The pathogenic activation of calpain: A marker and mediator of cellular toxicity and disease states

International Journal of Experimental Pathology

Volumn 81, Issue 5, 2000, Pages 323-339

  Vanderklish, Peter W ^b   Bahr, Ben A ^a,b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Age; Alzheimer's disease; Excitotoxicity; Ischemia; Review; Spectrin breakdown

Indexed keywords

ANTIBODY; CALCIUM; CALPAIN; ENZYME INHIBITOR; SPECTRIN;

AGING; ALZHEIMER DISEASE; APOPTOSIS; BRAIN DEGENERATION; BRAIN VASOSPASM; CALCIUM HOMEOSTASIS; CELL TYPE; CYTOTOXICITY; DISEASE MARKER; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; KIDNEY DISEASE; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; STROKE;

AGING; ALZHEIMER DISEASE; BRAIN DISEASES; BRAIN INJURIES; CALPAIN; ENZYME ACTIVATION; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; SPECTRIN;

EID: 0034524665     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.2000.00169.x     Document Type: Review

References (202)

1. Enhanced liver calpain protease activity is a risk factor for dysfunction of human liver allografts
2. Clinical and biochemical studies of bone destruction in cholesteatoma
3. Calpains in lens epithelium from patients with cataract
4. Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices
5. A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices
6. Improved posthypoxic recovery with a membrane-permeable calpain inhibitor
7. A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophy
8. Role of calcium-activated neutral protease (calpain) in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition
9. Long-term hippocampal slices: A model system for investigating synaptic mechanisms and pathologic processes
10. Integrin-type signaling has a distinct influence on NMDA-induced cytoskeletal disassembly
11. Age-related phosphorylation and fragmentation events influence the distribution profiles of distinct tau isoforms in mouse brain
12. Spectrin breakdown products increase with age in telencephalon of mouse brain
13. Mouse telencephalon exhibits an age-related decrease in glutamate (AMPA) receptors but no change in nerve terminal markers
14. Age-related changes in neural cell adhesion molecule (NCAM) isoforms in the mouse telencephalon
15. Induction of β-amyloid containing polypeptides in hippocampus: Evidence for a concomitant loss of synaptic proteins and interactions with an excitotoxin
16. Changes in the concentrations of tau and other structural proteins in the brains of aged mice
17. Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices
18. R antigen (GR53) in brain tissue
19. Structural chemistries underlying synaptic signaling and regulation
20. Calpain activity in adult and aged human brain regions
21. Alteration of protease levels in different brain areas of suicide victims
22. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage
23. Calpain inhibitor AK295 protects neurons from focal brain ischemia
24. Time-related neuronal changes following middle cerebral artery occlusion: Implications for therapeutic intervention and the role of calpain
25. Temporal ordering of pathogenic events following transient global ischemia
26. Cortical ablation induces a spreading calcium-dependent, secondary pathogenesis which can be reduced by inhibiting calpain
27. Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes
28. Identification of muscle-specific calpain and beta-sarcoglycan genes in progressive autosomal recessive muscular dystrophies
29. Translational suppression of calpain 1 reduces NMDA-induced spectrin proteolysis and pathophysiology cultured hippocampal slices
30. Regional distribution and time-course of calpain activation following kainate-induced seizure activity in adult rat brain
31. A quantitative study of the actions of excitatory amino acids and antagonists in rat hippocampal slices
32. The calpain proteolytic system in neonatal hypoxic-ischemia
33. Calpastatin is up-regulated in response to hypoxia and is a suicide substrate to calpain after neonatal cerebral hypoxia-ischemia
34. In vitro digestion of spectrin, protein 4.1 and ankyrin by erythrocyte calcium dependent neutral protease (calpain I)
35. pH-dependent nonlysosomal proteolysis contributes to lethal anoxic injury in rat hapatocytes
36. A 27-kDa matrix receptor from rat brain synaptosomes: Selective recognition of the Arg-Gly-Asp-Ser domain and unique resistance to calcium-dependent proteolysis
37. Caspase and calpain substrates: Roles in synaptic plasticity and cell death
38. Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170
39. Suppression of okadaic acid-induced apoptosis by overexpression of calpastatin in human UVr-1 cells
40. Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases
41. Focal adhesion kinase (pp. 125FAK) cleavage and regulation by calpain
42. NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain
43. Calcium-activated neutral protease (calpain) system: Structure, function, and regulation
44. Development of hippocampal long-term potentiation is reduced by recently introduced calpain inhibitors
45. Stimulation of NMDA receptors activates calpain in cultured hippocampal slices
46. Calpain inhibitors block long-term potentiation
47. Specific degradation of troponin T and I by Mu-calpain and its modulation by substrate phosphorylation
48. Dystrophin-related protein in the platelet membrane skeleton. Integrin-induced change in detergent-insolubility and cleavage by calpain in aggregating platelets
49. The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury
50. Modulation of hypoxia-induced calpain activity in rat renal proximal tubules
51. Effect of glycine on prelethal and postlethal increases in calpain activity in rat renal proximal tubules
52. The nature of renal cell injury
53. 2 injury to rat kidney proximal tubule epithelial cells
54. Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo
55. Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro
56. Anti-brain spectrin immunoreactivity in Alzheimer's disease: Degradation of spectrin in an animal model of cholinergic degeneration
57. Distinct secretases, a cysteine protease and a serene protease, generate the C termini of amyloid beta-proteins
58. Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin glycoprotein IIbIIIa
