메뉴 건너뛰기




Volumn 104, Issue 3 A, 1998, Pages

Mechanism of action of nonsteroidal anti-inflammatory drugs

Author keywords

[No Author keywords available]

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FLOSULIDE; GCP 28237; IBUPROFEN; INDOMETACIN; MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PIROXICAM; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE INHIBITOR; SALICYLATE SODIUM; UNCLASSIFIED DRUG;

EID: 0032579940     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9343(97)00203-9     Document Type: Conference Paper
Times cited : (608)

References (58)
  • 1
    • 0001187267 scopus 로고
    • An account of the success of the bark of the willow in the cure of agues
    • Stone E. An account of the success of the bark of the willow in the cure of agues. Phil Trans Roy Soc. 1763;53:195-200.
    • (1763) Phil Trans Roy Soc , vol.53 , pp. 195-200
    • Stone, E.1
  • 2
    • 0001189016 scopus 로고
    • Pharmacologisches über Aspirin (Acetylsalicylsaüre)
    • Dreser H. Pharmacologisches über Aspirin (Acetylsalicylsaüre). Pflügers Arch. 1899;76:306-318.
    • (1899) Pflügers Arch , vol.76 , pp. 306-318
    • Dreser, H.1
  • 3
    • 0016227738 scopus 로고
    • Drugs which inhibit prostaglandin biosynthesis
    • Flower RJ. Drugs which inhibit prostaglandin biosynthesis. Pharmacol. Rev. 1974;26:33-67.
    • (1974) Pharmacol. Rev. , vol.26 , pp. 33-67
    • Flower, R.J.1
  • 4
    • 0001791921 scopus 로고
    • Ability of some antirheumatic drugs to uncouple oxidative phosphorylation
    • Whitehouse MW, Haslam JM. Ability of some antirheumatic drugs to uncouple oxidative phosphorylation. Nature 1962; 196:1323-1324.
    • (1962) Nature , vol.196 , pp. 1323-1324
    • Whitehouse, M.W.1    Haslam, J.M.2
  • 6
    • 0345211844 scopus 로고
    • Inhibition of rat brain glutamate decarboxylase activity by salicylate in vitro
    • Gould BJ, Smith MJH. Inhibition of rat brain glutamate decarboxylase activity by salicylate in vitro. J Pharm Pharmacol. 1965;17:15-18.
    • (1965) J Pharm Pharmacol , vol.17 , pp. 15-18
    • Gould, B.J.1    Smith, M.J.H.2
  • 8
    • 0008006567 scopus 로고
    • Anti-inflammatory effects of salicylate in the rat
    • Dixon A StJ, Martin BK, Smith MJH, Wood PHN, eds. Boston: Little, Brown
    • Spector WG, Willoughby DA. Anti-inflammatory effects of salicylate in the rat. In: Dixon A StJ, Martin BK, Smith MJH, Wood PHN, eds. Salicylates: An International Symposium. Boston: Little, Brown, 1963:141-147.
    • (1963) Salicylates: An International Symposium , pp. 141-147
    • Spector, W.G.1    Willoughby, D.A.2
  • 9
    • 75449150093 scopus 로고
    • Aspirin
    • Collier HOJ. Aspirin. Sci Am. 1963;209:97-108.
    • (1963) Sci Am , vol.209 , pp. 97-108
    • Collier, H.O.J.1
  • 10
    • 0014651374 scopus 로고
    • A pharmacological analysis of aspirin
    • Collier HOJ. A pharmacological analysis of aspirin. Adv Pharmacol Chemother. 1969;7:333-405.
    • (1969) Adv Pharmacol Chemother , vol.7 , pp. 333-405
    • Collier, H.O.J.1
  • 11
    • 0007912460 scopus 로고
    • The release of prostaglandins during anaphylaxis in guinea-pig isolated lungs
    • Mantegazza P, Horton EW, eds. London, New York: Academic Press
    • Piper PJ, Vane JR. The release of prostaglandins during anaphylaxis in guinea-pig isolated lungs. In: Mantegazza P, Horton EW, eds. Prostaglandins, Peptides and Amines. London, New York: Academic Press, 1969:15-19.
