Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disorders

Journal of Laboratory and Clinical Medicine

Volumn 133, Issue 4, 1999, Pages 321-325

  Heinecke, Jay W ^a  

^a Nutrition and Lipid Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033117503     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2143(99)90061-6     Document Type: Article

References (32)

1. 1. Klebanoff SJ. Oxygen metabolism and the toxic properties of phagocytes. Ann Intern Med 1980;93:480-9.
2. 2. Hurst JK, Barrette WC Jr. Leukocytic oxygen activation and microbicidal oxidative toxins. CRC Crit Rev Biochem Mol Biol 1989;24:271-328.
3. 3. Heinecke JW. Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis. Curr Opin Lipid 1997;8:268.
4. 4. Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci 1979;76:333-6.
5. 5. Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis, J Clin Invest 1991;88:1785-92.
6. 6. Berliner JA, Heinecke JW. The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med 1996;20:707-27.
7. 7. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996;347:781-6.
8. 8. Nauseef WM. Myeloperoxidase deficiency-phagocytic defects I. Hematol Oncol Clin North Am 1988;2:135-58.
9. 9. Daugherty A, Dunn JL, Rateri DL, Heinecke JW. Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J Clin Invest 1994;94:437-44.
10. 10. Harrison JE, Schultz J. Studies on the chlorinating activity of myeloperoxidase. J Biol Chem 1976;251:1371-4.
11. 11. Thomas EL, Grisham MB, Jefferson MM. Preparation and characterization of chloramines. Methods Enzymol 1986;132:569-85.
12. 12. Albrich JM, McCarthy CA, Hurst JK. Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase. Proc Natl Acad Sci USA 1981;78:210-4.
13. 13. Weiss SJ, Test ST, Eckmann CM, Ross D, Regiani S. Brominating oxidants generated by human eosinophils. Science 1986;234:200.
14. 14. Prince RC. Tyrosine radicals. Trends Biochem Sci 1988;13:286-8.
15. 15. Heinecke JW, Li W, Daehnke HL, Goldstein JA. Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages. J Biol Chem 1993;268:4069-77.
16. 16. Jacob JS, Cistola D, Hsu FF, Muzaffar S, Mueller DM, Hazen SL, et al. Human phagocytes employ myeloperoxidase to synthesize dityrosine, trityrosine, pulcherosine and isodityrosine by a tyrosyl radical-dependent mechanism. J Biol Chem 1996;271:19950-6.
17. 17. McCormick ML, Gaut JP, Lin T, Britigan B, Buettner GR, Heinecke JW. Electron paramagnetic resonance detection of free lyrosyl radical generated by myeloperoxidase, lactoperoxidase, and horseradish peroxidasc. J Biol Chem. In press.
18. 18. Heinecke JW, Li W, Francis GA, Goldstein JA. Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative crosslinking of proteins. J Clin Invest 1993;91:2866-72.
19. 19. Francis GA, Mendez AJ, Bierman EL, Heinecke JW. Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fibroblasts and macrophage foam cells. Proc Natl Acad Sci 1993;90;6631-5.
20. 2-Cl--mediated aldehyde formation and its relationship to antimicrobial activity. Infect Immun 1971;3:595-602.
21. 21. Zgliczynski JM, Stelmaszynska T, Domanski J, Ostrowski W. Chloramines as intermediates of oxidation reaction of amino acids by myeloperoxidase. Biochem Biophys Acta 1971;235:419-24.
22. 22. Hazen SL, Hsu FF, Heinecke JW. p-Hydroxyphenyl-acetaldehyde is the major product of tyrosine oxidation by activated human phagocytes. J Biol Chem 1996;27:1861-7.
23. 2chloride system of phagocytes, covalently modifies-amino groups of protein lysine residues. J Biol Chem 1997;272:16990-8.
24. 24. Anderson MM, Hazen SL, Hsu FF, Heinecke JW. Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy amino acids into glycolaldehyde, 2-hydroxypropanal and acrolein. J Clin Invest 1997:99:424-32.
25. 25. Hazen SL, Hsu FF, d'Avignon A, Anderson MM, Heinecke JW. Human neutrophils employ myeloperoxidase to convert alpha-amino acids into a battery of reactive aldehydes. Biochem 1998:37:6864-73.
26. 26. Hazen SL, d'Avignon A, Anderson MM, Hsu FF, Heinecke JW. Human neutrophils employ the myeloperoxidase-hydrogen peroxidase-chloride system to oxidize-amino acids to a family of reactive aldehydes: mechanistic studies identifying labile intermediates along the reaction pathway. J Biol Chem 1998;273:4997-5005.
27. 27. Baynes JW. Perspectives in diabetes: role of oxidative stress in development of complications in diabetes. Diabetes 1991:40:405-12.
28. 28. Hazen SL, Hsu FF, Mueller DM, Crowley JR, Heinecke JW. J Clin Invest 1996;98:1283-9.
29. 29. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997:336:973-9.
30. 30. Danesh J, Collins R, Peto R. Chronic infection and coronary artery disease: is there a link? Lancet 1997:350:430-6.
31. 31. Leeuwenburgh C, Rasmussen JE, Hsu FF, Mueller DM, Pennathur S, Heinecke JW. Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques. J Biol Chem 1997;272:3520-6.
32. 32. Hazen SL, Hsu FF, Mueller DM, Crowley JR, Heinecke JW. 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. J Clin Invest 1997;99:2075-81.