59. Immunohistochemical distribution of calcium-activated neutral proteinases and endogenous CANP inhibitor in the rabbit hippocampus
60. Calpain (Ca (2+) -dependent thiol protease) in erythrocytes of young and old individuals
61. Caspase-mediated degradation of AMPA receptor subunits: A mechanism for preventing excitotoxic necrosis and ensuring apoptosis
62. Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease
63. Independent regulation of calcium revealed by imaging dendritic spines
64. The calmodulin-binding site in α-fodrin is near the calcium-dependant protease-I cleavage site
65. Immunohistochemical investigation of ischemic and postischemic damage after bilateral carotid occlusion in gerbils
66. Decreased inositol (1,4,5) -trisphosphate receptor levels in Alzheimer's disease cerebral cortex: Selectivity of changes and possible correlation to pathological severity
67. Improved posthypoxic recovery of synaptic transmission in gerbil neocortical slices treated with a calpain inhibitor
68. Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia
69. Calcium-activated proteolysis in rat neocortex induced by transient focal ischemia
70. Activation mechanism of calcium-activated neutral protease. Evidence for the existence of intramolecular and intermolecular autolyses
71. Involvement of calpain in integrin-mediated signal transduction
72. Presence of brain spectrin in dendrites of mammalian brain: Technical factors involved in immunocytochemistry detection
73. New inhibitors of calpain prevent degradation of cytoskeletal and myelin proteins in spinal cord in vitro
74. Load dependence of secondary diaphragm inflammation and injury after acute inspiratory loading
75. Role of calpain-and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture
76. Neuroprotective effects of glutamate antagonists and extracellular acidity
77. Mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury
78. Increased proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease
79. Caspases cleave the amino-terminal calpain inhibitory unit of calpastatin during apoptosis in human Jurkat T cells
80. Variants of the receptor/channel clustering molecule gephyrin in brain: Distinct distribution patterns, developmental profiles, and proteolytic cleavage by calpain
81. Isolation and characterization of cysteine proteinase in thrombotic thrombocytopenic purpura
82. The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities
83. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
84. Pharmacologic studies of the neuroprotective actions of a glutamate antagonistin ischemia
85. Calpain is a mediator of preservation-reperfusion injury in rat liver transplantation
86. Immunohistochemical study of calpain and its endogenous inhibitor in the skeletal muscle of muscular dystrophy
87. Calpain and cathepsins in the skeletal muscle of inflammatory myopathies
88. The role of calcium-activated proteolysis in ischemic brain injury
89. Inhibition of proteolysis protects hippocampal neurons from ischemia
90. The role of calcium-activated proteolysis in vasospasm after subarachnoid hemorrhage
91. Calcium-activated proteolysis as a therapeutic target in cerebrovascular disease
92. Neurotoxicity induces cleavage of p35 to p25 by calpain
93. Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets
94. Novel peptidyl α-keto amide inhibitors of calpains and other cysteine proteases
95. Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord
96. Ischemic cell death in brain neurons
97. Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain
98. Adrenalectomy attenuates kainic acid-induced spectrin proteolysis and heat shock protein 70 induction in hippocampus and cortex
99. The biochemistry of memory: A new and specific hypothesis
100. Links between long-term potentiation and neuropathology. An hypothesis involving calcium-activated proteases
101. Delayed therapy of experimental ischemia with competitive N-methyl-D-aspartate antagonists in rabbits
102. Neuroprotection by the N-methyl-D-aspartate receptor antagonist CGP 40116 in vivo and in vitro studies
103. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats
104. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis
105. Increased immunoreactivity of brain spectrin in Alzheimer disease: A marker for synapse loss
106. Quantitative synaptic alterations in the human neocortex during normal aging
107. Calcium as sculptor and destroyer of neural circuitry
108. Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise
109. The calpains
110. Mechanism of action of a new component of the Ca (2+) -dependent proteolytic system in rat brain: The calpain activator
111. Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau, and PHF-tau
112. Very early changes in pulmonary protein kinase C-alpha and calpain II contents following injection of butylated hydroxytoluene (BHT) into mice
113. Effects of inhibitors of protein kinase C and calpain in experimental delayed cerebral vasospasm
114. Generation of diversity in nonerythroid spectrin. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin
115. Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neuro-degenerative disorders involving the mesencephalon: A role in nerve cell death?
116. NPS 1506, a novel NMDA receptor antagonist and neuroprotectant. Review of preclinical and clinical studies
117. Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses
118. The calpain-calpastatin system in obsessive-compulsive disorder
119. Positive modulation of hippocampal AMPA receptors promotes recovery several hours after trimethyltin-induced excitotoxicity
120. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells
121. Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid
122. Complex interactions between polyamines and calpain-mediated proteolysis in rat brain
123. Effect of treatment with difluoromethylornithine on polyamine and spectrin breakdown levels in neonatal rat brain
124. Changes in polyamine levels and spectrin degradation following kainate-induced seizure activity: Effect of difluoromethylornithine
125. Concurrent assessment of calpain and caspase-3 activity by means of Western blots of protease-specific spectrin breakdown products
126. Calpain and calpastatin in normal and Alzheimer-degenerated human brain tissue
