Glycine protection against hypoxic injury in isolated rat proximal tubules: The role of proteases

Nephrology Dialysis Transplantation

Volumn 12, Issue 12, 1997, Pages 2549-2556

  Tijsen, M J H ^a   Peters, S M A ^a   Bindels, R J M ^a   Van Os, C H ^a   Wetzels, J F M ^a,b  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Calpain; Cell injury; Glycine; Hypoxia; Protease

Indexed keywords

CALPAIN; COUMARIN DERIVATIVE; CYSTEINE PROTEINASE; FLUORESCENT DYE; GLYCINE; LACTATE DEHYDROGENASE; PROTEINASE; SERINE PROTEINASE;

ANIMAL TISSUE; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME RELEASE; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; MALE; MEMBRANE DAMAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

EID: 0030716310     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/12.12.2549     Document Type: Article

References (33)

1. Weinberg JM. The cell biology of ischemic renal injury. Kidney Int 1991; 39: 476-500
2. Weinberg JM, Davis JA, Abarzua M, Rajan T. Cytoprotective effects of glycine and glutathione against hypoxic injury to renal tubules. J Clin Invest 1987; 80: 1446-1454
3. 2-induced injury in rat proximal tubules. Am J Physiol 1993; 264: F94-F99
4. Weinberg JM, Davis JA, Abarzua M, Smith RK, Kunkel R. Ouabain-induced lethal proximal tubule cell injury is prevented by glycine. Am J Physiol 1990; 258: F346-F355
5. Weinberg JM, Davis JA, Abarzua M, Kiani T, Kunkel R. Protection by glycine of proximal tubules from injury due to inhibitors of mitochondrial ATP production. Am J Physiol 1990; 258: C1127-C1140
6. Weinberg JM, Davis JA, Roeser NF, Venkatachalam MA. Role of increased cytosolic free calcium in the pathogenesis of rabbit proximal tubule cell injury and protection by glycine or acidosis. J Clin Invest 1991; 87: 581-590
7. Almeida ARP, Wetzels JFM, Bunnachak D et al. Acute phosphate depletion and in vitro rat proximal tubule injury:protection by glycine and acidosis. Kidney Int 1992; 41: 1494-1500
8. Baines AD, Shaikh N, Ho P. Mechanisms of perfused kidney cytoprotection by alanine and glycine. Am J Physiol 1990; 259: F80-F87
9. Silva P, Rosen S, Spokes K, Epstein FH. Effect of glycine on medullary thick ascending limb injury in perfused kidneys. Kidney Int 1991; 39: 653-658
10. Weinberg JM, Buchanan DN, Davis JA, Abarzua M. Metabolic aspects of protection by glycine against hypoxic injury to isolated proximal tubules. J Am Soc Nephrol 1991; 1: 949-958
11. Weinberg JM, Nissim I, Roeser NF, Davis JA, Schultz S, Nissim IT. Relationships between intracellular amino acid levels and protection against injury to isolated proximal tubules. Am J Physiol 1991; 260: F410-F419
12. Weinberg JM, Davis JA, Abarzua M, Kiani T. Relationship between cell adenosine triphosphate and glutathione content and protection by glycine against hypoxic tubule cell injury. J Lab Clin Med 1989; 113: 612-622
13. Weinberg JM, Davis JA, Roeser NF, Venkatachalam MA. Role of intracellular pH during cytoprotection of proximal tubule cells by glycine or acidosis. J Am Soc Nephrol 1994; 5: 1314-1323
14. Bond JS, Butler PE. Intracellular proteases. Anna Rev Biochem 1987; 56: 333-364
15. Bronk SF, Gores GJ. pH-dependent nonlysosomal proteolysis contributes to lethal anoxic injury of rat hepatocytes. Am J Physiol 1993; 264: G744-G751
16. Ferguson DM, Gores GJ, Bronk SF, Krom RAF. An increase in cytosolic protease activity during liver preservation: inhibition by glutathione and glycine. Transplantation 1993; 55: 627-633
17. Nichols JC, Bronk SF, Mellgren RL, Gores GJ. Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes. Gastroenterology 1994; 106: 168-176
18. Edelstein CL, Wieder ED, Yaqoob MM et al. The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury. Proc Natl Acad Sci USA 1995; 92: 7662-7666
19. Peters SMA, Tijsen MJH, Bindels RJM, van Os CH, Wetzels JFM. Protection against hypoxic injury of rat proximal tubules by felodipine via a calcium-independent mechanism. Pflugers Arch 1995; 431: 20-27
20. Almeida ARP, Bunnachak D, Burnier M, Wetzels JFM, Burke TJ, Schrier RW. Time-dependent protective effects of calcium channel blockers on anoxia- and hypoxia-induced proximal tubule injury. J Pharmacot Exp Ther 1992; 260: 526-532
21. Sasaki T, Kikuchi T, Yumoto N, Yoshimura N, Murashi T. Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occuring peptides and synthetic fluorogenic substrates. J Biol Client 1984; 259: 12489-12494
22. Bergmeyer HU. In: Methods in Enzymatic Analysis. Academic Press, New York, 1974; 574-589
23. Wetzels JFM, Yu L, Wang X, Kribben A, Burke TJ, Schrier RW. Calcium modulation and cell injury in isolated rat proximal tubules. J Pharmacol Exp Ther 1993; 267: 176-180
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275
25. Saido TC, Sorimachi H, Suzuki K. Calpain: new perspectives in molecular diversity and physiological-pathophysiological involvement. FASEB J 1994; 8: 814-822
26. Mellgren RL. Calcium-dependent proteases: an enzyme system active at cellular membranes. FASEB J 1987; 1: 110-115
27. 2+-dependent proteolytic system is critically correlated with the kinetics of differentiation of murine erythroleukemia cells. Eur J Biochem 1994; 225: 173-178
28. Bartus RT, Baker KL, Heiser AD et al. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J Cereb Blood Flow Metab 1994; 14: 537-544
29. Arai A, Vanderklish P, Kessler M, Lee K, Lynch G. A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices. Brain Res 1991; 555: 276-280
30. Lee KS, Frank S, Vanderklish P, Arai A, Lynch G. Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc Natl Acad Sci USA 1991; 88: 7233-7237
31. Salamino F, Sparatore B, Melloni E et al. The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte. Cell Calcium 1994; 15: 28-35
32. Iizuka K, Kawaguchi H, Kitabatake A. Effects of thiol protease inhibitors on fodrin degradation during hypoxia in cultured myocytes. J Mol Cell Cardiol 1993; 25: 1101-1109
33. Suzuki K, Imajoh S, Emori Y, Kawasaki H, Minami Y, Ohno S. Calcium-activated neutral protease and its endogenous inhibitor: activation at the cell membrane and biological function. FEBS Lett 1987; 220: 271-277