    • (1969) Prostaglandins, Peptides and Amines , pp. 15-19
    • Piper, P.J.1    Vane, J.R.2
  • 12
    • 78651164158 scopus 로고
    • The use of isolated organs for detecting active substances in the circulating blood
    • Vane JR. The use of isolated organs for detecting active substances in the circulating blood. Br J Pharmacol Chemother. 1964;23:360-373.
    • (1964) Br J Pharmacol Chemother , vol.23 , pp. 360-373
    • Vane, J.R.1
  • 13
    • 0016748441 scopus 로고
    • Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides
    • Hamberg M, Svensson J, Samuelsson B. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA. 1975;72:2994-2998.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 2994-2998
    • Hamberg, M.1    Svensson, J.2    Samuelsson, B.3
  • 14
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature. 1971;231: 232-235..
    • (1971) Nature , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 15
    • 0015237275 scopus 로고
    • Aspirin selectively inhibits prostaglandin production in human platelets
    • Smith JH, Willis AL. Aspirin selectively inhibits prostaglandin production in human platelets. Nature. 1971;231:235-237.
    • (1971) Nature , vol.231 , pp. 235-237
    • Smith, J.H.1    Willis, A.L.2
  • 16
    • 0015237263 scopus 로고
    • Indomethacin and aspirin abolish prostaglandin release from spleen
    • Ferreira SH, Moncada S, Vane JR. Indomethacin and aspirin abolish prostaglandin release from spleen. Nature. 1971; 231:237-239.
    • (1971) Nature , vol.231 , pp. 237-239
    • Ferreira, S.H.1    Moncada, S.2    Vane, J.R.3
  • 17
    • 0017094438 scopus 로고
    • Purification of the cyclooxygenase that forms prostaglandins; demonstration of the two forms of iron in the holoenzyme
    • Hemler M, Lands WEM, Smith WL. Purification of the cyclooxygenase that forms prostaglandins; demonstration of the two forms of iron in the holoenzyme. J Biol Chem. 1976; 251:5575-5579.
    • (1976) J Biol Chem , vol.251 , pp. 5575-5579
    • Hemler, M.1    Lands, W.E.M.2    Smith, W.L.3
  • 18
    • 0022559202 scopus 로고
    • Prostaglandin biosynthesis and its compartmentation in vascular smooth muscle and endothelial cells
    • Smith WL Prostaglandin biosynthesis and its compartmentation in vascular smooth muscle and endothelial cells. Annu Rev Physiol. 1986;48:251-262.
    • (1986) Annu Rev Physiol , vol.48 , pp. 251-262
    • Smith, W.L.1
  • 21
    • 0029911267 scopus 로고    scopus 로고
    • Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2
    • Luong C, Miller A, Barnett J, et al. Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2. Nat Struct Biol. 1996;3:927-933.
    • (1996) Nat Struct Biol , vol.3 , pp. 927-933
    • Luong, C.1    Miller, A.2    Barnett, J.3
  • 22
    • 0017094798 scopus 로고
    • An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
    • Moncada S, Gryglewski R, Bunting S, Vane JR. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. 1976;263:663-665.
    • (1976) Nature , vol.263 , pp. 663-665
    • Moncada, S.1    Gryglewski, R.2    Bunting, S.3    Vane, J.R.4
  • 23
    • 0018904225 scopus 로고
    • Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa
    • Whittle BJR, Higgs GA, Eakins KE, et al. Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature. 1980;284:271-273.
    • (1980) Nature , vol.284 , pp. 271-273
    • Whittle, B.J.R.1    Higgs, G.A.2    Eakins, K.E.3
  • 24
    • 0026588961 scopus 로고
    • Mitogen-inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs
    • Xie W, Robertson DL, Simmons DL. Mitogen-inducible prostaglandin G/H synthase: a new target for nonsteroidal antiinflammatory drugs. Drug Dev Res. 1992;25:249-265.
    • (1992) Drug Dev Res , vol.25 , pp. 249-265
    • Xie, W.1    Robertson, D.L.2    Simmons, D.L.3
  • 26
    • 0025187588 scopus 로고
    • Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice
    • Masferrer JL, Zweifel BS, Seibert K, Needleman P. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest. 1990;86:1375-1379.
