Legionella pneumophila pathogenesis: A fateful journey from amoebae to macrophages

Annual Review of Microbiology

Volumn 54, Issue , 2000, Pages 567-613

  Swanson, M S ^a   Hammer, B K ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Intracellular pathogen; Opportunistic; Phagosome lysosome fusion; Stringent response; Virulence regulation

Indexed keywords

AMINO ACID; BACTERIAL TOXIN; FRESH WATER; GUANOSINE 3' DIPHOSPHATE 5' DIPHOSPHATE;

AMOEBA; BACTERIAL GROWTH; BACTERIAL VIRULENCE; COXIELLA; GENE REPLICATION; LEGIONELLA PNEUMOPHILA; LEISHMANIA; LYSOSOME; MACROPHAGE; MEMBRANE FUSION; MYCOBACTERIUM; NONHUMAN; OPPORTUNISTIC INFECTION; PARASITE TRANSMISSION; PNEUMONIA; PRIORITY JOURNAL; REVIEW; TOXOPLASMA; ANIMAL; CELL VACUOLE; DISEASE CARRIER; DISEASE TRANSMISSION; LEGIONNAIRE DISEASE; LUNG ALVEOLUS MACROPHAGE; MICROBIOLOGY; PATHOGENICITY;

AMOEBA; ANIMALS; DISEASE RESERVOIRS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; MACROPHAGES, ALVEOLAR; VACUOLES;

EID: 0034566380     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.micro.54.1.567     Document Type: Review

References (252)

