Isolation and characterization of cysteine proteinase in thrombotic thrombocytopenic purpura

British Journal of Haematology

Volumn 93, Issue 2, 1996, Pages 421-426

  Kelton, John G ^a   Moore, Jane C ^a   Warkentin, Theodore E ^a   Hayward, Catherine P M ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

calpain; cathepsin L.; thrombotic thrombocytopenic purpura

Indexed keywords

CALPAIN; CATHEPSIN L; CYSTEINE PROTEINASE; THROMBOCYTE ACTIVATING FACTOR;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; PRIORITY JOURNAL; THROMBOCYTOPENIC PURPURA;

EID: 0029923139     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.4891031.x     Document Type: Article

References (18)

1. Adelson, E., Heitzman, E.J. & Fermessey, J.F. (1954) Thrombohemolytic thrombocytopenic purpura. Archives of Internal Medicine, 94, 42-60.
2. Amorosi, E.L. & Ultman, J.K. (1966) TTP: report of 16 cases and review of the literature. Medicine, 45, 139-157
3. Consonni, R., Falanga, A. & Barbui, T. (1994) Further characterization of platelet-aggregating cysteine proteinase activity in thrombotic thrombocytopenic purpura. British Journal of Haematology, 87, 321-324.
4. Crawford, C., Mason, R.W., Wilkstrom, P. & Shaw, E. (1988) The design of peptidyldiazomethane inhibitors to distinguish between cysteine proteinases calpain II. cathepsin L and cathepsin B. Biochemical Journal, 253, 751-758.
5. Falanga, A., Consonni, R., Ruggenenti, P. & Barbui, T. (1991) A cathepsin-like proteinase activity in thrombotic thrombocytopenic purpura. British Journal of Haematology, 79, 474-480.
6. Kelton, J.G., Moore. J.C. & Murphy, W.G. (1987) Studies investigating platelet aggregation and release initiated by sera from patients with thrombotic thrombocytopenic purpura. Blood, 69, 924-928.
7. Kelton, J.G., Moore, J.C., Santos, A. & Sheridan, D. (1984) Detection of a platelet agglutinating factor in thrombotic thrombocytopenic purpura. Annals of Internal Medicine, 101, 589-593.
8. Kelton, J.G., Warkentin, T.E., Hayward, C.P.M., Murphy, W.G. & Moore, J.C. (1992) Calpain activity in patients with thrombotic thrombocytopenic purpura is associated with platelet microparticles. Blood, 80, 2246-2251.
9. Lian, E.C.Y., Harkness, D.R., Byrnes, J.J., Wallach, H. & Wunez, R. (1979) The presence of a platelet aggregating factor in the plasma of patients with thrombotic thrombocytopenic purpura and its inhibition by normal plasma. Blood, 53, 333-338.
10. Mason, R.W., Green, G.D.J. & Barrett, A.J. (1985) Human liver cathepsin L. Biochemical Journal 226, 233-241.
11. Moake, J.L., Rudy, C.K., Troll, J.H., Weistein, M.J., Colannine, N.M., Azocar, J., Seder, R.H., Hong, S.L. & Deykin, D. (1982) Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. New England Journal of Medicine, 307, 1432-1435.
12. Moore, J.C., Murphy, W.G. & Kelton, J.G. (1990) Calpain proteolysis of von Willebrand factor enhances its binding to platelet membrane glycoprotein IIb/IIIa: an explanation for platelet aggregation in thrombotic thrombocytopenic purpura. British Journal of Haematology, 74, 457-464.
13. Murphy, W.G., Moore, J.C., Barr, R.D., Pal, M.K.R. & Kelton, J.G. (1987a) Relationship between platelet aggregating factor and von Willebrand factor in thrombotic thrombocytopenic purpura. British Journal of Haematohgy, 66, 509-513.
14. Murphy, W.G., Moore, J.C. & Kelton, J.G. (1987b) Calcium-dependent cysteine protease activity in the sera of patients with thrombotic thrombocytopenic purpura. Blood, 70, 1683-1687.
15. Samis, J.A., Zboril, G. & Elce, J.S. (1987) Calpain: remains intact and intercellular during platelet activation. Biochemical Journal, 246, 481-488
16. b) on the platelet glycoprotein Ia/IIb complex. British Journal of Haematology, 72, 534-538.
17. Turk, B., Dolec, I., Turk, V. & Bieth, J.G. (1993) Kinetics of the pH inactivation of human cathepsin L. Biochemistry, 32, 375-380.
18. Yoshida, N., Weksler, B. & Nachman, R. (1985) Purification of human platelet calcium-activated protease. Journal of Bioloaical Chemistry, 258, 7168-7174.