    • (1990) J Clin Invest , vol.86 , pp. 1375-1379
    • Masferrer, J.L.1    Zweifel, B.S.2    Seibert, K.3    Needleman, P.4
  • 27
    • 0025754779 scopus 로고
    • Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
    • Xie W, Chipman JG, Robertson DL, et al. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA. 1991;88:2692-2696.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2692-2696
    • Xie, W.1    Chipman, J.G.2    Robertson, D.L.3
  • 28
    • 0026322957 scopus 로고
    • A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein
    • O'Banion MK, Sadowski HB, Winn V, Young DA. A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J Biol Chem. 1991;266: 23261-23267.
    • (1991) J Biol Chem , vol.266 , pp. 23261-23267
    • O'Banion, M.K.1    Sadowski, H.B.2    Winn, V.3    Young, D.A.4
  • 29
    • 0025871150 scopus 로고
    • TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
    • Kujubu DA, Fletcher BS, Varnum BC, et al. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem. 1991;266:12866-12872.
    • (1991) J Biol Chem , vol.266 , pp. 12866-12872
    • Kujubu, D.A.1    Fletcher, B.S.2    Varnum, B.C.3
  • 30
    • 0026744831 scopus 로고
    • Purification and characterisation of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles
    • Sirois J, Richards JS. Purification and characterisation of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles. J Biol Chem. 1992; 267:6382-6388.
    • (1992) J Biol Chem , vol.267 , pp. 6382-6388
    • Sirois, J.1    Richards, J.S.2
  • 31
    • 0026969308 scopus 로고
    • Prostaglandins as modulators rather than mediators of inflammation
    • Weissmann G. Prostaglandins as modulators rather than mediators of inflammation. J Lipid Med. 1993;6:275-286.
    • (1993) J Lipid Med , vol.6 , pp. 275-286
    • Weissmann, G.1
  • 32
    • 0025961094 scopus 로고
    • Aspirin
    • Weissmann G. Aspirin. Sci Am. 1991;264:84-90.
    • (1991) Sci Am , vol.264 , pp. 84-90
    • Weissmann, G.1
  • 33
    • 0026034248 scopus 로고
    • Aspirin inhibits interleukin-1 induced prostaglandin H synthase expression in cultured endothelial cells
    • Wu KK, Sanduja R, Tsai AL, et al. Aspirin inhibits interleukin-1 induced prostaglandin H synthase expression in cultured endothelial cells. Proc Natl Acad Sci USA. 1991;88: 2384-2387.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2384-2387
    • Wu, K.K.1    Sanduja, R.2    Tsai, A.L.3
  • 34
    • 0022917632 scopus 로고
    • Paracetamol and phenacetin
    • Clissold SP. Paracetamol and phenacetin. Drugs. 1986; 32(suppl 4):46-59.
    • (1986) Drugs , vol.32 , Issue.4 SUPPL. , pp. 46-59
    • Clissold, S.P.1
  • 35
    • 0015511847 scopus 로고
    • Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of paracetamol (4-acetamidophenol)
    • Flower RJ, Vane JR. Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of paracetamol (4-acetamidophenol). Nature. 1972;240:410-411.
    • (1972) Nature , vol.240 , pp. 410-411
    • Flower, R.J.1    Vane, J.R.2
  • 36
    • 0028843881 scopus 로고
    • Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    • Langenbach R, Morham SG, Tiano HF, et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 1995;83:483-492.
    • (1995) Cell , vol.83 , pp. 483-492
    • Langenbach, R.1    Morham, S.G.2    Tiano, H.F.3
  • 37
    • 0028807498 scopus 로고
    • Prostaglandin synthase 2 gene disruption causes renal pathology in the moust
    • Morham SG, Langenbach R, Loftin CD, et al. Prostaglandin synthase 2 gene disruption causes renal pathology in the moust. Cell. 1995;83:473-482.
    • (1995) Cell , vol.83 , pp. 473-482
    • Morham, S.G.1    Langenbach, R.2    Loftin, C.D.3
  • 38
    • 0028818913 scopus 로고
    • Renal abnormalities and an altered inflammatory response in mice lacking cycloxygenase II
    • Dinchuck JE, Car BD, Focht RJ, et al. Renal abnormalities and an altered inflammatory response in mice lacking cycloxygenase II. Nature. 1995;378:406-409.
    • (1995) Nature , vol.378 , pp. 406-409
    • Dinchuck, J.E.1    Car, B.D.2    Focht, R.J.3
  • 39
    • 0027664991 scopus 로고
    • Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: Integrity in the balance
    • Whittle BJR. Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: integrity in the balance. Br J Pharmacol. 1993;110:3-17.