1. The phagosome containing Legionella pneumophila within the protozoan Hartmonella vermiformis is surrounded by the rough endoplasmic reticulum
2. Phenotypic modulation by L. pneumophila upon infection of macrophages
3. Transcriptional regulation of the macrophage-induced gene (gspA) of Legionella pneumophila and phenotypic characterization of a null mutant
4. The use of differential display-PCR to isolate and characterize a Legionella pneumophila locus induced during the intracellular infection of macrophages
5. Lysosomal response of a murine macrophage-like cell line persistantly infected with Coxiella burnetii
6. Identification of a novel periplasmic catalase-peroxidase KatA of Legionella pneumophila
7. Ultrastructural morphometric analysis of Brucella abortus-infected trophoblasts in experimental placentitis
8. Identification of linked Legionella pneumophila genes essential for growth and evasion of the endocytic pathway
9. Response of cultured macrophages to M. tuberculosis with observations on fusion of lysosomes with phagosomes
10. Coordinated expression of stationary phase and virulence traits: The role of RpoS in Legionella
11. Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli
12. Cytolytic and phospholipase C activity in Legionella species
13. A phospholipase C from the Dallas 1E strain of Legionella pneumophila serogroup 5; purification of conditions for optimal activity with an artificial substrate
14. Legionella pneumophila catalase-peroxidases: Cloning of the katB gene and studies of KatB function
15. Isolation of protozoa from water associated with a legionellosis outbreak and demonstration of intracellular multiplication of Legionella pneumophila
16. Relationship between Legionella pneumophila and Acanthamoeba polyphaga: Physiological status and susceptibility to chemical inactivation
17. Influence of intra-amoebic and other growth conditions on the surface properties of Legionella pneumophila
18. Intraphagocytic growth induces an antibiotic-resistant phenotype of Legionella pneumophila
19. Monoclonal antibodies demonstrate that superoxide dismutase contributes to protection of Nocardia asteroides within the intact host
20. Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes
21. Classification of the genus Legionella
22. Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila
23. Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene
24. Interferon-γ-activated human monocytes inhibit the intracellular multiplication of Legionella pneumophila
25. Inhibition of VirB-mediated transfer of diverse substrates from Agrobacterium tumerfaciens by the IncQ plasmid RSF1010
26. Interaction of Legionella pneumophila with Acanthamoeba castellanii: Uptake by coiling phagocytosis and inhibition of phagosomelysosome fusion
27. The Legionella pneumophila icm locust a set of genes required for intracellular multiplication in human macrophages
28. Association of shower use with Legionnaires' disease
29. Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice
30. Coinoculation with Hartmannella vermiformis enhances replicative Legionella pneumophila lung infection in a murine model of Legionnaires' disease
31. The role of Legionella pneumophila-infected Hartmannella vermiformis as an infectious particle in a routine model of Legionnaires' disease
32. In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxide
33. Unexplored reservoirs of pathogenic bacteria: Protozoa and biofilms
34. Induction of Salmonella stress proteins upon infection of macrophages
35. Interferon gamma-activated human monocytes down-regulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron
36. Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes
37. Expression of Legionella pneumophila virulence traits in response to growth conditions
38. Risk factors for nosocomial Legionella pneumophila pneumonia
39. Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
40. The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation
41. Leishmania donovani promastigote-macrophage surface interactions in vitro
42. Agrobacterium tumefaciens T-complex transport apparatus: A paradigm for a new family of multifunctional transporters in eubacteria
43. A mutation in the mip gene results in an attenuation of Legionella pneumophila virulence
44. Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages
45. A Legionella pneumophila gene encoding a species-specific surface protein potentiates the initiation of intracellular infection
46. Intracellular growth in Acanthamoeba castellanii affects monocyte entry mechanisms and enhances virulence of Legionella pneumophila
47. Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion
48. Interaction of Mycobacterium avium with environmental amoebae enhances virulence
49. Membrane sorting during phagocytosis: Selective exclusion of major histocompatibility complex molecules but not complement receptor CR3 during conventional and coiling phagocytosis
50. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited
51. Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth
52. Separation of Legionella pneumophila proteases and purification of a protease which produces lesions like those of Legionnaires' disease in guinea pig lung
53. Bacterial biofilms: A common cause of persistent infections
54. Evidence that vesicles containing living, virulent Mycobacterium tuberculosis or Mycobacterium avium in cultured human macrophages are not acidic
55. Inhibition of phagolysomal biogenesis by the Leishmania lipophosphoglycan
56. Penetration and intracellular growth of Brucella abortus in nonphagocytic cells in vitro
57. A flaA negative mutant strain of Legionella pneumophila shows reduced efficiency of invasion and cytotoxicity
58. Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13
59. The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila
60. Genetic regulation of bacterial virulence
61. An outbreak of Legionnaires' disease associated with a contaminated air-conditioning cooling tower
62. Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death: Involvement of serine but not cysteine proteases
63. Purification and characterization of an extracellular protease of Legionella pneumophila
64. Localization of Helicobacter pylori urease and heat shock protein in human gastric biopsies
65. Autophagy and related mechanisms of lysosome-mediated protein degradation
66. Effects of concanavalin A on mouse peritoneal macrophages. II. Metabolism of endocytized proteins and reversibility of the effects by mannose
67. Influence of growth temperature on virulence of Legionella pneumophila
68. Discovery of virulence genes of Legionella pneumophila by using signature tagged mutagenesis in a guinea pig pneumonia model
69. Proteins as molecular chaperones
70. DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity
71. A 66-kilodalton heat shock protein of Salmonella typhimurium is responsible for binding of the bacterium to intestinal mucus
72. The alternative sigma factor KatF (RpoS) regulates Salmonella virulence
73. Bacterial copper- and zinc-cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosis
74. Rab7: An important regulator of late endocytic membrane traffic
75. The molecular ecology of legionellae
76. Comparison of guinea pig and protozoan models for determining virulence of Legionella species
77. Intracellular multiplication of Legionella pneumophila in amoebae isolated from hospital hot water tanks
78. Mip protein of Legionella pneumophila exhibits peptidylprolyl-cis/trans isomerase (PPIase) activity
79. Low pH adaptation and the acid tolerance response of Salmonella typhimurium
80. Contribution of superoxide dismutase and catalase activities to Shigella flexneri pathogenesis
81. Legionnaires' disease: Description of an epidemic of pneumonia
82. Immunologic response and pathophysiology of Legionella infection
83. The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes
84. Interaction of L Cells and Chlamydia psittaci: Entry of the parasite and host responses to its development
85. GroEL heat shock protein of Haemophilus ducreyi: Association with cell surface and capacity to bind to eukaryotic cells
86. Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity
87. Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa
88. Different fates of Legionella pneumophila pmi and mil mutants within macrophages and alveolar epithelial cells
89. Heterogeneity in intracellular replication and cytopathogenicity of Legionella pneumophila and Legionella micdadei in mammalian and protozoan cells
90. Inhibition of human caspases by peptide-based and macromolecular inhibitors
91. Immunolocalization of Hsp60 in Legionella pneumophila
92. Surface-associated Hsp60 chaperonin of Legionella pneumophila mediates invasion in a HeLa cell model
93. Synthesis of the stationary-phase sigma factor σ(s) is positively regulated by ppGpp
94. Adherence of Legionella pneumophila to U937 cells, guinea pig alveolar macrophages, and MRC-5 cells by a novel, complement-independent binding mechanism
95. Ultrastructure of lung in Legionnaires' disease
96. Pontiac fever. An epidemic of unknown etiology in a health department. I. Clinical and epidemiologic aspects
97. Ammonia inhibits phagosome-lysosome fusion in macrophages
98. Prevention of phagosome-lysosome fusion in cultured macrophages by sulfatides of Mycobactyerium tuberculosis
99. Protein tyrosine phosphatase activity of essential virulence determinants in Yersinia
100. Growth-phase regulation of plasmid virulence genes in Salmonella
101. Legionella pneumophila kills human phagocytes but not protozoan host cells by inducing apoptotic death
102. Legionella pneumophila contains a type II general secretion pathway required for growth in amoebae as well as for secretion of the Msp protease
103. The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii
104. Nosocomial Legionnaires' disease: A continuing common-source epidemic at the Wadsworth Medical Center
105. Coordination of Legionella pneumophila virulence with entry into stationary phase by ppGpp
106. Heterogeneity in the attachment and uptake mechanisms of the Legionnaires' disease bacterium, Legionella pneumophila, by protozoan hosts
107. The guanosine nucleotide (p)ppGpp initiates development and A-factor production in Myxococcus xanthus
108. Developmental biology of Coxiella burnetii
109. Differential interaction with the endocytic and exocytic pathways distinguish parasitophorus vacuoles of Coxiella burnetti and Chlamydia trachomatis
110. Cloning and genetic characterization of the flagellum subunit gene (flaA) of Legionella pneumophila serogroup 1
111. The expression of the flagellum of Legionella pneumophila is modulated by different environmental factors
112. Cloning and sequencing of the Legionella pneumophila fur gene
113. An iron- and fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetases
114. Cloning and temperature-dependent expression in Escherichia coli of a Legionella pneumophila gene coding a genus-common 60-kilodalton antigen
115. Legionella pneumophila htpAB heat shock operon: Nucleotide sequence and expression of the 60-kilodalton antigen in L. pneumophila-infected HeLa cells
116. Cloning and nucleotide sequence of a gene (ompS) encoding the major outer membrane protein of Legionella pneumophila
117. Cell-mediated immunity in Legionnaires' disease
118. Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes
119. The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome lysosome fusion in human monocytes
120. Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: Engulfment within a pseudopod coil
121. Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes
122. Legionella pneumophila inhibits acidification of its phagosome in human monocytes
123. Interaction of the Legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes but does not inhibit intracellular replication
124. The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts
125. Cytotoxicity of extracellular Legionella pneumophila
126. Outbreak of Legionnaires' disease among cruise ship passengers exposed to a contaminated whirlpool spa
127. Nucleotide sequence and transcriptional initiation site of two Pseudomonas aeruginosa pilin genes
128. The interaction between Toxoplasma gondii and mammalian cells
129. Comparative analysis of Legionella pneumophila and Legionella micdadei virulence traits
130. Electron microscopic examination of the inflammatory response to Legionella pnemophila in guinea pigs
131. Pontiac fever: Isolation of the etiologic agent (Legionella pneumophila) and demonstration of its mode of transmission
132. Characterization of a Legionella pneumophila extracellular protease exhibiting hemolytic and cytotoxic activities
133. Effects of cytochalasin D and methylamine on intracellular growth of Legionella pmeumophila in amoebae and human monocyte-like cells
134. Sustained transmission of nosocomial Legionnaires' disease: Arizona and Ohio
135. Legionnaires' disease: The pore macrophage and the legion of terror within
136. Evidence of pore-forming ability by Legionella pneumophila
137. The structure of the O-specific chain of Legionella pneumophila serogroup 1 lipopolysaccharide
138. Expression and use of the green fluorescent protein as a reporter system in Legionella pneumophila
139. Role of the 25 kDa major outer membrane protein of Legionella pneumophila in attachment to U-937 cells and its potential as a virulence factor for chick embryos
140. Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila
141. Identification and temperature regulation of Legionella pneumophila genes involved in type IV pilus biogenesis and type II protein secretion
142. The prepilin peptidase is required for protein secretion by and the virulence of the intracellular pathogen Legionella pneumophila
143. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
144. Defective triggering of polymorphonuclear leukocyte oxidative metabolism by Legionella pneumophila toxin
145. Chlamydia trachomatis Mip-like protein has peptidyl-prolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection
146. Phase-variable expression of lipopolysaccharide contributes to the virulence of Legionella pneumophila
147. The broad-range phospholipase C and a metalloprotease mediate listeriolysin O-independent escape of Listeria monocytogenes from the primary vacuole in human epithelial cells
148. Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages
149. Surveillance for Legionnaires' disease
150. Growth temperature reversibly modulates the virulence of Legionella pneumophila
151. Phagolysosomes of Coxiella burnetii-infected cell lines maintain an acidic pH during persistent infection
152. Environmental signals controlling expression of virulence determinants in bacteria
153. Analysis of the Legionella pneumophila fliI gene: Intracellular growth of a defined mutant defective for flagellum biosynthesis
154. Pilus genes of Neisseria gonorrheae: Chromosomal orgarnization and DNA sequence
155. Coordinate regulation and sensory transduction in the control of bacterial virulence
156. Effects of an isogenic Zn-metalloprotease-deficient mutant of L. pneumophila in a guinea-pig model
157. Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanism of entry
158. Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection
159. Community-acquired Legionnaires' disease
160. Mode of transmission of Legionella pneumophila
161. RpoS (sigma-S) controls expression of rsmA, a global regulator of secondary metabolites, harpin, and extracellular proteins in Erwinia carotovora
162. Evidence for apoptosis of human macrophage-like HL60 cells by Legionella pneumophila infection
163. The intracellular multiplication of Legionella pneumophila in protozoa from hospital plumbing systems
164. Interaction between the Legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages
165. A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion system is essential for intracellular survival of Brucella suis
166. Temperature-dependent expression of flagella in Legionella
167. Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptor
168. Surface localization of Helicobacter pylori urease and a heat shock protein homolog requires bacterial autolysis
169. Legionella pneumophila mutants that are defective for iron acquisition and assimiliation and intracellular infection
170. Summary of Notifiable Disease, United States
171. Association of flagellum expression and intracellular growth of Legionella pneumophila
172. The Legionella pneumophila icmGCDJBF genes are required for killing of human macrophages
173. Analysis of a cloned sequence of Legionella pneumophila encoding a 38 kD metalloprotease possessing haemolytic and cytotoxic activites
174. Identification of Legionella pneumophila promoters regulated by the macrophage intracellular environment
175. Identification of a 68 kd surface antigen of Mycobacterium avium that binds to human macrophages
176. Interspecies sequence differences in the Mip protein from the genus Legionella: Implications for function and evolutionary relatedness
177. Production of mouse monoclonal antibodies which inhibit in vitro adherence of Entamoeba histolytica trophozoites
178. Engulfment of the Philadelphia strain of Legionella pneumophila within the pseudopod coils in human phagocytes: Comparison with other Legionella stains and species
179. Effect of Legionella pneumophila cytotoxic protease on human neutrophil and monocyte function
180. Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage
181. Coiling phagocytosis: When the zipper jams, the cup is deformed
182. Coiling phagocytosis of Trypanosomatids and fungal cells
183. Opsonin-independent adherence and intracellular development of Legionella pneumophila within U-937 cells
184. Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae
185. Current views on the relationships between amoebae, Legionellae and man
186. Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake
187. Topology of Legionella pneumophila DotA: An inner membrane protein required for replication in macrophages
188. Macromolecular assembly and secretion across the bacterial cell envelope: Type II protein secretion systems
189. Identification of Legionella pneumophila genes required for growth within and killing of human macrophages
190. The iron superoxide dismutase of Legionella pneumophila is essential for viability
191. Inhibition of polymorphonuclear leukocyte function by Legionella pneumophila exoproducts
192. Parasitophorous vacuoles of Leishmania mexicano acquire macromolecules from the host cell cytosol via two independent routes
193. Vesicles containing Chlamydia trachomatis serovar L2 remain above pH 6 within HEC-1B cells
194. Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome
195. Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila
196. Characterization of a new region required for macrophage killing by Legionella pneumophila
197. Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components of IncQ plamid RSF1010
198. Legionella pneumophila utilize the same genes to multiply within Acanthamoeba castellanii and human macrophages
199. Possible origin of the Legionella pneumophila virulence genes and their relation to Coxiella burnetii
200. Phagosome acidification blocked by intracellular Toxoplasma gondii
201. Alveolar macrophage activation in experimental legionellosis
202. Acid and base resistance in Escherichia coli and Shigella flexneri: Role of rpoS and growth pH
203. Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes
204. Bacterial phospholipases and their role in virulence
205. The starvation-stress response (SSR) of Salmonella
206. The conjugal intermediate of plasmid RSF1010 inhibits Agrobacterium tumefaciens virulence and VirB-depedent export of VirE2
207. Mycobacterium avium bacilli grow saprozoically in coculture with Acanthamoeba polyphaga and survive within cyst walls
208. Periplasmic copper-zinc superoxide dismutase of Legionella pneumophila: Role in stationary phase survival
209. Expression of multiple pili by Legionella pneumophila: Identification and characterization of a type IV pilin gene and its role in adherence to mammalian and protozoan cells
210. Natural competence for DNA transformation by Legionella pneumophila and its association with expression of type IV pili
211. Current concepts: Legionellosis
212. Nosocomial legionnaires' disease
213. Structure-function and biogenesis of the type IV pili
214. Association of Legionella pneumophila with the macrophage endoplasmic reticulum
215. Identification of Legionella pneumophila mutants that have aberrant intracellular fates
216. The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing
217. Construction of Cu-Zn superoxide dismutase deletion mutants of Brucella abortus: Analysis of survival in vitro in epithelial and phagocytic cells and in vivo in mice
218. Antigenic relatedness of a strongly immunogenic 65 kDa mycobacterial protein antigen with a similarly sized ubiquitous bacterial common antigen
219. The lipophosphoglycan of Leishmania parasites
220. Identification of a Ga1/Ga1NAc lectin in the protozoan Hartmannella vermiformis as a potential receptor for attachment and invasion by the Legionnaires' disease bacterium
221. 2+ as an extracellular signal: Environmental regulation of Salmonella virulence
222. The Legionella pneumophila iraAB locus is required for iron assimilation, intracellular infection, and virulence
223. Conjugative transfer by the virulence system of Legionella pneumophila
224. Growth-supporting activity for Legionella pneumophila in tap water cultures and implications of Hartmannellid amoebae as growth factors
225. Identification of sigma S-dependent genes associated with the stationary-phase acid-resistance phenotype of Shigella flexneri
226. Interaction of Legionella micdadei with human monocytes
227. Phylogenetic diversity of the rickettsia
228. Molecular characterization of an operon required for pertussis toxin secretion
229. Cloning and characterization of a relA/spoT homologue from Bacillus subtilis
230. Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila
231. Legionnaires' disease in the Netherlands: Update
232. Adaptation of a conjugal transfer system for the export of pathogenic macromolecules
233. Free-living amoebae protecting Legionella in water: The tip of an iceberg?
234. The pathology of the legionella pneumonias
235. Sequence determination and mutational analysis of the lly locus of Legionella pneumophila
236. Influence of site specifically altered Mip proteins on intracellular survival of Legionella pneumophila in eukaryotic cells
237. Characteriziation of legiolysin (lly), responsible for hemolytic activity, colour production, and fluorescence of Legionella pneumophila
238. Elevation of neuronal expression of NAIP reduces ischemic damage in the hippocampus
239. Induction of Yersinia enterocolitica stress proteins by phagocytosis with macrophage
240. Differential morphologic and metabolic alterations in permissive versus nonpermissive murine macrophages infected with Legionella pneumophila
241. Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J mice
242. Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein)
243. Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila multiplication in vitro
244. Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth