Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila

Molecular Microbiology

Volumn 34, Issue 4, 1999, Pages 799-809

  Segal, Gil ^a,b   Russo, James J ^a   Shuman, Howard A ^a  

^a Columbia University ^*  (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACANTHAMOEBA CASTELLANII; ARTICLE; BACTERIAL GROWTH; CHROMOSOME; CONJUGATION; DNA SEQUENCE; GENE MAPPING; GENE MUTATION; HOST CELL; HUMAN; HUMAN CELL; LEGIONELLA PNEUMOPHILA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SECRETION; SEQUENCE HOMOLOGY; VIRULENCE;

ACANTHAMOEBA CASTELLANII; ANIMALIA; BACTERIA (MICROORGANISMS); LEGIONELLA PNEUMOPHILA; NEGIBACTERIA; PROKARYOTA;

EID: 0032701004     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01642.x     Document Type: Article

References (57)

1. Abu Kwaik, Y. (1996) The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum. Appl Environ Microbiol 62: 2022-2028.
2. Andersson, S.G., Zomorodipour, A., Andersson, J.O., Sicheritz-Ponten, T., Alsmark, U.C., Podowski, R.M., et al. (1998) The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature 396: 133-140.
3. Andrews, H.L., Vogel, J.P., and Isberg, R.R. (1998) Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway. Infect Immun 66: 950-958.
4. Armstrong, J.A., and D'Arcy Hart, P. (1971) Response of cultured macrophages to Mycobacterium tuberculosis with observations on fusion of lysosomes with phagosomes. J Exp Med 134: 713-740.
5. Beijersbergen, A., Dulk-Ras, A.D., Schilperoort, R.A., and Hooykaas, P.J.J. (1992) Conjugative transfer by the virulence system of Agrobacterium tumefaciens. Science 256: 1324-1327.
6. Berger, K.H., Merriam, J.J., and Isberg, R.R. (1994) Altered intracellular targeting properties associated with mutations in the Legionella dotA gene. Mol Microbiol 14: 809-822.
7. Binns, A.N., Beaupre, C.E., and Dale, E.M. (1995) Inhibition of VirB-mediated transfer of diverse substrates from Agrobacterium tumefaciens by the IncQ plasmid RSF1010. J Bacteriol 177: 4890-4899.
8. Bozue, J.A., and Johnson, W. (1996) Interaction of Legionella pneumophila with Acanthamoeba castellanii: Uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion. Infec Immun 64: 668-673.
9. Brand, B.C., Sadosky, A.B., and Shuman, H.A. (1994) The Legionella pneumophila icm locus: A set of genes required for intacellular multiplication in human macrophages. Mol Microbiol 14: 797-808.
10. Brenner, D.J., Steigerwalt, A.G., Weaver, R.E., McDade, J.E., Feeley, J.C., and Mandel, M. (1978) Classification of the Legionnaires' disease bacterium: An interim report. Curr Microbiol 1: 71-75.
11. Burns, D.L. (1999) Biochemistry of type IV secretion. Curr Opin Microbiol 2: 25-29.
12. Christie, P.J. (1997) Agrobacterium tumefaciens T-complex transport apparatus: A paradigm for a new family of multifunctional transporters in eubacteria. J Bacteriol 179: 3085-3094.
13. Covacci, A., Falkow, S., Berg, D.E., and Rappuoli, R. (1997) Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori? Trends Microbiol 5: 205-208.
14. Covacci, A., Telford, J.L., Del Giudice, G., Parsonnet, J., and Rappuoli, R. (1999) Helicobacter pylori virulence and genetic geography. Science 284: 1328-1333.
15. Fields, B.S. (1996) The molecular ecology of Legionellae. Trends Microbiol 4: 286-290.
16. Fields, B.S., Shotts Jr, E.B., Feeley, J.C., Gorman, G.W., and Martin, W.T. (1984) Proliferation of Legionella pneumophila as an intracellular parasite of the ciliated protozoan Tetrahymena pyriformis. Appl Environ Microbiol 47: 467-471.
17. Friis, R.R. (1972) Interaction of L cells and Chlamydia psittaci: Entry of the parasite and host responses to its development. J Becteriol 110: 706-721.
18. Fullner, K.J. (1998) Role of Agrobacterium virB genes in transfer of T complexes and RSF1010. J Bacteriol 180: 430-434.
19. Hales, L.M., and Shuman, H.A. (1999) Legionella pneumophila contains a type-II general secretion pathway required for growth in amoebae as well as for secretion of the Msp protease. Infect Immun 67: 3662-3666.
20. Hobbs, M., and Mattick, J.S. (1993) Common components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: A general system for the formation of surface-associated protein complexes. Mol Microbiol 10: 233-243.
21. Horwitz, M.A. (1983a) The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J Exp Med 168: 2108-2126.
22. Horwitz, M.A. (1983b) Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med 158: 1319-1331.
23. Horwitz, M.A. (1984) Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: Engulfment within a pseudopod coil. Cell 36: 27-33.
24. Horwitz, M.A. (1987) Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. J Exp Med 166: 1310-1328.
25. Horwitz, M.A., and Silverstein, S.C. (1980) Legionnaires' disease bacterium (Legionella pneumophila) multiplies intracellularly in human monocytes. J Clin Invest 60: 441-450.
26. Horwitz, M.A., and Maxfield, F.R. (1984) Legionella pneumophila inhibits acidification of its phagosome in human monocytes. J Cell Biol 99: 1936-1943.
27. Jones, T.C., and Hirsch, J.G. (1972) The interactions between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. J Exp Med 136: 1173-1184.
