G(i)-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc

EMBO Journal

Volumn 16, Issue 11, 1997, Pages 3097-3105

  Kranenburg, Onno ^a   Verlaan, Ingrid ^a   Hordijk, Peter L ^a   Moolenaar, Wouter H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

G protein coupled receptors; Grb2; MAP kinase; Shc; Src

Indexed keywords

CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; PHOSPHOTYROSINE; RAS PROTEIN; ANDROSTANE DERIVATIVE; CALCIUM; CARRIER PROTEIN; GRB2 PROTEIN, RAT; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOPROTEIN; PROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TYROSINE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; NONHUMAN; ONCOGENE RAS; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RAT; SEQUENCE HOMOLOGY; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CELL STRAIN COS1; DRUG ANTAGONISM; ENZYME ACTIVATION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANDROSTADIENES; ANIMALS; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CARRIER PROTEINS; COS CELLS; ENZYME ACTIVATION; GRB2 ADAPTOR PROTEIN; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; MODELS, BIOLOGICAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RAS PROTEINS; RATS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TYROSINE;

EID: 0030924612     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.11.3097     Document Type: Article

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