Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

Nature Medicine

Volumn 3, Issue 9, 1997, Pages 997-1004

  Xu, D G ^a   Crocker, S J ^a   Doucet, J P ^a   St Jean, M ^a   Tamai, K ^b   Hakim, A M ^a   Ikeda, J E ^c   Liston, P ^d   Thompson, C S ^d   Korneluk, R G ^d   MacKenzie, A ^d   Robertson, G S ^a,d  

^a UNIVERSITY OF OTTAWA   (Canada)

^b Medical & Biological Laboratories Co Ltd   (Japan)

^c TOKAI UNIVERSITY   (Japan)

^d CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; K 252A; NEURONAL APOPTOSIS INHIBITORY PROTEIN; UNCLASSIFIED DRUG; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FOREBRAIN; HIPPOCAMPUS; NERVE CELL LESION; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; STROKE; SUBCUTANEOUS DRUG ADMINISTRATION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CARBAZOLES; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HIPPOCAMPUS; ISCHEMIC ATTACK, TRANSIENT; MALE; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONAL APOPTOSIS-INHIBITORY PROTEIN; NEURONS; RATS; RATS, WISTAR;

ADENOVIRIDAE; ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0030848529     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0997-997     Document Type: Article

References (28)

1. Pulsinelli, W.A., Brierly, J.B. & Plum, F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11, 491-498 (1982).
2. Smith, M.L., Auer, R.N. & Siesjo, B.K. The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol. (Berl) 64, 319-332 (1984).
3. MacManus, J.P., Buchan, A.M., Hill, I.E., Rasquinha, I. & Preston, E. Differences in DNA fragmentation following transient cerebral or decapitation ischemia in rats. J. Cerebral. Blood Flow Metab. 15, 728-737 (1995).
4. Nitatori, T. et al. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J. Neurosci. 15, 1001-1011 (1995).
5. Martinou, J.-C. et al. Overexpression of bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13, 1017-1030 (1994).
6. Lawrence, M.S., Ho, D.Y., Sun, G.H., Steinberg, G.K. & Sapolsky, R.M. Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J. Neurosci. 16, 486-496 (1996).
7. Krajewski, S. et al. Up regulation of bax levels in neurons following cerebral ischemia. J Neurosci. 15, 6364-6376 (1995).
8. Roy, N. et al. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80, 167-178 (1995).
9. Liston, P. et al. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379, 349-353 (1996).
10. Xu, D.G. et al. Distribution of NAIP-LI in the rat central nervous system. J. Comp. Neurol. 382, 247-259 (1997).
11. Smith-Swintosky, V.L. et. al. Bacterial alkaloids mitigate seizure-induced hippocampal damage and spatial memory deficits. Exp. Neurol. 141, 287-296 (1996)
12. Thilman, R., Xie, Y., Kleihues, P. & Kiessling, M. Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus. Acta Neuropathol. 71, 88-93 (1986).
13. Maruno, M. & Yanagihara, T. Progressive loss of messenger RNA and delayed neuronal death following transient cerebral ischemia in gerbils. Neurosci. Lett. 115, 155-160 (1990).
14. 14C]Leucine incorporation into brain proteins in gerbils after transient ischemia: Relationship to selective vulnerability of hippocampus. J. Neurochem. 56, 789-796 (1991).
15. Glicksman, M.A. et al. K252a and staurosporine promote choline acetyltransferase activity in rat spinal cord cultures. J. Neurochem. 61, 210-221 (1993).
16. Glicksman M.A., Forbes, M.E., Prantner J.E. & Neff, N.T. K-252a promotes survival and choline acetyltransferase activity in striatal and basal forebrain neuronal cultures. J. Neurochem. 64, 1502-1512 (1995).
17. Knusel, B. & Hefti, F. K252 compounds: Modulators of neurotrophin signal transduction. J. Neurochem. 59, 1987-1996 (1992).
18. Maroney, A.C. et al. K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SYS cells. J. Neurochem. 64, 540-549 (1995).
19. Cheng, B., Barger, S.W. & Mattson, M.P. Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose. J. Neurochem. 62, 1319-1329 (1994).
20. Paxinos, C. & Watson, C. The Rat Brain in Stereotaxic Coordinates, 2nd edn. (Academic Press, New York, 1986).
21. Fliss, H. & Gattinger, D. Apoptosis in ischemic and reperfused rat myocardium. Circ. Res. 79, 949-956 (1996).
22. Canadian Council on Animal Care. Guide to the Care and Use of Experimental Animals. (eds., Olfert, E.D., Cross, B.M. & McWilliam, A.A.) (Canadian Council on Animal Care, Ottawa, 1993).
23. Pulsinelli, W.A. & Buchan, A.M. The four-vessel occlusion rat model: Method for complete occlusion of vertebral arteries and control of collateral circulation. Stroke 19, 913-914 (1988).
24. Mullen, R.J., Buck, C.R., & Smith A.M. NeuN, a neuronal specific nuclear protein in vertebrates. Development 116, 201-211 (1992).
25. Evan, G.I., Lewis, G.K., Ramsy, G. & Bishop, J.M. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell Biol. 5, 3610-3616 (1985).
26. Shu, S., Ju, G. & Fan, L. The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci. Lett. 85, 169-171 (1988).
27. Doucet, J.-P., Murphy, B.J. & Tuana, B.S. Modification of a discontinuous and highly porous sodium dodecyl sulfate-polyacrylamide gel system for minigel electrophoresis. Anal. Biochem. 190, 209-211 (1990).
28. Towbin, H., Staehelin, T. & Gordon, T. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354 (1979).