    • (1993) Br J Pharmacol , vol.110 , pp. 3-17
    • Whittle, B.J.R.1
  • 40
    • 0019975343 scopus 로고
    • Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production
    • Rainsford KD, Willis C. Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production. Dig Dis Sci. 1982;27: 624-635.
    • (1982) Dig Dis Sci , vol.27 , pp. 624-635
    • Rainsford, K.D.1    Willis, C.2
  • 41
    • 0027945466 scopus 로고
    • Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene
    • Chen XS, Sheller JR, Johnson EN, Funk CD. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature. 1994;372:179-182.
    • (1994) Nature , vol.372 , pp. 179-182
    • Chen, X.S.1    Sheller, J.R.2    Johnson, E.N.3    Funk, C.D.4
  • 42
    • 0027146692 scopus 로고
    • Selectivity of non-steroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
    • Mitchell JA, Akarasereenont P, Thiemermann C, et al. Selectivity of non-steroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Sci USA. 1993;90:11693-11697.
    • (1993) Proc Natl Sci USA , vol.90 , pp. 11693-11697
    • Mitchell, J.A.1    Akarasereenont, P.2    Thiemermann, C.3
  • 43
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs
    • Meade EA, Smith WL, DeWitt DL Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1993;268:6610-6614.
    • (1993) J Biol Chem , vol.268 , pp. 6610-6614
    • Meade, E.A.1    Smith, W.L.2    DeWitt, D.L.3
  • 44
    • 0024452740 scopus 로고
    • A review of gastric ulcer and gastroduodenal injury in normal volunteers receiving aspirin and other nonsteroidal anti-inflammatory drugs
    • Lanza FL. A review of gastric ulcer and gastroduodenal injury in normal volunteers receiving aspirin and other nonsteroidal anti-inflammatory drugs. Scand J Gastroenterol. 1989;24(suppl 163):24-31.
    • (1989) Scand J Gastroenterol , vol.24 , Issue.163 SUPPL. , pp. 24-31
    • Lanza, F.L.1
  • 45
    • 0003049413 scopus 로고
    • Relative potency of nonsteroid anti-inflammatory drugs as inhibitors of cyclooxygenase-1 or cyclooxygenase-2
    • Akarasereenont P, Mitchell JA, Thiemermann C, Vane JR. Relative potency of nonsteroid anti-inflammatory drugs as inhibitors of cyclooxygenase-1 or cyclooxygenase-2. Br J Pharmacol. 1994;112(suppl):183P.
    • (1994) Br J Pharmacol , vol.112 , Issue.SUPPL.
    • Akarasereenont, P.1    Mitchell, J.A.2    Thiemermann, C.3    Vane, J.R.4
  • 46
    • 0028327671 scopus 로고
    • Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs
    • Garcia Rodríguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs. Lancet. 1994;343:769-772.
    • (1994) Lancet , vol.343 , pp. 769-772
    • Garcia Rodríguez, L.A.1    Jick, H.2
  • 47
    • 0028926813 scopus 로고
    • New insights into the mode of action of anti-inflammatory drugs
    • Vane JR, Botting RM. New insights into the mode of action of anti-inflammatory drugs, Inflamm Res. 1995;44:1-10.
    • (1995) Inflamm Res , vol.44 , pp. 1-10
    • Vane, J.R.1    Botting, R.M.2
  • 48
    • 0027944075 scopus 로고
    • Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
    • Seibert K, Zhang Y, Leahy K, et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Nat Acad Sci USA. 1994; 91:12013-12017.
    • (1994) Proc Nat Acad Sci USA , vol.91 , pp. 12013-12017
    • Seibert, K.1    Zhang, Y.2    Leahy, K.3
  • 49
    • 33646124789 scopus 로고    scopus 로고
    • SC-58635, a highly selective inhibitor of COX-2, is an effective analgesic in an acute post-surgical pain model
    • Hubbard RC, Mehlisch DR, Jasper DR, et al. SC-58635, a highly selective inhibitor of COX-2, is an effective analgesic in an acute post-surgical pain model. J Invest Med. 1996; 44:293A.