28. Lessl, M., Balzer, D., Pansegrau, W., and Lanka, E. (1992) Sequence similarities between the RP4 Tra2 and the Ti VirB region strongly support the conjugation model for T-DNA transfer. J Biol Chem 267: 20471-20480.
29. Li, P.L., Everhart, D.M., and Farrand, S.K. (1998) Genetic and sequence analysis of the pTiC58 trb locus, encoding a mating-pair formation system related to members of the type IV secretion family. J Bacteriol 180: 6164-6172.
30. Ules, M.R., Viswanathan, V.K., and Cianciotto, N.P. (1998) Identification and temperature regulation of Legionella pneumophila genes involved in type IV pilus biogenesis and type II protein secretion. Infect Immun 66: 1776-1782.
31. Marra, A., Blander, S.J., Horwitz, M.A., and Shuman, H.A. (1992) Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc Natl Acad Sci USA 89: 9607-9611.
32. Newsome, A.L., Baker, R.L., Miller, R.D., and Roland, R.R. (1985) Interactions between Naegleria fowleri and Legionella pneumophila. Infect Immun 50: 449-452.
33. Pohlman, R.F., Genetti, H.D., and Winans, S.C. (1994) Common ancestry between IncN conjugal transfer genes and macromolecular export systems of plant and animal pathogens. Mol Microbiol 14: 655-668.
34. Purcell, M.W., and Shuman, H.A. (1998) The Legionella pneumophila icmGCDJBF genes are required for killing of human macrophages. Infect Immun 66: 2245-2255.
35. Regensburg-Tuink, A.J., and Hooykaas, P.J. (1993) Transgenic N. glauca plants expressing bacterial virulence gene virF are converted into hosts for nopaline strains of A Tumefaciens. Nature 363: 69-71.
36. Rivas, S., Bolland, S., Cabezon, E., de Goni, F.M., and la Cruz, F. (1997) TrwD, a protein encoded by the IncW plasmid R388, displays an ATP hydrolase activity essential for bacterial conjugation. J Biol Chem 272: 25583-22590.
37. Rowbotham, T.J. (1980) Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae. J Clin Pathol 33: 1179-1183.
38. Russo, J.J., Bohenzky, R.A., Chien, M.C., Chen, J., Yan, M., Maddalena, D., et al. (1996) Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA 93: 14862-14867.
39. Sadosky, A.B., Wiater, L.A., and Shuman, H.A. (1993) Identification of Legionella pneumophila genes required for growth within and killing of human macrophages. Infect Immun 61: 5361-5373.
40. Segal, G., Purcell, M., and Shuman, H.A. (1998) Host cell killing and bacterial conjugation require overlapping sets of genes within a 22 kb region of the Legionella pneumophila genome. Proc Natl Acad Sci USA 95: 1669-1674.
41. Segal, G., and Ron, E.Z. (1993) Heat shock transcription of the groESL operon of Agrobacterium tumefacience may involve a hairpin-loop structure. J Bacteriol 175: 3083-3088.
42. Segal, G., and Shuman, H.A. (1997) Characterization of a new region required for macrophage killing by Legionella pneumophila. Infect Immun 65: 5057-5066.
43. Segal, G., and Shuman, H.A. (1998a) How is the intracellular fate of the Legionella pneumophila phagosome determined? Trends Microbiol 6: 253-255.
44. Segal, G., and Shuman, H.A. (1998b) Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components on IncQ plasmid RSF1010. Mol Microbiol 30: 197-208.
45. Segal, G., and Shuman, H.A. (1999a) Legionella pneumophila utilize the same genes to multiply within Acanthamoeba castellanii and human macrophages. Infect Immun 67: 2117-2124.
46. Segal, G., and Shuman, H.A. (1999b) Possible origin of the Legionella pneumophila virulence genes and their relation to Coxiella burnetii. Mol Microbiol 33: 669-670.
47. Swanson, M.S., and Isberg, R.R. (1995) Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun 64: 3609-3620.
48. Szeto, L., and Shuman, H.A. (1990) The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing. Infect Immun 58: 2585-2592.
49. Vogel, J.P., and Isberg, R.R. (1999) Cell biology of Legionella pneumophila. Curr Opin Microbiol 2: 30-34.
50. Vogel, J.P., Andrews, H.L., Wong, S.K., and Isberg, R.R. (1998) Conjugative transfer by the virulence system of Legionella pneumophila. Science 279: 873-876.
51. Wiater, L.A., Sadosky, A.B., and Shuman, H.A, (1994) Mutagenesis of Legionella pneumophila using Tn903dlllacZ: Identification of a growth-phase-regulated pigmentation gene. Mol Microbiol 11: 641-653.
52. Weiss, A.A., Johnson, F.D., and Burns, D.L. (1993) Molecular characterization of an operon required for pertussis toxin secretion. Proc Natl Acad Sci USA 90: 2970-2974.
53. Whitchurch, C.B., Hobbs, M., Livingston, S.P., Krishnapillai, V., and Mattick, J.S. (1991) Characterisation of a Pseudomonas aeruginosa twitching motility gene and evidence for a specialised protein export system widespread in eubacteria. Gene 101: 33-44.
54. Winans, S.C., and Walker, G.C. (1985) Conjugal transfer system of the IncN plasmid pKM101. J Bacteriol 161: 402-410.
55. Yanish-Perron, C., Viera, J., and Messing, J. (1985) Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33: 103-119.
56. Zheng, Z., Schäffer, A.A., Miller, W., Madden, T.L.J.L.D., Koonin, E.V., and Altschul, S.F. (1998) Protein sequence similarity searches using patterns as seeds. Nucleic Acids Res 26: 3986-3990.
57. Zupan, J.R., Ward, D., and Zambryski, P. (1998) Assembly of the VirB transport complex for DNA transfer from Agrobacterium tumefaciens to plant cells. Curr Opin Microbiol 1: 649-655.