Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation

Journal of Biological Chemistry

Volumn 272, Issue 34, 1997, Pages 21565-21574

  Landino, Lisa M ^a   Crews, Brenda C ^a   Gierse, James K ^b   Hauser, Scott D ^b   Marnett, Lawrence J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; HISTIDINE; HYDROPEROXIDE; PEROXIDASE; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME PURIFICATION; LEPIDOPTERA; MONKEY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ANIMALS; ARACHIDONIC ACID; BINDING SITES; CATALYSIS; CYCLOOXYGENASE 2; ENZYME ACTIVATION; FATTY ACIDS; GLUTAMINE; HISTIDINE; HYDROGEN PEROXIDE; IMIDAZOLES; ISOENZYMES; LEUKOTRIENES; LIPID PEROXIDES; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; OXYGEN; PEROXIDASES; PEROXIDES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECOMBINANT PROTEINS; SPODOPTERA; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; LEPIDOPTERA;

EID: 0030845234     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.34.21565     Document Type: Article

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