    • (1996) J Invest Med , vol.44
    • Hubbard, R.C.1    Mehlisch, D.R.2    Jasper, D.R.3
  • 50
    • 0029033219 scopus 로고
    • Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: A novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach
    • Chan C-C, Boyce S, Brideau C, et al. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J Pharm Exp Ther. 1995;274:1531-1537.
    • (1995) J Pharm Exp Ther , vol.274 , pp. 1531-1537
    • Chan, C.-C.1    Boyce, S.2    Brideau, C.3
  • 51
    • 0002180220 scopus 로고    scopus 로고
    • Differential inhibition of COX-1/COX-2 by NSAIDs
    • Bazan N, Botting J, Vane JR, eds. Lancaster, London: Kluwer Academic Publishers and William Harvey Press
    • Pairet M, Churchill L, Englehardt G. Differential inhibition of COX-1/COX-2 by NSAIDs. In: Bazan N, Botting J, Vane JR, eds. New Targets in Inflammation. Lancaster, London: Kluwer Academic Publishers and William Harvey Press, 1996; 23-38.
    • (1996) New Targets in Inflammation , pp. 23-38
    • Pairet, M.1    Churchill, L.2    Englehardt, G.3
  • 52
    • 0029882063 scopus 로고    scopus 로고
    • Selective inhibition of human cyclooxygenase-2 by meloxicam
    • Churchill L, Graham A, Shih C-K, et al. Selective inhibition of human cyclooxygenase-2 by meloxicam. Inflammopharmacology. 1996;4:125-135.
    • (1996) Inflammopharmacology , vol.4 , pp. 125-135
    • Churchill, L.1    Graham, A.2    Shih, C.-K.3
  • 53
    • 0025160887 scopus 로고
    • Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor
    • Gans KR, Galbraith W, Roman RJ, et al. Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J Pharmacol Exp Ther. 1990; 254:180-187.
    • (1990) J Pharmacol Exp Ther , vol.254 , pp. 180-187
    • Gans, K.R.1    Galbraith, W.2    Roman, R.J.3
  • 54
    • 0023227128 scopus 로고
    • A sulphonamido-indanone CGP 28237 (ZK 34228), a novel nonsteroidal anti-inflammatory agent without gastrointestinal ulcerogenicity in rats
    • Böttcher I, Schweizer A, Glatt M, Werner H. A sulphonamido-indanone CGP 28237 (ZK 34228), a novel nonsteroidal anti-inflammatory agent without gastrointestinal ulcerogenicity in rats. Drugs Exp Clin Res. 1987; 13:237-245.
    • (1987) Drugs Exp Clin Res , vol.13 , pp. 237-245
    • Böttcher, I.1    Schweizer, A.2    Glatt, M.3    Werner, H.4
  • 55
    • 0022972486 scopus 로고
    • Comparison of the systemic inhibition of thromboxane synthesis, anti-inflammatory activity and gastro-intestinal toxicity of non-steroidal anti-inflammatory drugs in the rat
    • Carr DP, Henn R, Green JR, Böttcher I. Comparison of the systemic inhibition of thromboxane synthesis, anti-inflammatory activity and gastro-intestinal toxicity of non-steroidal anti-inflammatory drugs in the rat. Agents Actions. 1986;19:374-375.
    • (1986) Agents Actions , vol.19 , pp. 374-375
    • Carr, D.P.1    Henn, R.2    Green, J.R.3    Böttcher, I.4
  • 56
    • 0028089109 scopus 로고
    • NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
    • Futaki N, Takahashi S, Yokoyama M, et al. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994;47:55-59.
    • (1994) Prostaglandins , vol.47 , pp. 55-59
    • Futaki, N.1    Takahashi, S.2    Yokoyama, M.3
  • 57
    • 0025998557 scopus 로고
    • Aspirin use and reduced risk of fatal colon cancer
    • Thun MJ, Namboodiri MM, Heath CWJ. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med. 1991 ;325: 1593-1596.
    • (1991) N Engl J Med , vol.325 , pp. 1593-1596
    • Thun, M.J.1    Namboodiri, M.M.2    Heath, C.W.J.3
  • 58
    • 0027993458 scopus 로고
    • Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • Eberhart CE, Coffey RJ, Radhika A, et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 1994; 104:1183-1188.
    • (1994) Gastroenterology , vol.104 , pp. 1183-1188
    • Eberhart, C.E.1    Coffey, R.J.2    Radhika, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.