Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170

Brain Research

Volumn 769, Issue 1, 1997, Pages 188-192

  Chen, Zong Fu ^a   Schottler, Frank ^a   Lee, Kevin S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Calcium; Calpain inhibitor; Hippocampus; Hypoxia; Neuroprotection; Penumbra

Indexed keywords

[1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; CALPAIN; CALPASTATIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; MALE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

ANIMALS; ANOXIA; CALPAIN; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPSES;

EID: 0030709420     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00848-2     Document Type: Article

References (33)

1. Arai A., Kessler M., Lee K.S., Lynch G. Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices. Brain Res. 532:1990;63-68.
2. Arai A., Vanderklish P., Kessler M., Lee K.S., Lynch G. A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices. Brain Res. 555:1991;276-280.
3. Arlinghaus L., Lee K.S. Endogenous adenosine mediates the sustained inhibition of excitatory synaptic transmission during moderate hypoxia. Brain Res. 724:1996;265-268.
4. Arlinghaus L., Mehdi S., Lee K.S. Improved posthypoxic recovery with a membrane-permeable calpain inhibitor. Eur. J. Pharmacol. 209:1991;123-125.
5. Back T., Kohno K., Hossmann K.-A. Cortical negative DC deflections following middle cerebral artery occlusion and KCL-induced spreading depression: effect on blood flow, tissue oxygenation, and electroencephalogram. J. Cereb. Blood Flow Metab. 14:1994;12-19.
6. M. Balestrino, P.G. Aitken, L.S. Jones, G.G. Somjen, The role of spreading depression-like hypoxic depolarization in irreversible neuron damage, and its prevention, in: G.G. Somjen (Ed.), Mechanisms of Cerebral Hypoxia and Stroke, Plenum Press, New York, 1988, pp. 291-301.
7. Bartus R.T., Baker K.L., Heiser A.D., Sawyer S.D., Dean R.L., Elliott P.J., Straub J.A. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J. Cereb. Blood Flow Metab. 14:1994;537-544.
8. Bartus R.T., Dean R.L., Cavanaugh K., Eveleth D., Carriero D.L., Lynch G. Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain. J. Cereb. Blood Flow Metab. 15:1995;969-979.
9. Bartus R.T., Hayward N.J., Elliott P.J., Sawyer S.D., Baker K.L., Dean R.L., Akiyama A., Straub J.A., Harbeson S.L., Li Z., Powers J. Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration. Stroke. 25:1994;2265-2270.
10. Caner H., Collins J.L., Harris S.M., Kassell N.F., Lee K.S. Attenuation of AMPA-induced neurotoxicity by a calpain inhibitor. Brain Res. 607:1993;354-356.
11. Chen Z.F., Schottler F., Arlinghaus L., Kassell N.F., Lee K.S. Hypoxic neuronal damage in the absence of hypoxic depolarization in rat hippocampal slices: the role of glutamate receptors. Brain Res. 708:1996;82-92.
12. D.W. Choi, D.M. Hartley, Calcium and glutamate-induced cortical neuronal death, in: S.G. Waxman (Ed.), Molecular and Cellular Approaches to the Treatment of Neurological Disease, Raven Press, New York, 1993, pp. 23-34.
13. Gido G., Kristian T., Siesjo B.K. Extracellular potassium in a neocortical core area after transient focal ischemia. Stroke. 28:1997;206-210.
14. Gill R., Andine P., Hillered L., Persson L., Hagberg H. The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischemia in the rat. J. Cereb. Blood Flow Metab. 12:1992;371-379.
15. Hansen A.J., Nedergaard M. Brain ion homeostasis in cerebral ischemia. Neurochem. Pathol. 9:1988;195-209.
16. Hiramatsu K., Kassell N.F., Lee K.S. Improved posthypoxic recovery of synaptic transmission in gerbil neocortical slices treated with a calpain inhibitor. Stroke. 24:1993;1725-1728.
17. Hong S.G., Goto Y., Lazino G., Soleau S., Kassell N.F., Lee K.S. Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia. Stroke. 25:1994;663-669.
18. Hossmann K.-A. Glutamate-mediated injury in focal cerebral ischemia: the excitotoxin hypothesis revised. Brain Pathol. 4:1994;23-36.
19. Hossmann K.-A. Periinfarct depolarizations. Cerebrovasc. Brain Metab. Rev. 8:1996;195-208.
20. Iijima T., Mies G., Hossmann K.-A. Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: effect on volume of ischemic injury. J. Cereb. Blood Flow Metab. 12:1992;727-733.
21. Koroleva V.I., Bures J. The use of spreading depression waves for acute and long-term monitoring of the penumbra zone of focal ischemic damage in rats. Proc. Natl. Acad. Sci. USA. 93:1996;3710-3714.
22. K.S. Lee, The role of calcium-activated proteolysis in ischemic brain injury, in: P.L. Peterson, J.W. Phillis (Eds.), Novel Therapies for CNS Injuries: Rationales and Results, CRC Press, Boca Raton, FL, 1996, pp. 347-361.
23. Lee K.S., Frank S., Vanderklish P., Arai A., Lynch G. Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc. Natl. Acad. Sci. USA. 88:1991;7233-7237.
24. Mehdi S. Cell-penetrating inhibitors of calpain. Trends Biochem. Sci. 16:1991;150-153.
25. 14C]2-deoxyglucose phosphorylation. J. Cereb. Blood Flow Metab. 6:1986;607-615.
26. Ogata N., Yonekawa Y., Taki W. Degradation of neurofilament protein in cerebral ischemia. J. Neurosurg. 70:1989;103-107.
27. Pettigrew L.C., Holtz M.L., Craddock S.D., Minger S.L., Hall N., Geddes J.W. Microtubular proteolysis in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16:1996;1189-1202.
28. Roberts-Lewis J.M., Savage M.J., Marcy V.R., Pinsker L.R., Siman R. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J. Neurosci. 14:1994;3934-3944.
29. Saido T.C., Yokota M., Nagao S., Yamaura I., Tani E., Tsuchiya T., Suzuki K., Kawashima S. Spatial resolution of fodrin proteolysis in postischemic brain. J. Biol. Chem. 268:1993;25239-25243.
30. Seubert P., Lee K.S., Lynch G. Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus. Brain Res. 492:1989;366-370.
31. Siesjo B.K. Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment. J. Neurosurg. 77:1992;337-354.
32. Siesjo B.K., Bengtsson F. Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis. J. Cereb. Blood Flow Metab. 9:1989;127-140.
33. Siesjo B.K., Zhao Q., Pahlmark K., Siesjo P., Katsura K.-I., Folbergrova J. Glutamate, calcium, and free radicals as mediators of ischemic brain damage. Ann. Thorac. Surg. 59:1995;1316-1320.