127. Trimethyltin (TMT) neurotoxicity in organotypic rat hippocampal slice cultures
128. The protease inhibitor leupeptin interferes with the development of LTP in hippocampal slices
129. Nerve growth factor-induced decrease in the calpain activity of PC12 cells
130. Distribution of calcium-activated protease calpain in rat brain
131. Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors
132. Increased spectrin proteolysis in fibroblasts from aged and Alzheimer donors
133. Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis
134. Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells
135. Following association to the membrane, human erythrocyte procalpain is converted and released as fully active calpain
136. Cleavage of the calpain inhibitor, calpastatin, during apoptosis
137. A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat
138. Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo
139. Calpain activity and translational expression increased in spinal cord injury
140. Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells
141. Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A
142. Spectrin proteolysis in the hippocampus: A biochemical marker for neuronal injury and neuroprotection
143. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
144. Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events
145. Implication of calpain in caspase activation during B cell clonal deletion
146. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat
147. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat
148. Spatial resolution of proteolytic reactions in brain ischemia and Alzheimer's disease
149. Autolytic transition of μ-calpain upon activation as resolved by antibodies distinguishing between pre- and post-autolysis forms
150. Spatial resolution of fodrin proteolysis in postischemic brain
151. Calpain: New perspectives in molecular diversity and physiological-pathological involvement
152. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: A potential molecular basis for neuronal degeneration
153. Calcium ionophore induced proteolysis and cataract: Inhibition by cell permeable calpain antagonists
154. Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery
155. Amyloid beta-induced neuronal death is bax-dependent but caspase-independent
156. Calmodulin stimulates the degradation of brain spectrin by calpain
157. Lesions of entorhinal cortex produce a calpain-mediated degradation of brain spectrin in dentate gyrus. I. Biochemical studies
158. Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus
159. Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus
160. Intrahippocampal colchicine injection results in spectrin proteorysis
161. Increased spectrin proteolysis in the brindled mouse mutation
162. Restriction of microM-calcium-requiring calpain activation to the plasma membrane in human neuroblastoma cells: Evidence for regionalized influence of a calpain activator protein
163. Phospholipids alter tau conformation, phosphorylation, proteolysis, and association with microtubules: Implication for tau function under normal and degenerative conditions
164. Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: Involvement of calpain-mediated hydrolysis of protein kinase C
165. Possible involvement of calpain in the growth of estrogen receptor positive breast cancer cells
166. Putative role of calpain in the pathophysiology of experimental optic neuritis
167. Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis
168. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain
169. Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo
170. Brain fodrin: Substrate for calpain I, an endogenous calcium-activated protease
171. Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage
172. Proteolytic processing of beta-amyloid precursor by calpain I
173. Calpains are activated in necrotic fibers from mdx dystrophic mice
174. A simple method for organotypic cultures of nervous tissue
175. Chronic epileptogenesis induced by kindling of the entorhinal cortex: The role of the dentate gyrus
176. Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions
177. Calpain substrate specificity
178. Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled
179. A calcium-protease activator associated with brain microsomal-insoluble elements
180. Glycine protection against hypoxic injury in isolated rat proximal tubules: The role of proteases
181. Calcium dependent proteolysis and its inhibition in ischemic rat myocardium
182. m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains
183. Proteolysis of spectrin by calpain accompanies theta-burst stimulation in cultured hippocampal slices
184. Translational suppression of calpain blocks long-term potentiation
185. Marking synaptic activity in dendritic spines with a calpain substrateexhibiting fluorescence resonance energy transfer
186. Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures
187. Neurotoxicity of acute glutamate transport blockage depends on coactivation of both NMDA and AMPA/kainate receptors in organotypic hippocampal cultures
188. Calpain and caspase: Can you tell the difference?
189. Mechanism of calcium-induced disintegrative globulization of rat lens fiber cells
190. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation
191. Caspase-dependent activation of calpain during drug-induced apoptosis
192. Calcineurin inhibition prevents calpain-mediated proteolysis of tau in differentiated PC12 cells
193. Calpain-calpastatin system of canine basilar artery in vasospasm
194. Effects of specific protease inhibitors on amyloid beta-protein 42 secretion
195. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition
196. Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments
197. Tau released from paired helical filaments with formic acid or guanidine is susceptible to calpain-mediated proteolysis
198. Local cerebral glucose utilization and cytoskeletal proteolysis as indices of evolving focal ischemic injury in core and penumbra
199. Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage
200. Therapeutic potential of calpain inhibitors in neurodegenerative disorders
201. Maitotoxin induces calpain but not caspase-3 activation and necrotic cell death in primary septo-hippocampal cultures