Aspirin-like molecules that covalently inactivate cyclooxygenase-2

Science

Volumn 280, Issue 5367, 1998, Pages 1268-1270

  Kalgutkar, Amit S ^a   Crews, Brenda C ^a   Rowlinson, Scott W ^a   Garner, Carlos ^a,c   Seibert, Karen ^b   Marnett, Lawrence J ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b PFIZER INC   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; O (ACETOXYPHENYL)HEPT 2 YNYL SULFIDE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME INACTIVATION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLATION; ACETYLENE; ALKYNES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BINDING SITES; CELL DIVISION; CELL LINE; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DRUG DESIGN; HUMANS; INDOMETHACIN; ISOENZYMES; MACROPHAGES; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; PROSTAGLANDIN D2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, INBRED LEW; SULFIDES; THROMBOXANE B2; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0032557710     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5367.1268     Document Type: Article

References (4)

1. J. R. Vane, R. J. Flower, R. M. Botting, Stroke 21 (suppl. 4), 12 (1990).
2. H. Dreser, Pfluegers Arch. 76, 306 (1899).
3. G. J. Roth, N. Stanford, P. W. Majerus, Proc. Natl. Acad. Sci. U.S.A. 72, 3073 (1975).
4. J. R. Vane, Nature New Biol. 231, 232 (1971).