldstein, J.L.5    Brown, M.S.6    Horton, J.D.7
  • 27
    • 0017894322 scopus 로고
    • Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase
    • Brown M.S., Faust J.R., Goldstein J.L. Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase. J. Biol. Chem. 253:1978;1121-1128.
    • (1978) J. Biol. Chem. , vol.253 , pp. 1121-1128
    • Brown, M.S.1    Faust, J.R.2    Goldstein, J.L.3
  • 28
    • 0028799622 scopus 로고
    • Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene
    • Sanchez H.B., Yieh L., Osborne T.F. Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene. J. Biol. Chem. 270:1995;1161-1169.
    • (1995) J. Biol. Chem. , vol.270 , pp. 1161-1169
    • Sanchez, H.B.1    Yieh, L.2    Osborne, T.F.3
  • 29
    • 0029744890 scopus 로고    scopus 로고
    • Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene
    • Ericsson J., Jackson S.M., Edwards P.A. Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene. J. Biol. Chem. 271:1996;24359-24364.
    • (1996) J. Biol. Chem. , vol.271 , pp. 24359-24364
    • Ericsson, J.1    Jackson, S.M.2    Edwards, P.A.3
  • 30
    • 10544235694 scopus 로고    scopus 로고
    • SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein
    • Oliner J.D., Andresen J.M., Hansen S.K., Zhou S., Tjian R. SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes. Dev. 10:1996;2903-2911.
    • (1996) Genes. Dev. , vol.10 , pp. 2903-2911
    • Oliner, J.D.1    Andresen, J.M.2    Hansen, S.K.3    Zhou, S.4    Tjian, R.5
  • 31
    • 0030745393 scopus 로고    scopus 로고
    • Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: A critical role for the Btd domain of Sp1
    • Athanikar J.N., Sanchez H.B., Osborne T.F. Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1. Mol. Cell Biol. 17:1997;5193-5200.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 5193-5200
    • Athanikar, J.N.1    Sanchez, H.B.2    Osborne, T.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.