Promotion of health by soy isoflavones: Efficacy, benefit and safety concerns

Drug Metabolism and Drug Interactions

Volumn 17, Issue 1-4, 2000, Pages 261-289

  Goldwyn, S ^a   Lazinsky, A ^a   Wei, H ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Cardiovascular disease; Daidzein; Genistein; Isoflavones; Osteoporosis; Phytoestrogens; Soya

Indexed keywords

ANDROSTANOLONE; CATHEPSIN D; CELL DNA; CYCLIC AMP; DAIDZEIN; DIETHYLSTILBESTROL; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTRADIOL; GENISTEIN; HIGH DENSITY LIPOPROTEIN; ISOFLAVONE DERIVATIVE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHYTOESTROGEN; PLATELET DERIVED GROWTH FACTOR; PRASTERONE SULFATE; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; PROTEIN PS2; SEX HORMONE BINDING GLOBULIN; TUMOR NECROSIS FACTOR ALPHA;

ANTINEOPLASTIC ACTIVITY; BLADDER CANCER; BREAST CANCER; CANCER INHIBITION; CANCER PREVENTION; CARDIOVASCULAR DISEASE; COLON CANCER; DRUG EFFICACY; DRUG SAFETY; HUMAN; LUNG CANCER; MELANOMA; MENOPAUSAL SYNDROME; NONHUMAN; OSTEOPOROSIS; PANCREAS CANCER; PROSTATE CANCER; REPRODUCTIVE TOXICITY; REVIEW; SKIN CANCER; SOYBEAN;

EID: 0034522066     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.2000.17.1-4.261     Document Type: Review

References (106)

1. Diet and its preventive role in prostatic disease
2. Mechanisms of action of the soy isoflavone genistein: Emerging role for its effects via transforming growth factor beta signalling pathways
3. The role of soy products in reducing risk of cancer
4. Usual dietary consumption of soyfoods and its correlation with the excretion rate of isoflavanoids in overnight urine samples among Chinese women in Shanghai
5. Antioxidant activities of isoflavones and their biological metabolites in a liposomal system
6. Legumes and soybeans: Overview of their nutritional profiles and health effects
7. Natural and synthetic isoflavones in the prevention of chronic diseases
8. Nutritional applications of dietary photochemicals
9. Clinical Review '97. Potential benefits of the clinical, epidemiological, and mechanistic evidence
10. The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function
11. Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast
12. Epidemiology of soy and cancer: Perspectives and direction
13. Evaluation of the biochemical targets of genistein in tumor cells
14. Genistein arrests cell cycle progression at G2-M
15. Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells
16. In vitro effects of soybean isoflavones
17. Receptor tyrosine kinase inhibition suppresses growth of pediatric renal tumor cells in vitro
18. Effects of protein tyrosine kinase inhibitors with different modes of action on topoisomerase activity and death of IL-2 CTLL-2 cells
19. Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II
20. Phytoestrogens and inhibition of angiogenesis
21. Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A431 cells by genistein
22. In vivo antioxidant activity of genistein in a murine model of singlet oxygen-induced cerebral stroke
23. Effects of soy isoflavones on atherosclerosis: Potential mechanisms
24. Cardiovascular and renal benefits of dry bean and soybean intake
25. Effects of a soy milk supplement on plasma cholesterol levels and oxidative DNA damage in men - A pilot study
26. Selective effects of different antioxidants on oxidation of lipoproteins from rats
27. Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention?
28. Incorporation of esterified soybean isoflavones with antioxidant activity into low density lipoprotein
29. Plant-derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism
30. Activation of mitogen activated protein kinase in human platelets by genistein
31. Dietary soy isoflavones inhibit in-vivo constrictor responses of coronary arteries to collagen-induced platelet activation
32. The effect of dietary soy supplementation on Hot Flushes
33. Phyto-oestrogen excretion and rate of bone loss in postmenopausal women
34. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats
35. Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency
36. Suppressive effect of genistein on rat bone osteoclasts: Involvement of protein kinase inhibition and protein tyrosine phosphatase activation
37. 2+ signaling
38. Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures
39. Anabolic effect of daidzein on cortical bone in tissue culture: Comparison with genistein effect
40. Soy intake and cancer risk: A review of the in vitro and in vivo data
41. Urinary excretion of isoflavonoids and the risk of breast cancer
42. Protection against breast cancer with genistein: A component of soy
43. Effect of intact and isoflavone-depleted soy protein on NMU-induced rat mammary tumorigenesis
44. Dietary genistein: Perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat
45. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis
46. Growth inhibition of human breast cancer cells by herbs and phytoestrogens
47. Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells
48. Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein
49. Tamoxifen and genistein synergistically down-regulate signal transduction and proliferation in estrogen receptor-negative human breast carcinoma MDA-MB-435 cells
50. Phytoestrogens and diseases of the prostate gland
51. Certain aspects of molecular endocrinology that relate to the influence of dietary factors on the pathogenesis of prostate cancer
52. Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study
53. Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells
54. Inhibition of prostate specific antigen expression by genistein in prostate cancer cells
55. Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP
56. p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by isoflavone genistein in human prostate carcinoma cells
57. Decreased growth of human prostate LNCaP tumors in SCID mice fed a low-fat, soy protein diet with isoflavones
58. Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats
59. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice
60. Soyfoods, isoflavones and risk of colonic cancer; a review of the in vitro and in vivo data
61. Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells
62. Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells
63. Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium
64. The potential of soybean foods as a chemoprevention approach for human urinary tract cancer
65. Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis
66. Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression
67. Growth effects of regulatory peptides and intracellular signaling routes in human pancreatic cancer cell lines
68. Activation of MAP kinases in growth responsive pancreatic cancer cells
69. p53-independent apoptosis induced by genistein in lung cancer cells
70. Genistein-induced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line
71. Enhancement of chemosensitivity and programmed cell death by tyrosine kinase inhibitors correlates with EGFR expression in non-small cell lung cancer cells
72. Tumor necrosis factor-alpha stimulates attachment of small cell lung carcinoma to endothelial cells
73. Cancer statistics, 1999
74. Genistein inhibits growth of B16 melanoma cells in vivo and in vitro and promotes differentiation in vitro
75. Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells
76. Soybean isoflavones reduce experimental metastasis in mice
77. Effect of isflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells
78. Nonmelanoma skin cancer in the United States: Incidence
79. Inhibition of tumor promoter-induced hydrogen peroxide production in vitro and in vivo by genistein
80. Antioxidant and antipromotional effects of the soybean isoflavone genistein
81. Inhibition of Fenton reaction and UV light-induced oxidative DNA damage by soybean isoflavone genistein
82. The inhibition of tumor promoter-induced proto-oncogene expression mouse skin by soybean isoflavone genistein
83. Differential expression of p53 and bcl-2 by ultraviolet B and A
84. Effects of dietary gensitein on antioxidant enzyme activities in Sencar mice
85. Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis
86. Photoprotective action of isoflavone genistein: Models, mechanisms, and relevance to clinical dermatology
87. Isoflavone genistein: A potential new agent in dermatology
88. Isoflavone genistein blocks ultraviolet irradiation-induced epidermal growth factor-receptor activation, mitogen-activated protein kinase activity and matrix metalloproteinase gene expression in human skin in vivo
89. Effect of genistein on steroid hormone production in the pregnant rhesus monkey
90. The phytoestrogens coumoestrol and genistein induce structural chromosomal aberrations in cultured human peripheral blood lymphocytes
91. Xeno-oestrogens and phyto-oestrogens induce the synthesis of leukaemia inhibitory factor by human and bovine oviduct cells
92. Phytoestrogens alter adrenocroticoid function: Genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells
93. In vivo toxicity and pharmacokinetic features of B43(anti-CD19)-genistein immunoconjugate
94. Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring
95. Influence of perinatal exposure on the development of MNU-induced mammary carcinoma in female Sprague-Dawley rat
96. Reproductive sequelae in female rats after in utero and neonatal exposure to the phytoestrogen genistein
97. Cytotoxic potential of the phytochemical genistein isoflavone (4′,5′,7-trihydroxyisoflavone) and environmental chemical compounds on testicular cells
98. Tyrosine kinase inhibitors as antiproliferative agents against an estrogen-dependent breast cancer cell line in vitro
99. The anti-proliferative effects of tyrosine kinase inhibitors towards tamoxifen-sensitive and tamoxifen-resistant human breast cancer cell lines in relation to the expression of epidermal growth factor receptors (EGF-R) and the inhibition of EGF-R tyrosine kinase
100. Estrogen synthesis in human colon cancer epithelial cells
101. Enhancement of experimental colon cancer by genistein
102. The effects of phytoestrogens on human pancreatic tumor cells in vitro
103. p53, mutations, and apoptosis in genistein-exposed human lymphoblastoid cells
104. Infantile leukemia and soybeans - A hypothesis
105. Soybean isoflavones, genistein and genistin, inhibit rat myoblast proliferation, fusion and myotube protein synthesis